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公开(公告)号：US07993894B2
公开(公告)日：2011-08-09
申请号：US12354255
申请日：2009-01-15
申请人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. DaVila-Aponte , Siqun Xu , Anita M. Frevert
发明人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. DaVila-Aponte , Siqun Xu , Anita M. Frevert
IPC分类号： C12N9/02 , C12N1/20 , C12N15/00 , C12N9/00 , C12P21/04 , C12Q1/68 , C12Q1/48 , C12Q1/00 , C07H21/04
CPC分类号： C12N9/0083 , C12N15/8247 , C12N15/8285 , G01N33/573 , G01N2333/4353 , Y02A40/164
摘要： Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
摘要翻译： 描述了编码脂肪酸去饱和酶多肽的线虫的核酸分子。 还提供了脂肪酸去饱和酶样多肽序列，以及用于产生脂肪酸去饱和酶样核苷酸和多肽的载体，宿主细胞和重组方法。 还描述了用于鉴定脂肪酸去饱和酶样多肽的抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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公开(公告)号：US20090203127A1
公开(公告)日：2009-08-13
申请号：US12354282
申请日：2009-01-15
申请人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. Davila-Aponte , Siqun Xu , Anita M. Frevert
发明人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. Davila-Aponte , Siqun Xu , Anita M. Frevert
CPC分类号： C12N9/0083 , C12N15/8247 , C12N15/8285 , G01N33/573 , G01N2333/4353 , Y02A40/164
摘要： Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as arc vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
摘要翻译： 描述了编码脂肪酸去饱和酶多肽的线虫的核酸分子。 还提供了脂肪酸去饱和酶样多肽序列作为电弧载体，宿主细胞和用于产生脂肪酸去饱和酶样核苷酸和多肽的重组方法。 还描述了用于鉴定脂肪酸去饱和酶样多肽的抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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公开(公告)号：US07479382B2
公开(公告)日：2009-01-20
申请号：US12061072
申请日：2008-04-02
申请人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. Davila-Aponte , Siqun Xu , Anita M. Frevert
发明人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. Davila-Aponte , Siqun Xu , Anita M. Frevert
IPC分类号： C12N9/02 , C12N1/20 , C12N15/00 , C12P21/04 , C12Q1/68 , C12Q1/48 , C07H21/04 , C12Q1/00 , C12N9/00
CPC分类号： C12N9/0083 , C12N15/8247 , C12N15/8285 , G01N33/573 , G01N2333/4353 , Y02A40/164
摘要： Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
摘要翻译： 描述了编码脂肪酸去饱和酶多肽的线虫的核酸分子。 还提供了脂肪酸去饱和酶样多肽序列，以及用于产生脂肪酸去饱和酶样核苷酸和多肽的载体，宿主细胞和重组方法。 还描述了用于鉴定脂肪酸去饱和酶样多肽的抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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公开(公告)号：US07666642B2
公开(公告)日：2010-02-23
申请号：US12354282
申请日：2009-01-15
申请人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. Davila-Aponte , Siqun Xu , Anita M. Frevert
发明人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. Davila-Aponte , Siqun Xu , Anita M. Frevert
IPC分类号： C12N9/02 , C12N1/20 , C12N15/00 , C12P21/04 , C12Q1/68 , C12Q1/48 , C07H21/04 , C12Q1/00 , C12N9/00
CPC分类号： C12N9/0083 , C12N15/8247 , C12N15/8285 , G01N33/573 , G01N2333/4353 , Y02A40/164
摘要： Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
摘要翻译： 描述了编码脂肪酸去饱和酶多肽的线虫的核酸分子。 还提供了脂肪酸去饱和酶样多肽序列，以及用于产生脂肪酸去饱和酶样核苷酸和多肽的载体，宿主细胞和重组方法。 还描述了用于鉴定脂肪酸去饱和酶样多肽的抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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公开(公告)号：US07442533B2
公开(公告)日：2008-10-28
申请号：US10602268
申请日：2003-06-23
申请人： Deryck J. Williams , Merry B. McLaird , Michelle Coutu Hresko , Anita M. Frevert , Ronald E. Worthington , Andrew P. Kloek , Jennifer A. Davila-Aponte , John D. Bradley , Siqun Xu
发明人： Deryck J. Williams , Merry B. McLaird , Michelle Coutu Hresko , Anita M. Frevert , Ronald E. Worthington , Andrew P. Kloek , Jennifer A. Davila-Aponte , John D. Bradley , Siqun Xu
CPC分类号： C12N9/1007
摘要： Nucleic acid molecules from nematodes encoding phosphoethanolamine n-methyltransferase polypeptides are described. PEAMT-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PEAMT-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
摘要翻译： 描述了编码磷酸乙醇胺正甲基转移酶多肽的线虫的核酸分子。 还提供了PEAMT样多肽序列，载体，宿主细胞和用于产生PEAMT样核苷酸和多肽的重组方法也是如此。 还描述了用于鉴定抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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公开(公告)号：US07339044B2
公开(公告)日：2008-03-04
申请号：US11191588
申请日：2005-07-28
