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公开(公告)号：US12014491B2
公开(公告)日：2024-06-18
申请号：US17271651
申请日：2019-08-28
申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED , NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED, MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY
CPC分类号： G06T7/0012 , A61B6/4411 , A61B6/527 , G06T7/246 , G06T7/38 , G06T11/006 , G06T2207/10028 , G06T2207/10084 , G06T2207/20201 , G06T2207/30012 , G06T2211/408
摘要： A method comprising: receiving a radiographic image dataset representing a sequential radiographic scan of a region of a human subject; receiving three-dimensional (3D) image data representing an optical scan of a surface of said region, wherein said 3D image data is performed simultaneously with said sequential radiographic scan; estimating a time-dependent motion of said subject during said acquisition, relative to a specified position, based, at least in part, on said 3D image data; and using said estimating to determine corrections for said radiographic image dataset, based, at least in part, on a known transformation between corresponding coordinate systems of said radiographic image dataset and said 3D image data.
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公开(公告)号：US11660044B2
公开(公告)日：2023-05-30
申请号：US16884511
申请日：2020-05-27
发明人： Carl Imhauser
IPC分类号： A61B5/00
CPC分类号： A61B5/4585 , A61B5/6835
摘要： An apparatus for evaluating motions of a joint is provided that is designed for determining stability of an anatomical joint. The apparatus includes a support frame, a fixation assembly for securing a first body segment of a joint, and a displacement assembly mounted to the support frame. The fixation assembly includes an axis of rotation moveable relative to the support frame. The displacement assembly includes a first frame pivotably mounted to the support frame and rotatably connected to a first end of the fixation assembly, and a second frame pivotably mounted to the support frame and rotatably connected to a second end of the fixation assembly.
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公开(公告)号：US09579106B2
公开(公告)日：2017-02-28
申请号：US13075378
申请日：2011-03-30
申请人： Darrick Lo , Joseph Lipman , Andrew D. Pearle
发明人： Darrick Lo , Joseph Lipman , Andrew D. Pearle
CPC分类号： A61B17/15 , A61B17/1778 , A61B2017/568 , A61B2034/108
摘要： Patient specific shoulder component implant instruments are described for hemi and total, normal and reverse shoulder arthroplasty.
摘要翻译： 描述患者特殊的肩部组件植入器械用于半身和全身，正常和反向肩关节置换术。
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4.发明授权
公开(公告)号：US6126692A
公开(公告)日：2000-10-03
申请号：US104562
申请日：1998-06-25
CPC分类号： A61F2/389 , A61F2/3886 , A61F2002/30153 , A61F2002/30169 , A61F2002/30176 , A61F2002/30383 , A61F2002/30388 , A61F2002/30481 , A61F2002/305 , A61F2002/30604 , A61F2002/30772 , A61F2002/30777 , A61F2002/30878 , A61F2220/0025 , A61F2230/0019 , A61F2230/0047 , A61F2230/0054
摘要： The present invention provides a tibial prosthetic knee component. The prosthesis includes a tibial tray having a posterior rail and an anterior rail, and a tibial insert. The tibial insert has a posterior dovetailed surface matching the posterior rail in the tibial tray, and an anterior surface matching the anterior rail in the tibial tray. The posterior rail of the tibial tray and the posterior dovetailed surface of the tibial insert are curved to provide clearance for the posterior cruciate ligament. A retaining clip is provided for retaining the tibial insert in the tibial tray. The clip includes a tab which extends through the tray into the insert and a resilient holding member remains unloaded when loads are applied to the knee, reducing the likelihood of dissociation of the tray and insert.
