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公开(公告)号：US20230096151A1
公开(公告)日：2023-03-30
申请号：US17936340
申请日：2022-09-28
发明人： Dean Michael Karantonis , Robert Bruce Gorman , Matthew Marlon Williams , Samuel Nicholas Gilbert , Milan Obradovic
摘要： Disclosed is an implantable device for lead offset determination, comprising first and second electrode leads. A stimulus is delivered from one lead to tissue, and a signal is sensed from the tissue by the other lead. The sensed signal is processed to produce a measure of a stimulus artefact present in the signal. The stimulus artefact measure is used to produce a measure of an offset between the first electrode lead and the second electrode lead, such as by applying a distance-squared. analytical model to measures of stimulus artefact obtained from at least two sense electrodes. And/or, a compound action potential evoked by the stimulus is sensed from neural tissue, a latency of the evoked compound action potential is measured, and a measure of an offset between the first electrode lead and the second electrode lead is produced from the latency.
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公开(公告)号：US11420064B2
公开(公告)日：2022-08-23
申请号：US17478793
申请日：2021-09-17
发明人： John Louis Parker , James Hamilton Wah , Dean Michael Karantonis , Milan Obradovic , Robert Bruce Gorman
摘要： A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.
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公开(公告)号：US20210387004A1
公开(公告)日：2021-12-16
申请号：US17287419
申请日：2019-10-23
发明人： Peter SINGLE , Dean KARANTONIS
摘要： This disclosure relates to implantable neuro stimulation devices with a feedback loop to control an amount of energy delivered into a neural tissue based on a measured evoked neural response. Stimulation electrodes deliver stimulation energy to neural tissue and a stimulator comprises a microprocessor and program memory with program code, which causes the microprocessor to perform closed-loop control of the stimulation energy based on a feedback signal that is indicative of an evoked neural response. A charge monitor monitors the delivery of energy to the stimulation electrodes by determining an amount of charge delivered by the stimulation electrodes and connected to the stimulator to provide a status signal indicative of the charge delivered to the stimulator. The device adjusts the control of the stimulation energy in response to the status signal from the charge monitor indicating undesirable charge delivery to the stimulation electrodes.
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公开(公告)号：US20210268293A1
公开(公告)日：2021-09-02
申请号：US17255916
申请日：2019-06-26
摘要： An implantable neural stimulation device (101) having a body (103) containing stimulation electronics (105) and a battery (107). The device (101) has a first header (109) and a second header (117) that are respectively coupled to the body (103). In some examples the first header (109) contains a charge coil (111) and a connector (113) for stimulation leads (115) and the second header (117) contains a communication antenna (119). There is also disclosed a method of manufacturing an implantable neural stimulation device.
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公开(公告)号：US20210008373A1
公开(公告)日：2021-01-14
申请号：US16969886
申请日：2019-02-15
发明人： Peter SINGLE , James LAIRD
摘要： This disclosure relates to a device for applying a neural stimulus. A battery supplies electrical energy at a battery voltage and an electrode applies the electrical energy to neural tissue. A circuit measures the nervous response of the tissue and a voltage converter receives the electrical energy from the battery and controls a voltage applied to the electrode based on the measured nervous response of the tissue. This direct voltage control is energy efficient because losses across a typical current mirror are avoided. Further, the control based on the measured nervous response leads to automatic compensation of impedance variation due to in-growth or change in posture. As a result, the stimulation results in a desired neural response.
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公开(公告)号：US09872990B2
公开(公告)日：2018-01-23
申请号：US14844929
申请日：2015-09-03
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/36071 , A61N1/36167
摘要： A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.
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公开(公告)号：US08923984B2
公开(公告)日：2014-12-30
申请号：US12549899
申请日：2009-08-28
申请人： John L. Parker , David Robinson
发明人： John L. Parker , David Robinson
CPC分类号： A61N1/05 , A61M25/0009 , A61N1/0472 , A61N1/0484 , A61N1/0529 , A61N1/375
摘要： An active implantable medical device (AIMD). The AIMD comprises an electronics module; and a knitted electrode assembly comprising: at least one biocompatible, electrically non-conductive filament arranged in substantially parallel rows each stitched to an adjacent row, and at least one biocompatible, electrically conductive filament intertwined with the at least one non-conductive filament, and configured to be electrically connected to the electronics module.
