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公开(公告)号:US20230075092A1
公开(公告)日:2023-03-09
申请号:US17792403
申请日:2021-01-12
申请人: UNIVERSITE CLAUDE BERNARD LYON 1 , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE LAVAL , SIGNIA THERAPEUTICS , ECOLE NORMALE SUPERIEURE DE LYON
IPC分类号: A61K31/554 , A61K9/00 , A61K31/5383 , A61K45/06 , A61P31/16
摘要: The invention relates to a combination of Diltiazem and at least one viral polymerase inhibitor compound selected from among Baloxavir marboxil, Pimodivir, RO-7 and CC-42344. The invention relates in particular to the therapeutic use of said combination in the prevention and/or treatment of a viral infection, in particular of the respiratory and/or intestinal tract of a human or animal body.
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公开(公告)号:US11504424B2
公开(公告)日:2022-11-22
申请号:US17262263
申请日:2019-07-12
申请人: UNIVERSITE CLAUDE BERNARD LYON 1 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , ECOLE NORMALE SUPERIEURE DE LYON , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE LAVAL
发明人: Manuel Rosa-Calatrava , Guy Boivin , Julia Dubois , Mario Andres Pizzorno , Olivier Terrier , Marie-Eve Hamelin , Marie-Helene Cavanagh
IPC分类号: A61K39/155 , A61P31/14 , C12N7/00 , A61K39/00
摘要: The present invention relates to an attenuated virus strain derived from a human metapneumovirus strain comprising the genome sequence represented by sequence SEQ ID NO. 1, said attenuated strain comprising one or more genetic modifications of said sequence SEQ ID NO. 1 attenuating the virulence of said strain.
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公开(公告)号:US11266705B2
公开(公告)日:2022-03-08
申请号:US15771328
申请日:2016-10-27
申请人: ACTIV'INSIDE , Specialites Pet Food , Universite Laval , Institut National De La Recherche Scientifique (INRS)
发明人: David Gaudout , Stephane Rey , Benoit Lemaire , Julien Bensalem , Anne Lepoudere , Delphine Lethuillier , Marie-Eve Paradis , Stephanie Dudonne , Yves Desjardins , Frederic Calon , Alexandre Dal-Pan , Charles Ramassamy
IPC分类号: A61K36/45 , A61K36/87 , A61K31/353 , A61K45/06 , A61K9/20 , A61K9/48 , A61K31/7048 , A61K31/05 , A23L33/105 , A61P25/28 , A61P3/10 , A61P25/18 , A61P25/24 , A61P25/16 , A61K31/192
摘要: The invention concerns a nutritional or therapeutic agent comprising a molecule mix obtained from Vitis vinifera and Vaccinium angustifolium, comprising: at least 1% of catechins and epicatechins, the percentage being given by weight in relation to the total weight of the mix, preferably at least 5%, at least 5 ppm (parts per million in the mix) of ferulic acid, preferably at least 10 ppm. The invention also relates to the use of this agent due to its effects on cognitive functions in particular.
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公开(公告)号:US20210369478A1
公开(公告)日:2021-12-02
申请号:US17272707
申请日:2019-09-05
申请人: UNIVERSITE LAVAL
摘要: An apparatus comprises a main arm having links extending from a ground end to an effector end and allowing movement of the effector end from a first position to a second position, the links including at least a base link adapted to be pivotally connected to a base, and a spacing link pivotally mounted to a free end of the base link and extending to the effector end. A first 4-bar parallelogram has pivot joints at its corners and including the base link of the main arm. A second 4-bar parallelogram has pivot joints at its corners and including the spacing link of the main arm and an effector link at the effector end adapted to support an object. A serial interconnection is between the first 4-bar parallelogram and the second 4-bar parallelogram constraining the effector link to maintaining a constant orientation in at least two rotational degrees of freedom relative to the base.
