公开(公告)号：US20190064166A1

公开(公告)日：2019-02-28

申请号：US15752230

申请日：2016-08-12

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Jonathan BARASCH ,  Katherine XU ,  Paul ROSENSTIEL ,  Paolo GUARNIERI

IPC分类号： G01N33/573 ,  G01N33/68 ,  G01N33/70

摘要： The present invention provides methods for treatment of volume-dependent Acute Kidney Injury (vAKI) and ischemic Acute Kidney Injury (iAKI), as well as methods for diagnosing vAKI and iAKI. The methods are based on determining the levels of PAPPA2, NGAL, KRT20, or TAC-STD2 protein in a sample from a patient, such as a urine sample. The present invention also provides a device and a diagnostics kit for determining whether a sample from a subject contains PAPPA2, NGAL, KRT20, or TACSTD2 protein.

公开(公告)号：US20240344055A1

公开(公告)日：2024-10-17

申请号：US18618660

申请日：2024-03-27

申请人： The Trustees of Columbia University in the City of New York ,  The Broad Institute, Inc. ,  President and Fellows of Harvard College

发明人： Peter M.J. Quinn ,  Bruna Lopes da Costa ,  Stephen H. Tsang ,  David R. Liu

IPC分类号： C12N15/10 ,  A61K38/00 ,  C12N9/12 ,  C12N9/22 ,  C12N15/11

CPC分类号： C12N15/102 ,  C12N9/1276 ,  C12N9/22 ,  C12N15/111 ,  A61K38/00 ,  C07K2319/85 ,  C12N2310/20 ,  C12Y207/07049

摘要： The present disclosure provides systems, methods, and compositions for modifying the crumbs homologue-1 gene. Particularly the present disclosure provides systems, methods, and compositions for prime editing insertion or correction of mutations in the crumbs homologue-1 gene.

公开(公告)号：US20240342116A1

公开(公告)日：2024-10-17

申请号：US18629157

申请日：2024-04-08

申请人： The Trustees of Columbia University in the City of New York

发明人： Lei Ding ,  Shawn M. Sarkaria ,  Junsong Zhou

IPC分类号： A61K31/137 ,  A61K45/06

CPC分类号： A61K31/137 ,  A61K45/06

摘要： Methods and compositions for treating a myelofibrosis with an agent that depletes, or inhibits proliferation of, Sox10+ glial cells in a subject and/or ErbB3+ glial cells in a subject.

公开(公告)号：US20240342076A1

公开(公告)日：2024-10-17

申请号：US18618528

申请日：2024-03-27

申请人： The Trustees of Columbia University in the City of New York ,  George Mason University

发明人： Samuel K. Sia ,  Rachel D. Field ,  Margaret A. Jakus ,  Parag V. Chitnis

IPC分类号： A61K9/00 ,  A61K9/50 ,  A61K38/18 ,  A61K38/19 ,  A61K45/06

CPC分类号： A61K9/0009 ,  A61K9/5031 ,  A61K38/18 ,  A61K38/19 ,  A61K45/06

摘要： An aqueous biphasic microcapsule comprising a core comprising a payload-containing polymer and a shell encapsulating the core, the shell comprising a photopolymerized polymer, wherein the payload-containing polymer and photopolymerized polymer are phase separated, and methods of production and use.

公开(公告)号：US12091695B2

公开(公告)日：2024-09-17

申请号：US18501967

申请日：2023-11-03

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Henry M. Colecraft ,  Scott Kanner

IPC分类号： C12N9/64 ,  A61K38/00 ,  C12N15/85 ,  C12Q1/6883

CPC分类号： C12N9/6472 ,  C12N15/85 ,  C12Q1/6883 ,  C12Y304/22 ,  A61K38/00 ,  C12Q2600/156

摘要： The present disclosure provides, inter alia, a recombinant engineered deubiquitinase (DUB) and methods for treating or ameliorating an inherited ion channelopathy, such as long QT syndrome, Brugada syndrome, or cystic fibrosis, in a subject. Further provided are methods for screening mutations causing such inherited ion channelopathies for a trafficking-deficient mutation that is treatable by the recombinant engineered DUB disclosed herein.

公开(公告)号：US20240299513A1

公开(公告)日：2024-09-12

申请号：US18572241

申请日：2022-06-22

申请人： The Trustees of Columbia University in the City of New York

发明人： Remi J. Creusot ,  Rebuma Firdessa Fite ,  Jorge Postigo Fernandez

IPC分类号： A61K39/00 ,  A61P3/10

CPC分类号： A61K39/0008 ,  A61P3/10 ,  A61K2039/53 ,  A61K2039/55555

摘要： This disclosure describes a nucleic acid construct that contains sequences for an Endotope construct, a STAT1c, and miR142 target sites. In one example, disclosed is composition comprising an Endotope construct and a STAT1 construct including a nucleic acid sequence encoding a constitutively active STAT1 (e.g. STAT1c), wherein the Endotope and the STAT1 constructs each include miR142 target sites. In alternative examples, disclosed is a single construct that includes the Endotope construct and STAT1 construct along with miR142 target sites. The nucleic acid constructs can be packaged into polycationic molecules or liposome to create nanoparticles for efficient cell transfection.

