公开(公告)号：US11613719B2

公开(公告)日：2023-03-28

申请号：US16577824

申请日：2019-09-20

申请人： Becton, Dickinson and Company

发明人： He Bai ,  Marc Weimer

IPC分类号： C10M105/76 ,  A61L29/14 ,  A61L29/08 ,  C10M171/00 ,  C08G18/48 ,  A61L31/06 ,  C08G18/76 ,  C08G18/75 ,  C08G18/28 ,  A61L29/06 ,  C10N40/00

摘要： Medical articles formed from a polyurethane-based resin including a modifying oligomer provide enhanced properties. A modifying oligomer incorporated into a backbone, as a side chain, or both of the polyurethane-based resin formed by a diisocyanate, a polyglycol, and a diol chain extender has at least one, preferably two, alcohol moieties (C—OH) and a functional moiety. Exemplary modifying oligomers are: a diol-containing perfluoropolyether incorporated into the backbone, a monofunctional polysiloxane (e.g., monodialcohol-terminated polydimethylsiloxane) incorporated as the side chain, and combinations thereof. Medical articles herein are self-lubricating and/or anti-fouling.

公开(公告)号：US11559257B2

公开(公告)日：2023-01-24

申请号：US16840150

申请日：2020-04-03

申请人： Covidien LP

发明人： David J. Miller

IPC分类号： A61B5/20 ,  A61B5/00 ,  A61B5/03 ,  A61B5/145 ,  A61B5/0538 ,  A61B5/11 ,  A61L29/04 ,  A61L29/14 ,  A61B5/103 ,  A61B5/01 ,  A61L29/08 ,  A61M25/00 ,  A61M25/01

摘要： In some examples, a device includes a catheter insert elongated body defining a body lumen, the catheter insert elongated body being configured to be at least partially inserted to a catheter lumen defined by a catheter without covering a first fluid opening of the catheter and to form a fluidically tight coupling with the catheter, and one or more sensors positioned on the elongated body. At least one of the one or more sensors are configured to sense a substance of interest. The catheter insert elongated body includes a material that is a substantially non-permeable to the substance of interest.

公开(公告)号：US20230017481A1

公开(公告)日：2023-01-19

申请号：US17935882

申请日：2022-09-27

申请人： MicroVention, Inc.

发明人： Wenmar Badbada ,  Nga Ting Wong ,  Heath Bowman ,  Matt Biggers ,  Joseph Rye ,  Jared Shimizu

IPC分类号： A61M27/00 ,  A61L29/08 ,  A61L29/14 ,  A61M25/00

摘要： A shunt system used to treat excess cerebrospinal fluid (CSF) accumulation is described. In some embodiments, the system utilizes various mechanical, electrical, or electromechanical concepts designed to either clean a portion of the shunt system, or customize CSF drainage.

公开(公告)号：US20230001163A1

公开(公告)日：2023-01-05

申请号：US17944259

申请日：2022-09-14

申请人： Urotronic, Inc.

发明人： Lixiao Wang ,  Peter Barnett ,  David Hendrickson

IPC分类号： A61M25/10 ,  A61L29/08 ,  A61L29/06 ,  A61L29/16 ,  A61B1/307 ,  A61B1/00 ,  A61M25/00

摘要： Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

公开(公告)号：US11529440B2

公开(公告)日：2022-12-20

申请号：US16847272

申请日：2020-04-13

申请人： Surmodics, Inc.

发明人： Joram Slager ,  Toni M. Heyer ,  David E. Babcock

IPC分类号： A61L29/08 ,  A61L29/16 ,  A61L29/14 ,  A61K31/337 ,  A61K31/713 ,  A61K47/34 ,  A61M25/10 ,  C12N15/113 ,  A61K9/50

摘要： Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.

