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公开(公告)号：US11845968B2
公开(公告)日：2023-12-19
申请号：US17592869
申请日：2022-02-04
申请人： Codexis, Inc.
发明人： Da Duan , Oscar Alvizo , Jovana Nazor , Harvinder Chagger Maniar , James Nicholas Riggins , Jonathan Vroom , Santhosh Sivaramakrishnan , Hao Yang , Anna Fryszkowska , Mark A. Huffman , Joshua N. Kolev , Iman Farasat , Agustina Rodriguez-Granillo , Deeptak Verma
CPC分类号： C12N9/88 , C12N15/63 , C12P21/02 , C12Y401/02004
摘要： The present invention provides engineered deoxyribose-phosphate aldolase polypeptides useful under industrial process conditions for the production of pharmaceutical and fine chemical compounds.
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公开(公告)号：US20170191095A1
公开(公告)日：2017-07-06
申请号：US15313416
申请日：2015-05-22
发明人： Philippe Marliere
CPC分类号： C12P9/00 , C12N9/1025 , C12N9/88 , C12N9/92 , C12P7/24 , C12P7/26 , C12P19/02 , C12P19/40 , C12Y203/01008 , C12Y203/03015 , C12Y401/02004 , C12Y401/02009 , C12Y503/01005
摘要： Described is a method for the production of D-erythrose and acetyl phosphate comprising the enzymatic conversion of D-fructose into D-erythrose and acetyl phosphate by making use of a phosphoketolase. The produced D-erythrose can further be converted into glycolaldehyde by a method for the production of glycolaldehyde comprising the enzymatic conversion of D-erythrose into glycolaldehyde by making use of an aldolase, wherein said aldolase is a 2-deoxyribose-5-phosphate aldolase (EC 4.1.2.4) or a fructose-bisphosphate aldolase (EC 4.1.2.13). The produced glycolaldehyde can finally be converted into acetyl phosphate by the enzymatic conversion of the thus produced glycolaldehyde into acetyl phosphate by making use of a phosphoketolase or a sulfoacetaldehyde acetyltransferase.
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公开(公告)号：US20170356016A1
公开(公告)日：2017-12-14
申请号：US15515441
申请日：2015-09-30
申请人： ZUVASYNTHA LIMITED
发明人： Michelle GRADLEY , Alex PUDNEY , Dana HELDT
CPC分类号： C12P7/24 , C07K2319/00 , C12N9/0008 , C12N9/88 , C12N15/52 , C12P7/18 , C12Y102/01003 , C12Y401/01001 , C12Y401/02004 , Y02P20/582
摘要： Non-naturally occurring microbial organisms and related methods, processes and materials are for microbial organisms that include a genetic modification which enhances production of 3-hydroxybutanal or a downstream product of 3-hydroxybutanal such as 1,3-butanediol from endogenous central metabolic intermediates such as acetyl CoA or pyruvate which are converted to acetaldehyde. Two molecules of acetaldehyde are condensed to form the 3-hydroxybutanal using an aldolase capable of accepting acetaldehyde as both the acceptor and donor in an aldol condensation. The aldolase may be a deoxyribose phosphate aldolase type enzyme, and is typically introduced into the organisms. Energetically favorable pathways produce 3-hydroxybutanal or downstream products thereof.
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