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公开(公告)号:US20210220430A1
公开(公告)日:2021-07-22
申请号:US17056231
申请日:2019-05-17
申请人: UNIVERSITE LAVAL
发明人: Serge RIVEST , Jean GOSSELIN
摘要: Disclosed is a new treatment for reducing amyloid beta (Aβ), for treating Alzheimer's disease (AD), for improvement of cognitive disorder or learning and memory disorder associated with AD and for the treatment of multiple sclerosis. It was found that a NOD2 agonist could improve phagocytosis of Aβ across the blood brain barrier, to be scavenged by increased concentration of patrolling monocytes caused by the NOD2 agonist, removing Aβ from circulation, thereby preventing its eventual deposit. Also disclosed is a composition for such use.
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公开(公告)号:US10459168B2
公开(公告)日:2019-10-29
申请号:US16114590
申请日:2018-08-28
申请人: UNIVERSITÉ LAVAL
发明人: Wei Shi
摘要: The optical device coupleable to a waveguide to receive an optical signal from the waveguide generally has at least two optical grating devices optically coupled to one another and having corresponding spectral responses, the spectral response of at least one of said optical grating devices being tunable to adjust an amount of overlapping between the spectral responses of the at least two optical grating devices.
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7.
公开(公告)号:US20180208634A1
公开(公告)日:2018-07-26
申请号:US15746540
申请日:2016-07-19
申请人: UNIVERSITÉ LAVAL
发明人: Christian Salesse , Line Cantin
CPC分类号: C07K14/4728 , C07K1/13 , C07K1/22 , C07K14/47 , C07K2319/00 , C07K2319/20 , C12N9/1029 , C12Y203/01135
摘要: Herein presented is a new, versatile fusion protein tool (tag) to improve the solubility and purification of proteins. Particularly, the fusion tag is the substantially full-length (about 23 kD) Recoverin molecule (TagR) that is used for protein purification in a single step, even in the presence of detergents.
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公开(公告)号:US09782379B2
公开(公告)日:2017-10-10
申请号:US14763080
申请日:2014-01-23
申请人: Universite Laval
发明人: Andre Marette , Philip J. White
IPC分类号: A61K31/20 , A01N37/00 , A61K31/202 , A61K38/17
CPC分类号: A61K31/202 , A61K38/1709
摘要: The present invention provides a method for the stimulation of secretion or expression of muscular IL-6 in a subject with the administration of Protectin DX (PDX). Particularly, the increase in circulating levels of IL-6 originating from the subject muscles is useful for regulating blood glucose and suppressing lipid-induced inflammation and other related inflammatory conditions such as insulin resistance, metabolic syndrome, type-2 diabetes, hypertension and cardiovascular diseases. Alternatively, the increase in muscular IL-6 expression in a subject may also be useful for increasing energy supply during exercise, or facilitating muscular recovery after strenuous effort.
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公开(公告)号:US20170182006A1
公开(公告)日:2017-06-29
申请号:US15233023
申请日:2016-08-10
发明人: Michel G. BERGERON , Jian GAO , Rabeea F. OMAR , Mary Ann WALTER
CPC分类号: A61K31/4164 , A61K9/0034 , A61K9/06 , A61K47/10 , A61K47/12 , A61K47/22 , A61K47/34
摘要: The present disclosure provides novel formulations suitable for the intravaginal delivery of tinidazole, as well as methods of using the same.
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10.
公开(公告)号:US20160046587A1
公开(公告)日:2016-02-18
申请号:US14776483
申请日:2014-03-12
申请人: UNIVERSITE LAVAL
IPC分类号: C07D243/08 , C07C211/53
CPC分类号: C07D243/08 , A61K9/0075 , A61K31/551 , C07B2200/13 , C07C211/53
摘要: The present disclosure relates to a novel active compound having the formula Ia: solid preparations, uses and methods for the treatment or prevention of respiratory diseases comprising said compound as well as process of preparation thereof.
摘要翻译: 本公开涉及具有式Ia的新型活性化合物:包含所述化合物的固体制剂,用途和用于治疗或预防呼吸系统疾病的方法及其制备方法。
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