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公开(公告)号：US07939713B2
公开(公告)日：2011-05-10
申请号：US11552681
申请日：2006-10-25
申请人： Michelle L. Verbsky , Catherine Baublite , Deryck J. Williams , Andrew P. Kloek , Jennifer A. Davila-Aponte , Michelle Coutu Hresko , Merry B. McLaird , Rodolfo Zentella
发明人： Michelle L. Verbsky , Catherine Baublite , Deryck J. Williams , Andrew P. Kloek , Jennifer A. Davila-Aponte , Michelle Coutu Hresko , Merry B. McLaird , Rodolfo Zentella
CPC分类号： C12N15/8285 , C12N15/8247 , Y02A40/164 , Y02A40/166
摘要： The present invention provides DNA constructs, transgenic plants containing such constructs, and methods of making the plants. The DNA constructs encode a polypeptide that when expressed results in the production of fatty acid compounds having anthelmintic activity. Transgenic plants expressing such a polypeptide can exhibit enhanced resistance to plant parasitic nematodes, particularly when expressed in vegetative tissues.
摘要翻译： 本发明提供了DNA构建体，含有这种构建体的转基因植物和制备植物的方法。 DNA构建体编码多肽，当表达导致产生具有驱肠虫活性的脂肪酸化合物时。 表达这种多肽的转基因植物可以表现出对植物寄生线虫的增强的抗性，特别是当在营养组织中表达时。
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公开(公告)号：US07993894B2
公开(公告)日：2011-08-09
申请号：US12354255
申请日：2009-01-15
申请人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. DaVila-Aponte , Siqun Xu , Anita M. Frevert
发明人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. DaVila-Aponte , Siqun Xu , Anita M. Frevert
IPC分类号： C12N9/02 , C12N1/20 , C12N15/00 , C12N9/00 , C12P21/04 , C12Q1/68 , C12Q1/48 , C12Q1/00 , C07H21/04
CPC分类号： C12N9/0083 , C12N15/8247 , C12N15/8285 , G01N33/573 , G01N2333/4353 , Y02A40/164
摘要： Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
摘要翻译： 描述了编码脂肪酸去饱和酶多肽的线虫的核酸分子。 还提供了脂肪酸去饱和酶样多肽序列，以及用于产生脂肪酸去饱和酶样核苷酸和多肽的载体，宿主细胞和重组方法。 还描述了用于鉴定脂肪酸去饱和酶样多肽的抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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公开(公告)号：US07919680B2
公开(公告)日：2011-04-05
申请号：US12693483
申请日：2010-01-26
申请人： Michelle L. Gasper , Catherine Baublite , Andrew P. Kloek , Jennifer A. Davila-Aponte , Michelle Coutu Hresko , Merry B. McLaird , Rodolfo Zentella , Deryck J. Williams
发明人： Michelle L. Gasper , Catherine Baublite , Andrew P. Kloek , Jennifer A. Davila-Aponte , Michelle Coutu Hresko , Merry B. McLaird , Rodolfo Zentella , Deryck J. Williams
CPC分类号： C12N9/0071 , C11B1/00 , C12N9/0073 , C12N15/8223 , C12N15/8247 , C12N15/8285 , Y02A40/164
摘要： The present invention provides DNA constructs, transgenic plants containing such constructs, and methods of making the plants. The DNA constructs encode a polypeptide that when expressed results in the production of fatty acid compounds having anthelmintic activity. Transgenic plants expressing such a polypeptide can exhibit enhanced resistance to plant parasitic nematodes, particularly when expressed in vegetative tissues. Transgenic plants expressing such a polypeptide can also be useful for non-pesticidal industrial uses.
