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    Gene encoding chondroitinase ABC and uses therefor
    1.
    发明申请
    Gene encoding chondroitinase ABC and uses therefor 审中-公开
    基因编码软骨素酶ABC并用于此

    公开(公告)号：US20060154337A1

    公开(公告)日：2006-07-13

    申请号：US11313169

    申请日：2005-12-20

    申请人： Nobuyuki Sato ,  Masahiko Shimada ,  Hiroshi Oda

    发明人： Nobuyuki Sato ,  Masahiko Shimada ,  Hiroshi Oda

    IPC分类号： C12N9/24 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C12Y402/02004 ,  A61K38/00 ,  C12N9/88 ,  G01N33/573

    摘要： Nucleic acid sequences coding for the chondroitinase ABC gene and isolated chondroitinase ABC protein produced in a host cell transformed with a nucleic acid vector directing the expression of a nucleotide sequence coding for chondroitinase ABC protein are described. Chondroitinase ABC prepared by chemical synthesis is also described. Monoclonal and polyclonal antibodies which are specifically reactive with chondroitinase ABC protein are disclosed. The isolated chondroitinase ABC can be used in methods of treating intervertebral disc displacement, promoting neurite regeneration, and detecting galactosaminoglycans.

    摘要翻译： 描述了编码软骨素酶ABC基因的核酸序列和在用指导编码软骨素酶ABC蛋白的核苷酸序列的表达的核酸载体转化的宿主细胞中产生的分离的软骨素酶ABC蛋白。 还描述了通过化学合成制备的软骨素酶ABC。 公开了与软骨素酶ABC蛋白特异性反应的单克隆和多克隆抗体。 分离的软骨素酶ABC可用于治疗椎间盘置换，促进神经突再生和检测半乳糖胺聚糖的方法。

    Gene encoding chondroitinase ABC and uses therefor
    2.
    发明授权
    Gene encoding chondroitinase ABC and uses therefor 失效
    基因编码软骨素酶ABC并用于此

    公开(公告)号：US07008783B1

    公开(公告)日：2006-03-07

    申请号：US08488960

    申请日：1995-06-07

    申请人： Nobuyuki Sato ,  Masahiko Shimada ,  Hiroshi Oda

    发明人： Nobuyuki Sato ,  Masahiko Shimada ,  Hiroshi Oda

    IPC分类号： C12N9/88 ,  C12N15/60 ,  C12N15/63 ,  C12N5/10 ,  C12N1/00 ,  C12N1/21

    CPC分类号： C12Y402/02004 ,  C12N9/88

    摘要： Nucleic acid sequences coding for the chondroitinase ABC gene and isolated chondroitinase ABE protein produced in a host cell transformed with a nucleic acid vector directing the expression of a nucleotide sequence coding for chondroitinase ABE protein described. Chondroitinase ABC prepared by chemical synthesis also described. Monoclonal and polyclonal antibodies which are specifically reactive with chondroitinase ABC protein are disclosed. The isolated chondroitinase ABC can be used in methods of treating intervertebral disc replacement, promoting neurite regeneration, and detecting galactosaminoglycans.

    摘要翻译： 编码软骨素酶ABC基因的核酸序列和分离的软骨素酶ABE蛋白质在用指导编码软骨素酶ABE蛋白质的核苷酸序列的表达的核酸载体转化的宿主细胞中产生。 通过化学合成制备的软骨素酶ABC也有描述。 公开了与软骨素酶ABC蛋白特异性反应的单克隆和多克隆抗体。 分离的软骨素酶ABC可用于治疗椎间盘置换，促进神经突再生和检测半乳糖胺聚糖的方法。

    Gene encoding chondroitinase ABC and uses therefor
    3.
    再颁专利
    Gene encoding chondroitinase ABC and uses therefor 有权
    基因编码软骨素酶ABC并用于此

    公开(公告)号：USRE43166E1

    公开(公告)日：2012-02-07

    申请号：US12613119

    申请日：2009-11-05

    申请人： Nobuyuki Sato ,  Masahiko Shimada ,  Hiroshi Oda

    发明人： Nobuyuki Sato ,  Masahiko Shimada ,  Hiroshi Oda

    IPC分类号： C12N15/60 ,  C12N15/63 ,  C12N5/10 ,  C12N1/00 ,  C12N1/21 ,  C12N9/88

    CPC分类号： C12Y402/02004 ,  C12N9/88

    摘要： Nucleic acid sequences coding for the chondroitinase ABC gene and isolated chondroitinase ABE protein produced in a host cell transformed with a nucleic acid vector directing the expression of a nucleotide sequence coding for chondroitinase ABE protein described. Chondroitinase ABC prepared by chemical synthesis also described. Monoclonal and polyclonal antibodies which are specifically reactive with chondroitinase ABC protein are disclosed. The isolated chondroitinase ABC can be used in methods of treating intervertebral disc replacement, promoting neurite regeneration, and detecting galactosaminoglycans.

