STERILIZING BIOLOGICAL TISSUE WITH SUPERCRITICAL CARBON DIOXIDE

    公开(公告)号:US20240173443A1

    公开(公告)日:2024-05-30

    申请号:US18504822

    申请日:2023-11-08

    申请人: InnovMedics, LLC

    发明人: Bin Tian

    IPC分类号: A61L2/00

    CPC分类号: A61L2/0088 A61L2101/38

    摘要: A method of sterilizing biological tissue such as soft mammalian tissue that can be used to make bioprosthetic devices is disclosed. The method comprises contacting biological tissue with a bioburden reduction mixture, contacting biological tissue with a tissue drying mixture, and thereafter sterilizing the dry tissue with supercritical carbon dioxide. Bioprosthetic devices made using the methods disclosed herein include bioprosthetic heart valves and surgical tissue patches.