公开(公告)号：US06486178B1

公开(公告)日：2002-11-26

申请号：US09701281

申请日：2000-11-28

申请人： Keizo Tanikawa ,  Kazuhiko Ohrai ,  Masayuki Sato ,  Kazufumi Yanagihara ,  Yukihiro Shigeta ,  Toru Yamashita

发明人： Keizo Tanikawa ,  Kazuhiko Ohrai ,  Masayuki Sato ,  Kazufumi Yanagihara ,  Yukihiro Shigeta ,  Toru Yamashita

IPC分类号： A61K314418

CPC分类号： C07D207/335 ,  C07C233/44 ,  C07C233/55 ,  C07C235/34 ,  C07C235/38 ,  C07C235/78 ,  C07C237/20 ,  C07C237/22 ,  C07C255/57 ,  C07C255/60 ,  C07C261/04 ,  C07C275/40 ,  C07C275/42 ,  C07C2601/02 ,  C07C2602/08 ,  C07D207/337 ,  C07D209/14 ,  C07D209/18 ,  C07D213/38 ,  C07D213/40 ,  C07D213/56 ,  C07D239/26 ,  C07D295/135 ,  C07D303/36 ,  C07D303/38 ,  C07D303/40 ,  C07D303/46 ,  C07D307/52 ,  C07D307/54 ,  C07D333/20 ,  C07D333/24

摘要： The present invention provides medicines for treating cardiac insufficiency which contain as an active ingredient indane derivatives of formula (I) wherein R1 represents hydrogen atom, nitro group, cyano group, C1-6 alkylcarbonylamino, R2 and R3 each independently represent C1-6 alkyl group, R4 represents hydroxyl group or C1-6 alkylcarbonyloxy group or represents a bond or oxygen atom together with R5, R5 represents hydrogen atom or represents a bond or oxygen atom together with R4, R6 represents hydrogen atom, hydroxyl group or NR7R8, n means 0 or an integer of 1 to 4, X represents C═O, CH2, SO2 or NR16, Y represents NR17 when X is C═O, CH2 or SO2 and represents C═O when X is NR16, Z is absent when Y represents NR17 or represents NR18 when Y is C═O, W represents aromatic groups or lactam rings, or pharmaceutically acceptable salt thereof.

摘要翻译： 本发明提供了治疗心功能不全的药物，其含有作为活性成分的式（I）的二氢化茚衍生物，其中R 1表示氢原子，硝基，氰基，C 1-6烷基羰基氨基，R 2和R 3各自独立地表示C 1-6烷基 R 4表示羟基或C 1-6烷基羰基氧基，或表示键或氧原子连同R 5，R 5表示氢原子，或表示键或氧原子与R 4，R 6表示氢原子，羟基或NR 7 R 8，n表示0 或1〜4的整数，X表示C = O，CH2，SO2或NR16，当X为C = O，CH2或SO2时，Y表示NR17，当X为NR16时，表示C = O，当Y表示NR17时Z不存在 或当Y为C = O时表示NR18，W表示芳族基团或内酰胺环，或其药学上可接受的盐。

公开(公告)号：US6066631A

公开(公告)日：2000-05-23

申请号：US232645

申请日：1999-01-19

申请人： Keizo Tanikawa ,  Kazuhiko Ohrai ,  Masayuki Sato ,  Toru Yamashita ,  Kazufumi Yanagihara

发明人： Keizo Tanikawa ,  Kazuhiko Ohrai ,  Masayuki Sato ,  Toru Yamashita ,  Kazufumi Yanagihara

IPC分类号： C07D311/68 ,  C07D311/70 ,  C07D405/04 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07F7/18 ,  A61K31/352 ,  C07D251/00 ,  C07D405/00 ,  C07D401/00

CPC分类号： C07D405/04 ,  C07D311/70 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07F7/1856

