公开(公告)号：US20240285723A1

公开(公告)日：2024-08-29

申请号：US18573517

申请日：2022-06-22

申请人： RAMOT AT TEL-AVIV UNIVERSITY LTD.

发明人： Yankel GABET ,  Josef MOGRABI

IPC分类号： A61K38/08 ,  A61K31/015 ,  A61K31/497 ,  A61K31/566 ,  A61K31/573 ,  A61P31/00 ,  A61P37/06

CPC分类号： A61K38/08 ,  A61K31/015 ,  A61K31/497 ,  A61K31/566 ,  A61K31/573 ,  A61P31/00 ,  A61P37/06

摘要： Pharmaceutical compositions are provided, comprising at least one selective CB2 receptor agonist and at least one steroid. The provided compositions are effective in treating inflammation and/or pathogen related inflammation and associated complications thereof. Also provided are methods for treating a subject infected with a pathogen as well as inflammation, using said compositions.

公开(公告)号：US20240277660A1

公开(公告)日：2024-08-22

申请号：US18416811

申请日：2024-01-18

申请人： SKINTECH LIFE SCIENCE LIMITED

发明人： David ALPERT

IPC分类号： A61K31/404 ,  A61K9/00 ,  A61K31/07 ,  A61K31/203 ,  A61K31/215 ,  A61K31/216 ,  A61K31/22 ,  A61K31/23 ,  A61K31/341 ,  A61K31/566 ,  A61K45/06

CPC分类号： A61K31/404 ,  A61K9/0014 ,  A61K9/0053 ,  A61K31/07 ,  A61K31/203 ,  A61K31/215 ,  A61K31/216 ,  A61K31/22 ,  A61K31/23 ,  A61K31/341 ,  A61K31/566 ,  A61K45/06

摘要： Provided is a composition for use in treating a skin condition, the composition comprising:



(a) a first component comprising a substituted or unsubstituted diindolylmethane compound; and
(b) a second component comprising a substituted or unsubstituted retinoid compound.

公开(公告)号：US20240238264A1

公开(公告)日：2024-07-18

申请号：US18406825

申请日：2024-01-08

申请人： Washington University ,  Disarm Therapeutics, Inc.

发明人： Jeffrey MILBRANDT ,  Kow ESSUMAN ,  Yo SASAKI ,  Aaron DIANTONIO ,  Xianrong MAO ,  Rajesh DEVRAJ ,  Raul Eduardo KRAUSS ,  Robert Owen HUGHES

IPC分类号： A61K31/4439 ,  A61K31/047 ,  A61K31/145 ,  A61K31/198 ,  A61K31/41 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4535 ,  A61K31/566 ,  A61K31/7048 ,  A61K31/7084 ,  A61K33/243 ,  A61K33/245 ,  A61K33/28 ,  A61K33/30 ,  A61K47/52 ,  A61K47/55 ,  A61P25/28

CPC分类号： A61K31/4439 ,  A61K31/047 ,  A61K31/145 ,  A61K31/198 ,  A61K31/41 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4535 ,  A61K31/566 ,  A61K31/7048 ,  A61K31/7084 ,  A61K33/243 ,  A61K33/245 ,  A61K33/28 ,  A61K33/30 ,  A61K47/52 ,  A61K47/55 ,  A61P25/28

摘要： The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.

公开(公告)号：US20240182516A1

公开(公告)日：2024-06-06

申请号：US18551249

申请日：2022-03-17

申请人： TRUSTEES OF DARTMOUTH COLLEGE

发明人： Glenn C. MICALIZIO

IPC分类号： C07J75/00 ,  A61K31/566 ,  C07J1/00

CPC分类号： C07J75/005 ,  A61K31/566 ,  C07J1/00

摘要： The present disclosure relates to stereodefined polycyclic (e.g., tetracyclic) compounds that contain quaternary centers at one or multiple ring fusions, synthetic methods for preparing such compounds. In one aspect, the present disclosure relates to preparing a C9-alpha-substituted or a C9-beta-substituted compound (steroid numbering), the method comprising the steps of providing a tertiary allylic substrate and performing a regio- and stereoselective cyclization reaction to form a C9-C10 bond and to set a quaternary center at C9.

公开(公告)号：US20230404911A1

公开(公告)日：2023-12-21

申请号：US18240284

申请日：2023-08-30

申请人： LUPIN INC.

发明人： Vinita GUPTA ,  Richard HOLL ,  James GAREGNANI ,  Gregory KAUFMAN

IPC分类号： A61K9/00 ,  A61P15/18 ,  A61K31/566 ,  A61K47/32

CPC分类号： A61K9/0036 ,  A61P15/18 ,  A61K31/566 ,  A61K47/32

摘要： The invention relates to a drug delivery system for contraception including a steroidal estrogenic compound, a steroidal progestogenic compound or a combination thereof for the purposes of contraception in a subject, and provides for an ultra-low dose delivery of a steroidal estrogenic compound which minimizes or eliminates a burst release effect. The invention also relates to a method of contraception using the drug delivery system and method of manufacturing the drug delivery system.

