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    NASAL DELIVERY DEVICES
    3.
    发明申请
    NASAL DELIVERY DEVICES 有权

    公开(公告)号：US20210290867A1

    公开(公告)日：2021-09-23

    申请号：US17316779

    申请日：2021-05-11

    申请人： OptiNose AS

    发明人： Per Gisle DJUPESLAND ,  Michael LECLERC ,  Ramy A. MAHMOUD ,  Shane SIWINSKI ,  Joseph GORDON ,  Justin FISK

    IPC分类号： A61M15/08 ,  A61M15/00

    摘要： A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece (117) for fitting to a nasal cavity of a subject, a mouthpiece (119) into which the subject in use exhales; a delivery unit, which comprises an actuation part which is manually displaceable to actuate the delivery unit to deliver substance from the nosepiece; and a valve assembly (127) which is fluidly connected to the nosepiece and the mouthpiece, wherein the valve assembly comprises a body element (128) and a valve element (131) which is movably disposed to the body element between closed and open configurations by manual displacement of the actuation part of the delivery unit to provide for an air flow through the nosepiece simultaneously with delivery of substance.

    Nasal Administration
    4.
    发明申请
    Nasal Administration 有权

    公开(公告)号：US20210187216A1

    公开(公告)日：2021-06-24

    申请号：US16939694

    申请日：2020-07-27

    申请人： OptiNose AS

    发明人： Per Gisle Djupesland ,  Roderick Peter Hafner

    IPC分类号： A61M15/08 ,  A61M15/00 ,  A61K31/4045

    摘要： A delivery device for and method of delivering a powdered substance, in particular a triptan, such as sumatriptan, to the posterior region of a nasal cavity of a subject, in particular for the treatment of headaches, for example, cluster headaches and migraine, and neuropathic pain, the delivery device comprising: a nosepiece for insertion into a nasal cavity of a subject through which the powdered substance is delivered to the posterior region of the nasal cavity of the subject, in particular the upper posterior two thirds of the nasal cavity; and a substance supply unit which is operable to deliver the powdered substance through the nosepiece.

    Nasal delivery devices
    5.
    发明授权
    Nasal delivery devices 有权

    公开(公告)号：US10525218B2

    公开(公告)日：2020-01-07

    申请号：US14674103

    申请日：2015-03-31

    申请人： OptiNose AS

    发明人： Per Gisle Djupesland ,  Colin David Sheldrake ,  Simon Smith ,  Rachel Striebig ,  Andy Pidgeon ,  Tom St. Quintin

    IPC分类号： A61M15/08 ,  A61M15/00 ,  A61M16/10

    摘要： A nasal delivery device for and method of delivering particulate substance to the nasal airway of a subject. The delivery device includes a body assembly including a mouthpiece unit which includes a mouthpiece through which the subject in use exhales, and a substance-supply unit which is fluidly connected to the mouthpiece unit and actuatable to provide particulate substance for delivery to the nasal airway of the subject. The body assembly is configured to receive a replaceable nosepiece unit which includes a nosepiece and contains a container containing particulate substance.

    Delivery Device and Method
    7.
    发明授权
    Delivery Device and Method 有权
    交付设备和方法

    公开(公告)号：US09566402B2

    公开(公告)日：2017-02-14

    申请号：US14822404

    申请日：2015-08-10

    申请人： OptiNose AS

    发明人： Per Gisle Djupesland

    IPC分类号： A61N1/30 ,  A61M15/00 ,  A61M15/08 ,  A61M16/04 ,  A61M16/00

    CPC分类号： A61M15/0098 ,  A61M15/0021 ,  A61M15/009 ,  A61M15/0091 ,  A61M15/08 ,  A61M16/0434 ,  A61M16/0493 ,  A61M16/0495 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2202/064 ,  A61M2202/30 ,  A61M2210/065

    摘要： A delivery device for and method of delivering substance, in particular a vaccine, to a mucosal surface within the oral cavity of a subject, the device comprising: a mouthpiece unit to be gripped in the mouth of a subject, wherein the mouthpiece unit is configured such that, on exhalation or attempted exhalation by the subject, a pressure is developed in the oral cavity which is such as to close the oropharyngeal velum of the subject; and an oral outlet unit including at least one outlet from which substance is in use delivered to a mucosal surface within the oral cavity of the subject.

    摘要翻译： 用于将物质特别是疫苗递送到受试者的口腔内的粘膜表面的递送装置和方法，所述装置包括：待夹持在受试者口腔中的接口单元，其中所述接口单元被配置 使得在受试者的呼气或尝试呼气时，在口腔中产生压力以使得关闭受试者的口咽膜; 以及包括至少一个出口的口腔出口单元，所述至少一个出口被用于将物质运送到受试者口腔内的粘膜表面。