    摘要翻译： 编码软骨素酶ABC基因的核酸序列和分离的软骨素酶ABE蛋白质在用指导编码软骨素酶ABE蛋白质的核苷酸序列的表达的核酸载体转化的宿主细胞中产生。 通过化学合成制备的软骨素酶ABC也有描述。 公开了与软骨素酶ABC蛋白特异性反应的单克隆和多克隆抗体。 分离的软骨素酶ABC可用于治疗椎间盘置换，促进神经突再生和检测半乳糖胺聚糖的方法。

    Method of detection and disease state management for renal diseases
    8.
    发明授权
    Method of detection and disease state management for renal diseases 失效
    肾脏疾病的检测和疾病状态管理方法

    公开(公告)号：US07109044B1

    公开(公告)日：2006-09-19

    申请号：US09786503

    申请日：1999-04-09

    申请人： Hiroshi Oda ,  Kosuke Seiki ,  Hiroshi Nakajima ,  Nobuyuki Sato ,  Yoshihiro Urade ,  Nobuhito Hirawa ,  Yoshio Uehara

    发明人： Hiroshi Oda ,  Kosuke Seiki ,  Hiroshi Nakajima ,  Nobuyuki Sato ,  Yoshihiro Urade ,  Nobuhito Hirawa ,  Yoshio Uehara

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6893 ,  G01N33/573 ,  G01N33/70 ,  G01N33/88 ,  G01N2800/347 ,  Y10S436/811

    摘要： The present invention relates to a method of detection of an early-stage renal disease, comprising determining the concentration of human lipocalin-type prostaglandin D synthase in a body fluid sample taken from a subject and comparing the determined concentration with a reference value set by determining the concentrations of human lipocalin-type prostaglandin D synthase in body fluid samples taken from healthy subjects; and a method of disease state management for a renal disease, comprising determining the concentration of human lipocalin-type prostaglandin D synthase in a body fluid sample taken from a subject and evaluating the glomerular filtration ability of the subject from the determined concentration.

    摘要翻译： 本发明涉及一种早期肾病的检测方法，包括测定取自受试者的体液样品中人脂笼蛋白型前列腺素D合成酶的浓度，并将测定的浓度与通过确定 来自健康受试者的体液样品中人脂笼蛋白型前列腺素D合成酶的浓度; 以及肾病疾病状态管理方法，包括测定取自对象的体液样品中人脂质运载蛋白型前列腺素D合成酶的浓度，并根据测定的浓度评价受试者的肾小球滤过能力。

    Method for predicting pregnancy-induced hypertension
    9.
    发明授权
    Method for predicting pregnancy-induced hypertension 失效
    预测妊娠高血压的方法

    公开(公告)号：US07399596B2

    公开(公告)日：2008-07-15

    申请号：US10573072

    申请日：2004-09-24

    申请人： Hiroshi Oda ,  Kosuke Seiki ,  Yasuhiko Shiina ,  Nobuyuki Sato ,  Satoru Takeda ,  Naomi Eguchi ,  Yoshihiro Urade

    发明人： Hiroshi Oda ,  Kosuke Seiki ,  Yasuhiko Shiina ,  Nobuyuki Sato ,  Satoru Takeda ,  Naomi Eguchi ,  Yoshihiro Urade

    IPC分类号： G01N33/53

    CPC分类号： C12Q1/533 ,  G01N33/689 ,  G01N2800/368

    摘要： Provided are: a method for predicting the onset of pregnancy-induced hypertension (PIH) by precisely detecting abnormalities that occur before the onset of PIH (where such abnormalities have been impossible to detect by various conventional testing methods for PIH) while imposing less of a burden on a subject; a method for evaluating a fetus and placental functions in PIH; and a method for detecting PIH, which comprises measuring the level of human lipocalin-type prostaglandin D synthase (L-PGDS) in a body fluid sample collected from a subject.

    摘要翻译： 提供：通过精确检测在PIH发病之前发生的异常（其中这种异常不可能通过各种常规的PIH检测方法检测）而预测妊娠诱发的高血压（PIH）的发作的方法，同时施加较少的 一个主题的负担; 用于评估PIH中胎儿和胎盘功能的方法; 以及检测PIH的方法，其包括测量从受试者收集的体液样品中的人脂笼蛋白型前列腺素D合成酶（L-PGDS）的水平。