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    DEVICE AND METHOD FOR BIOELECTRIC STIMULATION ACCELERATING BONE INTEGRATION INTO IMPLANT HEALING
    1.
    发明公开
    DEVICE AND METHOD FOR BIOELECTRIC STIMULATION ACCELERATING BONE INTEGRATION INTO IMPLANT HEALING 审中-公开

    公开(公告)号：US20230293268A1

    公开(公告)日：2023-09-21

    申请号：US18186811

    申请日：2023-03-20

    申请人： Leonhardt Ventures LLC

    发明人： Howard J. Leonhardt ,  Tom Newman

    IPC分类号： A61C8/02 ,  A61N1/32

    CPC分类号： A61C8/0007 ,  A61N1/326

    摘要： Described are a device, system, and method for bioelectric stimulation to accelerate bone integration of an implant and/or bone graft in order to aid healing. Specifically described are devices and methods for enhancing bone integration of a body implant (e.g., a dental implant) or bone graft by modulating (e.g., stimulating) the controlled expression and/or release of selected proteins, which proteins promote osteogenesis and osseointegration via specific bioelectric signals delivered via, e.g., a specialized mouthpiece, electrodes, and/or wireless means. The description particularly relates to the acceleration of the healing of dental implants and/or bone grafts via promoting bone osteointegration more quickly with bioelectric stimulation.

    SYSTEM AND METHOD FOR INCREASING ORGANIC CELL REGENERATION IN A CELLULAR MEDIUM
    3.
    发明申请
    SYSTEM AND METHOD FOR INCREASING ORGANIC CELL REGENERATION IN A CELLULAR MEDIUM 审中-公开
    在细胞培养基中增加有机细胞再生的系统和方法

    公开(公告)号：US20170007373A1

    公开(公告)日：2017-01-12

    申请号：US15093639

    申请日：2016-04-07

    申请人： Bogdan Constantin VLADILA

    发明人： Bogdan Constantin VLADILA

    IPC分类号： A61C8/02 ,  A61K6/00 ,  A61N2/02 ,  A61C8/00 ,  A61N2/00

    CPC分类号： A61C8/0007 ,  A61C8/0018 ,  A61C8/0022 ,  A61C8/0071 ,  A61K6/0008 ,  A61K6/0067 ,  A61M2037/0007 ,  A61M2202/066 ,  A61N2/002 ,  A61N2/004 ,  A61N2/02

    摘要： A system for increasing organic cell regeneration in a cellular medium includes an electromagnetic (EN) field generating device adapted to produce a constant EM field of less then 1 mT at a radiation frequency of substantially 7.69 Hz, which comprises at least one coil and is adapted to generate the EM field so that the cellular medium is substantially within the generated EM field. A resonance medium is also provided for locating substantially at or adjacent the cellular medium, wherein the resonance medium comprises a composition which is adapted to resonate at the frequency of The EM field generated by the device, wherein the composition is a biologically active composition containing at least a composition comprising crystalline structure minerals.

    摘要翻译： 用于增加细胞介质中的有机细胞再生的系统包括电磁（EN）场产生装置，其适于在基本上为7.69Hz的辐射频率处产生小于1mT的恒定EM场，其包括至少一个线圈并且被适配 以产生EM场，使得蜂窝介质基本上在所生成的EM场内。 还提供了共振介质，用于基本上位于或邻近多孔介质，其中所述共振介质包括适于以由所述装置产生的EM场的频率谐振的组合物，其中所述组合物是含有 至少一种包含晶体结构矿物的组合物。

    METHODS AND SYSTEMS COMBINING AC ELECTROOSMOSIS WITH DIELECTROPHORESIS TO ENHANCE DELIVERY OF ACTIVE AGENTS INTO INTRAORAL STRUCTURES
    4.
    发明申请
    METHODS AND SYSTEMS COMBINING AC ELECTROOSMOSIS WITH DIELECTROPHORESIS TO ENHANCE DELIVERY OF ACTIVE AGENTS INTO INTRAORAL STRUCTURES 有权
    结合交流电磁学与电化学方法和系统，以增强活性物质输送到内部结构

