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公开(公告)号:US20110257888A1
公开(公告)日:2011-10-20
申请号:US12904529
申请日:2010-10-14
Applicant: YASUHIRO OTOMO , MASAKI KOBAYASHI , HIROHIKO KURATSUNE , YASUYOSHI WATANABE
Inventor: YASUHIRO OTOMO , MASAKI KOBAYASHI , HIROHIKO KURATSUNE , YASUYOSHI WATANABE
IPC: G06F19/00
Abstract: The present invention provides a method of determining whether or not a subject is affected with chronic fatigue syndrome (CFS) comprising: measuring, in a biological sample from the subject, an expression level of a transcript of at least one gene respectively from at least two gene groups selected from six specific gene groups; calculating a value representing a deviation of the measured expression level based on an expression level of a transcript of the corresponding gene in a population of healthy subjects; obtaining an average of the value(s) representing a deviation; and determining whether or not the subject is affected with CFS by using the average.
Abstract translation: 本发明提供了一种确定受试者是否受到慢性疲劳综合征(CFS)影响的方法,其包括:在来自受试者的生物样品中测量至少一种基因的转录物的表达水平,所述转录物的至少两种 选自六个特定基因组的基因组; 基于健康受试者群体中相应基因的转录物的表达水平计算表示所测量的表达水平的偏差的值; 获得代表偏差的平均值; 并通过使用平均值确定受试者是否受到CFS的影响。
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公开(公告)号:US20220340646A1
公开(公告)日:2022-10-27
申请号:US17539926
申请日:2021-12-01
Applicant: OSAKA CITY UNIVERSITY , TEIJIN PHARMA LIMITED
Inventor: Hiroshi MORI , Takami TOMIYAMA , Yoichi MATSUMOTO , Hiroshi EGUCHI , Yuichi KUNORI
Abstract: [Summary]
[Purpose] The invention provides a novel therapeutic agent or prophylactic agent for cognitive disorders.
[Solution Means] The invention provides an antibody that participates in antigen-antibody reaction specifically with tau protein that has been phosphorylated in the vicinity of Ser413 of SEQ ID NO: 1, and a therapeutic agent or prophylactic agent for cognitive disorders comprising as an active ingredient a peptide that has been phosphorylated in the vicinity of Ser413.-
公开(公告)号:US10974062B2
公开(公告)日:2021-04-13
申请号:US16311527
申请日:2017-06-21
Inventor: Katsuji Iguchi , Hiroya Sato , Takashi Yoshimoto , Jun Mori , Toshiyuki Ozawa , Kunio Awazu
IPC: A61N5/06
Abstract: The present invention includes: a front-side positive trace (2P) disposed on a flexible substrate (5); a positive external connection line (12P) connected to the front-side positive trace (2P) to supply electric power; and LED chips (4) provided to the flexible substrate (5) and connected to the front-side positive trace (2P), wherein an electric resistance between the positive external connection line (12P) and one of the LED chips (4) which is farthest from the positive external connection line (12P) is less than an internal resistance of the one of the LED chips (4).
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公开(公告)号:US10905341B2
公开(公告)日:2021-02-02
申请号:US15743210
申请日:2016-07-11
Applicant: OSAKA CITY UNIVERSITY
Inventor: Souichi Saeki , Masatsugu Shiba
Abstract: A cancer invasiveness diagnosis system includes an endoscope; a microtomography probe which is introduced into a body cavity together with the endoscope, the microtomography probe emitting a low-coherence light on a target tissue in which a target tumor is present to obtain an optical interference signal; a determination portion which is configured to obtain a tomography image of the target tissue including the target tumor and a blood flow velocity information in a blood vessel in the tomography image based on the optical interference signal, wherein the determination portion is configured to determine the cancer invasiveness of the target tumor based on the tomography image and the blood flow velocity information.
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公开(公告)号:US10765451B2
公开(公告)日:2020-09-08
申请号:US16319908
申请日:2017-07-21
Applicant: OSAKA CITY UNIVERSITY , OZK CO., LTD. , SHINWA SYOJI CO., LTD.
Inventor: Toshihiko Shibata , Haruhiko Yamasaki , Katsunori Mitsuhashi , Yoshiro Morishita
Abstract: A retractor holds a surgical incision in a body in an opened state to ensure a surgical field in small-incision endoscopic surgery, and includes a base body that is a thin plate made of tin having a purity of not less than 99.9% and has an elongated rectangular shape in an extended state of the base body. The retractor, in an extended form in a rectangular shape or in a rounded form in a small shape, can be inserted from a small incision wound into the body, and can easily be delivered to the surgical incision in the body by a surgical instrument. The base body is bent and deformed into a desired shape by the surgical instrument and is applied to the surgical incision in the body, so that the surgical incision can be held in an opened state so as to ensure the surgical field.