摘要翻译： 本发明提供了DNA构建体，含有这种构建体的转基因植物和制备植物的方法。 DNA构建体编码多肽，当表达导致产生具有驱肠虫活性的脂肪酸化合物时。 表达这种多肽的转基因植物可以表现出对植物寄生线虫的增强的抗性，特别是当在营养组织中表达时。 表达这种多肽的转基因植物也可用于非农药工业用途。
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公开(公告)号：US20090203127A1
公开(公告)日：2009-08-13
申请号：US12354282
申请日：2009-01-15
申请人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. Davila-Aponte , Siqun Xu , Anita M. Frevert
发明人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. Davila-Aponte , Siqun Xu , Anita M. Frevert
CPC分类号： C12N9/0083 , C12N15/8247 , C12N15/8285 , G01N33/573 , G01N2333/4353 , Y02A40/164
摘要： Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as arc vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
摘要翻译： 描述了编码脂肪酸去饱和酶多肽的线虫的核酸分子。 还提供了脂肪酸去饱和酶样多肽序列作为电弧载体，宿主细胞和用于产生脂肪酸去饱和酶样核苷酸和多肽的重组方法。 还描述了用于鉴定脂肪酸去饱和酶样多肽的抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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公开(公告)号：US07479382B2
公开(公告)日：2009-01-20
申请号：US12061072
申请日：2008-04-02
申请人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. Davila-Aponte , Siqun Xu , Anita M. Frevert
发明人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. Davila-Aponte , Siqun Xu , Anita M. Frevert
IPC分类号： C12N9/02 , C12N1/20 , C12N15/00 , C12P21/04 , C12Q1/68 , C12Q1/48 , C07H21/04 , C12Q1/00 , C12N9/00
CPC分类号： C12N9/0083 , C12N15/8247 , C12N15/8285 , G01N33/573 , G01N2333/4353 , Y02A40/164
摘要： Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
摘要翻译： 描述了编码脂肪酸去饱和酶多肽的线虫的核酸分子。 还提供了脂肪酸去饱和酶样多肽序列，以及用于产生脂肪酸去饱和酶样核苷酸和多肽的载体，宿主细胞和重组方法。 还描述了用于鉴定脂肪酸去饱和酶样多肽的抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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公开(公告)号：US08198060B2
公开(公告)日：2012-06-12
申请号：US12260071
申请日：2008-10-28
申请人： Deryck J. Williams , Merry B. McLaird , Michelle Coutu Hresko , Anita M. Frevert , Ronald E. Worthington , Andrew P. Kloek , Jennifer A. Davila-Aponte , John D. Bradley , Siqun Xu
发明人： Deryck J. Williams , Merry B. McLaird , Michelle Coutu Hresko , Anita M. Frevert , Ronald E. Worthington , Andrew P. Kloek , Jennifer A. Davila-Aponte , John D. Bradley , Siqun Xu
IPC分类号： C12N9/12
CPC分类号： C12N9/1007
摘要： Nucleic acid molecules from nematodes encoding phosphoethanolamine n-methyltransferase polypeptides are described. PEAMT-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PEAMT-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
摘要翻译： 描述了编码磷酸乙醇胺正甲基转移酶多肽的线虫的核酸分子。 还提供了PEAMT样多肽序列，载体，宿主细胞和用于产生PEAMT样核苷酸和多肽的重组方法也是如此。 还描述了用于鉴定抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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公开(公告)号：US20100248357A1
公开(公告)日：2010-09-30
申请号：US12354255
申请日：2009-01-15
申请人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. DaVila-Aponte , Siqun Xu , Anita M. Frevert
发明人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. DaVila-Aponte , Siqun Xu , Anita M. Frevert
CPC分类号： C12N9/0083 , C12N15/8247 , C12N15/8285 , G01N33/573 , G01N2333/4353 , Y02A40/164
摘要： Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
摘要翻译： 描述了编码脂肪酸去饱和酶多肽的线虫的核酸分子。 还提供了脂肪酸去饱和酶样多肽序列，以及用于产生脂肪酸去饱和酶样核苷酸和多肽的载体，宿主细胞和重组方法。 还描述了用于鉴定脂肪酸去饱和酶样多肽的抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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公开(公告)号：US20100138960A1
公开(公告)日：2010-06-03
申请号：US12693483
申请日：2010-01-26
申请人： Michelle L. Verbsky , Catherine Baublite , Andrew P. Kloek , Jennifer A. Davila-Aponte , Michelle Coutu Hresko , Merry B. McLaird , Rodolfo Zentella , Deryck J. Williams
发明人： Michelle L. Verbsky , Catherine Baublite , Andrew P. Kloek , Jennifer A. Davila-Aponte , Michelle Coutu Hresko , Merry B. McLaird , Rodolfo Zentella , Deryck J. Williams
CPC分类号： C12N9/0071 , C11B1/00 , C12N9/0073 , C12N15/8223 , C12N15/8247 , C12N15/8285 , Y02A40/164
摘要： The present invention provides DNA constructs, transgenic plants containing such constructs, and methods of making the plants. The DNA constructs encode a polypeptide that when expressed results in the production of fatty acid compounds having anthelmintic activity. Transgenic plants expressing such a polypeptide can exhibit enhanced resistance to plant parasitic nematodes, particularly when expressed in vegetative tissues. Transgenic plants expressing such a polypeptide can also be useful for non-pesticidal industrial uses.