    公开(公告)号：US20140162206A1

    公开(公告)日：2014-06-12

    申请号：US14092269

    申请日：2013-11-27

    申请人： University of Tennessee Research Foundation

    发明人： Chris S. Ivanoff ,  Timothy L. Hottel ,  Franklin Garcia-Godoy

    IPC分类号： A61N1/04 ,  A61N1/05 ,  A61N1/08 ,  A61C19/06

    CPC分类号： A61N1/0428 ,  A61C8/0007 ,  A61C19/063 ,  A61N1/044 ,  A61N1/0548 ,  A61N1/325

    摘要： Methods and systems for delivering an active agent into an intraoral structure are disclosed. One embodiment of a method for implementing the subject matter described herein includes generating an electrical signal that includes a first frequency, a second frequency, and a third frequency, and supplying the electrical signal to an embedded circuit contained in an intraoral delivery tray, wherein the embedded circuit includes at least one electrode that includes projections positioned proximally to a surface of an intraoral structure. The method further includes providing the first frequency and the second frequency to the at least one electrode to generate an electrical field that electrically motivates the active agent suspended in a fluid medium contained in the intraoral delivery tray toward the intraoral structure via dielectrophoresis and providing the third frequency to the at least one electrode to increase the uptake of the active agent into intraoral structure via alternating current electroosmosis.

    摘要翻译： 公开了将活性剂递送至口内结构的方法和系统。 用于实现本文所述主题的方法的一个实施例包括生成包括第一频率，第二频率和第三频率的电信号，并将电信号提供给包含在口内输送托盘中的嵌入式电路，其中， 嵌入式电路包括至少一个电极，其包括位于口内结构表面的近侧的突起。 所述方法还包括向所述至少一个电极提供所述第一频率和第二频率以产生电场，所述电场通过介电电泳将悬浮在包含在所述口内输送托盘中的流体介质中的活性剂电激励到所述口腔结构，并且提供所述第三频率 频率到至少一个电极，以通过交流电渗析来增加活性剂对口内结构的摄取。

    ALVEOLAR BONE REGENERATIVE APPARATUS
    5.
    发明申请
    ALVEOLAR BONE REGENERATIVE APPARATUS 审中-公开
    宝宝骨再生装置

    公开(公告)号：US20120283798A1

    公开(公告)日：2012-11-08

    申请号：US13100244

    申请日：2011-05-03

    申请人： Toshihiko Tominaga

    发明人： Toshihiko Tominaga

    IPC分类号： A61N1/00

    CPC分类号： A61C8/0007 ,  A61B18/1477 ,  A61B2018/00321 ,  A61B2018/00589 ,  A61C5/40

    摘要： Provided is an alveolar bone regenerative unit and an alveolar bone regenerative apparatus capable of regeneration treatment for an alveolar bone by sterilizing a periodontium and activating an osteoblast. The alveolar bone regenerative unit includes an active needle electrode of a metal electrode generating heat by power supply and a handle attached to a base of the active needle electrode. The active needle electrode is 25.0 to 41.0 mm long and 0.08 to 0.47 mm in diameter, on which a strippable coat is formed with silicon resin. Supplying power to the active needle electrode causes heat generation at a high temperature because of the thin diameter. The high temperature and electric energy can kill bacteria around a root, thereby being able to activate an osteoblast and regenerate an alveolar bone.

    摘要翻译： 提供一种牙槽骨再生单元和能够通过消毒牙周膜并激活成骨细胞来再生处理牙槽骨的牙槽骨再生装置。 牙槽骨再生单元包括通过电源产生热量的金属电极的活性针电极和附接到有源针电极的基部的手柄。 活性针状电极的长度为25.0〜41.0mm，直径为0.08〜0.47mm，用硅树脂形成可剥离的涂层。 由于薄的直径，向活性针电极供电导致高温下的发热。 高温和电能可以杀死根部周围的细菌，从而能够激活成骨细胞并再生牙槽骨。

    Endosteal implant and method for performing implantation thereof
    7.
    发明授权
    Endosteal implant and method for performing implantation thereof 失效
    骨内植入物及其植入方法

