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    Illudin Analogs Useful as Anticancer Agents
    2.
    发明申请
    Illudin Analogs Useful as Anticancer Agents 有权
    Illudin类似物作为抗癌剂有用

    公开(公告)号：US20080306147A1

    公开(公告)日：2008-12-11

    申请号：US11997432

    申请日：2006-08-03

    申请人： Trevor C. McMorris ,  Michael J. Kelner

    发明人： Trevor C. McMorris ,  Michael J. Kelner

    IPC分类号： A61K31/27 ,  C07C275/04 ,  A61K31/17 ,  A61P35/00 ,  C07C335/02 ,  C07C271/06

    CPC分类号： C07C275/26 ,  C07C2603/97

    摘要： Acylfulvene analogs, which inhibit tumor growth, especially solid tumor growth, and which have an adequate therapeutic index to be effective for in vivo treatment are provided herein. The compounds described herein are useful as anti-neoplastic agents, i.e., to inhibit tumor cell growth in vitro or in vivo, in mammalian hosts, such as humans or animals, e.g., domestic animals, and are effective against solid tumors, hematologic malignancies and multi-drug resistant cancers/tumors. The present compounds can be used alone or they can be used in combination with one or more anti-cancer or anti-tumor agents.

    摘要翻译： 本文提供了抑制肿瘤生长，特别是实体瘤生长的，具有足够的治疗指数以有效体内治疗的酰基类似物。 本文所述的化合物可用作抗肿瘤剂，即在体内或体内抑制哺乳动物宿主例如人或动物（例如家畜）中的肿瘤细胞生长，并且可有效抵抗实体瘤，血液恶性肿瘤和 多药耐药性癌症/肿瘤。 本发明化合物可以单独使用，也可以与一种或多种抗癌剂或抗肿瘤剂组合使用。

    Therapeutic platelets and methods
    3.
    发明申请
    Therapeutic platelets and methods 审中-公开
    治疗性血小板和方法

    公开(公告)号：US20060223050A1

    公开(公告)日：2006-10-05

    申请号：US10567593

    申请日：2004-08-06

    申请人： John Crowe ,  Fern Tablin ,  Willem Wolkers ,  Naomi Walker ,  Joong-Hyuck Auh ,  Minke Tang ,  Sheri Looper

    发明人： John Crowe ,  Fern Tablin ,  Willem Wolkers ,  Naomi Walker ,  Joong-Hyuck Auh ,  Minke Tang ,  Sheri Looper

    IPC分类号： A01N1/02 ,  C12N5/08 ,  C12N5/00

    CPC分类号： A01N1/0221 ,  A01N1/02

    摘要： The invention provides methods for loading a preservative into blood platelets comprising providing a preservative solution having a preservative, water and protein, and loading blood platelets with the preservative solution to produce preservative-loaded blood platelets having the preservative solution generally including higher glass transition temperatures than glass transition temperatures for a preservative solution having the preservative, water and no protein. A process for processing blood platelets comprising suspending blood platelets in a preservative solution at a concentration greater than about 108 platelets per ml. of preservative solution to produce preservative-loaded blood platelets, freeze-drying the preservative-loaded blood platelets, and recovering at least 75% of the freeze died platelets. A platelet composition comprising blood platelets loaded with a preservative solution having a preservative, water, and protein, and generally further having higher glass transition temperatures than glass transition temperatures for blood platelets loaded with the preservative, water, but no protein.

    摘要翻译： 本发明提供了将防腐剂装载到血小板中的方法，其包括提供具有防腐剂，水和蛋白质的防腐剂溶液，并将血小板与防腐剂溶液加载以产生具有防腐剂溶液的血小板，所述血小板具有通常包含较高玻璃化转变温度 具有防腐剂，水和无蛋白质的防腐溶液的玻璃化转变温度。 一种处理血小板的方法，包括以大于约108个血小板/ ml的浓度将血小板悬浮在防腐溶液中。 的防腐溶液以产生防腐剂血小板，冷冻干燥载有防腐剂的血小板，并回收至少75％的冷冻死亡血小板。 一种血小板组合物，其包含负载有防腐剂，水和蛋白质的防腐溶液的血小板，并且通常进一步具有比装有防腐剂，水但不含蛋白质的血小板的玻璃化转变温度更高的玻璃化转变温度。

    Supported group-4, group-5, and group-6 metal clusters, preparation of the material and use of the material as a catalyst
    4.
    发明申请
    Supported group-4, group-5, and group-6 metal clusters, preparation of the material and use of the material as a catalyst 审中-公开
    支持的第4族，第5族和第6族金属簇，材料的制备和材料的使用作为催化剂

    公开(公告)号：US20060160694A1

    公开(公告)日：2006-07-20

    申请号：US11292787

    申请日：2005-12-01

    申请人： Sailendra Nemana ,  Bruce Gates

    发明人： Sailendra Nemana ,  Bruce Gates

    IPC分类号： B01J29/04 ,  B01J27/187 ,  B01J23/00 ,  B01J29/87 ,  B01J27/14 ,  C07F9/00

    CPC分类号： C07C6/10 ,  B01J21/08 ,  B01J31/12 ,  B01J31/122 ,  B01J35/002 ,  B01J37/0203 ,  B01J37/0209 ,  B01J37/18 ,  C07B2200/11 ,  C07C2523/16 ,  C07F9/00

