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公开(公告)号:US11617753B2
公开(公告)日:2023-04-04
申请号:US16348867
申请日:2017-11-06
申请人: OYAGEN, INC. , The United States of America, as represented by the Secretary of Health and Human Services
发明人: Harold C. Smith , Ryan P. Bennett , Peter Jahrling
IPC分类号: A61K31/52 , A61K31/7064
摘要: Disclosed herein are methods for treating an Ebola virus and inhibiting the transmission and propagation thereof.
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公开(公告)号:US20220378815A1
公开(公告)日:2022-12-01
申请号:US17880464
申请日:2022-08-03
申请人: OYAGEN, INC.
发明人: Harold C. Smith , Ryan P. Bennett
IPC分类号: A61K31/7064 , A61K31/706 , A61K9/00 , A61P31/14
摘要: Disclosed herein are methods, formulations, and kits for treating coronavirus infections, including Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infections and SARS-CoV-2 infections. Further disclosed are stop-gap methods for controlling the spread of coronavirus infections and the emergence of drug resistant strains of coronavirus.
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公开(公告)号:US20220233566A1
公开(公告)日:2022-07-28
申请号:US17619379
申请日:2020-06-17
发明人: Hitoshi MIYAKOSHI , Nozomu TANAKA , Yu KOBAYAKAWA
IPC分类号: A61K31/7064 , C07H19/14 , A61P35/00 , A61K31/495 , A61N5/10
摘要: There is provided a novel carbonate compound of a nucleoside having a pyrrolopyrimidine skeleton having an excellent antitumor effect, or a pharmaceutically acceptable salt thereof and a method for preventing and/or treating a tumor in combination with an alkylating agent and/or a radiation therapy. According to one aspect of the present invention, there is provided a compound represented by the following general formula (1): or a pharmaceutically acceptable salt thereof, and a method for preventing and/or treating a tumor in combination with an alkylating agent and/or a radiation therapy.
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公开(公告)号:US20220184111A1
公开(公告)日:2022-06-16
申请号:US17682655
申请日:2022-02-28
申请人: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
IPC分类号: A61K31/713 , A61K31/704 , A61K31/52 , A61K31/137 , A61K31/365 , A61K31/65 , A61K31/706 , A61K39/395 , A61K31/711 , A61K31/7064 , A61K31/437 , A61K31/505 , A61K31/712 , C07K16/28 , A61P39/00 , A61K31/351 , A61K31/787 , A61P35/00 , A61K31/513 , A61K45/06
摘要: Disclosed herein are methods of reducing cytotoxicity of a chemotherapeutic agent to non-cancer cells by administering to a subject with cancer an effective amount of an agent that inhibits CD47 signaling and a chemotherapeutic agent. Example disclosed methods reduce cardiotoxicity of a chemotherapeutic agent. Also disclosed are methods of increasing cytotoxicity of a chemotherapeutic agent in cancer cells by administering to a subject with a tumor an effective amount of an agent that inhibits CD47 signaling and a chemotherapeutic agent. In some embodiments, the inhibitor of CD47 signaling is administered to the subject before, during, or after the administration of the chemotherapeutic agent.
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公开(公告)号:US20220152072A1
公开(公告)日:2022-05-19
申请号:US17601479
申请日:2020-04-03
发明人: Hong Lin , Juan Luengo , Rupa Shetty , Michael Hawkins
IPC分类号: A61K31/7064
摘要: The disclosure is directed to methods of treating disease using compounds of Formula (I).
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公开(公告)号:US20210330732A1
公开(公告)日:2021-10-28
申请号:US17192155
申请日:2021-03-04
发明人: Niamh O'Kennedy
IPC分类号: A61K36/81 , A61K31/7048 , A61K31/7064
摘要: Provided are methods of making an extract of fruit of the Solanaceae family wherein fruit is processed to optimise the platelet aggregation inhibiting activity of the extract. The methods involve preparing a start mix of homogenised fruit; separating a water soluble fraction from fruit solids; filtration of the water soluble fraction; and concentration of active agents in the filtration permeate. The invention also provides fruit extracts manufactured by such methods, and also fruit extracts containing glycosylated phenolic acid or a phenolic ester, or derivatives thereof; a glycosylated flavonoid; and a nucleoside. The extracts of the invention are useful as medicaments for the treatment or prevention of a medical condition characterised by inappropriate platelet aggregation. In particular, the medicaments may be of use in maintaining heart health by reducing platelet aggregation; benefiting the circulation; and/or normalizing or otherwise benefiting blood flow.
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公开(公告)号:US11001603B2
公开(公告)日:2021-05-11
申请号:US17009590
申请日:2020-09-01
发明人: Laurent Pierre Paul Debien , Juan Carlos Jaen , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif
IPC分类号: A01N43/04 , A61K31/70 , C07H19/23 , A61K31/7076 , C07H19/16 , C07H19/20 , C07H19/207 , C07F9/6561 , C07H19/04 , A61K31/706 , A61K45/06 , A61K31/7052 , A61K31/7064 , C07H19/14
摘要: Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号:US20210122776A1
公开(公告)日:2021-04-29
申请号:US17135256
申请日:2020-12-28
IPC分类号: C07H15/203 , C07H15/26 , A61K31/7034 , A61K31/7042 , A61K31/7056 , A61K31/706 , A61K31/7064 , A61K45/06
摘要: The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused by bacteria containing type 1 pili and FimH. The present invention also encompasses compounds and methods for treating inflammatory bowel disease specifically Crohn's Disease.
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公开(公告)号:US10953029B2
公开(公告)日:2021-03-23
申请号:US15761742
申请日:2016-09-19
IPC分类号: C07H19/14 , A61K31/7064 , C07D307/33 , A61K45/06 , C07H1/00 , C07H23/00 , C07H19/16 , A61P31/18
摘要: The present invention is directed to 4′-substituted nucleoside derivatives of Formula (I) and their use in the inhibition of HIV reverse transcriptase, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS and/or ARC. The present invention also provides processes for the preparation of 4′-substituted nucleoside derivatives of Formula (I) and derivatives thereof.
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公开(公告)号:US20210053981A1
公开(公告)日:2021-02-25
申请号:US16938767
申请日:2020-07-24
发明人: Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James G. Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
IPC分类号: C07D491/052 , A61K47/60 , A61K31/7064 , A61K31/7072 , A61K31/4188 , A61K45/06 , A61K31/7056 , A61K38/21 , C07F5/02 , A61K38/06 , A61K38/07 , C07D405/12
摘要: The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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