摘要翻译： 本发明提供了一种胫骨假体膝盖部件。 假体包括具有后轨和前轨的胫骨托和胫骨插入物。 胫骨插入物具有与胫骨托中的后轨匹配的后燕尾形表面，以及与胫骨托中的前轨匹配的前表面。 胫骨托的后导轨和胫骨插入物的后部燕尾形表面弯曲，为后十字韧带提供间隙。 提供保持夹以将胫骨插入物保持在胫骨托中。 该夹子包括一个突出部，该突出部通过托盘延伸到插入件中，并且当将负载施加到膝部时，弹性保持件保持卸载，从而降低托盘和插入物的解离的可能性。
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公开(公告)号：US6060474A
公开(公告)日：2000-05-09
申请号：US186452
申请日：1998-11-05
申请人： Riley J. Williams , Jo A. Hannafin
发明人： Riley J. Williams , Jo A. Hannafin
IPC分类号： A61K9/22 , A61K31/497 , A61K31/538 , A61K31/495
CPC分类号： A61K31/497 , A61K31/538
摘要： Disclosed herein are methods for reducing or preventing scar tissue formation by administering an antifibrotic amount of a fluoroquinolone. Also disclosed are means for inhibiting the activity of fibroblast cells, including their proliferation, metabolism, and invasion into tissue. The invention further contemplates methods and compositions for the delivery of a fluoroquinolone to prevent or treat scar tissue formation, including oral and intravenous delivery means.
摘要翻译： 本文公开了通过施用抗纤维化量的氟喹诺酮来减少或预防瘢痕组织形成的方法。 还公开了用于抑制成纤维细胞活性的方法，包括其增殖，代谢和侵入组织。 本发明进一步考虑了用于递送氟喹诺酮以预防或治疗瘢痕组织形成的方法和组合物，包括口服和静脉内输送装置。
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公开(公告)号：US5686116A
公开(公告)日：1997-11-11
申请号：US461724
申请日：1995-06-05
申请人： Richard Bockman , Peter Guidon
发明人： Richard Bockman , Peter Guidon
IPC分类号： A61K9/70 , A61K31/28 , A61K33/06 , A61K33/22 , A61K33/24 , A61K38/40 , A61L26/00 , A61K38/16
CPC分类号： A61K33/22 , A61K31/28 , A61K33/06 , A61K33/24 , A61K38/40 , A61K9/7023 , A61L26/0004
摘要： Tissue and organ repair, healing and augmentation are enhanced by administering pharmaceutically acceptable group IIIa element-containing compounds in amounts sufficient to provide therapeutic levels of the elements. Group IIIa element-containing compounds mimic the beneficial biological effects of endogenous growth factors to induce cells responsible for repair, healing and augmentation of tissues and organs. Group IIIa element-containing compounds are suitable for a variety of applications such as wound healing, bone fracture repair, treatment of dermatologic conditions and successful bonding of implanted tissue grafts and prostheses.
摘要翻译： 通过施用足以提供治疗水平的元件的量的含有药学上可接受的含IIIa族元素的化合物来增强组织和器官修复，愈合和增加。 IIIa族元素化合物模拟内源性生长因子诱导负责组织和器官修复，愈合和增加的细胞的有益生物学效应。 含IIIa族元素的化合物适用于各种应用，例如伤口愈合，骨折修复，皮肤病学治疗和植入组织移植物和假体的成功结合。
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公开(公告)号：US11992517B2
公开(公告)日：2024-05-28
申请号：US16368042
申请日：2019-03-28
IPC分类号： C12N5/077 , A61K9/00 , A61K31/195 , A61K31/675 , A61K31/7076 , A61K31/7088 , A61K31/713 , A61K35/32 , A61K38/19 , A61K38/20 , A61K38/46 , A61K39/00 , A61K45/06 , A61K48/00 , A61L27/36 , A61L27/38 , A61L27/54 , A61L27/58 , A61P19/02 , C07K14/47 , C12N5/10 , C12N15/11 , C12N15/113 , C12N15/55 , C12N15/86
CPC分类号： A61K38/465 , A61K9/0019 , A61K9/0085 , A61K31/195 , A61K31/675 , A61K31/7076 , A61K31/7088 , A61K31/713 , A61K35/32 , A61K38/191 , A61K38/2006 , A61K39/00 , A61K45/06 , A61K48/00 , A61L27/3658 , A61L27/3687 , A61L27/3821 , A61L27/3856 , A61L27/3895 , A61L27/54 , A61L27/58 , C07K14/4702 , C12N5/0655 , C12N15/1138 , C12N15/86 , A61L2300/412 , A61L2300/45 , A61L2300/604 , A61L2300/64 , A61L2400/06 , A61L2430/38 , C12N2310/122 , C12N2310/14 , C12N2310/531 , C12N2320/31 , C12N2320/32 , C12N2501/2301 , C12N2501/73 , C12N2740/16043 , C12Y301/03001 , A61K31/195 , A61K2300/00 , A61K31/675 , A61K2300/00 , A61K31/7076 , A61K2300/00
摘要： This invention relates to compositions and methods for activating and promoting mineralization in tissue that does not normally mineralize, specifically intervertebral discs. The composition comprises agents that increase the expression of the gene that encodes TNAP and/or the activation, amount or activity of TNAP protein, and agents that decrease the expression of ANK and/or ENPP and/or the activation, amount or activity of these proteins. The composition can be in the form of a cell or cells. The invention also relates to methods of using the composition.