摘要： The present invention relates to chroman derivatives of the formula (I): ##STR1## [wherin R.sup.1 represents a hydrogen atom, a halogen atom, a C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a C.sub.3-6 alkoxymethyl group, etc., R.sup.3 and R.sup.4 each independently represent a hydrogen atom, a C.sub.1-6 alkyl group, etc., R.sup.5 represents a hydroxyl group or a C.sub.1-6 alkylcarbonyloxyl group or forms a bond together with R.sup.5, R.sup.6 represents a hydrogen atom or forms a bond together with R.sup.5, R.sup.7 and R.sup.8 each independently represent a hydrogen atom, a C.sub.1-6 alkyl group, a C.sub.3-6 cycloalkyl group, a phenyl group, etc. n is 0 or an integer of 1, 2, 3 or 4, W represents a phenyl group, etc., X represents C.dbd.O, CH.sub.2, SO.sub.2, etc., Y represents NR.sup.17 (in which R.sup.17 represents a hydrogen atom, a C.sub.1-4 alkyl group, a phenyl group, etc.), etc., Z does not exist or represents CH.sub.2 or NR.sup.18 (R.sup.18 represents a hydrogen atom, a C.sub.1-4 alkyl group, or a phenyl group, etc.)] or their salts.

摘要翻译： 本发明涉及式（I）的苯并二氢吡喃衍生物：其中R1表示氢原子，卤素原子，C1-6烷基，C1-6烷氧基，C3-6烷氧基甲基等， R 3和R 4各自独立地表示氢原子，C 1-6烷基等，R 5表示羟基或C 1-6烷基羰氧基，或与R 5一起形成键，R 6表示氢原子或者一起形成键 R5，R7和R8各自独立地表示氢原子，C1-6烷基，C3-6环烷基，苯基等，n为0或1,2,3或4的整数，W表示 苯基等，X表示C = O，CH 2，SO 2等，Y表示NR 17（其中R 17表示氢原子，C 1-4烷基，苯基等）等， Z不存在或表示CH2或NR18（R18表示氢原子，C1-4烷基或苯基等）]或其盐。

公开(公告)号：US5817828A

公开(公告)日：1998-10-06

申请号：US999493

申请日：1997-12-29

申请人： Keizo Tanikawa ,  Yoshimasa Kamikawaji ,  Keisuke Odoi ,  Tsutomu Higashiyama ,  Masayuki Sato ,  Yukinori Masuda

发明人： Keizo Tanikawa ,  Yoshimasa Kamikawaji ,  Keisuke Odoi ,  Tsutomu Higashiyama ,  Masayuki Sato ,  Yukinori Masuda

IPC分类号： C07D231/38 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07F9/6558 ,  A61K31/415

CPC分类号： C07D231/38 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07F9/65583

摘要： Pyrazole compounds of formula �1! and their tautomers and salts: ##STR1## (wherein R.sup.1 is an alkyl group, etc.; R.sup.2 is a carboxyl group, etc.; R.sup.3 is a halogen atom, an alkyl group, a phenyl group, etc.; R.sup.4, R.sup.5 and R.sup.6 each are a hydrogen atom, a halogen atom, etc.; R.sup.7 is a carboxyl group, a 5-tetrazolyl group, etc.; X is a nitrogen atom, etc.; Y and Z each are CH, a nitrogen atom, etc.; A and E each are a methylene group, etc.; D is a phenyl group, etc.; G is a covalent bond, etc.). The compounds of the invention have an antagonistic effect against angiotensin II and are useful for prevention and remedy of hypertension, congestive cardiac insufficiency, chronic renal insufficiency, aldosteronism, hyper-intraocular pressure, etc.

公开(公告)号：US5846991A

公开(公告)日：1998-12-08

申请号：US998671

申请日：1997-12-29

申请人： Keizo Tanikawa ,  Yoshimasa Kamikawaji ,  Keisuke Odoi ,  Tsutomu Higashiyama ,  Masayuki Sato ,  Yukinori Masuda

发明人： Keizo Tanikawa ,  Yoshimasa Kamikawaji ,  Keisuke Odoi ,  Tsutomu Higashiyama ,  Masayuki Sato ,  Yukinori Masuda

IPC分类号： C07D231/38 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07F9/6558 ,  A61K31/415 ,  A61K31/44

CPC分类号： C07D231/38 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07F9/65583

