公开(公告)号：US4289648A

公开(公告)日：1981-09-15

申请号：US22244

申请日：1979-03-20

申请人： Michael K. Hoskins ,  Gary D. Christiansen

发明人： Michael K. Hoskins ,  Gary D. Christiansen

IPC分类号： A61B5/145 ,  A61B5/1473 ,  A61B5/1495 ,  A61J1/06 ,  G01N27/416 ,  G01N33/50 ,  G01N33/96 ,  C09K3/00 ,  G01N31/00 ,  G01N33/16

CPC分类号： A61J1/062 ,  G01N33/4925 ,  G01N33/96 ,  G01N2496/30 ,  G01N2496/70 ,  Y10T436/102499

摘要： A hermetically sealed ampoule containing blood gas control fluid is provided wherein the fluid occupies the entire ampoule with no appreciable head space. The ampoule is provided with a plunger-like seal adapted to be directed against the contents of the ampoule and a pierceable seal through which may extend a hollow needle to act as a conduit for the contents upon expulsion from the ampoule. A syringe is also provided for expelling the contents from the ampoule.

摘要翻译： 提供了一种包含血液气体控制流体的密封安瓿，其中流体占据整个安瓿，没有明显的顶部空间。 安瓿设置有适于被引导到安瓿的内容物上的柱塞状密封件和可刺破的密封件，通过该密封件可以将中空针头延伸以用作内容物从安瓿中排出时的导管。 还提供用于从安瓿中排出内容物的注射器。

公开(公告)号：US5547874A

公开(公告)日：1996-08-20

申请号：US417270

申请日：1995-04-05

申请人： Masaaki Terashima

发明人： Masaaki Terashima

IPC分类号： G01N33/52 ,  G01N33/66 ,  G01N33/96 ,  G01N31/00 ,  G01N21/77

CPC分类号： G01N33/96 ,  G01N33/526 ,  G01N2496/10 ,  G01N2496/25 ,  G01N2496/30 ,  G01N33/66 ,  Y10S516/922 ,  Y10S516/923 ,  Y10T436/104165 ,  Y10T436/106664 ,  Y10T436/108331

摘要： An aqueous dispersion used for control or calibration of a dry analysis element comprising at least one color producing reagent and a porous layer, which comprises water-insoluble liquid particles having a mean particle size of from about 0.01 to about 10 .mu.m selected from the group consisting of phthalates, trimellitates, phosphates, benzoates, amides, phenols, aliphatic esters, hydrocarbons, halogenated hydrocarbons, adipates, sebacates and natural polymers dispersed therein and a substance which is the same as or similar to the analyte to be determined wherein said substance is selected from the group consisting of glucose, urea, uric acid, creatinine, bilirubin, hemoglobin, triolein, glycerine, cholesterol, triglyceride, (NH.sub.4).sub.2 SO.sub.4, NH.sub.4 Cl, CaCl.sub.2, Ca(NO.sub.3).sub.2, MgCl.sub.2, NaCl, KCl, K.sub.2 HPO.sub.4, (NH.sub.4).sub.2 SO.sub.4, Ca(NO.sub.3).sub.2, and NaNO.sub.3.

摘要翻译： 用于控制或校准干分析元件的水性分散体，其包含至少一种产色试剂和多孔层，其包含平均粒度为约0.01至约10μm的水不溶性液体颗粒，所述水不溶性液体颗粒选自组 由邻苯二甲酸酯，偏苯三酸酯，磷酸酯，苯甲酸酯，酰胺，酚，脂肪族酯，烃，卤代烃，己二酸酯，癸二酸酯和分散在其中的天然聚合物组成，以及与待测分析物相同或类似的物质，其中所述物质为 选自葡萄糖，尿素，尿酸，肌酸酐，胆红素，血红蛋白，三油酸甘油酯，甘油，胆固醇，甘油三酯，（NH4）2SO4，NH4Cl，CaCl2，Ca（NO3）2，MgCl2，NaCl，KCl，K2HPO4， （NH4）2SO4，Ca（NO3）2和NaNO3。

公开(公告)号：US5308767A

公开(公告)日：1994-05-03

申请号：US915290

申请日：1992-07-20

申请人： Masaaki Terashima

发明人： Masaaki Terashima

IPC分类号： G01N33/52 ,  G01N33/66 ,  G01N33/96 ,  G01N31/00 ,  G01N21/77

CPC分类号： G01N33/526 ,  G01N33/96 ,  G01N2496/10 ,  G01N2496/25 ,  G01N2496/30 ,  G01N33/66 ,  Y10T436/10 ,  Y10T436/103332 ,  Y10T436/104998 ,  Y10T436/106664

摘要： A method for control or calibration in a chemical analytical determination using a dry analysis element comprising at least one color-producing reagent and a porous layer, wherein the method comprises applying an aqueous dispersion onto the porous layer and measuring the optical density of the color produced, wherein the aqueous dispersion comprises a substance which is the same as or similar to an analyte to be determined and water-insoluble particles dispersed therein, wherein the particles are particles of a homopolymer, a copolymer, phthalates, trimellitates, phosphates, benzoates, amides, phenols, aliphatic esters, hydrocarbons, halogenated hydrocarbons, adipates, sebacates and natural polymers.

