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    SYSTEM FOR MONITORING BACTERIAL TUMOR TREATMENT
    1.
    发明申请
    SYSTEM FOR MONITORING BACTERIAL TUMOR TREATMENT 审中-公开
    用于监测细菌性肿瘤治疗的系统

    公开(公告)号：US20090249500A1

    公开(公告)日：2009-10-01

    申请号：US12422863

    申请日：2009-04-13

    申请人： Ming ZHAO ,  Xiao-MING LI ,  Meng YANG ,  Mingxu XU ,  Ping JIANG ,  Lingna LI

    发明人： Ming ZHAO ,  Xiao-MING LI ,  Meng YANG ,  Mingxu XU ,  Ping JIANG ,  Lingna LI

    IPC分类号： A01K67/027

    CPC分类号： A61K49/0045 ,  A61K49/0008 ,  A61K49/0047 ,  A61K49/0097

    摘要： A method to follow the progress of tumor treatment in subjects utilizes bacteria that have been modified to express a fluorescent protein. The method can also monitor expression of genes associated with the bacteria that produce therapeutic agents during the course of treatment, optionally against a background of fluorescence generated by the tumor itself. The method permits visualization of the progress of treatment in live subjects so that treatments can be modified according to their efficacy.

    摘要翻译： 用于跟踪肿瘤治疗进展的方法利用已被修饰以表达荧光蛋白的细菌。 该方法还可以监测在治疗过程中产生治疗剂的细菌相关基因的表达，任选地与肿瘤本身产生的荧光背景相关。 该方法允许对活体受试者的治疗进展的可视化，使得可以根据其疗效来修改治疗。

    Methioninase gene therapy for tumor treatment
    4.
    发明授权
    Methioninase gene therapy for tumor treatment 失效
    甲硫氨酸酶基因治疗肿瘤治疗

    公开(公告)号：US06524571B1

    公开(公告)日：2003-02-25

    申请号：US09195055

    申请日：1998-11-18

    申请人： Mingxu Xu ,  Yuying Tan

    发明人： Mingxu Xu ,  Yuying Tan

    IPC分类号： A01N4304

    CPC分类号： G02B5/32 ,  A01K67/0271 ,  A61K38/51 ,  A61K48/00

    摘要： A depletion method to inhibit tumor growth includes introducing a viral expression system capable of expressing methioninase or a fusion protein containing methioninase into a tumor contained in a vertebrate subject or cells thereof. The fusion protein may contain a fluorescent protein to permit monitoring of the completeness of the depletion method. The fusion protein can be used in vivo as well as in vitro screening protocols which employ the viral expression system. The expression system includes control sequences and means to integrate the nucleotide sequence into the genome of a host cell for expression. The method may also include treating the cells with isolated methioninase and/or with a therapeutic cell. The depletion method can be with other known therapies, such as maintaining the animal having the tumor on a methionine depleted diet.

    摘要翻译： 抑制肿瘤生长的消耗方法包括将能够表达蛋氨酸酶的病毒表达系统或含有蛋氨酸酶的融合蛋白引入到脊椎动物对象或其细胞中所含的肿瘤中。 融合蛋白可以含有荧光蛋白以允许监测耗尽方法的完整性。 融合蛋白可以在体内以及使用病毒表达系统的体外筛选方案中使用。 表达系统包括将核苷酸序列整合到宿主细胞的基因组中用于表达的控制序列和方法。 该方法还可以包括用分离的蛋氨酸酶和/或用治疗细胞处理细胞。 耗尽方法可以与其他已知的疗法一起使用，例如将具有肿瘤的动物维持在消耗蛋氨酸的饮食上。

    Methods for identifying markers for early-stage human cancer, cancer progression and recurrence
    5.
    发明授权
    Methods for identifying markers for early-stage human cancer, cancer progression and recurrence 失效
    识别早期人类癌症标志物，癌症进展和复发的方法