摘要： Pyrazole compounds of formula �1! and their tautomers and salts: ##STR1## (wherein R.sup.1 is an alkyl group, etc.; R.sup.2 is a carboxyl group, etc.; R.sup.3 is a halogen atom, an alkyl group, a phenyl group, etc.; R.sup.4, R.sup.5 and R.sup.6 each are a hydrogen atom, a halogen atom, etc.; R.sup.7 is a carboxyl group, a 5-tetrazolyl group, etc.; X is a nitrogen atom, etc.; Y and Z each are CH, a nitrogen atom, etc.; A and E each are a methylene group, etc.; D is a phenyl group, etc.; G is a covalent bond, etc.). The compounds of the invention have an antagonistic effect against angiotensin II and are useful for prevention and remedy of hypertension, congestive cardiac insufficiency, chronic renal insufficiency, aldosteronism, hyper-intraocular pressure, etc.

公开(公告)号：US5721264A

公开(公告)日：1998-02-24

申请号：US525555

申请日：1995-09-29

申请人： Keizo Tanikawa ,  Yoshimasa Kamikawaji ,  Keisuke Odoi ,  Tsutomu Higashiyama ,  Masayuki Sato ,  Yukinori Masuda

发明人： Keizo Tanikawa ,  Yoshimasa Kamikawaji ,  Keisuke Odoi ,  Tsutomu Higashiyama ,  Masayuki Sato ,  Yukinori Masuda

IPC分类号： C07D231/38 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07F9/6558 ,  A61K31/415

CPC分类号： C07D231/38 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07F9/65583

摘要： Pyrazole compounds of formula �1! and their tautomers and salts: ##STR1## (wherein R.sup.1 is an alkyl group, etc.; R.sup.2 is a carboxyl group, etc.; R.sup.3 is a halogen atom, an alkyl group, a phenyl group, etc.; R.sup.4, R.sup.5 and R.sup.6 each are a hydrogen atom, a halogen atom, etc.; R.sup.7 is a carboxyl group, a 5-tetrazolyl group, etc.; X is a nitrogen atom, etc.; Y and Z each are CH, a nitrogen atom, etc.; A and E each are a methylene group, etc.; D is a phenyl group, etc.; G is a covalent bond, etc.). The compounds of the invention have an antagonistic effect against angiotensin II and are useful for prevention and remedy of hypertension, congestive cardiac insufficiency, chronic renal insufficiency, aldosteronism, hyper-intraocular pressure, etc.

摘要翻译： PCT No.PCT / JP94 / 00587第 371 1995年9月29日第 102（e）1995年9月29日PCT PCT 1994年4月7日PCT公布。 公开号WO94 / 22838 日期：1994年10月13日式[1]吡唑化合物及其互变异构体和盐：其中R1是烷基等; R2是羧基等; R3是卤素原子， 烷基，苯基等; R4，R5和R6各自为氢原子，卤素原子等; R7为羧基，5-四唑基等; X为氮原子， Y和Z各自为CH，氮原子等; A和E各自为亚甲基等; D为苯基等; G为共价键等）。 本发明化合物对血管紧张素II具有拮抗作用，可用于预防和治疗高血压，充血性心功能不全，慢性肾功能不全，醛固酮增多症，超眼压等。

公开(公告)号：US5840909A

公开(公告)日：1998-11-24

申请号：US998669

申请日：1997-12-29

申请人： Keizo Tanikawa ,  Yoshimasa Kamikawaji ,  Keisuke Odoi ,  Tsutomu Higashiyama ,  Masayuki Sato ,  Yukinori Masuda

发明人： Keizo Tanikawa ,  Yoshimasa Kamikawaji ,  Keisuke Odoi ,  Tsutomu Higashiyama ,  Masayuki Sato ,  Yukinori Masuda

IPC分类号： C07D231/38 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07F9/6558 ,  A61K31/415

CPC分类号： C07D231/38 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07F9/65583