    摘要： A method of forming supported group 4, and/or 5, and/or 6 metal clusters, which may be used as a catalyst for alkane reactions. The method includes combining a solid support and a precursor compound of group 4, 5, or 6 metals, or precursor compounds of group 4, and/or 5, and/or 6 metals, or a precursor compound of a combination of group 4, 5, and/or 6 metals, and combinations thereof; and optionally treating the combination to form the supported group 4, and/or 5, and/or 6 clusters. The material formed by the combination of the precursor or precursors with a solid support following an optional treatment can be used as a catalyst for disproportionation of alkanes and/or conversion of one or more alkanes with another alkane or other alkanes by contacting the material with the alkanes.

    摘要翻译： 形成负载基团4和/或5和/或6个金属簇的方法，其可用作烷烃反应的催化剂。 该方法包括将固体支持物与组4,5或6金属的前体化合物或第4族，/或5种和/或6种金属的前体化合物或组4的组合的前体化合物， 5和/或6种金属及其组合; 并任选地处理组合以形成被支持的基团4，和/或5和/或6个簇。 通过前体或前体与固体支持物的组合在任选处理之后形成的材料可以用作烷烃歧化和/或一种或多种烷烃与另一种烷烃或其它烷烃的转化的催化剂，通过使材料与 烷烃

    Receptor-binding cyclic peptides and methods of use
    5.
    发明申请
    Receptor-binding cyclic peptides and methods of use 审中-公开
    受体结合环肽和使用方法

    公开(公告)号：US20060029544A1

    公开(公告)日：2006-02-09

    申请号：US11198884

    申请日：2005-08-05

    申请人： Julie Sutcliffe-Goulden ,  John Marshall ,  Mark Howard ,  Michael O'Doherty

    发明人： Julie Sutcliffe-Goulden ,  John Marshall ,  Mark Howard ,  Michael O'Doherty

    IPC分类号： A61K51/00 ,  C07K7/64

    CPC分类号： C07K1/006 ,  A61K51/082 ,  A61K51/088 ,  C07K1/04 ,  C07K7/64

    摘要： The present invention provides novel receptor-binding cyclic peptides that advantageously display high receptor binding affinity and selectively. More particularly, the present invention provides integrin-binding cyclic peptides containing an integrin-binding motif such as an RGD motif, an aromatic amino acid such as a tyrosine residue, and a lysine residue having a pi-pi stacking moiety conjugated to its ε-amino group. Methods for identifying receptor-binding cyclic peptides and for using the cyclic peptides of the present invention for imaging a tumor, organ, or tissue and for treating cancer, inflammatory diseases, and autoimmune diseases are also provided.

    摘要翻译： 本发明提供了有利地显示高受体结合亲和力和选择性的新的受体结合环肽。 更具体地，本发明提供了整合素结合的环肽，其含有整联蛋白结合基序，例如RGD基序，芳族氨基酸例如酪氨酸残基，以及赖氨酸残基，其具有与其ε- 氨基。 还提供了用于鉴定受体结合环肽和使用本发明的环肽来成像肿瘤，器官或组织以及用于治疗癌症，炎性疾病和自身免疫性疾病的方法。

    Open circuit potential amperometry and voltammetry
    8.
    发明申请
    Open circuit potential amperometry and voltammetry 失效
    开路电位电流分析法和伏安法

    公开(公告)号：US20020180446A1

    公开(公告)日：2002-12-05

    申请号：US10098996

    申请日：2002-03-14

    申请人： The Regents of the University of California Office of Technology Transfer

    发明人： Werner Kuhr ,  David Bocian ,  Jonathan S. Lindsey ,  Kristian A. Roth

    IPC分类号： G01N027/416

    CPC分类号： B82Y30/00 ,  B82Y10/00 ,  G01N27/3277

    摘要： This invention provides approaches to improve the signal to noise ratio (S/N) in electrochemical measurements (e.g. amperometry, voltammetry, etc.). In particular, a method is described wherein the faradaic current is temporally dissociated from the charging current associated with reading the charge of a redox-active species (e.g. a self-assembled monolayer (SAM)). This method, designated herein as open circuit potential amperometry (OCPA), quantitatively reads the charge of the redox species bound to (electrically coupled to) an electrode surface, while discriminating against both charging current(s) and amperometric signal(s) that arise, e.g. from diffusion-based species in solution.

    摘要翻译： 本发明提供了改善电化学测量（例如电流分析法，伏安法等）中的信噪比（S / N）的方法。 特别地，描述了一种方法，其中法拉第电流与读取氧化还原活性物质（例如自组装单层（SAM））的电荷相关的充电电流暂时解离。 该方法在本文中指定为开路电位电流分析法（OCPA），定量地读取结合到（电耦合到）电极表面的氧化还原物质的电荷，同时区分出现的充电电流和电流测量信号 ，例如 从溶液中的基于扩散的物种。