    公开(公告)号：US08217222B2

    公开(公告)日：2012-07-10

    申请号：US11529938

    申请日：2006-09-29

    申请人： Mingxu Xu ,  Yuying Tan ,  Levy Kopelovich

    发明人： Mingxu Xu ,  Yuying Tan ,  Levy Kopelovich

    IPC分类号： G01N33/00 ,  A01K67/00 ,  A01K67/033 ,  C12N5/00 ,  C12N5/02 ,  C12N15/00 ,  C12N15/87

    CPC分类号： C12N15/1051 ,  C12N15/1086

    摘要： A method is described to identify secreted proteins identified with stages of malignancy of cancer. The proteins are initially identified by trapping them with a fluorescent protein containing vector that can insert in any gene. The secreted proteins are initially identified by their fluorescence. Secreted proteins identifying tumors with specific degrees of malignancy are isolated to determine if they can serve as markers of cancer progression.

    摘要翻译： 描述了一种鉴定鉴定为癌症恶性程度的分泌蛋白的方法。 最初通过用含有可插入任何基因的含荧光蛋白的载体捕获蛋白质来鉴定蛋白质。 分泌的蛋白质最初通过其荧光来鉴定。 分离识别具有特定恶性程度的肿瘤的分泌蛋白，以确定它们是否可以作为癌症进展的标志物。

    Modulators of methylation for control of bacterial virulence
    8.
    发明授权
    Modulators of methylation for control of bacterial virulence 失效
    用于控制细菌毒力的甲基化调节剂

    公开(公告)号：US06632430B2

    公开(公告)日：2003-10-14

    申请号：US10334532

    申请日：2002-12-30

    申请人： Mingxu Xu ,  Quinghong Han ,  Yuying Tan

    发明人： Mingxu Xu ,  Quinghong Han ,  Yuying Tan

    IPC分类号： A61K3851

    CPC分类号： A61K31/7076 ,  A61K31/198 ,  A61K38/51

    摘要： Compositions and methods which ameliorate the virulence of bacterial infection are described wherein the active ingredient modulates transmethylation reactions in bacterial cells. Particularly useful compounds are inhibitors of S-adenosyl methionine synthetase (SAMS), of S-adenosyl homocysteine hydrolase (SAHH) and of transmethylases.

    摘要翻译： 描述了改善细菌感染的毒力的组合物和方法，其中活性成分调节细菌细胞中的转甲基化反应。 特别有用的化合物是S-腺苷甲硫氨酸合成酶（SAMS），S-腺苷同型半胱氨酸水解酶（SAHH）和转甲基酶的抑制剂。

    METHODS FOR IDENTIFYING MARKERS FOR EARLY-STAGE HUMAN CANCER, CANCER PROGRESSION AND RECURRENCE
    9.
    发明申请
    METHODS FOR IDENTIFYING MARKERS FOR EARLY-STAGE HUMAN CANCER, CANCER PROGRESSION AND RECURRENCE 审中-公开
    识别早期人类癌症标志物的方法，癌症进展和复发

    公开(公告)号：US20120316321A1

    公开(公告)日：2012-12-13

    申请号：US13525174

    申请日：2012-06-15

    申请人： Mingxu XU ,  Yuying Tan ,  Levy Kopelovich

    发明人： Mingxu XU ,  Yuying Tan ,  Levy Kopelovich

    IPC分类号： C40B40/02 ,  C40B30/06 ,  C40B40/08 ,  C07K14/00

    CPC分类号： C12N15/1051 ,  C12N15/1086

    摘要： A method is described to identify secreted proteins identified with stages of malignancy of cancer. The proteins are initially identified by trapping them with a fluorescent protein containing vector that can insert in any gene. The secreted proteins are initially identified by their fluorescence. Secreted proteins identifying tumors with specific degrees of malignancy are isolated to determine if they can serve as markers of cancer progression.

    摘要翻译： 描述了一种鉴定鉴定为癌症恶性程度的分泌蛋白的方法。 最初通过用含有可插入任何基因的含荧光蛋白的载体捕获蛋白质来鉴定蛋白质。 分泌的蛋白质最初通过其荧光来鉴定。 分离识别具有特定恶性程度的肿瘤的分泌蛋白，以确定它们是否可以作为癌症进展的标志物。