Crystalline Minocycline Base and Processes for its Preparation
    5.
    发明申请
    Crystalline Minocycline Base and Processes for its Preparation 有权
    结晶米诺环素基质及其制备方法

    公开(公告)号:US20100286417A1

    公开(公告)日:2010-11-11

    申请号:US12528209

    申请日:2008-02-22

    IPC分类号: C07C215/88 C07C213/10

    CPC分类号: C07C237/26

    摘要: The invention provides crystalline minocycline base. In particular, three crystalline polymorphic forms, designated Form I, Form II and Form III, of minocycline base are provided. These are characterised by XRD and IR data. Processes for preparing the new polymorphic forms are also provided. For example, Form I is prepared by dissolving and/or suspending amorphous minocycline base in an organic solvent chosen from ethers followed by crystallisation from the mixture.

    摘要翻译: 本发明提供了结晶米诺环素碱。 特别地,提供了三环结构的多晶型形式,称为米诺环素碱的I型,II型和III型。 其特征在于XRD和IR数据。 还提供了制备新多晶型体的方法。 例如,通过将无定形米诺环素碱溶解和/或悬浮在选自醚的有机溶剂中,然后从混合物中结晶来制备形式I。