    公开(公告)号：US4781591A

    公开(公告)日：1988-11-01

    申请号：US34661

    申请日：1987-04-06

    申请人： James P. Allen

    发明人： James P. Allen

    IPC分类号： A61B8/00 ,  A61B17/68 ,  A61C8/00 ,  A61F2/28 ,  A61F5/04

    CPC分类号： A61B17/68 ,  A61B8/00 ,  A61C8/00 ,  A61C8/0007

    摘要： An endosteal implant, and the method for performing the implantation thereof, which promotes rapid and complete securing of the inplant to bone tissue. Soft tissure at a bone site is incised and a bore is drilled in the exposed bone. An implant housing is inserted in the bore. The implant housing is constructed so as to be able to receive a selectively removable electrical power source therewithin. When the power source is received within the housing located in the bore in the bone, and the soft tissue is sealed over the implant housing site, the power source produces an electrical current travelling through the tissue and the bone surrounding the site. Such current promotes cellular adhesion activity thereby substantially reducing the time for securing the implant housing to the bone. Subsequently, the electrical power source may be removed and replaced with a suitable abutment for affixing a desired prosthesis to the implant housing. Alternatively, the power source may be permanently left within the implant housing.

    摘要翻译： 骨内植入物及其植入方法，其促进将植入物快速且完全固定到骨组织。 在骨部位处的软组织被切开并且在暴露的骨中钻孔。 植入物壳体插入孔中。 植入物壳体被构造成能够在其中接收可选择性地移除的电力源。 当电源被接收在位于骨中的孔内的壳体内并且软组织被密封在植入物容纳部位上时，电源产生穿过组织和围绕该部位的骨的电流。 这种电流促进细胞粘附活性，从而大大减少将植入物外壳固定到骨骼上的时间。 随后，可以移除电源并用适当的邻接替换以将期望的假体附接到植入物外壳。 或者，电源可以永久地留在植入物外壳内。

    Dental implant
    8.
    发明授权
    Dental implant 失效
    牙种植体

    公开(公告)号：US4252525A

    公开(公告)日：1981-02-24

    申请号：US104156

    申请日：1979-12-17

    申请人： Frank W. Child

    发明人： Frank W. Child

    IPC分类号： A61C8/00 ,  A61F2/00

    CPC分类号： A61C8/0086 ,  A61C8/0007 ,  A61C8/0012 ,  A61C8/0018 ,  A61F2/0077 ,  A61C8/0013 ,  A61C8/0016

    摘要： A tooth prothesis located in a mandible tooth socket having a root supporting a crown. The root has a cone-shaped head located in a recess in the bottom of the crown and a stem extended into the socket. An elastic body of ethylene vinyl acetate (EVA) copolymer surrounds and is bonded to the stem. The outer surface of the elastic body is bonded to the inside surface of a porous fabric which permits bone ingrowth to anchor the prothesis to the mandible. The fabric has a Pyrolite carbon outer skin. The upper edge of the fabric is spaced from the crown and head whereby the elastic body allows limited movement of the crown relative to the fabric. A plurality of bands of silver surround the body adjacent the lower edge of the crown. Ionic silver is released from the bands, which provides anti-bacterial action. In one form, a silver wire contained in the root and connected to a band and a source of direct current releases ionic silver into the surrounding tissue. In another form, the root, crown, and body have passages for accommodating drug materials and silver compounds.

    摘要翻译： 位于下颌牙槽中的牙齿假体，其具有支撑牙冠的根部。 根部具有位于冠部底部的凹部中的锥形头部和延伸到插座中的杆部。 乙烯乙酸乙烯酯（EVA）共聚物的弹性体围绕并结合到茎上。 弹性体的外表面结合到多孔织物的内表面，其允许骨向内生长以将假体锚固到下颌骨。 织物有一个Pyrolite碳外皮。 织物的上边缘与冠部和头部间隔开，由此弹性体允许冠部相对于织物的有限运动。 多个银色带围绕主体的下边缘附近。 离子银从带中释放出来，提供抗菌作用。 在一种形式中，包含在根中并连接到带和直流电源的银线将离子银释放到周围组织中。 在另一种形式中，根，冠和身体具有用于容纳药物材料和银化合物的通道。