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12 条记录 (耗时 0.011 秒)

    3-thiazol-4'-oxy-aminopropanol cardiovascular agents
    1.
    发明授权
    3-thiazol-4'-oxy-aminopropanol cardiovascular agents 失效
    3-THIAZOL-4'-氧 - 氨基丙酸脂血管病毒

    公开(公告)号：US3850947A

    公开(公告)日：1974-11-26

    申请号：US26997172

    申请日：1972-07-10

    申请人： SYNTEX INC

    发明人： EDWARDS J

    IPC分类号： C07D277/34 ,  C07D91/30

    CPC分类号： C07D277/34

    摘要： 1. A COMPOUND SELECTED FROM THE GROUP HAVING THE FORMULA:

    4-(R1-N(-R2)-CH2-CH(-OH)-CH2-O-)-THIAZOLE

    WHEREIN R1 AND R2 ARE INDEPENDENTLY SELECTED FROM THE GROUP OF HYDROOGEN, LOWER ALKYL, CYCLOALKYL HAVING FROM 3 THROUGH 7 RING ATOMS, PHENYL, PHENYLALKYL HAVING UP TO 10 CARBON ATOMS, ALKYLPHENYL HAVING UP TO 10 CARBON ATOMS, HYDROXY LOWER ALKYL, (LOWER ALKOXY) LOWER ALKYL, ADAMANTLY, AND THE GROUP HAVING THE FORMULAS

    -R''-X OR -(CH2)N-N(-R6)-R7

    WHEREIN R'' IS LOWER ALKYL, X IS MORPHOLINO, PYRROLIDINO, OR PIPERIDINO, R& AND R'' ARE INDEPENDENTLY HYDROGEN OR LOWER ALKYL, AND N IS A WHOLE INTEGER OF FROM 2 TO 6; OR R1 AND R2 TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE JOINED FROM A NITROGEN HETEROCYCLE SELECTED FROM THE GROUP OF MORPHOLINE, PYRROLIDINE, AND PIPERIDINE; AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF.

    3-thiazol-5'-oxy-aminopropanol cardiovascular agents
    4.
    发明授权
    3-thiazol-5'-oxy-aminopropanol cardiovascular agents 失效
    3-THIAZOL-5'-OXY-氨基丙酸脂血管病毒

    公开(公告)号：US3850946A

    公开(公告)日：1974-11-26

    申请号：US26997472

    申请日：1972-07-10

    申请人： SYNTEX INC

    发明人： EDWARDS J

    IPC分类号： C07D277/34 ,  C07D91/30

    CPC分类号： C07D277/34

    摘要： 1. A COMPOUND SELECTED FROM THE HAVING THE FORMULA:

    5-(R1-N(-R2)-CH2-CH(-OH)-CH2-O-)-THIAZOLE

    WHEREIN R1 ANF R2 ARE INDEPENDENTLY SELCTED FROM THE GROUP OF HYDROGEN, LOWER ALKYL, CYCLOALKYL HAVING FROM 3 THROUGH 7 RING ATOMS, PHENYL, PHENYLALKYL HAVING UP TO 10 CARBON ATOMS, ALKYLPHENYL HAVING UP TO 10 CARBON ATOMS, HYDROXY LOWER ALKYL, (LOWER ALKOXY) LOWER ALKYL, ADAMANTYL, AND THE GROUP HAVING THE FORMULAS -R''X OR

    -(CH2)N-N(-R6)-R7

    WHEREIN R'' IS LOWER ALKYL, X IS MORPHOLINO, PYRROLIDINO, OR PIPERIDINO, R6 AND R7 ARE INDEPENDENTLY HYDROGEN OR LOWER ALKYL, AND N IS A WHOLE INTEGER OF FROM 2 TO 6; OR R1 AND R2 TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE JOINED FORM A NITROGEN HETEROCYCLE SELECTED FROM THE GROUP OF MORPHOLINE, PYRROLIDINE, AND PIPERIDINE; AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF.

