公开(公告)号：US20230364029A1

公开(公告)日：2023-11-16

申请号：US18218575

申请日：2023-07-05

申请人： PTC THERAPEUTICS, INC.

发明人： Paul MOLLARD ,  Peter GIANNOUSIS ,  Shazad SUCHIT ,  Mahmoud MIRMEHRABI ,  Christopher R. CORNELL ,  Kieron E. WESSON

IPC分类号： A61K31/122 ,  C07C215/30 ,  C07C215/08 ,  C07C235/78 ,  C07C215/28 ,  A61K31/164 ,  C07C231/12 ,  C07B57/00

CPC分类号： A61K31/122 ,  A61K31/164 ,  C07B57/00 ,  C07C215/08 ,  C07C215/28 ,  C07C215/30 ,  C07C231/12 ,  C07C235/78 ,  C07B2200/13 ,  C07C2601/16

摘要： Disclosed herein are polymorphic and amorphous forms of anhydrate, hydrate, and solvates of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide and methods of using such compositions for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging. Further disclosed are methods of making such polymorphic and amorphous forms.

公开(公告)号：US11608309B2

公开(公告)日：2023-03-21

申请号：US16885800

申请日：2020-05-28

申请人： Francis Johnson ,  Lorne Golub

发明人： Francis Johnson ,  Lorne Golub

IPC分类号： C07C69/738 ,  C07C49/255 ,  C07C225/22 ,  C07C235/78 ,  C07C237/20 ,  C07D213/50 ,  C07C235/80 ,  C12N9/64

摘要： This invention provides a compound having the structure wherein α, β, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NFκ-B activation in a population of cells.

公开(公告)号：US20220213080A1

公开(公告)日：2022-07-07

申请号：US17525116

申请日：2021-11-12

申请人： HUSCION CO., LTD.

发明人： Seong Soo JOO ,  Nareum HA ,  Jungmin YU ,  Youngsoo GYOUNG ,  Jonggab JUN ,  Heonse JEONG ,  Sukil JANG

IPC分类号： C07D413/12 ,  A61K9/00 ,  A61P37/06 ,  C07D211/86 ,  C07D295/185 ,  C07D207/38 ,  C07C235/88 ,  C07C235/78 ,  C07D211/76 ,  C07D405/06 ,  A23L33/00 ,  A23L33/10

摘要： Disclosed are a novel piperlongumine-based compound, an immuno regulator containing as an active ingredient the compound, or a pharmaceutically acceptable salt or solvate thereof, and a health functional food for immune regulation.

公开(公告)号：US11370739B2

公开(公告)日：2022-06-28

申请号：US16679154

申请日：2019-11-09

申请人： NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED

发明人： Lei Chen ,  Guodong Sun ,  Xiaodong Han ,  Shun Li ,  Jiebin Zeng ,  Zhongqing Wang ,  Zhonghua Luo

IPC分类号： C07C59/205 ,  C07C231/02 ,  C07C233/47 ,  C07C51/09 ,  C12P13/00 ,  C07C235/78 ,  C07C59/84 ,  C07C69/738 ,  C07C49/245 ,  C07C49/255 ,  C07D498/04 ,  C07C45/65 ,  C07C49/35 ,  C07C67/317 ,  C07C69/716 ,  C07C231/12 ,  C07C233/11 ,  C07F7/18

摘要： The present invention relates to a sacubitril intermediate and a preparation method thereof. The sacubitril intermediate disclosed herein can be prepared by a deprotection reaction of a compound. In addition, the intermediate can be used as a raw material to synthesize sacubitril.

公开(公告)号：US20220017462A1

公开(公告)日：2022-01-20

申请号：US17296088

申请日：2019-11-21

申请人： Wuxi Biologics Ireland Limited ,  Versitech Limited

发明人： Xuechen LI ,  Mingzhi JIN ,  Yue ZHANG ,  Li YIN ,  Jun WANG

IPC分类号： C07D207/452 ,  C07C235/78 ,  C07D241/04 ,  C07C233/61 ,  C07K1/113 ,  A61K47/68

摘要： Provided herein are novel ortho-Phthalaldehyde (OPA) containing linkers (OPA-L) and the use of OPA-L for the preparation of Antibody-drug conjugate (ADC) via the formation of Phthalimidine through the reaction of primary amine on antibody (e.g., residue of Lysine) and ortho-Phthalaldehyde. The advantage of this OPA-L is high reactivity and can be applied in different types of antibodies to form stably-linked conjugates. The use of OPA-L for the preparation of ADC is advantageous for mild and wide condition of conjugation, for instance, low percentage of organic solvent required, wide range of pH and temperature can be used.

