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公开(公告)号：US11463804B2
公开(公告)日：2022-10-04
申请号：US16592357
申请日：2019-10-03
摘要： A loudspeaker system with viscoelastic material affixed between two flexible panels is disclosed. The loudspeaker system dissipates the energy of motion, resulting in less pronounced resonant peaks. The effect may be especially evident at high frequencies, where energy is dissipated over many cycles in a shorter period of time. Also disclosed are the method of making the loudspeaker system and a method of using the loudspeaker system.
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公开(公告)号：US20220266582A1
公开(公告)日：2022-08-25
申请号：US17678222
申请日：2022-02-23
IPC分类号： B32B37/00
摘要： Describes are methods of contacting printing with a shape-memory stamp. For example, disclosed herein are methods of patterning thin films using shape memory contact printing.
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公开(公告)号：US11076231B2
公开(公告)日：2021-07-27
申请号：US16896572
申请日：2020-06-09
摘要： Systems and methods of driving plate loudspeakers with different parameters based on frequency region in a way similar to typical cone driver crossover networks are described. These systems and methods may be implemented using arrays of independently controlled drivers which allow a designer to emphasize or de-emphasize certain modes in certain frequency bands. Tuning the characteristics of the plate's motion can also affect the acoustical properties in a larger space rather than just at a single location. The systems and methods described herein can grant a designer a degree of control over the characteristics and performance of the plate.
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公开(公告)号：US10966042B2
公开(公告)日：2021-03-30
申请号：US16799286
申请日：2020-02-24
摘要： A loudspeaker system composed of a flexible panel with an affixed array of force actuators, a signal processing system, and interface electronic circuits is described. The system described is capable of creating a pattern of standing bending waves at any location on the panel and the instantaneous amplitude, velocity, or acceleration of the standing waves can be controlled by an audio signal to create localized acoustic sources at the selected locations in the plane of the panel.
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5.发明授权公开(公告)号：US10609500B2
公开(公告)日：2020-03-31
申请号：US16292836
申请日：2019-03-05
发明人： Mark F. Bocko
摘要： A loudspeaker system composed of a flexible panel with an affixed array of force actuators, a signal processing system, and interface electronic circuits is described. The system described is capable of creating a pattern of standing bending waves at any location on the panel and the instantaneous amplitude, velocity, or acceleration of the standing waves can be controlled by an audio signal to create localized acoustic sources at the selected locations in the plane of the panel.
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公开(公告)号：US09899212B2
公开(公告)日：2018-02-20
申请号：US15130208
申请日：2016-04-15
发明人： Alexander Shestopalov , James McGrath , Xunzhi Li
CPC分类号： H01L21/0228 , C23C16/00 , C23C16/482 , H01L21/02112
摘要： Methods and compositions for depositing a monolayer onto a surface of a substrate are described. The method can include contacting the surface with a vapor phase comprising a carbene source, and reacting a carbene group from the carbene source with a functional group on the surface, to obtain a covalently bound monolayer on the surface of the substrate. The carbene source can be a diazirine compound. The functional group on the surface can be a C—H containing group, a Si—H containing group, among others, or combinations thereof. The method can further involve removing physisorbed molecules from the surface of the substrate.
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公开(公告)号：US09677066B2
公开(公告)日：2017-06-13
申请号：US14725968
申请日：2015-05-29
发明人： Lewis Rothberg , Barbara Stwertka
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/68 , G01N31/22 , B32B3/00 , C08F20/56 , C12N15/10 , C08F222/02 , C08F222/38
CPC分类号： C12N15/1006 , C08F222/02 , C08F222/38 , Y10T428/249978 , Y10T428/2982
摘要： Compositions and methods for separating double-stranded nucleic acids out of a mixture comprising single-stranded nucleic acids and/or dNTPs and/or enzymes. The method uses spatially inhomogeneously functionalized nanoporous materials. For example, the compositions and methods of the present invention can be used to purify DNA amplification reaction products.