公开(公告)号：US20240299347A1

公开(公告)日：2024-09-12

申请号：US18601908

申请日：2024-03-11

申请人： The Trustees of Columbia University in the City of New York

发明人： Wei GU

IPC分类号： A61K31/381 ,  A61K31/122 ,  A61K31/19 ,  A61K31/352 ,  A61K31/405 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4245 ,  A61K31/7088 ,  A61K38/46 ,  A61P25/28 ,  C12N15/113 ,  G01N33/68

CPC分类号： A61K31/381 ,  A61K31/122 ,  A61K31/19 ,  A61K31/352 ,  A61K31/405 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4245 ,  A61K31/7088 ,  A61K38/465 ,  A61P25/28 ,  C12N15/1137 ,  C12Y113/11034 ,  G01N33/6896 ,  C12N2310/14 ,  G01N2333/90241 ,  G01N2800/2835

摘要： Disclosed herein are compositions and methods for treating or preventing Huntington's disease. In one aspect, the disclosed methods relate to targeting arachidonate 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (FLAP). The compositions and methods disclosed herein can be used as disease modifying therapies to enable treatment of Huntington's disease and related disorders earlier in disease progression and improve clinical outcomes.

公开(公告)号：US12079960B2

公开(公告)日：2024-09-03

申请号：US17693166

申请日：2022-03-11

申请人： TERRAN BIOSCIENCES INC. ,  THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK ,  THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.

发明人： Samuel Clark ,  Kenneth Wengler ,  Guillermo Horga Hernandez

IPC分类号： G06T5/50 ,  A61B5/055 ,  G06T5/90 ,  G06T7/00 ,  G16H50/20

CPC分类号： G06T5/50 ,  A61B5/055 ,  G06T5/90 ,  G06T7/0014 ,  G16H50/20 ,  G06T2207/10088 ,  G06T2207/20081 ,  G06T2207/30016

摘要： An exemplary system, method and computer-accessible medium for harmonizing neuromelanin (NM) data using combat directly on a NM database or using combat generated coefficients to harmonize future data can include, for example, receiving imaging information of a brain of the patient(s), from one MRI scanner, receiving imaging information of a brain of the patient(s), from a second MRI scanner and using combat to harmonize the data between scanners against a reference dataset. The Neuromelanin (NM) concentration of the patient(s) can then be determined based on the harmonized data. The NM concentration can be determined using a voxel-wise analysis procedure. The voxel-wise analysis procedure can be used to determine a topographical pattern(s) within a substantia nigra (SN) of the brain of the patient(s).

公开(公告)号：US12079102B2

公开(公告)日：2024-09-03

申请号：US17376120

申请日：2021-07-14

申请人： Ronghui Gu ,  Jason Nieh ,  Runzhou Tao

发明人： Ronghui Gu ,  Jason Nieh ,  Runzhou Tao

IPC分类号： G06F11/36

CPC分类号： G06F11/3604

摘要： Mechanisms for proving the correctness of software on relaxed memory hardware are provided, the mechanisms comprising: receiving a specification, a hardware model, and an implementation for the software to be executed on the relaxed memory hardware; evaluating the software using a sequentially consistent hardware model; evaluating the software using a relaxed memory hardware model and at least one of the following conditions: a data-race-free (DRF)-kernel condition; a no-barrier-misuse condition; a memory-isolation condition; a transactional-page-table condition; a write-once-kernel-mapping condition; and a weak-memory-isolation condition; and outputting an indication of whether the software is correct based on the evaluating the software using the sequentially consistent hardware model and the evaluating the software using the relaxed memory hardware model.

公开(公告)号：US20240287530A1

公开(公告)日：2024-08-29

申请号：US18607341

申请日：2024-03-15

申请人： The Trustees of Columbia University in the City of New York

发明人： Antonio IAVARONE ,  Anna LASORELLA

IPC分类号： C12N15/62 ,  C07K14/47 ,  C07K14/71 ,  C07K14/82 ,  C07K16/18 ,  C07K16/28 ,  C12N9/12 ,  C12Q1/6886 ,  G01N33/574

CPC分类号： C12N15/62 ,  C07K14/47 ,  C07K14/71 ,  C07K14/82 ,  C07K16/18 ,  C07K16/2863 ,  C12N9/12 ,  C12Q1/6886 ,  G01N33/57492 ,  C07K2319/00 ,  C07K2319/73 ,  C12Q2600/158 ,  G01N2333/91205

摘要： The invention discloses oncogenic fusion proteins. The invention provides methods for treating gene-fusion based cancers.