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    Fiberoptic assembly useful in optical spectroscopy
    3.
    发明授权
    Fiberoptic assembly useful in optical spectroscopy 失效
    光纤组件可用于光谱学

    公开(公告)号：US6006001A

    公开(公告)日：1999-12-21

    申请号：US982332

    申请日：1997-12-02

    申请人： Robert R. Alfano ,  Stavros G. Demos ,  Gang Zhang

    发明人： Robert R. Alfano ,  Stavros G. Demos ,  Gang Zhang

    IPC分类号： A61B5/00 ,  G02B6/04 ,  G02B6/24

    CPC分类号： G02B6/241 ,  A61B5/0059 ,  G02B6/04

    摘要： A fiberoptic assembly for optical spectroscopic analysis of a sample. In a preferred embodiment, the assembly is well-suited for use inside the working channel of an endoscope and comprises a tubular outer jacket and a tubular inner jacket, the inner jacket being coaxial with and positioned inside the outer jacket. The open front end of the inner jacket is spaced rearwardly a short distance relative to the open front end of the outer jacket. The outer jacket has an outer diameter of approximately 2.2 mm. The assembly also includes a plug made of fused silica. The plug has a front cylindrical portion of comparatively large cross-sectional diameter and a rear cylindrical portion of comparatively small cross-sectional diameter. The front portion is mounted within the outer jacket by a friction-fit and extends longitudinally from the open front end thereof to the open front end of the inner jacket. The rear portion of the plug is mounted within the inner jacket by a friction-fit and extends rearwardly from its open front end for a short distance. A narrow-band filter in the form of a dielectric-coating is formed on the rear end of the rear portion of the plug. The assembly also includes an illumination fiber centered within the inner jacket and spaced rearwardly a short distance from the narrow-band filter. The output end of the illumination filter is shaped to collimate light emergent therefrom. The assembly additionally comprises a plurality of light collection fibers, which fibers are disposed within the outer tubular jacket and are spaced about the outside of the inner tubular jacket.

    摘要翻译： 用于光谱分析样品的光纤组件。 在优选实施例中，该组件非常适合于在内窥镜的工作通道内部使用，并且包括管状外护套和管状内护套，内护套与外护套同轴并位于外护套内。 内护套的开放前端相对于外护套的敞开前端向后隔开一短距离。 外护套的外径约为2.2mm。 组件还包括由熔融石英制成的塞子。 插头具有比较大的横截面直径的前圆柱形部分和相对较小横截面直径的后圆柱形部分。 前部通过摩擦配合安装在外护套内，并从其敞开的前端纵向延伸到内护套的敞开的前端。 插头的后部通过摩擦配合安装在内护套内，并从其敞开的前端向后延伸短距离。 在插头后部的后端形成电介质涂层形式的窄带滤波器。 该组件还包括以内护套为中心并与窄带过滤器相隔一定距离的照明纤维。 照明滤光器的输出端被成形为使从其出射的光准直。 组件还包括多个聚光纤维，该纤维布置在外部管状护套内并且围绕内部管状护套的外部间隔开。

    Method and system for examining biological materials using low power CW excitation raman spectroscopy
    4.
    发明授权
    Method and system for examining biological materials using low power CW excitation raman spectroscopy 失效

