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公开(公告)号：US20230279364A1
公开(公告)日：2023-09-07
申请号：US18319918
申请日：2023-05-18
申请人： Eligo Bioscience
发明人： Jesus FERNANDEZ RODRIGUEZ , Antoine DECRULLE , Aymeric LEVEAU , Ines CANADAS BLASCO , Aurélie MATHIEU , Thibault CARLIER
CPC分类号： C12N7/00 , C12N1/20 , C12N15/74 , C12N15/70 , C12N2795/10322 , C12N2795/10352 , C12N2800/101 , C12N2800/40
摘要： The present invention concerns a production bacterial cell for producing phage particles or phage-derived delivery vehicles, said production bacterial cell stably comprising at least one phage structural gene(s) and at least one phage DNA packaging gene(s), said phage structural gene(s) and phage DNA packaging gene(s) being derived from a first type of bacteriophage,
wherein the expression of at least one of said phage structural gene(s) and/or at least one of said phage DNA packaging gene(s) in said production bacterial cell is controlled by at least one induction mechanism, and
wherein said production bacterial cell is from a bacterial species or strain different from the bacterial species or strain from which said first type of bacteriophage comes and/or that said first type of bacteriophage targets.-
公开(公告)号：US20140147890A1
公开(公告)日：2014-05-29
申请号：US14131320
申请日：2012-07-06
申请人： Cedric Szpirer
发明人： Cedric Szpirer
IPC分类号： C12N15/73
CPC分类号： C12N7/00 , C12N15/70 , C12N2795/10343 , C12N2795/10351 , C12N2795/10352 , C12P1/04 , C12P21/02
摘要： The present invention relates to a genetically modified phage and use thereof in a method for producing a bio molecule of interest.
摘要翻译： 本发明涉及遗传修饰的噬菌体及其在生产感兴趣的生物分子的方法中的用途。
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公开(公告)号：US20130011898A1
公开(公告)日：2013-01-10
申请号：US13178402
申请日：2011-07-07
申请人： Cédric Szpirer
发明人： Cédric Szpirer
CPC分类号： C12N15/70 , C12N7/00 , C12N2795/10351 , C12N2795/10352 , C12P1/04
摘要： The present invention relates to a genetically modified phage and use thereof in a method for producing a biomolecule of interest.
摘要翻译： 本发明涉及遗传修饰的噬菌体及其在生产感兴趣的生物分子的方法中的用途。
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4.发明申请公开(公告)号：US20170327910A1
公开(公告)日：2017-11-16
申请号：US15663614
申请日：2017-07-28
发明人： Diego Ariel Rey , Nikol de Forest , Heather Cox , Soni Shukla
CPC分类号： C12Q1/6897 , C12N1/20 , C12N7/00 , C12N15/70 , C12N15/74 , C12N2795/10143 , C12N2795/10152 , C12N2795/10343 , C12N2795/10352 , C12Q1/14 , C12Q1/18 , C12Q1/66 , C12Y113/12007 , G01N2333/31 , G01N2333/90241
摘要： Methods and systems are provided for packaging reporter nucleic acid molecules into non-replicative transduction particles for use as reporter molecules. The non-replicative transduction particles can be constructed from viruses and use viral transduction and replication systems. The reporter nucleic acid molecules include a reporter gene, such as a reporter molecule or selectable marker, for detecting target genes or cells. Methods and systems are provided for detection of cells and target nucleic acid molecules using the non-replicative transduction particles as reporter molecules.
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5.发明申请公开(公告)号：US20160281180A1
公开(公告)日：2016-09-29
申请号：US15183303
申请日：2016-06-15
发明人： Diego Ariel Rey , Nikol de Forest , Heather Cox , Soni Shukla
CPC分类号： C12Q1/6897 , C12N1/20 , C12N7/00 , C12N15/70 , C12N15/74 , C12N2795/10143 , C12N2795/10152 , C12N2795/10343 , C12N2795/10352 , C12Q1/14 , C12Q1/18 , C12Q1/66 , C12Y113/12007 , G01N2333/31 , G01N2333/90241
摘要： Methods and systems are provided for packaging reporter nucleic acid molecules into non-replicative transduction particles for use as reporter molecules. The non-replicative transduction particles can be constructed from viruses and use viral transduction and replication systems. The reporter nucleic acid molecules include a reporter gene, such as a reporter molecule or selectable marker, for detecting target genes or cells. Methods and systems are provided for detection of cells and target nucleic acid molecules using the non-replicative transduction particles as reporter molecules.
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6.发明授权Non-replicative transduction particles and transduction particle-based reporter systems 有权非复制转导颗粒和基于转导粒子的报告系统公开(公告)号：US09388453B2
公开(公告)日：2016-07-12
申请号：US14550335
申请日：2014-11-21
发明人： Diego Ariel Rey
CPC分类号： C12Q1/6897 , C12N1/20 , C12N7/00 , C12N15/70 , C12N15/74 , C12N2795/10143 , C12N2795/10152 , C12N2795/10343 , C12N2795/10352 , C12Q1/14 , C12Q1/18 , C12Q1/66 , C12Y113/12007 , G01N2333/31 , G01N2333/90241
摘要： Methods and systems are provided for packaging reporter nucleic acid molecules into non-replicative transduction particles for use as reporter molecules. The non-replicative transduction particles can be constructed from viruses and use viral transduction and replication systems. The reporter nucleic acid molecules include a reporter gene, such as a reporter molecule or selectable marker, for detecting target genes or cells. Methods and systems are provided for detection of cells and target nucleic acid molecules using the non-replicative transduction particles as reporter molecules.