    3-thiazol-2'-oxy-aminopropanol cardiovascular agents
    5.
    发明授权
    3-thiazol-2'-oxy-aminopropanol cardiovascular agents 失效
    3-THIAZOL-2'-OXY-AMINOPROPANOL CARDIOVASCARAR AGENTS

    公开(公告)号：US3850945A

    公开(公告)日：1974-11-26

    申请号：US28973072

    申请日：1972-09-15

    申请人： SYNTEX INC

    发明人： EDWARDS J

    IPC分类号： C07D277/20 ,  A61K31/425 ,  C07D277/32 ,  C07D277/34 ,  C07D277/36 ,  C07D277/40 ,  C07D277/46 ,  C07D277/48 ,  C07D277/56 ,  C07D277/58 ,  C07D417/12 ,  C07D91/30

    CPC分类号： A61K31/425 ,  C07D277/32 ,  C07D277/34 ,  C07D277/36 ,  C07D277/40 ,  C07D277/46 ,  C07D277/48 ,  C07D277/56 ,  C07D277/58 ,  C07D417/12

    摘要： 1. A COMPOUND SELECTED FROM THE GROUP HAVING THE FORMULA:

    2-(R1-N(-R2)-CH2-CH(-OH)-CH2-O-),R3-THIAZOLE

    WHEREIN R1 AND R2 ARE INDEPENDENTLY SELECTED FROSM THE GROUP OF HYDROGEN, LOWER ALKYL, CYCLOALKYL HAVING FROM 3 THROUGH 7 RING ATOMS, LOWER ALKENYL, PHENYL, PHENYLALKYL HAVING UP TO 12 CARBON ATOMS AND ALKYLPHENYL HAVING UP TO 10 CARBON ATOMS, HYDROXY LOWER ALKYL, (LOWER ALKOXY) LOWER ALKYL, AND THE GROUPS HAVING THE FORMULAS

    -R''-X OR -(CH2)N-N(-R7)-R8

    WHEREIN R'' IS LOWER ALKYL, X IS MORPHOLINE, PIPERIDINE OR PYRROLIDINE; R7 AND R8 ARE INDEPENDENTLY HYDROGEN OR LOWER ALKYL AND IS A WHOLE INTEGER OF FROM 1 THROUGH 4; OR R1 AND R2 TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE JOINED FORM A NITROGWN HETEROCYCLE SELECTED FROM THE GROUP MORPHOLINE, PIPERIDINE, OR PYRROLIDINE; R3 IS A SUBSTITUENT ON THE THIAZOLE RING AT EITHER THE 4OR 5-POSITION SELECTED FROM THE GROUP OF HYDROGEN, LOWER ALKYL, LOWER CYCLOALKYL, LOWER ALKOXY, HYDROXY (LOWER ALKYL), ACYLOXY (LOWER ALKYL) WHEREIN SAID ACYLOXY IS FREE OF ALIPHATIC UNSATURATION AND HAS FROM ONE THROUGH 12 CARBON ATOMS, HALO, TRIFLUOROMETHYL, ACYL HAVING FROM ONE THROUGH 12 CARBON ATOMS AND FREE OF ALIPHATIC UNSATURATION, CARBOXY, CYANO, AMINE, LOWER ALKYLAMINO, LOWER DIALKYL AMINO, AND GROUPS HAVING THE FORMULAS:

    H2N-CO-NH-, R1''-NH-CO-NH-, R1''-NH-CO-N(-R2'')-, R1''-N(-R1")

    -CO-N(-R2'')-, R1''-SO2-NH-, R1''-SO2-N(-R2'')-, R1''-S-,

    R1''-SO2-, HO-SO2-, R1''-O-SO2-, H2N-SO2-, R1''-NH-SO2-,

    R1''-R2''-SO2-, R3''-OOC-, R5''-PHENYLENE-R4''-

    WHEREIN R1'', R1" AND R2'' ARE INDEPENDENTLY SELECTED FROM THE GROUP OF LOWER ALKYL, PHENYL AND PHENYLALKYL HAVING UP TO 12 CARBON ATOMS; R3'' IS ALKYL HAVING FROM 1 THROUGH 11 CARBON ATOMS, CYCLOALKYL HAVING FROM 5 THROUGH 7 CARBON ATOMS, PHENYL OR PHENYLALKYL HAVING UP TO 12 CARBON ATOMS; R4'' AND R5'' ARE INDEPENDENTLY SELECTED FROM THE GROUP OF HYDROGEN, LOWER ALKYL, HYDROXY (LOWER ALKYL) AND HALO; AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF.