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公开(公告)号:US10697004B2
公开(公告)日:2020-06-30
申请号:US15524656
申请日:2015-11-06
Applicant: Osaka City University
Inventor: Akira Tachibana , Toshizumi Tanabe
IPC: C12Q1/6827 , C12N15/09 , C12Q1/68 , G01N33/574 , C12Q1/6806 , C12Q1/6809 , C12Q1/6811 , C12Q1/6851 , C12Q1/6883
Abstract: A method in which a mutant gene present in a gene pool mixedly with a large number of wild-type genes can be simply, inexpensively and sensitively detected is developed and provided. A clamping probe that is connected to a target nucleic acid molecule in two regions of first and second target nucleic acid complementary regions so that a wild-type target nucleic acid molecule and a mutant-type target nucleic acid molecule can be distinguished from each other depending on a difference in complementarity to these target nucleic acid molecules is provided.
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公开(公告)号:US20190085027A1
公开(公告)日:2019-03-21
申请号:US16144266
申请日:2018-09-27
Applicant: NATIONAL UNIVERSITY CORPORATION, IWATE UNIVERSITY , OSAKA CITY UNIVERSITY , IWATE MEDICAL UNIVERSITY EDUCATIONAL FOUNDATION , LOTTE CO., LTD.
Inventor: Koichi SUZUKI , Shinichi ISHIGURO , Mayumi KARIMAZAWA , Makiko EBATA , Piyamas SILLAPAKONG , Takashi HIRAGA , Masaaki TSUSHIMA , Tetsuro SHINADA , Eiji NISHIMURA , Yasuo TERAYAMA , Hideyuki YASUDA
IPC: C07K5/12 , A61K36/062 , C07K5/107 , A61K38/00
Abstract: Provided is a cyclic peptide derivative which is derived from Paecilomyces tenuipes having an astrocyte proliferative activity, or a salt thereof.
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公开(公告)号:US10120001B2
公开(公告)日:2018-11-06
申请号:US14400023
申请日:2013-05-09
Applicant: OSAKA CITY UNIVERSITY
Inventor: Hiroaki Tsujimoto
Abstract: A small-sized power factor measurement apparatus capable of measuring a power factor by one element is desired. The power factor measurement apparatus includes a pair of coupling ends (12) for coupling to a power supply in parallel with a load, two magnetic elements (21, 22) whose changes in electric resistance are different from each other due to the same external magnetic field, a pair of measurement terminals (13) for outputting a differential voltage between the two magnetic elements, a power factor sensor (10) including a pair of sensor terminals (10t) connected to the pair of coupling ends (12), a voltage detector (15) for measuring a voltage between the measurement terminals (13), a low-pass filter (16) connected to the output of the voltage detector (15), a high-pass filter (17) connected to the output of the voltage detector (15), a rectifier (18) connected to the high-pass filter (17), and a divider (19) for dividing the output of the low-pass filter (16) and the output of the rectifier (18).
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公开(公告)号:US20170291921A1
公开(公告)日:2017-10-12
申请号:US15512619
申请日:2015-09-18
Applicant: NATIONAL UNIVERSITY CORPORATION, IWATE UNIVERSITY , OSAKA CITY UNIVERSITY , IWATE MEDICAL UNIVERSITY EDUCATIONAL FOUNDATION , LOTTE CO., LTD.
Inventor: Koichi SUZUKI , Shinichi ISHIGURO , Mayumi KARIMAZAWA , Makiko EBATA , Piyamas SILLAPAKONG , Takashi HIRAGA , Masaaki TSUSHIMA , Tetsuro SHINADA , Eiji NISHIMURA , Yasuo TERAYAMA , Hideyuki YASUDA
IPC: C07K5/12 , A61K36/062
CPC classification number: C07K5/126 , A61K36/062 , A61K38/00 , C07K5/1016
Abstract: Provided is a cyclic peptide derivative which is derived from Paecilomyces tenuipes having an astrocyte proliferative activity, or a salt thereof.
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公开(公告)号:US09642938B2
公开(公告)日:2017-05-09
申请号:US13000838
申请日:2009-06-26
Applicant: Shinya Fukumoto , Hidenori Koyama , Yoshiki Nishizawa , Tsutomu Furuzono , Masahiro Okada
Inventor: Shinya Fukumoto , Hidenori Koyama , Yoshiki Nishizawa , Tsutomu Furuzono , Masahiro Okada
CPC classification number: A61L27/3804 , A61K9/16 , A61K31/74 , A61L27/32 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/414 , A61L2300/426
Abstract: In order to provide (i) a medical composition that has a strong angiogenic effect, has low invasiveness to a body of a patient, and is easy to administer to a living subject and (ii) a medical kit using a medical composition, the medical composition includes: a carrier in a particle form, the carrier having (a) a support made from a bioabsorbable polymer and (b) a surface layer made from hydroxyapatite and provided on the support; and cells provided on a surface of the carrier.
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