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8.发明申请公开(公告)号：US20160106743A1
公开(公告)日：2016-04-21
申请号：US14885224
申请日：2015-10-16
申请人： David Goldfarb
发明人： David Goldfarb
IPC分类号： A61K31/4985 , A61K31/704 , A61K45/06
CPC分类号： A61K31/4985 , A61K31/473 , A61K31/475 , A61K31/498 , A61K31/704 , A61K31/7048 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are compositions of Formula I and an optional anticancer drug. Also disclosed herein are methods of treating or preventing cancer using the same.
摘要翻译： 本文公开了式I的组合物和任选的抗癌药物。 本文还公开了使用其治疗或预防癌症的方法。
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公开(公告)号：US20110289605A1
公开(公告)日：2011-11-24
申请号：US13130490
申请日：2009-11-25
申请人： Di Chen
发明人： Di Chen
IPC分类号： A01K67/027 , A61K39/395 , A61K38/02 , A61K38/45 , A61P19/02 , G01N33/573 , A61K31/138 , C12N5/10 , C12Q1/02 , C12Q1/68 , G01N33/566 , G01N33/00 , A61K31/713 , A61P19/00
CPC分类号： A01K67/0275 , A01K2217/15 , A01K2217/206 , A01K2227/105 , A01K2267/035 , C12N15/8509 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： Provided herein is a transgenic animal whose genome comprises a first nucleic acid sequence encoding a fusion polypeptide, wherein the fusion polypeptide comprises a Cre recombinase and a mutated ligand binding domain of human estrogen receptor (CreER), wherein the first nucleic acid is operably linked to a chondrocyte-specific promoter and a second nucleic acid sequence encoding a β-catenin polypeptide, wherein the second nucleic acid sequence comprises one or more loxP sequences. Also provided is a method of modifying a transgenic animal comprising administering tamoxifen to the transgenic animal. Also provided are methods of screening for an agent that reduces or prevents Cre-Negative Control one or more symptoms of osteoarthritis or intervertebral disc disease in a subject. Methods for identifying a subject with or at risk of developing osteoarthritis or intervertebral disc disease are also provided, as well as methods of treating or preventing osteoarthritis or intervertebral disc disease in a subject.
摘要翻译： 本文提供了一种转基因动物，其基因组包含编码融合多肽的第一核酸序列，其中所述融合多肽包含Cre重组酶和人雌激素受体（CreER）的突变配体结合结构域，其中所述第一核酸可操作地连接到 软骨细胞特异性启动子和编码β-连环蛋白多肽的第二核酸序列，其中所述第二核酸序列包含一个或多个loxP序列。 还提供了修饰转基因动物的方法，其包括向转基因动物施用三苯氧胺。 还提供了筛选减少或预防Cre阴性对照在受试者中骨关节炎或椎间盘疾病的一种或多种症状的药剂的方法。 还提供了用于鉴定患有或具有发展为骨关节炎或椎间盘疾病的风险的受试者的方法，以及治疗或预防受试者中的骨关节炎或椎间盘疾病的方法。
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公开(公告)号：US20100197784A1
公开(公告)日：2010-08-05
申请号：US12758462
申请日：2010-04-12
申请人： Kuo-Hsiung Lee , Li Lin , Charles C-Y Shih , Ching-Yuan Su , Junko Ishida , Hironori Ohtsu , Hui-Kang Wang , Hideji Itokawa , Chawnshang Chang
发明人： Kuo-Hsiung Lee , Li Lin , Charles C-Y Shih , Ching-Yuan Su , Junko Ishida , Hironori Ohtsu , Hui-Kang Wang , Hideji Itokawa , Chawnshang Chang
CPC分类号： C07D307/58 , C07C49/248 , C07C49/255 , C07C49/755 , C07C49/84 , C07C59/84 , C07C69/738 , C07C205/45
摘要： The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
摘要翻译： 本发明涉及能够作为雄激素受体拮抗剂的药物，含有它们的药物制剂及其使用方法。 这些用途包括但不限于用作抗肿瘤剂，特别是用于治疗诸如结肠癌，皮肤癌和前列腺癌的癌症，并且在受雄激素相关疾病影响的受试者中诱导雄激素受体拮抗剂活性。 雄激素相关疾病的实例包括但不限于秃发，多毛症，行为障碍，痤疮和未抑制的精子发生，其中精子发生的抑制是如此期望的。
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