公开(公告)号：US12016979B2

公开(公告)日：2024-06-25

申请号：US16567072

申请日：2019-09-11

申请人： TERUMO KABUSHIKI KAISHA

发明人： Takao Anzai ,  Takayuki Kido

IPC分类号： A61L33/06 ,  B01D63/02 ,  B01D67/00

CPC分类号： A61L33/06 ,  B01D63/02 ,  A61L2300/42 ,  A61L2420/02 ,  B01D67/00

摘要： A method is disclosed for producing an artificial lung including a plurality of porous hollow fiber membranes for gas exchange which have an outer surface, an inner surface forming a lumen, and an opening portion communicating the outer surface with the inner surface. The method includes bringing any of the outer surface and the inner surface into contact with a colloidal solution that contains an antithrombotic high-molecular compound to circulate carbon dioxide gas to a side of the other surface. According to the present disclosure, an artificial lung can be produced in which a coating amount of antithrombotic high-polymer material (an antithrombotic high-molecular compound) on a hollow fiber membrane is increased.

公开(公告)号：US11986573B2

公开(公告)日：2024-05-21

申请号：US17245150

申请日：2021-04-30

申请人： Toray Industries, Inc.

发明人： Rumiko Kitagawa ,  Masataka Nakamura

IPC分类号： A61L27/50 ,  A61K9/70 ,  A61L15/00 ,  A61L27/00 ,  A61L27/36 ,  A61L31/04 ,  A61L33/06 ,  B05D7/24 ,  B32B27/30

CPC分类号： A61L27/50 ,  A61K9/70 ,  A61L15/00 ,  A61L27/00 ,  A61L27/3683 ,  A61L31/04 ,  A61L33/06 ,  B05D7/24 ,  B32B27/30

摘要： A device includes a substrate and a hydrophilic polymer layer made of a hydrophilic polymer having a hydroxyl group. The hydrophilic polymer layer having a hydroxyl group is fixed to at least a part of a surface of the substrate and the hydrophilic polymer further has an amide group. A liquid film retention time of the device is 15 seconds or more. The device has a surface of a substrate which is hydrophilized. A method for producing the device by a simple method is also disclosed.

公开(公告)号：US11975125B2

公开(公告)日：2024-05-07

申请号：US18114088

申请日：2023-02-24

申请人： MicroVention, Inc.

发明人： Aaron Baldwin ,  Xinping Wu ,  Bryan Fiamengo ,  Garrett Ulrich ,  John Belletto

IPC分类号： A61L33/06 ,  A61L31/02 ,  A61L31/10 ,  B05D3/14 ,  B05D7/16

CPC分类号： A61L33/062 ,  A61L31/022 ,  A61L31/10 ,  B05D3/142 ,  B05D7/16 ,  A61L2420/02

摘要： Described are medical devices including expandable tubular bodies configured to be implanted into a lumen, wherein the outer surface of the expandable tubular bodies are coupled to a polymer(s).

公开(公告)号：US20240115776A1

公开(公告)日：2024-04-11

申请号：US18551653

申请日：2022-03-29

申请人： TOYOBO CO., LTD.

发明人： Yuta Kawakatsu ,  Shohei Nakayama

IPC分类号： A61L33/06

CPC分类号： A61L33/064 ,  A61L2300/42

摘要： An object of the present invention is to provide a surface treatment agent that is excellent in antithrombogenicity and biocompatibility and has higher hydrophilicity compared to conventional medical materials. The present invention is an antithrombogenic material containing a (meth)acrylate copolymer consisting of a hydrophobic (meth)acrylate and a hydrophilic (meth)acrylate, in which the hydrophobic (meth)acrylate is a silicone (meth)acrylate and/or an alkyl (meth)acrylate, the (meth)acrylate copolymer having a residual monomer content of 4,000 ppm or less, a reduced viscosity (ηsp/c) of 0.18 dl/g or more and 3.00 dl/g or less, and being water-insoluble, and being a viscous liquid at room temperature.

公开(公告)号：US11850335B2

公开(公告)日：2023-12-26

申请号：US17335130

申请日：2021-06-01

申请人： Medtronic ATS Medical, Inc.