摘要翻译： 主动植入式医疗器械（AIMD）。 AIMD包括电子模块; 以及针织电极组件，其包括：至少一个生物相容的，不导电的细丝，其布置成大致平行的行，每个线缝合到相邻的行，以及与所述至少一个非导电细丝缠结的至少一个生物相容的导电细丝，以及 被配置为电连接到电子模块。
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公开(公告)号：US20140288577A1
公开(公告)日：2014-09-25
申请号：US14359777
申请日：2012-11-23
发明人： David Robinson , Mark Fretz , David Thomas , John Louis Parker
IPC分类号： A61N1/05
CPC分类号： A61N1/0553 , Y10T29/49208
摘要： An electrode assembly for an active implantable medical device can be delivered by catheter but expands to become a paddle electrode once implanted. The electrode assembly comprises a support member carrying wires for electrically connecting a control unit to electrodes of the electrode assembly. At least one, and usually two resilient deformable paddle wings are mounted to the support member. The paddle wings can be furled close to the support member under a deformation force to permit implantation via an introducer. The paddle wings resiliently unfurl away from the support member upon release of the deformation force. The paddle wings bear rows and columns of electrodes, and the electrode assembly as a whole has sufficient longitudinal rigidity for implantation via an introducer.
摘要翻译： 用于有源可植入医疗装置的电极组件可以通过导管输送，但一旦植入就膨胀成桨电极。 电极组件包括承载用于将控制单元电连接到电极组件的电极的导线的支撑构件。 至少一个并且通常两个弹性变形的桨翼安装到支撑构件上。 桨翼可以在变形力下靠近支撑构件进行折叠，以允许通过导引器进行植入。 在释放变形力时，桨翼在支撑构件上弹性地展开。 桨翼承载行和列的电极，并且电极组件作为整体具有足够的纵向刚度用于通过导引器进行植入。
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公开(公告)号：US12121715B2
公开(公告)日：2024-10-22
申请号：US16489642
申请日：2018-03-01
IPC分类号： A61N1/04 , A61N1/05 , A61N1/375 , B29C64/118 , B29C64/245 , B29C64/295 , B32B3/30 , B32B7/12 , B32B37/12 , B33Y10/00 , B33Y30/00 , B33Y50/02 , B33Y80/00 , H01B1/00 , H05K3/12
CPC分类号： A61N1/0488 , A61N1/05 , B29C64/118 , B29C64/245 , B29C64/295 , B32B3/30 , B32B7/12 , H01B1/00 , H05K3/1241 , A61N1/3752 , B32B2037/1253 , B33Y10/00 , B33Y30/00 , B33Y50/02 , B33Y80/00
摘要： A method (100) of manufacturing a lead for an implantable medical device. The method includes: depositing (110) a base layer (3) of biocompatible, electrically non-conductive material; depositing (120) one or more complementary layers (5) of biocompatible, electrically non-conductive material to the base layer (3), wherein the base layer (3) and complementary layer (5) form at least one slot (7); and depositing (130) biocompatible, electrically conductive material (9) into the slot (7). There is also disclosed a lead for an implantable medical device and an apparatus (41) to manufacture the lead.
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公开(公告)号：US12102827B2
公开(公告)日：2024-10-01
申请号：US17285407
申请日：2019-10-23
发明人： Peter Single , Dean Karantonis , Robert Gorman , Milan Obradovic , Ivan Guelton , Michael Narayanan
CPC分类号： A61N1/36139 , A61N1/025 , A61N1/0551 , A61N1/16 , A61N1/36125 , H02J50/10
摘要： This disclosure relates to implantable neuro stimulation devices with a feedback loop to control an amount of energy delivered into a neural tissue based on a measured evoked neural response. Stimulation electrodes deliver stimulation energy to neural tissue. A microprocessor performs closed-loop control of the stimulation energy based on a feedback signal that is indicative of an evoked neural response. A supervisor is connected to the feedback signal and detects malfunction of the stimulator based on the feedback signal. The supervisor is also connected to the stimulator to provide a status signal to the stimulator and changes the status signal to indicate malfunction upon detecting malfunction based on the feedback signal. The microprocessor adjusts the control of the stimulation energy in response to the status signal from the supervisor indicating malfunction.
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