公开(公告)号：US20010025114A1

公开(公告)日：2001-09-27

申请号：US09764087

申请日：2001-01-19

发明人： Hendrik Louis Bijl ,  Johannes Hendrik Wolf ,  Albert Schaap ,  Johannes Martinus Jacobus Visser

IPC分类号： C07C057/02 ,  C12P007/64

CPC分类号： A61Q19/00 ,  A23D9/00 ,  A23K20/158 ,  A23L31/00 ,  A23L33/11 ,  A23L33/12 ,  A23L33/15 ,  A23V2002/00 ,  A61K8/375 ,  A61K8/67 ,  A61K8/92 ,  A61K8/9706 ,  A61K8/99 ,  A61K2800/85 ,  C07C51/47 ,  C11B1/02 ,  C11B1/10 ,  C11B1/104 ,  C12N1/005 ,  C12N1/14 ,  C12P7/6427 ,  C12P7/6463 ,  C12P7/6472 ,  C12P17/06 ,  C12P19/42 ,  C12P23/00 ,  C07C57/12 ,  C07C57/03 ,  A23V2250/1882 ,  A23V2250/706 ,  A23V2250/1868

摘要： The present invention discloses a microbial polyunsaturated fatty acid(PUFA)-containing oil with a high triglyceride content and a high oxidative stability. In addition, a method is described for the recovery of such oil from a microbial biomass derived from a pasteurized fermentation broth, wherein the microbial biomass is subjected to extrusion to form granular particles, dried and the oil then extracted from the dried granules using an appropriate solvent.

摘要翻译： 本发明公开了具有高甘油三酯含量和高氧化稳定性的微生物多不饱和脂肪酸（PUFA）的油。 此外，描述了从源自巴氏消毒发酵液的微生物生物质中回收这种油的方法，其中微生物生物质被挤出以形成颗粒，干燥，然后使用适当的方法从干燥的颗粒中提取油 溶剂。

公开(公告)号：US20040234556A1

公开(公告)日：2004-11-25

申请号：US10485595

申请日：2004-02-02

发明人： Istvan Kaldor ,  Brian Edgar Looker ,  Christopher James Lunniss ,  Alison Judith Redgrave

IPC分类号： A61L009/04 ,  C07C057/02 ,  A61K031/20

CPC分类号： A61K9/008 ,  A61K31/137 ,  A61K31/56 ,  A61K47/12 ,  C07C59/135 ,  C07C69/63 ,  C07C69/708 ,  C09K3/30

摘要： A pharmaceutical aerosol formulation comprising a particulate medicament, one or more fluorocarbon or hydrogen-containing fluorocarbon propellants and a compound of the general formula (I) or a salt or solvate thereof, wherein A represents a straight chain C1-16 alkylene substituted by n groups of formula B; n represents an integer 1 to 3; and B independently represents C1-4 fluoroalkylC0-6 alkylene-, C1-4 fluoroalkylC0-6 alkylene-Onull, or C1-4 alkylC0-6 alkylene-Onull wherein at least one substituent of formula B contains at least one fluorine atom and each C1-4 fluoroalkyl- moiety contains one or more fluorine atoms but not more than 3 consecutive perfluorinated carbon atoms. The invention also extends to uses of compounds of formula (I) and certain novel compounds within the definition of formula (I). 1

摘要翻译： 一种药物气溶胶制剂，其包含颗粒药物，一种或多种含氟碳或含氢碳氟化合物推进剂和通式（I）的化合物或其盐或溶剂合物，其中A表示被n个基团取代的直链C1-16亚烷基 的式B; n表示1〜3的整数， 和B独立地表示C 1-4氟烷基C 0-6亚烷基 - ，C 1-4氟烷基C 0-6亚烷基-O-或C 1-4烷基C 0-6亚烷基-O-，其中至少一个式B的取代基含有至少一个氟原子， 每个C 1-4氟烷基部分含有一个或多个氟原子，但不超过3个连续的全氟化碳原子。 本发明还延伸到式（I）化合物和式（I）定义中的某些新化合物的用途。