摘要翻译： 本发明提供DNA构建体，含有这种构建体的转基因植物，以及制备植物的方法。 DNA构建体编码多肽，当表达导致产生具有驱肠虫活性的脂肪酸化合物时。 表达这种多肽的转基因植物可以表现出对植物寄生线虫的增强的抗性，特别是当在营养组织中表达时。 表达这种多肽的转基因植物也可用于非农药工业用途。
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公开(公告)号：US20080250530A1
公开(公告)日：2008-10-09
申请号：US12035005
申请日：2008-02-21
申请人： Michelle L. Verbsky , Catherine Baublite , Andrew P. Kloek , Jennifer A. Davila-Aponte , Michelle Coutu Hresko , Merry B. McLaird , Rodolfo Zentella , Deryck J. Williams
发明人： Michelle L. Verbsky , Catherine Baublite , Andrew P. Kloek , Jennifer A. Davila-Aponte , Michelle Coutu Hresko , Merry B. McLaird , Rodolfo Zentella , Deryck J. Williams
CPC分类号： C12N9/0071 , C11B1/00 , C12N9/0073 , C12N15/8223 , C12N15/8247 , C12N15/8285 , Y02A40/164
摘要： The present invention provides DNA constructs, transgenic plants containing such constructs, and methods of making the plants. The DNA constructs encode a polypeptide that when expressed results in the production of fatty acid compounds having anthelmintic activity. Transgenic plants expressing such a polypeptide can exhibit enhanced resistance to plant parasitic nematodes, particularly when expressed in vegetative tissues. Transgenic plants expressing such a polypeptide can also be useful for non-pesticidal industrial uses.
摘要翻译： 本发明提供了DNA构建体，含有这种构建体的转基因植物和制备植物的方法。 DNA构建体编码多肽，当表达导致产生具有驱肠虫活性的脂肪酸化合物时。 表达这种多肽的转基因植物可以表现出对植物寄生线虫的增强的抗性，特别是当在营养组织中表达时。 表达这种多肽的转基因植物也可用于非农药工业用途。
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公开(公告)号：US06875595B2
公开(公告)日：2005-04-05
申请号：US10243468
申请日：2002-09-13
申请人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. Davila-Aponte , Siqun Xu , Anita M. Frevert
发明人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. Davila-Aponte , Siqun Xu , Anita M. Frevert
IPC分类号： C12N9/02 , C12N15/82 , G01N33/573 , C12N15/00 , C07H21/04
CPC分类号： C12N9/0083 , C12N15/8247 , C12N15/8285 , G01N33/573 , G01N2333/4353 , Y02A40/164
摘要： Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
摘要翻译： 描述了编码脂肪酸去饱和酶多肽的线虫的核酸分子。 还提供了脂肪酸去饱和酶样多肽序列，以及用于产生脂肪酸去饱和酶样核苷酸和多肽的载体，宿主细胞和重组方法。 还描述了用于鉴定脂肪酸去饱和酶样多肽的抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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