公开(公告)号：US20240335384A1

公开(公告)日：2024-10-10

申请号：US18700022

申请日：2022-10-13

申请人： XIAMEN SINOPEG BIOTECH CO., LTD.

发明人： Sheng LIN ,  Minggui LIN ,  Ailan WANG ,  Linlin WANG ,  Wengui WENG ,  Chao LIU ,  Jinchun YUAN ,  Qian LIN

IPC分类号： A61K9/127 ,  A61K45/00 ,  A61K47/18 ,  C07C217/08 ,  C07C219/06 ,  C07C229/10 ,  C07C229/26 ,  C07C235/10

CPC分类号： A61K9/1272 ,  A61K45/00 ,  A61K47/18 ,  C07C217/08 ,  C07C219/06 ,  C07C229/10 ,  C07C229/26 ,  C07C235/10

摘要： A novel cationic lipid having a structure as represented by general formula (1), which specifically relates to a nitrogen-containing cationic lipid, and also relates to a liposome containing the cationic lipid, a liposome pharmaceutical composition containing said cationic lipid, preparation and application thereof. A cationic liposome containing the cationic lipid represented by formula (1), can improve the loading rate and transport rate of drugs, particularly nucleic acid drugs. The terminus of the novel cationic lipid can contain a fluorescent group or a targeting group, so that the cationic liposome pharmaceutical composition containing the cationic lipid can have fluorescent or targeting function. A formulation of cationic liposome pharmaceutical composition containing nucleic acid exhibiting a very good gene complexing ability and high gene transfection ability, thereby further improves the gene therapeutic and/or gene diagnostic effect of the drug, and provides more selectable cationic lipids in the field of drug delivery.

公开(公告)号：US20220204439A1

公开(公告)日：2022-06-30

申请号：US17496530

申请日：2021-10-07

申请人： Acuitas Therapeutics, Inc.

发明人： Xinyao Du ,  Steven M. Ansell

IPC分类号： C07C233/36 ,  C07D295/13 ,  C07C211/09 ,  C07C235/10 ,  A61K9/51 ,  A61K31/713 ,  A61K9/14 ,  A61K31/7105 ,  A61K47/18 ,  A61K47/24 ,  C07C233/38 ,  C07D207/09 ,  C12N15/113

摘要： Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, G1, G2, G3, a, b, c and d are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

公开(公告)号：US20210380527A1

公开(公告)日：2021-12-09

申请号：US17288100

申请日：2019-10-18

申请人： Arkema France

发明人： Carine FOUILLIART ,  Virginie DUCASTEL ,  Vincent LEROY ,  Dmitri COLESNIC

IPC分类号： C07C235/10 ,  C09D7/43

摘要： The present invention relates to a rheology additive, according to which A) said additive consists of: a) at least one symmetrical fatty diamide of formula (I): (AGH)—CONH—(PMDA)-NHCO-(AGH) (I) with: (AGH): hydroxylated fatty acid residue R1CO2H, without —CO2H group, with R1 of C18 to C20 comprising a hydroxyl group, —NHCO— or —CONH—: amide group, —(PMDA): residue without amine groups of 1,5-pentamethylenediamine; or alternatively according to which: B) said additive comprises: a) at least one symmetrical fatty diamide as defined above according to formula (I) and, in addition, b) at least one other symmetrical fatty diamide of formula (II): (AGH)—CONH—(R)—NHCO-(AGH) (II) with (AGH), —NHCO— and —CONH— having the same definition as that above in said formula (I), and (R) being the residue without amine groups of a diamine, other than (PMDA), chosen from a cycloaliphatic, aliphatic or aromatic diamine.

公开(公告)号：US20210053908A1

公开(公告)日：2021-02-25

申请号：US16899376

申请日：2020-06-11

申请人： CORTEXYME, INC.

发明人： Andrei W. Konradi ,  Robert A. Galemmo, JR. ,  Stephen S. Dominy ,  Casey C. Lynch ,  Leslie J. Holsinger

IPC分类号： C07C233/62 ,  C07D213/82 ,  C07D239/34 ,  C07D239/36 ,  C07D413/12 ,  C07D257/04 ,  C07D261/12 ,  C07D213/70 ,  C07C317/28 ,  C07C233/78 ,  C07C235/10 ,  C07C235/50 ,  C07B59/00 ,  C07C237/42 ,  C07D401/12 ,  C07C381/00 ,  C07C323/42 ,  C07D213/65 ,  C07D213/68 ,  C07D239/38 ,  C07C247/18 ,  C07F5/02 ,  A61P31/04 ,  A61P25/00 ,  A61K31/165 ,  A61K31/167 ,  A61K31/41 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/505 ,  A61K31/513 ,  A61K31/655 ,  A61K45/06 ,  C07C245/08 ,  C07C247/16 ,  C07C323/40 ,  C07D213/81

摘要： The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.

公开(公告)号：US10759740B2

公开(公告)日：2020-09-01

申请号：US16086927

申请日：2017-03-24

申请人： Rutgers, The State University of New Jersey

发明人： Kathryn Uhrich ,  Yingyue Zhang ,  Allison Faig ,  Michael Chikindas

IPC分类号： C07C235/10 ,  A61K31/23 ,  A61K31/7036 ,  A61K31/4164 ,  A61K31/4168 ,  A61P31/04 ,  C07C235/06 ,  A61K45/06 ,  A61K31/164 ,  A61K31/7056

摘要： The invention provides an antibacterial compound of formula (I) or a salt thereof, as well as an antibacterial compound of formula (II) or a salt thereof, wherein R1, R2, W, X, Y and n have any of the values defined in the specification.