摘要： Pyrazole compounds of formula �1! and their tautomers and salts: ##STR1## (wherein R.sup.1 is an alkyl group, etc.; R.sup.2 is a carboxyl group, etc.; R.sup.3 is a halogen atom, an alkyl group, a phenyl group, etc.; R.sup.4, R.sup.5 and R.sup.6 each are a hydrogen atom, a halogen atom, etc.; R.sup.7 is a carboxyl group, a 5-tetrazolyl group, etc.; X is a nitrogen atom, etc.; Y and Z each are CH, a nitrogen atom, etc.; A and E each are a methylene group, etc.; D is a phenyl group, etc.; G is a covalent bond, etc.). The compounds of the invention have an antagonistic effect against angiotensin II and are useful for prevention and remedy of hypertension, congestive cardiac insufficiency, chronic renal insufficiency, aldosteronism, hyper-intraocular pressure, etc.

摘要翻译： 式[1]的吡唑化合物及其互变异构体和盐：其中R1是烷基等; R2是羧基等; R3是卤素原子，烷基， 苯基等; R4，R5和R6分别是氢原子，卤素原子等; R7是羧基，5-四唑基等; X是氮原子等; Y和 Z各自为CH，氮原子等; A和E各自为亚甲基等; D为苯基等; G为共价键等）。 本发明化合物对血管紧张素II具有拮抗作用，可用于预防和治疗高血压，充血性心功能不全，慢性肾功能不全，醛固酮增多症，超眼压等。

公开(公告)号：US09347559B2

公开(公告)日：2016-05-24

申请号：US14129050

申请日：2012-06-21

申请人： Takuma Sekiya ,  Yuuichi Murayama ,  Masayuki Sato ,  Yuji Shima ,  Junya Takahashi ,  Masaki Moronuki

发明人： Takuma Sekiya ,  Yuuichi Murayama ,  Masayuki Sato ,  Yuji Shima ,  Junya Takahashi ,  Masaki Moronuki

IPC分类号： C23C14/06 ,  F16J9/26 ,  C23C14/32 ,  C23C28/04

CPC分类号： F16J9/26 ,  C23C14/0641 ,  C23C14/325 ,  C23C28/044 ,  C23C28/046

摘要： A high-thermal-conductivity piston ring having excellent scuffing resistance and wear resistance, which can be used in a high-heat-load environment in engines is provided. Also, to provide a piston ring with low friction for contributing to the improvement of fuel efficiency, a TiN coating as thick as 10-60 μm, in which the texture coefficient of a (111) plane is 1.2-1.65 in X-ray diffraction on the coating surface, with the texture coefficient of a (111) plane>the texture coefficient of a (220) plane>the texture coefficient of a (200) plane, is formed under the optimized ion plating conditions on a peripheral surface of the piston ring. Further, to obtain excellent sliding characteristics with low friction without losing excellent thermal conductivity of TiN, a hard amorphous carbon coating is formed on the TiN coating.

摘要翻译： 提供了可用于发动机的高热负荷环境中的具有优异的耐擦伤性和耐磨性的高导热性活塞环。 此外，为了提供具有低摩擦力的活塞环以有助于提高燃料效率，TiN涂层厚度为10-60μm，其中（111）面的织构系数在X射线衍射中为1.2-1.65 在涂层表面上，在优化的离子镀条件下，在（111）面的纹理系数>（220）面的织构系数>（200）面的织构系数上形成在 活塞环。 此外，为了在不损失TiN的优异导热性的情况下以低摩擦获得优异的滑动特性，在TiN涂层上形成硬的无定形碳涂层。

公开(公告)号：US20140137733A1

公开(公告)日：2014-05-22

申请号：US14129022

申请日：2012-06-21

申请人： Takuma Sekiya ,  Yuuichi Murayama ,  Masayuki Sato ,  Yuji Shima ,  Junya Takahashi ,  Masaki Moronuki

发明人： Takuma Sekiya ,  Yuuichi Murayama ,  Masayuki Sato ,  Yuji Shima ,  Junya Takahashi ,  Masaki Moronuki

