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公开(公告)号：US09963720B2
公开(公告)日：2018-05-08
申请号：US15224900
申请日：2016-08-01
CPC分类号： C12P7/04 , C07K14/32 , C12N9/0042 , C12N9/0071 , C12N9/0077 , C12P7/06 , C12Y106/02004 , C12Y114/14001 , C12Y114/15 , C12Y114/15003 , Y02P20/52
摘要： This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
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公开(公告)号：US20170183689A1
公开(公告)日：2017-06-29
申请号：US15224900
申请日：2016-08-01
CPC分类号： C12P7/04 , C07K14/32 , C12N9/0042 , C12N9/0071 , C12N9/0077 , C12P7/06 , C12Y106/02004 , C12Y114/14001 , C12Y114/15 , C12Y114/15003 , Y02P20/52
摘要： This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
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公开(公告)号：US20180346947A1
公开(公告)日：2018-12-06
申请号：US15573874
申请日：2017-08-28
发明人： Guangsheng Li , Tao Yang , Gangqiang Wan , Xinxin Qu
CPC分类号： C12P17/12 , C12N1/20 , C12N9/0077 , C12P7/40 , C12R1/06 , C12Y114/15
摘要： The present invention belongs to microbial technology field and relates to a strain producing toluene o-xylene monooxygenase (Arthrobacter woluwensis) HW-1 and its application in preparation of 5-methylpyrazine-2-carboxylic acid by microbial fermentation. The present invention providing a new strain HW-1 which could produce toluene o-xylene monooxygenase, and the strain is identified as Arthrobacter woluwensis. The strain is firstly found to convert 2, 5-dimethylpyrazine by bio-fermentation to obtain the medicine intermediate 5-methylpyrazine-2-carboxylic acid. The concentration of accumulated product could reach 34.19 g/L and the yield rate is 81.4% by shake flask fermentation. Compared with 20.41 g/L reported in the literature, this method has a greater advantage and could be industrialized. The conditions to prepare 5-methylpyrazine-2-carboxylic acid provided in the present invention is mild, the reaction process is controllable and has good performance in environmental protection and energy saving. So this invention has great value in industry.
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公开(公告)号：US09404096B2
公开(公告)日：2016-08-02
申请号：US14788365
申请日：2015-06-30
CPC分类号： C12P7/04 , C07K14/32 , C12N9/0042 , C12N9/0071 , C12N9/0077 , C12P7/06 , C12Y106/02004 , C12Y114/14001 , C12Y114/15 , C12Y114/15003 , Y02P20/52
摘要： This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
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公开(公告)号：US20170267984A1
公开(公告)日：2017-09-21
申请号：US15454018
申请日：2017-03-09
CPC分类号： C12N9/18 , C12N1/12 , C12N9/001 , C12N9/0077 , C12N15/52 , C12N15/63 , C12P7/6409 , C12Y103/07 , C12Y114/15 , C12Y301/01014 , C12Y301/01082
摘要： Recombinant microorganisms and methods for using the same are disclosed herein for producing biomass or at least one biomolecule. These methods comprise culturing a photosynthetic microorganism that can overexpress a chlorophyllase, and optionally isolating biomass and/or at least one biomolecule from the culture.
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公开(公告)号：US20160024482A1
公开(公告)日：2016-01-28
申请号：US14788365
申请日：2015-06-30
IPC分类号： C12N9/02
CPC分类号： C12P7/04 , C07K14/32 , C12N9/0042 , C12N9/0071 , C12N9/0077 , C12P7/06 , C12Y106/02004 , C12Y114/14001 , C12Y114/15 , C12Y114/15003 , Y02P20/52
摘要： This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
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公开(公告)号：US09074178B2
公开(公告)日：2015-07-07
申请号：US14270268
申请日：2014-05-05
CPC分类号： C12P7/04 , C07K14/32 , C12N9/0042 , C12N9/0071 , C12N9/0077 , C12P7/06 , C12Y106/02004 , C12Y114/14001 , C12Y114/15 , C12Y114/15003 , Y02P20/52
摘要： This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
摘要翻译： 本发明涉及改性羟化酶。 本发明还涉及表达这种修饰的羟化酶的细胞和通过使合适的底物与这种细胞接触来制备羟基化烷烃的方法。
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公开(公告)号：US20080057577A1
公开(公告)日：2008-03-06
申请号：US11697404
申请日：2007-04-06
申请人： Frances Arnold , Peter Meinhold , Matthew Peters , Rudi Fasan , Mike Chen
发明人： Frances Arnold , Peter Meinhold , Matthew Peters , Rudi Fasan , Mike Chen
CPC分类号： C12P7/04 , C07K14/32 , C12N9/0042 , C12N9/0071 , C12N9/0077 , C12P7/06 , C12Y106/02004 , C12Y114/14001 , C12Y114/15 , C12Y114/15003 , Y02P20/52
摘要： This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
摘要翻译： 本发明涉及改性羟化酶。 本发明还涉及表达这种修饰的羟化酶的细胞和通过使合适的底物与这种细胞接触来制备羟基化烷烃的方法。
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公开(公告)号：US20230263829A1
公开(公告)日：2023-08-24
申请号：US18115846
申请日：2023-03-01
IPC分类号： A61K35/17 , C12N15/52 , C12N15/62 , C12N5/0783
CPC分类号： A61K35/17 , C12N15/52 , C12N15/62 , C12N5/0636 , C12Y103/01021 , C12N2820/60 , C12Y101/01051 , C12Y106/02004 , C12Y118/01002 , C12N2710/16141 , C12N2820/005 , C12Y114/15 , C07K2319/43 , C12Y103/99004 , C12Y101/01145 , C12Y114/15006 , C12N9/001
摘要： Compositions, methods, and systems for modifying sterol metabolism in a subject is disclosed. In some embodiments, the subjects may be administered one or more mammalian cells modified to express at least one sterol degrading enzyme derived from a bacterium. In many embodiments, the cell is a macrophage or monocyte stably expressing three or more enzymes that aid in opening the β ring of cholesterol. The disclosed compositions and methods may be useful in lowering cholesterol levels in a subject in need thereof. In some embodiments, the subject may have a genetic predisposition to atherosclerosis.
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10.发明申请公开(公告)号：US20190045812A1
公开(公告)日：2019-02-14
申请号：US16050012
申请日：2018-07-31
发明人： Eon Seon JIN , Sang Su BAE , Kwang Ryul BAEK , Duk Hyoung KIM , Joo Yeon JEONG
IPC分类号： A23K20/179 , A61K9/00 , C12R1/89
CPC分类号： A23K20/179 , A23K10/16 , A23K20/174 , A23L29/065 , A23L33/135 , A61K9/0053 , A61K9/2018 , C12N1/12 , C12N9/0073 , C12N9/0077 , C12P23/00 , C12R1/89 , C12Y114/1309 , C12Y114/15
摘要： The present invention relates to a new alga having an improved ability to produce a pigment, and when a mutant of the present invention is used, a carotenoid-based pigment, specifically, a xanthophyll can be produced by consuming less energy, so that it is possible to efficiently produce the pigment at the industrial level. Further, the pigment can be applied as a raw material for a food, a health functional food and a medicine, which include the pigment. In particular, since a DNA fragment is not likely to be inserted into a target base sequence or a base sequence other than the target, it is expected that the procedure of constructing the mutant is not regulated as a GMO, so that it is expected that the procedure of constructing the mutant can create a big economic effect in terms of an industry which produces lutein and zeaxanthin by using microalgae.
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