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38 条记录 (耗时 0.017 秒)

    Methods for concomitant administration of colchicine and a second active agent
    1.
    发明授权
    Methods for concomitant administration of colchicine and a second active agent 有权
    秋水仙素和第二活性剂的同时施用方法

    公开(公告)号：US07820681B1

    公开(公告)日：2010-10-26

    申请号：US12372046

    申请日：2009-02-17

    申请人： Matthew W. Davis

    发明人： Matthew W. Davis

    IPC分类号： A61K31/167 ,  C07C233/23 ,  C07C211/41

    CPC分类号： A61K31/165 ,  A61K31/496 ,  G06F19/00 ,  G06Q50/22 ,  A61K2300/00

    摘要： Methods for concomitant administration of colchicine together with one or more second active agents, e.g., ketoconazole and ritonavir, are disclosed. Such methods reduce the dangers commonly associated with such concomitant administration and provide additional benefits. Methods of notifying health care practitioners and patients regarding appropriate dosing for concomitant administration of colchicine together with second active agents are also provided.

    摘要翻译： 公开了将秋水仙碱与一种或多种第二活性剂（例如酮康唑和利托那韦）一起施用的方法。 这样的方法减少了通常与这种伴随管理相关联的危险并提供额外的益处。 还提供了通知卫生保健从业者和患者关于适当给药的方法，以及与第二活性剂一起施用秋水仙素。

    Methods for concomitant administration of colchicine and macrolide antibiotics in the treatment of gout flares
    6.
    发明授权
    Methods for concomitant administration of colchicine and macrolide antibiotics in the treatment of gout flares 有权
    秋水仙素和大环内酯类抗生素同时服用治疗痛风的方法

    公开(公告)号：US07601758B1

    公开(公告)日：2009-10-13

    申请号：US12368700

    申请日：2009-02-10

    申请人： Matthew W. Davis

    发明人： Matthew W. Davis

    IPC分类号： A61K31/167 ,  C07C233/23 ,  C07C211/41

    CPC分类号： A61K31/167 ,  A61K31/7048 ,  A61K2300/00

    摘要： Methods for treating gout flares comprising concomitant administration of colchicine together with one or more macrolide antibiotics, e.g., clarithromycin or erythromycin, are disclosed. Such methods reduce the dangers commonly associated with such concomitant administration and provide additional benefits. Methods of notifying health care practitioners and patients regarding appropriate dosing for co-administration of colchicine together with macrolide antibiotics are also provided.

    摘要翻译： 公开了用于治疗痛风火花的方法，其包括将秋水仙碱与一种或多种大环内酯类抗生素（例如克拉霉素或红霉素）一起施用。 这样的方法减少了通常与这种伴随管理相关联的危险并提供额外的益处。 还提供了通知卫生保健从业者和患者关于合适施用秋水仙素与大环内酯类抗生素共同给药的方法。

    Cyclopent [a] indene compounds
    9.
    发明授权
    Cyclopent [a] indene compounds 失效
    Cyclopent {8 a {9 {0茚化合物

    公开(公告)号：US3952050A

    公开(公告)日：1976-04-20

    申请号：US347477

    申请日：1973-04-03

    申请人： Barry John Price

    发明人： Barry John Price

    IPC分类号： C07C215/08 ,  C07C49/683 ,  C07C67/00 ,  C07C209/00 ,  C07C209/02 ,  C07C209/16 ,  C07C209/26 ,  C07C209/40 ,  C07C209/66 ,  C07C211/41 ,  C07C211/42 ,  C07C213/00 ,  C07C225/16 ,  C07C231/00 ,  C07C231/12 ,  C07D295/02 ,  C07D295/033 ,  C07C87/40

    CPC分类号： C07D295/033 ,  C07C49/683

    摘要： Indane derivatives of general formula (I): ##SPC1##in which:R.sub.1 and R.sub.2 represent a hydrogen atom, a lower alkyl group, preferably containing 1 to 6 and particularly 1 to 4 carbon atoms, or an arylalkyl group, or together form a cycloalkyl ring containing 3-6 carbon atoms; R.sub.3 is a hydrogen atom or a lower alkyl preferably containing 1 to 6 and particularly 1 to 4 carbon atoms; R.sub.4 represents the group --NR.sub.5 R.sub.6 in which R.sub.5 and R.sub.6 may be the same or different and each represent a hydrogen atom, a carbamoyl group or a lower alkyl radical preferably containing 1 to 6 and particularly 1 to 4 carbon atoms which may optionally be substituted by amino, alkylamino, dialkylamino, hydroxy, aryl or aroyl groups which aroyl groups may be substituted; or in which R.sub.5 and R.sub.6 may be joined to form a ring optionally containing other hetero atoms; and non-toxic pharmaceutically acceptable salts and esters thereof. The compounds have marked analgetic activity and are devoid of respiratory depressant action.

    摘要翻译： 通式（I）的茚满衍生物：