公开(公告)号：US20010049451A1

公开(公告)日：2001-12-06

申请号：US09731955

申请日：2000-12-07

发明人： Michael C. Seidel

IPC分类号： C07C057/02

CPC分类号： C07C303/28 ,  C07C51/377 ,  C07C57/03 ,  C07C309/73

摘要： A synthesis process is disclosed for producing a conjugated fatty acid at specified temperature in high yield, including providing an ester of a fatty acid having somewhere in its carbon chain a chain of four carbon atoms such that carbon one bears one hydrogen and one hydroxyl group, carbon two bears two hydrogen atoms, and a double bond is positioned between carbon three and carbon four and reacting with a chloride selected from the group consisting of toluenesulfonyl chloride, methanesulfonyl chloride, benzenesulfonyl chloride, alkylsulfonyl chloride, and aryl-sulfonyl chloride at a temperature in the range of 10null C.-100null C., preferably 20null C.-50null C. The synthesis process provides a conjugated fatty acid formed from the ester reacted with diazabicyclo-undecene. In one aspect, the ester is formed in a pyridine solvent. In one aspect, a mesylate is formed with mesyl chloride in acetonitrile and triethyl amine. In one aspect, the reaction with diazabicyclo-undecene is conducted in a polar, non-hydroxylic solvent of acetonitrile to form a preferred isomer at the specified temperature in high yield.

摘要翻译： 公开了一种合成方法，以高产率在特定温度下生产共轭脂肪酸，包括提供在其碳链中某处具有四个碳原子的链的脂肪酸的酯，使得碳一个具有一个氢和一个羟基， 碳二具有两个氢原子，并且双键位于碳三和碳四之间，并与选自甲苯磺酰氯，甲磺酰氯，苯磺酰氯，烷基磺酰氯和芳基磺酰氯的氯化物在温度 在10℃-100℃，优选20℃-50℃的范围内。合成方法提供由与二氮杂双环十一碳烯反应的酯形成的共轭脂肪酸。 在一个方面，酯在吡啶溶剂中形成。 在一个方面，在乙腈和三乙胺中与甲磺酰氯形成甲磺酸酯。 一方面，与二氮杂双环十一碳烯的反应在乙腈的极性非羟基溶剂中进行，以高产率在规定温度下形成优选的异构体。

公开(公告)号：US20030120110A1

公开(公告)日：2003-06-26

申请号：US10226474

申请日：2002-08-23

申请人： Board of Trustees operating Michigan State University

发明人： Dennis J. Miller ,  Dushyant Shekhawat ,  Kirthivasan Nagarajan ,  James E. Jackson

IPC分类号： C07C051/347 ,  C07C057/02

CPC分类号： C07D307/60 ,  C07C51/087 ,  C07C51/353 ,  C07C51/567 ,  C07C57/155 ,  C07C57/13

摘要： Processes for producing citraconic anhydride and citraconic acid using porous materials with specific surface acidities and surface areas are described. The preferred catalyst is a porous gamma alumina. Itaconic acid is produced from citraconic acid. Itaconic acid is an intermediate to a variety of compounds including polymers.

公开(公告)号：US20020019553A1

公开(公告)日：2002-02-14

申请号：US09839622

申请日：2001-04-20

发明人： Hashem Akhavan-Tafti ,  Renuka DeSilva ,  Kumar Thakur ,  Zahra Arghavani

IPC分类号： C07C057/02

CPC分类号： G01N33/582 ,  C07C69/734 ,  C07C2603/74 ,  C07D321/00 ,  C07F9/12 ,  C07F9/65512 ,  G01N33/5308 ,  G01N33/54326

摘要： Stable, enzymatically triggered chemiluminescent 1,2-dioxetanes with improved water solubility and storage stability are provided as well as synthetic processes and intermediates used in their preparation. Dioxetanes further substituted with two or more water-solubilizing groups disposed on the dioxetane structure and an additional fluorine atom or lower alkyl group provide superior performance by eliminating the problem of reagent carryover when used in assays performed on capsule chemistry analytical systems. These dioxetanes display substantially improved stability on storage. Compositions comprising these dioxetanes, a non-polymeric cationic surfactant enhancer and optionally a fluorescer, for providing enhanced chemiluminescence are also provided.

