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    Benzoquinone derivatives for treating oxidative stress disorders
    4.
    发明授权
    Benzoquinone derivatives for treating oxidative stress disorders 有权

    公开(公告)号：US09629815B2

    公开(公告)日：2017-04-25

    申请号：US14426135

    申请日：2013-09-06

    申请人： Edison Pharmaceuticals, Inc.

    发明人： William D. Shrader ,  Andrew W. Hinman ,  Viktoria Kheifets

    IPC分类号： A01N35/00 ,  A61K31/12 ,  A61K31/122 ,  A61K31/05 ,  A61K31/198 ,  C07C66/00

    CPC分类号： A61K31/122 ,  A61K31/05 ,  A61K31/198 ,  C07C66/00

    摘要： Disclosed herein are compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging, or for modulating one or more energy biomarkers, normalizing one or more energy biomarkers, or enhancing one or more energy biomarkers, wherein the compound is a compound of Formula I or Formula II: wherein: R1 and R2 are independently hydrogen, (C1-C6)alkyl or —O(C1-C6)alkyl; or R1 and R2 together represent —CH═CH—CH═CH—; R3 is (C1-C6)alkyl; X is —CH═CH— or —C≡C—; m is 1-10; n is 1-5; k is 1-3, with the proviso that when k is an integer of 2 or 3, n is independently 1-5 in each occurrence of the —X—(CH2)n— group; Y is —OR4, —CN, —C(═O)OR5, —C(═O)R5, or —C(═O)N(R6)2; R4 and R5 are independently selected from the group consisting of hydrogen, —(C1-C6)alkyl, —(C1-C6)haloalkyl, —C(═O)—(C1-C6)alkyl, —C(═O)—(C1-C6)haloalkyl, —C(═O)—NH(C1-C6)alkyl, —C(═O)—N((C1-C6)alkyl)2, —C(═O)—NH2, and phenyl, wherein the phenyl group may optionally be substituted with a substituent selected from the group consisting of —(C1-C6)alkyl, —O—(C1-C6)alkyl, —(C1-C6)haloalkyl, and halo; each R6 is independently hydrogen or —(C1-C6)alkyl; and M is —H, —C(O)—R7 or —C(O)O—R7, wherein R7 is —(C1-C6)alkyl or phenyl; or a stereoisomer, mixture of stereoisomers, pharmaceutically acceptable salt, crystalline form, non-crystalline form, hydrate or solvate thereof.

    Methods for attracting honey bee parasitic mites
    8.
    发明授权
    Methods for attracting honey bee parasitic mites 有权
    吸蜂蜜寄生螨的方法

    公开(公告)号：US08647615B1

    公开(公告)日：2014-02-11

    申请号：US13220017

    申请日：2011-08-29

    申请人： Peter EA Teal ,  Adrian J. Duehl ,  Mark J. Carroll

    发明人： Peter EA Teal ,  Adrian J. Duehl ,  Mark J. Carroll

    IPC分类号： A01N35/08 ,  A01N35/00

    CPC分类号： A01N37/02

    摘要： A method for attracting honey bee parasitic mites to an object or area, involving treating the object or area with a composition containing a honey bee parasitic mites attracting effective amount of at least one compound selected from butyric acid, isobutyric acid, or mixtures thereof, and optionally a carrier or carrier material.

    摘要翻译： 一种将蜂蜜寄生螨吸引到物体或区域的方法，涉及用含有蜂蜜寄生螨的组合物处理物体或区域，吸引有效量的至少一种选自丁酸，异丁酸或其混合物的化合物，以及 任选的载体或载体材料。