    公开(公告)号：US6151522A

    公开(公告)日：2000-11-21

    申请号：US270383

    申请日：1999-03-16

    申请人： Robert R. Alfano ,  Wubao Wang

    发明人： Robert R. Alfano ,  Wubao Wang

    IPC分类号： A61B5/00 ,  G01J3/44 ,  G01N21/65 ,  A61B6/00

    CPC分类号： A61B5/0075 ,  A61B5/0084 ,  A61B5/4312 ,  G01J3/44 ,  G01N21/65 ,  A61B5/0086

    摘要： A method and system for examining biological materials using low-power cw excitation Raman spectroscopy. In accordance with the teachings of the invention, a low-power continuous wave (cw) pump laser beam and a low-power cw Stokes (or anti-Stokes) probe laser beam simultaneously illuminate a biological material and traverse the biological material in collinearity. The pump beam, whose frequency is varied, is used to induce Raman emission from the biological material. The intensity of the probe beam, whose frequency is kept constant, is monitored as it leaves the biological material. When the difference between the pump and probe excitation frequencies is equal to a Raman vibrational mode frequency of the biological material, the weak probe signal becomes amplified by one or more orders of magnitude (typically up to about 10.sup.4 -10.sup.6) due to the Raman emission from the pump beam. In this manner, by monitoring the intensity of the probe beam emitted from the biological material as the pump beam is varied in frequency, one can obtain an excitation Raman spectrum for the biological material tested. The present invention may be applied to in the in vivo and/or in vitro diagnosis of diabetes, heart disease, hepatitis, cancers and other diseases by measuring the characteristic excitation Raman lines of blood glucose, cholesterol, serum glutamic oxalacetic transaminase (SGOT)/serum glutamic pyruvic tansaminase (SGPT), tissues and other corresponding Raman-active body constituents, respectively. For example, it may also be used to diagnose diseases associated with the concentration of Raman-active constituents in urine, lymph and saliva It may be used to identify cancer in the breast, cervix, uterus, ovaries and the like by measuring the fingerprint excitation Raman spectra of these tissues. It may also be used to reveal the growing of tumors or cancers by measuring the levels of nitric oxide in tissue.

    Composition and methods using myelin-associated glycoprotein (MAG) and inhibitors thereof
    5.
    发明授权
    Composition and methods using myelin-associated glycoprotein (MAG) and inhibitors thereof 失效
    使用髓磷脂相关糖蛋白（MAG）及其抑制剂的组合物和方法

    公开(公告)号：US5932542A

    公开(公告)日：1999-08-03

    申请号：US670511

    申请日：1996-06-27

    申请人： Marie T. Filbin

    发明人： Marie T. Filbin

    IPC分类号： C12Q1/02 ,  A61K31/70 ,  A61K31/7012 ,  A61K31/715 ,  A61K38/00 ,  A61K38/17 ,  A61K45/00 ,  A61P25/00 ,  C07H7/027 ,  C07K14/705 ,  A61K38/02 ,  A61K39/395

    CPC分类号： A61K31/7016 ,  A61K38/1709 ,  C07K14/70503 ,  C07K2319/00

    摘要： This invention relates to the novel identification of myelin-associated glycoprotein ("MAG") as a potent inhibitor of neural regeneration. More particularly, this invention relates to compositions and methods useful for reversing inhibition of neural regeneration in the central and peripheral nervous system. Assays to monitor the effects of MAG on neural regeneration and to identify agents which will block or promote the inhibitory effects of MAG on neural outgrowth are provided. Screening methods for identifying such agents are also provided. This invention also relates to compositions and methods using agents that can reverse the inhibitory effects of MAG on neural regeneration. Methods for regulating and for promoting neural growth or regeneration in the nervous system, methods for treating injuries or damage to nervous tissue or neurons, and methods for treating neural degeneration associated with disorders or diseases, comprising the step of administering at least one of the compositions according to this invention are provided.

    摘要翻译： 本发明涉及髓鞘相关糖蛋白（“MAG”）作为神经再生的有效抑制剂的新鉴定。 更具体地，本发明涉及可用于逆转中枢和周围神经系统神经再生抑制的组合物和方法。 提供了监测MAG对神经再生的影响的测定，并且确定将阻断或促进MAG对神经生长的抑制作用的药剂。 还提供了用于鉴定这种试剂的筛选方法。 本发明还涉及使用能够逆转MAG对神经再生的抑制作用的试剂的组合物和方法。 用于调节和促进神经系统中的神经生长或再生的方法，治疗神经组织或神经元的损伤或损伤的方法，以及用于治疗与疾病或疾病相关的神经变性的方法，包括施用至少一种组合物 根据本发明。