公开(公告)号：US20210387950A1

公开(公告)日：2021-12-16

申请号：US17419448

申请日：2019-12-26

申请人： Jing ZHANG

发明人： Jing ZHANG

IPC分类号： C07D211/16 ,  C07C235/78 ,  C07D203/18

摘要： An acetylsalicylic acid derivative and an application thereof. The present disclosure relates to the field of chemical pharmaceuticals, and in particular, to a compound shown in formula (I) or pharmaceutically acceptable salts thereof.

公开(公告)号：US20210130301A1

公开(公告)日：2021-05-06

申请号：US17142586

申请日：2021-01-06

申请人： Vectus Biosystems Limited

发明人： Karen Annette DUGGAN

IPC分类号： C07D239/26 ,  A61P11/00 ,  C07C39/15 ,  C07C215/54 ,  C07C233/11 ,  C07D207/408 ,  C07D213/56 ,  C07D237/08 ,  C07D261/14 ,  C07D263/44 ,  C07D277/30 ,  C07D401/10 ,  C07D403/10 ,  C07D333/24 ,  C07C233/07 ,  C07D231/56 ,  C07D235/26 ,  C07D235/06 ,  C07C59/52 ,  C07C275/42 ,  C07D213/73 ,  C07D277/68 ,  A61P11/06 ,  C07D231/12 ,  C07C211/29 ,  C07D207/38 ,  C07C255/00 ,  C07C271/28 ,  C07C217/48 ,  C07C261/04 ,  C07D241/12 ,  C07D309/10 ,  C07D233/78 ,  C07D261/08 ,  C07D209/48 ,  C07C237/20 ,  C07D207/327 ,  C07C237/22 ,  C07D307/54 ,  C07D249/18 ,  C07D209/34 ,  C07D263/38 ,  C07C307/10 ,  C07D207/26 ,  C07D207/444 ,  C07C235/34 ,  C07C311/03 ,  C07C311/08 ,  C07C239/20 ,  C07C235/78 ,  C07D209/18 ,  C07D263/58 ,  C07D215/14 ,  C07D207/40

摘要： The present invention relates to compounds and their use in the prophylactic and/or therapeutic treatment of pulmonary fibrosis and/or related conditions.

公开(公告)号：US20210015765A1

公开(公告)日：2021-01-21

申请号：US16919044

申请日：2020-07-01

申请人： PTC Therapeutics, Inc.

发明人： Paul MOLLARD ,  Peter GIANNOUSIS ,  Shazad SUCHIT ,  Mahmoud MIRMEHRABI

IPC分类号： A61K31/122 ,  C07C235/78 ,  C07C215/28 ,  C07C215/30 ,  C07C231/12 ,  C07B57/00 ,  A61K31/164 ,  C07C215/08

摘要： Disclosed herein are polymorphic and amorphous forms of anhydrate, hydrate, and solvates of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide and methods of using such compositions for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging. Further disclosed are methods of making such polymorphic and amorphous forms.

公开(公告)号：US10751302B2

公开(公告)日：2020-08-25

申请号：US16354070

申请日：2019-03-14

申请人： PTC Therapeutics, Inc.

发明人： Paul Mollard ,  Peter Giannousis ,  Shazad Suchit ,  Mahmoud Mirmehrabi

IPC分类号： C07C235/78 ,  C07D215/28 ,  C07C215/30 ,  C07C231/12 ,  C07C215/08 ,  A61K31/122 ,  C07C215/28 ,  C07B57/00 ,  A61K31/164

摘要： Disclosed herein are polymorphic and amorphous forms of anhydrate, hydrate, and solvates of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide and methods of using such compositions for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging. Further disclosed are methods of making such polymorphic and amorphous forms.

公开(公告)号：US20200079721A1

公开(公告)日：2020-03-12

申请号：US16679154

申请日：2019-11-09

申请人： NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED

发明人： Lei CHEN ,  Guodong SUN ,  Xiaodong HAN ,  Shun LI ,  Jiebin ZENG ,  Zhongqing WANG ,  Zhonghua LUO

IPC分类号： C07C59/205 ,  C07F7/18 ,  C07C233/11 ,  C07C231/12 ,  C07C69/716 ,  C07C67/317 ,  C07C49/35 ,  C07C45/65 ,  C07C51/09 ,  C07C233/47 ,  C07C231/02 ,  C07D498/04 ,  C07C49/255 ,  C07C49/245 ,  C07C69/738 ,  C07C59/84 ,  C07C235/78 ,  C12P13/00

摘要： The present invention relates to a sacubitril intermediate and a preparation method thereof. The sacubitril intermediate disclosed herein can be prepared by a deprotection reaction of a compound. In addition, the intermediate can be used as a raw material to synthesize sacubitril.