IPC分类号： F02F5/00

CPC分类号： F02F5/00 ,  C23C14/0641 ,  C23C14/325 ,  C23C28/044 ,  C23C28/046 ,  F16J9/26

摘要： To provide a high-thermal-conductivity piston ring having excellent scuffing resistance and wear resistance, which can be used in a high-heat-load environment in engines, a TiN coating as thick as 10-60 μm, in which the texture coefficient of a (220) plane is 1.1-1.8 in X-ray diffraction on the coating surface, larger than those of (111) and (200) planes, is formed under the optimized ion plating conditions on a peripheral surface of the piston ring. Also, to obtain excellent sliding characteristics with low friction without losing excellent thermal conductivity of TiN, a hard amorphous carbon coating is formed on the TiN coating.

摘要翻译： 为了提供可用于发动机的高热负荷环境中的具有优异的抗划伤性和耐磨性的高导热性活塞环，厚度为10-60μm的TiN涂层，其中织构系数 在优选的离子镀条件下，在活塞环的周面上形成涂层表面的X射线衍射中的（220）面为1.1〜1.8，大于（111）面和（200）面的X射线衍射面。 另外，为了在不损失TiN的优异导热性的情况下以低摩擦力获得优异的滑动特性，在TiN涂层上形成硬质无定形碳涂层。

公开(公告)号：US08310812B2

公开(公告)日：2012-11-13

申请号：US12688954

申请日：2010-01-18

申请人： Masashige Ashizaki ,  Nario Niibo ,  Masayuki Sato ,  Yasuyuki Ito ,  Yukiyasu Sugihara

发明人： Masashige Ashizaki ,  Nario Niibo ,  Masayuki Sato ,  Yasuyuki Ito ,  Yukiyasu Sugihara

IPC分类号： H01G9/00 ,  H01G4/228 ,  H01G9/10 ,  H05K5/03

CPC分类号： H01G9/155 ,  H01G9/016 ,  H01G9/06 ,  H01G9/10 ,  H01G11/12 ,  H01G11/52 ,  H01G11/74 ,  H01G11/78 ,  H01G11/82 ,  H01G11/84 ,  Y02E60/13

摘要： An electric double layer capacitor has an element, a first terminal, a second terminal, a resin-made case, and a resin-made lid. A pair of electrodes are led out of the element. Each of the electrodes is connected to each of the first terminal and the second terminal. The element and an electrolyte are accommodated in the case having an opening top surface, and the lid is bonded to the top surface of the case. The joints of the first and second terminals are disposed at positions higher than the inner bottom of the case, and are exposed upward. The rims of the joints and intermediate conductive sections continuing from them are buried in the case, and the terminal sections continuing from the intermediate conductive sections are led from the side surface of the case to the outside.

摘要翻译： 双电层电容器具有元件，第一端子，第二端子，树脂制壳体和树脂制盖子。 一对电极从元件中引出。 每个电极连接到第一端子和第二端子中的每一个。 元件和电解质容纳在具有开口顶表面的壳体中，并且盖子结合到壳体的顶表面。 第一端子和第二端子的接头设置在比壳体的内底高的位置，并向上露出。 接合部的边缘和从它们继续的中间导电部分被掩埋在壳体中，并且从中间导电部分延伸的端子部分从壳体的侧表面引导到外部。

公开(公告)号：US20120274539A1

公开(公告)日：2012-11-01

申请号：US13394211

申请日：2011-11-22

申请人： Hirohiko Tashiro ,  Hiroshi Tanioka ,  Yoshitaka Oba ,  Masayuki Sato ,  Kenji Hara

发明人： Hirohiko Tashiro ,  Hiroshi Tanioka ,  Yoshitaka Oba ,  Masayuki Sato ,  Kenji Hara

IPC分类号： G09G5/00

CPC分类号： H04N1/00442 ,  G03G15/502 ,  G03G15/5087 ,  G03G2215/00109 ,  H04N2201/0094

摘要： It was necessary to prepare display data for the portrait and landscape display modes respectively, since the arrangement of the objects differs between the portrait and landscape display modes.

摘要翻译： 由于在纵向和横向显示模式之间的对象的布置不同，因此需要分别准备用于纵向和横向显示模式的显示数据。