    Systems and methods for non-destructively detecting material abnormalities beneath a coated surface
    7.
    发明申请
    Systems and methods for non-destructively detecting material abnormalities beneath a coated surface 失效
    用于非破坏性地检测涂层表面下的材料异常的系统和方法

    公开(公告)号：US20030229458A1

    公开(公告)日：2003-12-11

    申请号：US10455662

    申请日：2003-06-05

    申请人： RESEARCH FOUNDATION OF CUNY

    发明人： Robert R. Alfano ,  Iosif Zeylikovich ,  Wubao Wang ,  Jamal Ali ,  Yury Budansky

    IPC分类号： G01B005/28

    CPC分类号： G01N21/88 ,  G01N21/8422 ,  G01N2021/889 ,  G01N2021/8918

    摘要： The present invention provides systems and methods for non-destructively detecting material abnormalities beneath a coated surface, comprising a mid-infrared (MIR) detection unit for illuminating an area of the coated surface and detecting light reflected from the illuminated area of the coated surface, and a processing unit for producing an image from optical characteristics received from the MIR detection unit. In addition, the system may further comprise a scanning unit for moving the MIR detection unit to a next area.

    摘要翻译： 本发明提供用于非破坏性地检测涂覆表面下方的材料异常的系统和方法，包括用于照射涂覆表面的区域并检测从涂覆表面的被照射区域反射的光的中红外（MIR）检测单元， 以及处理单元，用于从从MIR检测单元接收的光学特性产生图像。 另外，该系统还可以包括用于将MIR检测单元移动到下一个区域的扫描单元。

    Superimposing optical transmission modes
    8.
    发明授权
    Superimposing optical transmission modes 有权
    叠加光传输模式

    公开(公告)号：US08965217B2

    公开(公告)日：2015-02-24

    申请号：US13803872

    申请日：2013-03-14

    申请人： Corning Incorporated

    发明人： Daniel A. Nolan ,  Giovanni Milione ,  Robert R. Alfano

    IPC分类号： H04B10/12 ,  H04B10/2569 ,  H04B10/2581 ,  H04J14/04 ,  H04B10/079

    CPC分类号： H04B10/2569 ,  H04B10/0795 ,  H04B10/0799 ,  H04B10/2581 ,  H04J14/04

    摘要： A method of superimposing N optical transmission modes for collective transmission along a multimode optical fiber is provided where each of the N optical signals comprises N distinct superimposed transmission modes (M1, M2, . . . ) and a portion of each of the N propagating optical signals is sampled at a receiving end of the data transmission network. N2−1 distinct measurement conditions are derived from a transmission matrix T and a special unitary matrix group SU(N) corresponding to the superimposed transmission modes (M1, M2, . . . ) at the receiving end of the data transmission network and N2−1 measurements are extracted from the sampled signals. The extracted N2−1 measurements are used to solve a matrix equation corresponding to the generated SU(N) matrices and the output matrix transposed and used to generating principal state launch conditions from the eigenvectors of the transposed output matrix to form a principal state in each of the N optical signals.

    摘要翻译： 提供了一种叠加用于沿着多模光纤的集体传输的N个光传输模式的方法，其中每个N个光信号包括N个不同的叠加传输模式（M1，M2 ...）和N个传播光纤 在数据传输网络的接收端采样信号。 N2-1不同的测量条件从传输矩阵T和对应于在数据传输网络接收端的叠加传输模式（M1，M2 ...）的特殊酉矩阵组SU（N）导出，N2- 从采样信号中提取1个测量值。 提取的N2-1测量用于求解与生成的SU（N）矩阵相对应的矩阵方程和转置的输出矩阵，并用于从转置的输出矩阵的特征向量产生主状态发射条件，以在每个状态中形成主状态 的N个光信号。