公开(公告)号：US20040138499A1

公开(公告)日：2004-07-15

申请号：US10474368

申请日：2003-10-09

发明人： Thomas Buschulte ,  Volker Diehl ,  Bernd Hagen ,  Volker Huth ,  Wolfgang Kasten ,  Peter Schlemmer ,  Axel Schroth

IPC分类号： C07C051/16 ,  C07C057/02

CPC分类号： G01N21/3504 ,  B01J8/001 ,  B01J8/0442 ,  B01J8/0492 ,  B01J2208/00548 ,  B01J2219/0004 ,  B01J2219/00186 ,  B01J2219/00195 ,  B01J2219/00213 ,  B01J2219/00229 ,  B01J2219/00231 ,  C07C45/33 ,  C07C45/34 ,  C07C45/35 ,  C07C51/215 ,  C07C51/252 ,  C07C47/22 ,  C07C57/04

摘要： null,null-ethylenically unsaturated aldehydes and/or carboxylic acids are prepared by means of a two-stage catalytic gas-phase oxidation in which a gas mixture comprising at least an alkane or alkene having from three to six carbon atoms and oxygen is subjected to a catalytic oxidation reaction, in the first stage (1). oxygen is added to the gases produced in the first stage (1) and the resulting mixture is introduced into the second stage (2) in which it is subjected to a further catalytic oxidation reaction. In the process of the present invention, a signal which correlates with the oxygen content of the reaction gases before and/or after the addition of oxygen between the first and second stages (1, 2) is generated and the oxygen addition is regulated as a function of the signal. Also provided are an apparatus for regulating a process for preparing null,null-ethylenically unsaturated aldehydes and/or carboxylic acids and an apparatus for preparing these substances using the regulating apparatus of the present invention.

摘要翻译： α，β-烯属不饱和醛和/或羧酸是通过两阶段催化气相氧化制备的，其中将至少含有3至6个碳原子的烷烃或烯烃的气体混合物和氧气经受 催化氧化反应，在第一阶段（1）。 向第一阶段（1）中产生的气体中加入氧气，将所得混合物引入第二阶段（2），在其中进行进一步的催化氧化反应。 在本发明的方法中，产生与在第一和第二阶段（1,2）之间加入氧气之前和之后的反应气体的氧含量相关的信号，并且将氧气添加调节为 信号功能。 还提供了一种用于调节制备α，β-烯属不饱和醛和/或羧酸的方法的装置，以及使用本发明的调节装置制备这些物质的装置。

公开(公告)号：US20040006244A1

公开(公告)日：2004-01-08

申请号：US10437759

申请日：2003-05-14

发明人： Leo Ernest Manzer

IPC分类号： C07C057/02 ,  C07C069/52

CPC分类号： C07C51/353 ,  C07C67/343 ,  C07C57/04 ,  C07C69/54

摘要： The present invention relates to production of ethylenically unsaturated acids and ethylenically unsaturated esters by the catalytic reaction of an alkanoic acid or an alkanoic ester, with formaldehyde, in presence of a basic catalyst and optionally in the presence of an alcohol. More specifically, this invention relates to production of methyl methacrylate, an ester, by reaction of methyl propionate with formaldehyde, in presence of a basic catalyst, for example, cesium acetate on silica. This invention discloses a process for obtaining a high conversion of ethylenically unsaturated acids and esters.

摘要翻译： 本发明涉及通过链烷酸或链烷酸与甲醛的催化反应，在碱性催化剂和任选在醇存在下，通过烯属不饱和酸和烯属不饱和酯的制备。 更具体地，本发明涉及在碱性催化剂（例如二氧化硅上的乙酸铯）存在下，通过丙酸甲酯与甲醛的反应制备甲基丙烯酸甲酯酯。 本发明公开了一种获得烯属不饱和酸和酯的高转化率的方法。

公开(公告)号：US20020049346A1

公开(公告)日：2002-04-25

申请号：US09864881

申请日：2001-05-25

发明人： Scott Barclay ,  Krzysztof Piotr Rakowski ,  Victoria Taran

IPC分类号： C07C057/02 ,  A23D009/00

CPC分类号： C12P7/6436 ,  A23D7/013 ,  A23L33/12 ,  A23V2002/00 ,  C07C69/587 ,  C11C3/003 ,  C12P7/6472 ,  A23V2250/1866

摘要： The invention concerns with esters from conjugated linoleic acid and a food allowable alcohol from the group of terpene alcohols and sesquiterpene alcohols, these esters have good taste and display the health effects from the CLA part and from the food allowable alcohol part of the molecule.

摘要翻译： 本发明涉及来自共轭亚油酸的酯和来自萜烯醇和倍半萜烯醇的食品允许的醇，这些酯具有良好的味道并显示来自CLA部分和分子的食品允许的醇部分的健康效果。