公开(公告)号：US10730826B2

公开(公告)日：2020-08-04

申请号：US16353786

申请日：2019-03-14

申请人： CORTEXYME, INC.

发明人： Andrei W. Konradi ,  Robert A. Galemmo, Jr. ,  Stephen S. Dominy ,  Casey C. Lynch ,  Leslie J. Holsinger

IPC分类号： C07C233/62 ,  C07D213/82 ,  C07D239/34 ,  C07D239/36 ,  C07D413/12 ,  C07D257/04 ,  C07D261/12 ,  C07D213/70 ,  C07C317/28 ,  C07C233/78 ,  C07C235/10 ,  C07C235/50 ,  C07B59/00 ,  C07C237/42 ,  C07D401/12 ,  C07C381/00 ,  C07C323/42 ,  C07D213/65 ,  C07D213/68 ,  C07D239/38 ,  C07C247/18 ,  C07F5/02 ,  A61P31/04 ,  A61P25/00 ,  A61K31/165 ,  A61K31/167 ,  A61K31/41 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/505 ,  A61K31/513 ,  A61K31/655 ,  A61K45/06 ,  C07C245/08 ,  C07C247/16 ,  C07C323/40 ,  C07D213/81

摘要： The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.

公开(公告)号：US20200017754A1

公开(公告)日：2020-01-16

申请号：US16507649

申请日：2019-07-10

申请人： Ecolab USA Inc.

发明人： Jeremy Moloney ,  Jeremy Wayne Bartels ,  Jeffrey M. Servesko

IPC分类号： C09K8/54 ,  C09K15/22 ,  C09K8/524 ,  C07C235/10 ,  C07C69/675 ,  C23F11/14

摘要： Disclosed are alkyl lactone-derived hydroxyamide and alkyl lactone-derived hydroxyester used in compositions and methods for inhibiting corrosion. The alkyl lactone-derived hydroxyamide and alkyl lactone-derived hydroxyester are reaction products of an alkyl lactone and an amine, and an alkyl lactone and an alcohol, respectively.

公开(公告)号：US10266485B2

公开(公告)日：2019-04-23

申请号：US16005286

申请日：2018-06-11

申请人： ModernaTX, Inc.

发明人： Kerry E. Benenato

IPC分类号： A61K48/00 ,  A61K9/127 ,  C07C229/12 ,  C07C271/20 ,  C07C279/12 ,  C07C279/28 ,  C07C279/32 ,  C07D233/72 ,  C07D249/04 ,  C07D263/20 ,  C07D265/33 ,  C07D271/06 ,  C07D271/10 ,  C07D207/27 ,  C07D277/38 ,  C07C275/14 ,  C07C279/24 ,  C07C311/05 ,  C07C229/16 ,  C07C335/08 ,  C07C233/36 ,  C07C235/10 ,  C07C255/24 ,  C07F9/09 ,  A61K9/16 ,  A61K38/18 ,  C07K14/505 ,  A61K9/00 ,  A61K47/54 ,  A61K47/69 ,  C07C227/16 ,  A61K9/51 ,  A61K31/7105 ,  A61K38/17 ,  C07C227/18

摘要： The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US20190112539A1

公开(公告)日：2019-04-18

申请号：US16223485

申请日：2018-12-18

申请人： The Lubrizol Corporation

发明人： James H. Bush ,  Robert H. Barbour ,  David J. Moreton ,  Hannah Greenfield ,  Paul R. Stevenson ,  David C. Arters

IPC分类号： C10L10/04 ,  C10L10/06 ,  C08G63/91 ,  C10L1/22 ,  C10L1/222 ,  C07D207/408 ,  C10L1/08 ,  C07D303/04 ,  C10L10/18 ,  C07C235/10 ,  C10L1/2387 ,  C10L1/2383 ,  C10L1/238 ,  C10L1/224

摘要： The composition of the present invention related to a quaternary ammonium salt detergent and the use of such quaternary ammonium salt detergents in a fuel composition to reduce diesel injector deposits and remove or clean up existing deposits on the diesel injectors.

公开(公告)号：US09212131B2

公开(公告)日：2015-12-15

申请号：US13379191

申请日：2010-06-21

申请人： Otto Phanstiel ,  Jennifer J. Archer

发明人： Otto Phanstiel ,  Jennifer J. Archer

IPC分类号： C07C233/78 ,  C07C237/46 ,  C07D295/13 ,  A61K31/137 ,  A61K31/166 ,  C07C211/27 ,  C07C231/02 ,  C07C235/10

CPC分类号： A61K31/166 ,  A61K31/137 ,  A61K31/192 ,  A61K31/197 ,  A61K45/06 ,  C07C211/27 ,  C07C231/02 ,  C07C233/78 ,  C07C235/10 ,  C07C237/46 ,  C07D295/13

摘要： Novel polyamine transport inhibitors have been synthesized and demonstrated to block the uptake of native polyamines into human cancer cells. A combination therapy of the transport inhibitor and DFMO (a drug which blocks polyamine biosynthesis) provided synergistic activity against a metastatic human colon cancer cell line. The strategy uses polyamine depletion and polyamine metabolism to generate reactive oxygen species within cells as a novel way to treat cancers. This approach may be implemented for widespread use in the treatment of diseases which rely upon polyamine transport activity for proliferation.

摘要翻译： 已经合成了新的多胺转运抑制剂并证明阻止天然多胺进入人类癌细胞的吸收。 运输抑制剂和DFMO（阻断多胺生物合成的药物）的组合疗法提供了对转移性人结肠癌细胞系的协同作用。 该策略使用多胺消耗和多胺代谢在细胞内产生活性氧作为治疗癌症的新方法。 这种方法可以实施用于广泛用于治疗依赖于多胺转运活性以增殖的疾病。