公开(公告)号：US11524046B2

公开(公告)日：2022-12-13

申请号：US16391272

申请日：2019-04-22

申请人： ContraFect Corporation

发明人： Raymond Schuch ,  Robert C. Nowinski ,  Michael Wittekind ,  Babar Khan ,  Jimmy Rotolo

IPC分类号： A61K38/16 ,  C12N9/50 ,  A01N63/50 ,  A61L29/08 ,  A61L29/16 ,  C07K14/315 ,  A61K38/47 ,  A61K45/06

摘要： The present invention provides methods for the prevention, control, disruption and treatment of bacterial biofilms with lysin, particularly lysin having capability to kill Staphlococcal bacteria, including drug resistant Staphylococcus aureus, particularly the lysin PlySs2. The invention also provides compositions and methods for use in treatment or modulation of bacterial biofilm(s) and biofilm formation.

公开(公告)号：US11518782B2

公开(公告)日：2022-12-06

申请号：US16898309

申请日：2020-06-10

申请人： TissueTech, Inc.

发明人： Scheffer Tseng ,  Hua He ,  Sean Tighe ,  Suzhen Zhang ,  Ying-Tieng Zhu

IPC分类号： C07K1/36 ,  C07K14/47 ,  A61K47/69 ,  A61K38/19 ,  A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  C07K14/525 ,  C07K19/00 ,  A61K47/55 ,  A61K38/00 ,  C07K14/81

摘要： Provided herein are methods for the production of native and reconstituted hyaluronan (HA) complexes containing pentraxin-3 (PTX3) and heavy chain 1 (HC1) of inter alpha inhibitor (IαI). Compositions containing the complexes and therapeutic methods using the complexes are provided. Combinations and kits for use in practicing the methods also are provided.

公开(公告)号：US11505658B2

公开(公告)日：2022-11-22

申请号：US17570912

申请日：2022-01-07

申请人： Harland Medical Systems, Inc.

发明人： Paul Buscemi ,  Gregory Carlson

IPC分类号： C08J3/24 ,  A61L29/08 ,  A61L29/14 ,  C09D5/14 ,  C09D139/06 ,  C08J7/043 ,  C08J7/056

摘要： The present invention relates to coatings for devices such as medical devices that are useful for coating a variety of different types of material surfaces, including polymer and metal surfaces. The present invention also includes the method of using the coated device and methods to make the coated device and coating.

公开(公告)号：US11453191B2

公开(公告)日：2022-09-27

申请号：US16656141

申请日：2019-10-17

申请人： CAREFUSION 303, INC.

发明人： Fanqing Meng ,  Marc Weimer

IPC分类号： B32B1/08 ,  F16L11/10 ,  A61L29/06 ,  A61L29/08 ,  A61L29/12 ,  A61L29/14 ,  B32B7/022 ,  B32B27/08 ,  B32B27/18 ,  B32B27/20 ,  B32B27/22 ,  B32B27/30 ,  A61M5/14 ,  A61M25/00

摘要： Tubing, such as medical tubing for administration of intravenous fluid, can include an outer layer on an inner layer, and, optionally additional layers, in which at least the outer layer and the inner layer are made of a same polymeric material but the outer and inner layers have differing amounts or differing types of a plasticizer such that a hardness of the outer layer is greater than a hardness of the inner layer.

公开(公告)号：US20220288376A1

公开(公告)日：2022-09-15

申请号：US17832277

申请日：2022-06-03

申请人： ICU Medical, Inc.

发明人： Robert J. Ziebol ,  Keith J. Modert ,  Matthew Case Ziebol

IPC分类号： A61M39/20 ,  A61M25/00 ,  A61L29/08 ,  A61L29/16 ,  A61B50/30 ,  A61L2/18 ,  A61L31/16

摘要： Systems, methods, and articles for providing an antimicrobial composition to the proximal elements of a trans-dermal catheter and into the lumen of the transdermal catheter are disclosed. In an embodiment, an antimicrobial composition on surface a cap element transfers antimicrobial to the proximal end of the transdermal catheter. The system comprises an elongate member configured for insertion into a lumen of a catheter, the elongate member containing an antimicrobial.