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公开(公告)号：US11969265B2
公开(公告)日：2024-04-30
申请号：US16975910
申请日：2019-03-04
申请人： THE MEDICAL COLLEGE OF WISCONSIN, INC. , New York Society for the Relief of the Ruptured and Crippled, Maintaining the Hospital for Special Surgery
发明人： Kevin M. Koch , Andrew S. Nencka , Robin A. Karr , Bradley J. Swearingen , Hollis Potter , Matthew F. Koff
IPC分类号： A61B5/00 , A61B5/055 , G06F18/213 , G06F18/24 , G06N3/045 , G06N3/088 , G06T7/00 , G06T7/11 , G16H30/20 , G16H30/40 , G16H50/20 , G16H50/30 , G16H50/50 , G16H50/70
CPC分类号： A61B5/7267 , A61B5/055 , A61B5/4504 , A61B5/4851 , G06F18/213 , G06F18/24 , G06N3/045 , G06N3/088 , G06T7/0012 , G06T7/11 , G16H30/20 , G16H30/40 , G16H50/20 , G16H50/30 , G16H50/50 , G16H50/70 , A61B2576/02 , G06T2207/10088 , G06T2207/20081 , G06T2207/20084 , G06T2207/30008
摘要： Systems and methods for training and implementing a machine learning algorithm to generate feature maps depicting spatial patterns of features associated with osteolysis, synovitis, or both. MRI data, including multispectral imaging data, are input to the trained machine learning algorithm to generate the feature maps, which may indicate features such as a location and probability of a pathology classification, a severity of synovitis, a type of synovitis, a synovial membrane thickness, and other features associated with osteolysis or synovitis. In some implementations, synovial anatomy are segmented in the MRI data before inputting the MRI data to the machine learning algorithm. These segmented MRI data may be generated using another trained machine learning algorithm.
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公开(公告)号：USD980976S1
公开(公告)日：2023-03-14
申请号：US29788317
申请日：2021-04-30
设计人： Sohrab Virk , Harvinder Sandhu , Sheeraz Qureshi
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10.发明授权Methods of determining disease activity in SLE patients by correlating the level of soluble CD40 ligand 失效通过将可溶性CD40配体水平相关联来确定SLE患者疾病活动的方法
公开(公告)号：US6117642A
公开(公告)日：2000-09-12
申请号：US966123
申请日：1997-11-07
IPC分类号： G01N33/564 , G01N33/569 , G01N33/68 , G01N33/53 , G01N33/536
CPC分类号： G01N33/564 , G01N33/56972 , G01N33/6863 , G01N2333/70578
摘要： The present invention provides diagnostic methods for determining the severity of disease or disease activity in patients suffering from autoimmune, inflammatory, malignant, vascular, or viral diseases, which involves measuring the level of CD40 ligand (CD40L) in the patient's serum or other body fluid.
摘要翻译： 本发明提供用于确定患有自身免疫性，炎症性，恶性，血管性或病毒性疾病的患者的疾病或疾病活动的严重性的诊断方法，其涉及测量患者血清或其他体液中CD40配体（CD40L）的水平 。
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