    Ceritain 4-(n-alkenylcarbamyl) thiazoles
    6.
    发明授权
    Ceritain 4-(n-alkenylcarbamyl) thiazoles 失效
    CERITAIN 4-（N-亚苄基氨基）噻唑

    公开(公告)号：US3594389A

    公开(公告)日：1971-07-20

    申请号：US3594389D

    申请日：1969-06-12

    申请人： LILLY CO ELI

    发明人： COOPER ROBIN D G

    IPC分类号： C07D277/22 ,  C07D277/56 ,  C07D91/30

    CPC分类号： C07D277/56

    摘要： SUBSTITUED THIAZOLES USEFUL AS ANTIBIOTICS AND ANTIFUNGAL AGENTS OR AS ANTI-RADIATION CHEMICALS, ARE OBTAINED BY TREATMENT OF A THIAZOLINE AZETIDINONE WITH AN ACID OR A BASE TO OPEN THE B-LACTAM RING. THE THIAZOINE AZETIDINONE IS OBTAINED BY TREATMENT OF A PENICILLIN SULFOXIDE WITH TRIPHENYL PHOSPHINE OR A TRIALKYL PHOSPHITE.

    Alkoxynaphthalimidothiazolium salts,useful as optical bleaching agents
    8.
    发明授权
    Alkoxynaphthalimidothiazolium salts,useful as optical bleaching agents 失效
    有效用作光学漂白剂的烷氧基磷酸二氢钠盐

    公开(公告)号：US3804837A

    公开(公告)日：1974-04-16

    申请号：US20387371

    申请日：1971-12-01

    申请人： UGINE KUHLMANN

    发明人： MINGASSON G ,  DOMERGUE A

    IPC分类号： C07D221/14 ,  C07D403/04 ,  C07D417/04 ,  D06L3/12 ,  C07D91/30

    CPC分类号： C07D417/04 ,  C07D221/14 ,  C07D403/04 ,  D06L4/60

    摘要： COMPOUND OF THE FORMULA:

    2-(B(+)-X-),6-(R-O-)-2,3-DIHYDRO-1H-BENZ(DE)ISOQUINOLINE-

    1,3-DIONE A(-)

    IN WHICH R IS AN ALKYL RADICAL, OR A HYDROXY OR ALKOXY SUBSTITUTED ALKYL RADICAL, SAID ALKYL HAVING ONE TO FOUR CARBON ATOMS, X IS A DIRECT LINKAGE OR P-PHENYLENE, B& IS AN N&-(LOWER ALKYL) CYCLOAMMONIUM GROUP IN WHICH THE CYCLAMMONIUM GROUP IS THIAZOLIUM AND IS ATTACHED TO X THROUGH A CARBON ATOM, THE REMAINING CARBON ATOMS IN B& BEING UNSUBSTITUTED OR SUBSTITUTED BY CHLORINE , LOWER ALKYL, PHENYL, OR METHYLTHIO GROUPS, AND A& IS A COLORLESS MONOVALENT ANION. THESE COMPOUNDS CAN BE USED AS FLUORESCENT BRIGHTENING AGENTS FOR FIBERS BASED ON ACRYLONITRILE POLYMERS OR COPOLYMERS.

    Substituted thiazoles in flavoring processes and products produced thereby
    9.
    发明授权
    Substituted thiazoles in flavoring processes and products produced thereby 失效
    替代工艺中生产的THIAZOLES和生产的产品

    公开(公告)号：US3769040A

    公开(公告)日：1973-10-30

    申请号：US3769040D

    申请日：1970-11-09

    申请人： INT FLAVORS & FRAGRANCES INC

    发明人： PITTET A ,  HRUZA D

    IPC分类号： A23L27/20 ,  A24B15/36 ,  C07D277/22 ,  C07D277/24 ,  C07D277/34 ,  C07D277/36 ,  C11B9/00 ,  A23L1/26 ,  C07D91/30

    CPC分类号： C07D277/22 ,  A23L27/2056 ,  A24B15/36 ,  A24B15/365 ,  C07D277/24 ,  C07D277/36 ,  C11B9/0096

    摘要： Process for altering the flavors and/or fragrances of materials which comprise adding thereto effective amounts of at least one thiazole having the formula

    WHEREIN R is hydrogen, alkyl, or acyl; X is alkoxy, hydrogen, or, when R and Y are alkyl, alkyl; and Y is alkyl, acyl, alkoxy or hydrogen, no more than two of R, X, and Y being hydrogen; compositions containing such thiazoles and compositions; perfumed materials containing such thiazoles and compositions; and novel thiazoles and processes for producing same.

    摘要翻译： 用于改变材料的风味和/或香料的方法，其包括向其中加入有效量的至少一种具有式WHEREIN R的噻唑是氢，烷基或酰基; X是烷氧基，氢，或当R和Y是烷基时，烷基; 并且Y是烷基，酰基，烷氧基或氢，R，X和Y中不超过两个是氢; 含有这种噻唑和组合物的组合物; 含有这种噻唑和组合物的加香材料; 和新颖的噻唑及其制备方法。