METHODS AND COMPOSITIONS FOR DIAGNOSIS OR PROGNOSIS OF CARDIOVASCULAR DISEASE
    1.
    发明申请
    METHODS AND COMPOSITIONS FOR DIAGNOSIS OR PROGNOSIS OF CARDIOVASCULAR DISEASE 失效
    用于诊断或预防心血管疾病的方法和组合物

    公开(公告)号:US20120288880A1

    公开(公告)日:2012-11-15

    申请号:US13543745

    申请日:2012-07-06

    IPC分类号: H01J49/26 G01N33/53

    摘要: The invention provides methods of screening a mammalian subject to determine if the subject is at risk to develop or is suffering from, cardiovascular disease. In one embodiment, the method comprises detecting a measurable feature of at least two biomarkers in an EMT subfraction, or in a complex containing apoA-I or apoA-III isolated from a biological sample obtained from the subject, wherein the at least two biomarkers are selected from the group consisting of apoA-I, apoA-II, apoB-100, Lp(a), apoC-I, and apoC-III, combinations or portions and/or derivatives thereof, and comparing the measurable features of the at least two biomarkers from the biological sample to a reference standard, wherein a difference in the measurable features of the at least two biomarkers from the biological sample and the reference standard is indicative of the presence or risk of cardiovascular disease in the subject.

    摘要翻译: 本发明提供筛选哺乳动物受试者以确定受试者是否处于发展或正在患有心血管疾病的风险中的方法。 在一个实施方案中,所述方法包括检测EMT亚分级中的至少两个生物标志物的可测量特征,或在从受试者获得的生物样品中分离的含有载脂蛋白A-I或载脂蛋白-A-apo的复合物中,其中所述至少两种生物标志物是 选自由apoA-I,apoA-II,apoB-100,Lp(a),apoC-1和apoC-III组成的组,其组合或部分和/或衍生物,并将至少 来自生物样品的两个生物标志物到参考标准,其中来自生物样品和参考标准的至少两种生物标志物的可测量特征的差异指示受试者心血管疾病的存在或风险。

    TOOTHBRUSH EMPLOYING ACOUSTIC WAVEGUIDE
    3.
    发明申请
    TOOTHBRUSH EMPLOYING ACOUSTIC WAVEGUIDE 审中-公开
    牙刷使用声波

    公开(公告)号:US20110159461A1

    公开(公告)日:2011-06-30

    申请号:US13047229

    申请日:2011-03-14

    IPC分类号: A61C17/16

    摘要: A power toothbrush (10) is disclosed having a handle (15), battery (12), ultrasonic drive circuit (14), motor (16), control unit (18), and toothbrush head (20). The toothbrush head includes bristles (26) and a waveguide (24) that is operatively connected to an ultrasonic transducer (22). The waveguide facilitates the transmission of acoustic energy into the dental fluid to achieve improved cleaning and stain removal and improved cleaning in interproximal and subgingival regions. In one embodiment an ultrasound transducer module (30) includes a plurality of piezoelectric elements (32, 34) that may be mechanically connected in series, and electrically connected in parallel. One or more contacts (36) connect the elements, and a waveguide structure (50). An impedance matching layer (38) may be provided between the waveguide and the ultrasonic transducer module. The waveguide may be formed from a relatively soft material, for example, a polymer having a hardness between 10 and 65 Shore A.

    摘要翻译: 公开了具有手柄(15),电池(12),超声波驱动电路(14),马达(16),控制单元(18)和牙刷头(20)的动力牙刷(10)。 牙刷头包括刷毛(26)和可操作地连接到超声换能器(22)的波导(24)。 波导有助于将声能传输到牙科液体中,以实现改善的清洁和污渍去除以及改善邻近和龈下区域的清洁。 在一个实施例中,超声换能器模块(30)包括多个压电元件(32,34),其可以串联机械连接并并联电连接。 一个或多个触点(36)连接元件和波导结构(50)。 可以在波导和超声换能器模块之间设置阻抗匹配层(38)。 波导可以由相对柔软的材料形成,例如硬度在10和65肖氏A之间的聚合物。

    System and Method for Magnetically Concentrating and Detecting Biomarkers
    4.
    发明申请
    System and Method for Magnetically Concentrating and Detecting Biomarkers 失效
    用于磁集中和检测生物标志物的系统和方法

    公开(公告)号:US20110003392A1

    公开(公告)日:2011-01-06

    申请号:US12815217

    申请日:2010-06-14

    IPC分类号: G01N33/68 G01N27/00

    摘要: System and method for capturing, concentrating, and detecting a diagnostic target in a liquid, comprising applying a magnetic field to a mixture comprising a co-aggregate in the liquid to provide a collected co-aggregate in the liquid, wherein the co-aggregate comprises a magnetic particle having a stimuli-responsive polymer attached thereto and a non-magnetic particle having a stimuli-responsive polymer and a diagnostic target attached thereto.

    摘要翻译: 用于捕获,浓缩和检测液体中的诊断靶的系统和方法,包括对包含所述液体中的共聚集料的混合物施加磁场以在所述液体中提供收集的共聚集料,其中所述共聚集体包含 附着有刺激响应性聚合物的磁性颗粒和具有刺激响应性聚合物的非磁性颗粒和附着于其上的诊断目标。

    CONTACT LENS WITH INTEGRATED LIGHT-EMITTING COMPONENT
    10.
    发明申请
    CONTACT LENS WITH INTEGRATED LIGHT-EMITTING COMPONENT 有权
    带集成发光元件的接触镜头

    公开(公告)号:US20100001926A1

    公开(公告)日:2010-01-07

    申请号:US12463847

    申请日:2009-05-11

    IPC分类号: G09G5/00 H01K7/00 A61B3/113

    摘要: A light-emitting contact lens and a method and system for tracking a user's eye position using the light-emitting contact lens are disclosed. The eye position tracking can be used, for example, to allow the user to interact with a display device such that the position of the user's eye determines the image generated by the display device. Thus, as the user's eye moves, the image on the display device will be altered to represent the new position (e.g., viewing angle) of the user with regard to the display device.

    摘要翻译: 公开了一种发光隐形眼镜和用于使用发光隐形眼镜跟踪使用者的眼睛位置的方法和系统。 眼睛位置跟踪可以用于例如允许用户与显示设备交互,使得用户的眼睛的位置确定由显示设备产生的图像。 因此,当用户的眼睛移动时,显示设备上的图像将被改变以表示用户相对于显示设备的新位置(例如,视角)。