摘要翻译： 提供了用于将报道核酸分子包装成非复制转导颗粒以用作报道分子的方法和系统。 非复制转导颗粒可以由病毒构建并使用病毒转导和复制系统。 报道核酸分子包括用于检测靶基因或细胞的报告基因，例如报道分子或选择性标记。 提供了使用非复制转导颗粒作为报告分子来检测细胞和靶核酸分子的方法和系统。
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公开(公告)号：US11952595B2
公开(公告)日：2024-04-09
申请号：US18348910
申请日：2023-07-07
申请人： Eligo Bioscience
发明人： Jesus Fernandez Rodriguez , Antoine Decrulle , Aymeric Leveau , Ines Canadas Blasco , Aurelie Mathieu , Thibault Carlier
CPC分类号： C12N7/00 , C12N1/20 , C12N15/70 , C12N15/74 , C12N2795/10322 , C12N2795/10352 , C12N2800/101 , C12N2800/40
摘要： The present invention concerns a production bacterial cell for producing lytic phage particles or lytic phage-derived delivery vehicles, said production bacterial cell stably comprising at least one phage structural genes and at least one phage DNA packaging genes, said phage structural gene(s) and phage DNA packaging gene(s) being derived from a lytic bacteriophage, wherein the expression of at least one of said phage structural genes and/or at least one of said phage DNA packaging gene(s) in said production bacterial cell is controlled by an induction mechanism.
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公开(公告)号：US11739304B2
公开(公告)日：2023-08-29
申请号：US17742693
申请日：2022-05-12
申请人： Eligo Bioscience
发明人： Jesus Fernandez Rodriguez , Antoine Decrulle , Aymeric Leveau , Ines Canadas Blasco , Aurélie Mathieu , Thibault Carlier
CPC分类号： C12N7/00 , C12N1/20 , C12N15/70 , C12N15/74 , C12N2795/10322 , C12N2795/10352 , C12N2800/101 , C12N2800/40
摘要： The present invention concerns a production bacterial cell for producing lytic phage particles or lytic phage-derived delivery vehicles, said production bacterial cell stably comprising at least one phage structural genes and at least one phage DNA packaging genes, said phage structural gene(s) and phage DNA packaging gene(s) being derived from a lytic bacteriophage,
wherein the expression of at least one of said phage structural genes and/or at least one of said phage DNA packaging gene(s) in said production bacterial cell is controlled by an induction mechanism.-
公开(公告)号：US09771622B2
公开(公告)日：2017-09-26
申请号：US15180790
申请日：2016-06-13
发明人： Diego Ariel Rey , Nikol de Forest , Heather Cox , Soni Shukla
CPC分类号： C12Q1/6897 , C12N1/20 , C12N7/00 , C12N15/70 , C12N15/74 , C12N2795/10143 , C12N2795/10152 , C12N2795/10343 , C12N2795/10352 , C12Q1/14 , C12Q1/18 , C12Q1/66 , C12Y113/12007 , G01N2333/31 , G01N2333/90241
摘要： Methods and systems are provided for packaging reporter nucleic acid molecules into non-replicative transduction particles for use as reporter molecules. The non-replicative transduction particles can be constructed from viruses and use viral transduction and replication systems. The reporter nucleic acid molecules include a reporter gene, such as a reporter molecule or selectable marker, for detecting target genes or cells. Methods and systems are provided for detection of cells and target nucleic acid molecules using the non-replicative transduction particles as reporter molecules.
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公开(公告)号：US11939598B2
公开(公告)日：2024-03-26
申请号：US18319918
申请日：2023-05-18
申请人： Eligo Bioscience
发明人： Jesus Fernandez Rodriguez , Antoine Decrulle , Aymeric Leveau , Ines Canadas Blasco , Aurélie Mathieu , Thibault Carlier
CPC分类号： C12N7/00 , C12N1/20 , C12N15/70 , C12N15/74 , C12N2795/10322 , C12N2795/10352 , C12N2800/101 , C12N2800/40
摘要： The present invention concerns a production bacterial cell for producing phage particles or phage-derived delivery vehicles, said production bacterial cell stably comprising at least one phage structural gene(s) and at least one phage DNA packaging gene(s), said phage structural gene(s) and phage DNA packaging gene(s) being derived from a first type of bacteriophage,
wherein the expression of at least one of said phage structural gene(s) and/or at least one of said phage DNA packaging gene(s) in said production bacterial cell is controlled by at least one induction mechanism, and
wherein said production bacterial cell is from a bacterial species or strain different from the bacterial species or strain from which said first type of bacteriophage comes and/or that said first type of bacteriophage targets.
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