发明人： Brian Pederson

IPC分类号： A61L33/00 ,  A61L33/12 ,  A61N1/05 ,  A61L33/06 ,  A61N1/375

CPC分类号： A61L33/0094 ,  A61L33/0041 ,  A61L33/062 ,  A61L33/126 ,  A61L33/128 ,  A61N1/05 ,  A61L2300/42 ,  A61N1/375 ,  A61N1/37512 ,  Y10T428/31768

摘要： A method for passivating a biomaterial surface includes modifying proteinaceous material disposed at the biomaterial surface. The passivation may be effectuated by exposing the biomaterial surface to therapeutic electrical energy in the presence of blood or plasma.

公开(公告)号：US20230303743A1

公开(公告)日：2023-09-28

申请号：US18023296

申请日：2021-08-31

申请人： MicroVention, Inc.

发明人： Gregory M. Cruise ,  Xinping Wu

IPC分类号： C08F220/28 ,  C08L33/14 ,  A61L33/06

CPC分类号： C08F220/285 ,  C08F220/281 ,  C08L33/14 ,  A61L33/064 ,  A61L2420/02

摘要： Described herein are polymeric coatings, methods of preparing the polymeric coatings, methods of using the polymeric coatings, and substrates including one or more surfaces coated with the polymeric coatings.

公开(公告)号：US20230100493A1

公开(公告)日：2023-03-30

申请号：US17758586

申请日：2021-01-13

申请人： DKS Co. Ltd.

发明人： Takuma NISHIMURA ,  Masahito NISHIURA

IPC分类号： C08G18/83 ,  C09D175/04 ,  A61L33/06 ,  C08J7/12

摘要： Provided is a technology for exhibiting good ant ithrombogenicity.
A polyurethane or polyurethane urea has a graft chain having a specific structure. Two functional groups included in the specific structure are each an alkyl group having 1 to 20 carbon atoms, an aryl group having 6 to 12 carbon atoms, or an aralkyl group having 7 to 20 carbon atoms and may be the same or different from each other.

公开(公告)号：US20230036800A1

公开(公告)日：2023-02-02

申请号：US17818585

申请日：2022-08-09

申请人： Covidien LP

发明人： Xiaodong Ma ,  Min-Shyan Sheu ,  Lincoln Eramo ,  John Wainwright ,  Junwei Li

IPC分类号： A61F2/82 ,  A61L31/02 ,  A61L31/16 ,  A61F2/90 ,  A61L31/10 ,  A61F2/06 ,  A61L31/14 ,  A61L33/00 ,  A61L33/06

摘要： Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

公开(公告)号：US11369497B2

公开(公告)日：2022-06-28

申请号：US16586639

申请日：2019-09-27

申请人： Covidien LP

发明人： Xiaodong Ma ,  Min-Shyan Sheu ,  Lincoln Eramo ,  John Wainwright ,  Junwei Li

IPC分类号： A61M60/165 ,  A61F2/82 ,  A61L31/02 ,  A61L31/16 ,  A61F2/90 ,  A61L31/10 ,  A61F2/06 ,  A61L31/14 ,  A61L33/00 ,  A61L33/06 ,  B05D1/18 ,  B05D3/14

摘要： Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

公开(公告)号：US20220168471A1

公开(公告)日：2022-06-02

申请号：US17245150

申请日：2021-04-30

申请人： Toray Industries, Inc.

发明人： Rumiko Kitagawa ,  Masataka Nakamura

IPC分类号： A61L27/50 ,  A61L31/04 ,  A61L33/06 ,  A61K9/70 ,  A61L15/00 ,  B05D7/24 ,  B32B27/30 ,  A61L27/00 ,  A61L27/36

摘要： A device includes a substrate and a hydrophilic polymer layer made of a hydrophilic polymer having a hydroxyl group. The hydrophilic polymer layer having a hydroxyl group is fixed to at least a part of a surface of the substrate and the hydrophilic polymer further has an amide group. A liquid film retention time of the device is 15 seconds or more. The device has a surface of a substrate which is hydrophilized. A method for producing the device by a simple method is also disclosed.