公开(公告)号：US20230381137A1

公开(公告)日：2023-11-30

申请号：US18364621

申请日：2023-08-03

申请人： The Board of Trustees of the University of Illinois

发明人： Gregory R THATCHER ,  Rui XIONG ,  Jiong ZHAO ,  Yunlong LU ,  Lauren GUTGESELL ,  Carlo Ivan ROSALES ,  Yangfeng LI

IPC分类号： A61K31/397 ,  A61K31/138 ,  A61K31/167 ,  A61K31/277 ,  A61K31/4025 ,  A61K31/4196 ,  A61K31/4535 ,  A61K31/565 ,  A61K31/566 ,  A61K31/573 ,  A61K38/09 ,  A61K39/395 ,  A61K45/06 ,  C07D409/12

CPC分类号： A61K31/397 ,  A61K31/138 ,  A61K31/167 ,  A61K31/277 ,  A61K31/4025 ,  A61K31/4196 ,  A61K31/4535 ,  A61K31/565 ,  A61K31/566 ,  A61K31/573 ,  A61K38/09 ,  A61K39/3955 ,  A61K45/06 ,  C07D409/12 ,  C07B2200/05

摘要： In one aspect, the disclosure relates to relates to substituted benzothiophene analogs which are useful as selective degraders of estrogen receptor, methods of making same, pharmaceutical compositions comprising same, and methods of treating one or more clinical conditions associated with estrogen receptor, such as a cancer, including breast cancer, or osteoporosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US11760775B2

公开(公告)日：2023-09-19

申请号：US16858458

申请日：2020-04-24

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Amy Han ,  Andrew J. Murphy ,  William Olson

IPC分类号： A61K31/566 ,  C07J71/00 ,  C07J41/00 ,  A61K47/68 ,  A61P29/00 ,  A61K31/58 ,  A61K47/61 ,  A61K47/69

CPC分类号： C07J71/0026 ,  A61K31/566 ,  A61K31/58 ,  A61K47/61 ,  A61K47/6801 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6889 ,  A61K47/6951 ,  A61P29/00 ,  C07J41/005 ,  C07J41/0088 ,  C07J71/0031

摘要： Described herein are protein steroid conjugates that are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to cells.

公开(公告)号：US20230190770A1

公开(公告)日：2023-06-22

申请号：US18107965

申请日：2023-02-09

申请人： Washington University ,  Sage Therapeutics, Inc.

发明人： Douglas Covey ,  Albert Jean Robichaud

IPC分类号： A61K31/58 ,  C07J1/00 ,  C07J5/00 ,  C07J7/00 ,  C07J21/00 ,  C07J41/00 ,  C07J9/00 ,  C07J13/00 ,  A61K31/56 ,  A61K31/565 ,  A61K31/566 ,  A61K31/573

CPC分类号： A61K31/58 ,  C07J1/0011 ,  C07J1/0018 ,  C07J1/0029 ,  C07J5/0015 ,  C07J7/002 ,  C07J21/00 ,  C07J41/0005 ,  C07J41/0094 ,  C07J9/005 ,  C07J13/007 ,  A61K31/56 ,  A61K31/565 ,  A61K31/566 ,  A61K31/573 ,  C07J21/006 ,  C07J21/008 ,  C07J51/00

摘要： The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.

公开(公告)号：US20230158080A1

公开(公告)日：2023-05-25

申请号：US18057262

申请日：2022-11-21

申请人： SPINALCYTE, LLC

发明人： Pete O'HEERON ,  Thomas ICHIM

IPC分类号： A61K35/33 ,  A61K31/566 ,  A61K31/568 ,  A61K31/4045

CPC分类号： A61K35/33 ,  A61K31/566 ,  A61K31/568 ,  A61K31/4045

摘要： Disclosed are means of enhancing therapeutic activities of fibroblasts through manipulation of nuclear receptor activation accomplished by, intra alia, alteration in hormone levels. In some embodiments angiogenic, and/or neurogenic, and/or immunomodulatory activities of fibroblasts are increased by normalization or augmentation of sex-specific hormones. In one embodiment a candidate for fibroblast therapy is administered hormones, pro-hormones, or growth factors to augment therapeutic activities of fibroblasts. In some embodiments fibroblasts are treated in vitro prior to administration with various hormones and/or growth factors in order to augment therapeutic activities of said cells.

公开(公告)号：US20230118053A1

公开(公告)日：2023-04-20

申请号：US17914916

申请日：2021-03-26

申请人： JIANGSU ALPHAMAB BIOPHARMACEUTICALS CO., LTD.

发明人： Ting XU ,  Junfang XU ,  Pilin WANG ,  Jing YANG ,  Jiazhu FANG ,  Lihong YUN ,  Yanrong DONG

IPC分类号： A61K39/395 ,  A61K31/566 ,  A61P35/00 ,  A61P35/04 ,  A61K31/519

摘要： The present application provides a medicinal product comprising: an the HER2 inhibitor or a CDK inhibitor, wherein said CDK inhibitor inhibits CDK4 and/or CDK6. The present application also provides an the HER2 inhibitor for the use of treating tumor in combination with a CDK inhibitor, as well as their use in the preparation of a medicament for treating tumor. The combination in present will significantly enhance tumor inhibiting.