申请人： Michelle Coutu Hresko , Merry B. McLaird , Deryck J. Williams , Anita M. Frevert , Brandi Chiapelli , Catherine Baublite , Andrew P. Kloek , Jennifer A. Davila-Aponte , John D. Bradley , Siqun Xu
发明人： Michelle Coutu Hresko , Merry B. McLaird , Deryck J. Williams , Anita M. Frevert , Brandi Chiapelli , Catherine Baublite , Andrew P. Kloek , Jennifer A. Davila-Aponte , John D. Bradley , Siqun Xu
CPC分类号： C07K14/705
摘要： Nucleic acid molecules from nematodes encoding PAN and ZP domain containing receptor polypeptides are described. PANZP polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PANZP nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
摘要翻译： 描述了编码含有PAN和ZP结构域的受体多肽的线虫的核酸分子。 还提供PANZP多肽序列，载体，宿主细胞以及用于产生PANZP核苷酸和多肽的重组方法。 还描述了用于鉴定抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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公开(公告)号：US07265204B2
公开(公告)日：2007-09-04
申请号：US11191375
申请日：2005-07-28
申请人： Michelle Coutu Hresko , Merry B. McLaird , Deryck J. Williams , Anita M. Frevert , Brandi Chiapelli , Catherine Baublite , Andrew P. Kloek , Jennifer A. Davila-Aponte , John D. Bradley , Siqun Xu
发明人： Michelle Coutu Hresko , Merry B. McLaird , Deryck J. Williams , Anita M. Frevert , Brandi Chiapelli , Catherine Baublite , Andrew P. Kloek , Jennifer A. Davila-Aponte , John D. Bradley , Siqun Xu
CPC分类号： C07K14/705
摘要： Nucleic acid molecules from nematodes encoding PAN and ZP domain containing receptor polypeptides are described. PANZP polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PANZP nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
摘要翻译： 描述了编码含有PAN和ZP结构域的受体多肽的线虫的核酸分子。 还提供PANZP多肽序列，载体，宿主细胞以及用于产生PANZP核苷酸和多肽的重组方法。 还描述了用于鉴定抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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公开(公告)号：US08198060B2
公开(公告)日：2012-06-12
申请号：US12260071
申请日：2008-10-28
申请人： Deryck J. Williams , Merry B. McLaird , Michelle Coutu Hresko , Anita M. Frevert , Ronald E. Worthington , Andrew P. Kloek , Jennifer A. Davila-Aponte , John D. Bradley , Siqun Xu
发明人： Deryck J. Williams , Merry B. McLaird , Michelle Coutu Hresko , Anita M. Frevert , Ronald E. Worthington , Andrew P. Kloek , Jennifer A. Davila-Aponte , John D. Bradley , Siqun Xu
IPC分类号： C12N9/12
CPC分类号： C12N9/1007
摘要： Nucleic acid molecules from nematodes encoding phosphoethanolamine n-methyltransferase polypeptides are described. PEAMT-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PEAMT-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
摘要翻译： 描述了编码磷酸乙醇胺正甲基转移酶多肽的线虫的核酸分子。 还提供了PEAMT样多肽序列，载体，宿主细胞和用于产生PEAMT样核苷酸和多肽的重组方法也是如此。 还描述了用于鉴定抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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公开(公告)号：US20100248357A1
公开(公告)日：2010-09-30
申请号：US12354255
申请日：2009-01-15
申请人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. DaVila-Aponte , Siqun Xu , Anita M. Frevert
发明人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. DaVila-Aponte , Siqun Xu , Anita M. Frevert
CPC分类号： C12N9/0083 , C12N15/8247 , C12N15/8285 , G01N33/573 , G01N2333/4353 , Y02A40/164
摘要： Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
摘要翻译： 描述了编码脂肪酸去饱和酶多肽的线虫的核酸分子。 还提供了脂肪酸去饱和酶样多肽序列，以及用于产生脂肪酸去饱和酶样核苷酸和多肽的载体，宿主细胞和重组方法。 还描述了用于鉴定脂肪酸去饱和酶样多肽的抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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公开(公告)号：US06875595B2
公开(公告)日：2005-04-05
申请号：US10243468
申请日：2002-09-13
申请人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. Davila-Aponte , Siqun Xu , Anita M. Frevert
发明人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. Davila-Aponte , Siqun Xu , Anita M. Frevert
IPC分类号： C12N9/02 , C12N15/82 , G01N33/573 , C12N15/00 , C07H21/04
CPC分类号： C12N9/0083 , C12N15/8247 , C12N15/8285 , G01N33/573 , G01N2333/4353 , Y02A40/164
摘要： Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
摘要翻译： 描述了编码脂肪酸去饱和酶多肽的线虫的核酸分子。 还提供了脂肪酸去饱和酶样多肽序列，以及用于产生脂肪酸去饱和酶样核苷酸和多肽的载体，宿主细胞和重组方法。 还描述了用于鉴定脂肪酸去饱和酶样多肽的抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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