摘要翻译： 一种用于使用包含至少一种产色试剂和多孔层的干分析元素进行化学分析测定的控制或校准的方法，其中所述方法包括将水性分散体施加到多孔层上并测量产生的颜色的光密度 其中所述水性分散体包含与要测定的分析物和分散在其中的水不溶性颗粒相同或类似的物质，其中所述颗粒是均聚物，共聚物，邻苯二甲酸酯，偏苯三酸酯，磷酸酯，苯甲酸酯，酰胺的颗粒 ，酚，脂族酯，烃，卤代烃，己二酸酯，癸二酸酯和天然聚合物。

公开(公告)号：US12105091B2

公开(公告)日：2024-10-01

申请号：US16761786

申请日：2018-11-06

申请人： VIB VZW ,  Universiteit Gent

发明人： An Hendrix ,  Olivier De Wever ,  Edward Geeurickx ,  Joke Vandesompele ,  Pieter Mestdagh ,  Sven Eyckerman

IPC分类号： G01N33/58 ,  C07K14/16 ,  C07K14/435 ,  C12Q1/6876 ,  G01N21/64 ,  G01N33/53

CPC分类号： G01N33/582 ,  C07K14/161 ,  C07K14/43595 ,  C12Q1/6876 ,  G01N21/6428 ,  G01N33/5308 ,  C07K2319/60 ,  C12Q2600/158 ,  G01N2021/6439 ,  G01N2496/30

摘要： This disclosure relates to the field of research and clinical usage of extracellular vesicles. More in particular, this disclosure relates to usages of recombinant extracellular vesicles comprising a) a self-assembling protein that directs its own release through vesicles as a luminal membrane-bound protein and b) a heterologous marker. Indeed, the disclosure provides recombinant extracellular vesicles that can be used as a biological reference material in methods to quantify extracellular vesicles in a sample, and/or, that can be used to calibrate a device for sample extracellular vesicles analysis, and/or, that can be used to evaluate the isolation process of extracellular vesicles. This disclosure thus relates to improving the accuracy of an extracellular vesicle-based diagnosis.

公开(公告)号：US08741873B2

公开(公告)日：2014-06-03

申请号：US13433377

申请日：2012-03-29

申请人： Andreas Rechner ,  Norbert Zander

发明人： Andreas Rechner ,  Norbert Zander

IPC分类号： A61K31/727

CPC分类号： G01N33/86 ,  C12Q1/56 ,  G01N2496/05 ,  G01N2496/30

摘要： The present invention is in the field of coagulation diagnostics and relates to a kit and method for preparing controls for use in test methods for determining thrombocyte function.

摘要翻译： 本发明涉及凝血诊断领域，涉及一种用于制备用于测定血栓细胞功能的测试方法的对照试剂盒和方法。

公开(公告)号：US20120252044A1

公开(公告)日：2012-10-04

申请号：US13433377

申请日：2012-03-29

申请人： Andreas Rechner ,  Norbert Zander

发明人： Andreas Rechner ,  Norbert Zander

IPC分类号： C12Q1/56 ,  C12Q1/02

CPC分类号： G01N33/86 ,  C12Q1/56 ,  G01N2496/05 ,  G01N2496/30

摘要： The present invention is in the field of coagulation diagnostics and relates to a kit and method for preparing controls for use in test methods for determining thrombocyte function.

摘要翻译： 本发明涉及凝血诊断领域，涉及一种用于制备用于测定血栓细胞功能的测试方法的对照试剂盒和方法。

公开(公告)号：US4279775A

公开(公告)日：1981-07-21

申请号：US108480

申请日：1979-12-31

申请人： Allan L. Louderback ,  Paul R. Szatkowski

发明人： Allan L. Louderback ,  Paul R. Szatkowski

IPC分类号： A61B5/145 ,  A61B5/1473 ,  A61B5/1495 ,  G01N27/416 ,  G01N33/96 ,  G01N33/48

CPC分类号： G01N33/96 ,  G01N27/4163 ,  G01N2496/15 ,  G01N2496/30 ,  G01N2496/70 ,  Y10T436/102499 ,  Y10T436/108331

摘要： There is disclosed a synthetic liquid control standard for use in the quality assurance of blood gas instrumentation systems which comprises an aqueous solution of a dye buffered to a pH of from about 7.1 to about 7.7 and containing sufficient bicarbonate ion to provide a pCO.sub.2 of from about 20 to about 80, ethylene glycol to provide a viscosity of from about 3 to about 9 centipoises and gaseous oxygen to provide a pO.sub.2 of from about 50 to about 400 retained in a sealed receptacle.

摘要翻译： 公开了一种用于血气仪器系统的质量保证的合成液体控制标准，其包括缓冲至约7.1至约7.7的pH并且含有足够的碳酸氢根离子的染料的水溶液，以提供从约 20至约80，乙二醇以提供约3至约9厘泊的粘度和气态氧，以提供保留在密封容器中的约50至约400的pO 2。