公开(公告)号：US20240336583A1

公开(公告)日：2024-10-10

申请号：US18294262

申请日：2022-08-05

Applicant: SHUJING BIOPHARMA CO., LTD ,  JIANGSU NHWA PHARMACEUTICAL CO., LTD

Inventor： Jiaquan FENG ,  Yuanhai ZOU ,  Zehong WAN

IPC: C07D305/00 ,  A61K31/05 ,  A61K31/343 ,  A61K31/665 ,  C07C37/055 ,  C07C37/14 ,  C07C37/62 ,  C07C39/17 ,  C07F9/655

CPC classification number: C07D305/00 ,  A61K31/05 ,  A61K31/343 ,  A61K31/665 ,  C07C37/055 ,  C07C37/14 ,  C07C37/62 ,  C07C39/17 ,  C07F9/65517

Abstract: The present invention relates to a benzo-ring-containing derivative, and a preparation method therefor and the use thereof. Specifically, the present invention relates to a compound as represented by general formula (Ia), and a preparation method therefor, a pharmaceutical composition containing same, and the use thereof as a GABA receptor agonist in the field of the central nervous system, specifically in inducing and maintaining anesthesia of mammals.

公开(公告)号：US20240116883A1

公开(公告)日：2024-04-11

申请号：US18038317

申请日：2021-11-24

Applicant: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.

Inventor： Ruth GALLILY ,  Raphael MECHOULAM ,  Aviva BREUER ,  Natalya M KOGAN ,  Yarden LAVI ,  Zhanna YEKHTIN

IPC: C07D265/30 ,  A61P29/00 ,  C07C39/17 ,  C07C39/23 ,  C07C43/23

CPC classification number: C07D265/30 ,  A61P29/00 ,  C07C39/17 ,  C07C39/23 ,  C07C43/23 ,  C07C2601/16

Abstract: The invention provides cannabinoid derivatives, methods of their preparation, compositions comprising them and uses thereof in the treatment of inflammation and/or pain and/or obesity.

公开(公告)号：US11530230B2

公开(公告)日：2022-12-20

申请号：US16770956

申请日：2017-12-14

Applicant: ZHEJIANG UNIVERSITY

Inventor： Xufeng Lin ,  Linxi Yao ,  Shirui Chang ,  Lei Wang

IPC: C07F9/50 ,  B01J31/24 ,  C07C17/06 ,  C07C23/18 ,  C07C25/22 ,  C07C37/62 ,  C07C39/17 ,  C07C39/42 ,  C07C41/09 ,  C07C43/247 ,  C07F15/00

Abstract: The present application discloses a 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-based phosphine ligand, an intermediate, a preparation method and uses thereof. The compound of phosphine ligand is a compound having a structure represented by formula I or formula II, or an enantiomer, a raceme, or diastereomer thereof. The phosphine ligand can be prepared via a preparation scheme in which the cheap and easily available 6,6′-dihydroxyl-3,3,3′,3′-tetramethyl-1,1′-spirobiindane is used as a raw material and the compound represented by formula III serves as the key intermediate. The new phosphine ligand developed by the present application can be used in catalytic organic reaction, in particular as a chiral phosphine ligand that is widely used in many asymmetric catalytic reactions including asymmetric hydrogenation and asymmetric allyl alkylation, and thus it has economic practicability and industrial application prospect.

公开(公告)号：US11318148B2

公开(公告)日：2022-05-03

申请号：US16828145

申请日：2020-03-24

Applicant: SteadyMed, Ltd.

Inventor： Jonathan Rigby ,  Peter Noymer ,  Robert Zwolinski

IPC: A61K31/5575 ,  A61K9/00 ,  A61M5/142 ,  C07C39/17 ,  C07C59/72 ,  C07C405/00

Abstract: Embodiments include a system including a sealed prefilled drug-reservoir. The drug-reservoir may include a unit dosage of treprostinil in a sterile fluid composition. The composition may not include an antimicrobial preservative. The treprostinil may be present at a dosage of between 0.1 mg/mL and 25 mg/mL. In addition, the treprostinil may be treprostinil sodium Furthermore, the composition may include sodium chloride. The composition may also include a sodium ion from sodium chloride in a concentration from 3000 to 4500 ppm. The composition may not include metacresol.

公开(公告)号：US11168047B2

公开(公告)日：2021-11-09

申请号：US16636888

申请日：2018-08-06

Applicant: ENANTIA, S.L.

Inventor： Alexander Christian Comely ,  Nicolas Tesson ,  Carmen Jiménez González

IPC: C07C39/17 ,  C07C37/84 ,  C07C229/12 ,  C07C229/22 ,  C07D209/42

Abstract: The present invention relates to cocrystals of 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol and a zwitterion coformer, processes for their preparation, and their use as a medicament and for the purification of 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol. The invention also relates to compositions comprising the cocrystal.

公开(公告)号：US20210163514A1

公开(公告)日：2021-06-03

申请号：US16770956

申请日：2017-12-14

Applicant: ZHEJIANG UNIVERSITY

Inventor： Xufeng LIN ,  Linxi YAO ,  Shirui CHANG ,  Lei WANG

IPC: C07F9/50 ,  C07C39/17 ,  C07C17/06 ,  C07C23/18 ,  C07C37/62 ,  C07C39/42 ,  C07C43/247 ,  C07C41/09 ,  C07C25/22 ,  C07F15/00 ,  B01J31/24

Abstract: The present application discloses a 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-based phosphine ligand, an intermediate, a preparation method and uses thereof. The compound of phosphine ligand is a compound having a structure represented by formula I or formula II, or an enantiomer, a raceme, or diastereomer thereof. The phosphine ligand can be prepared via a preparation scheme in which the cheap and easily available 6,6′-dihydroxyl-3,3,3′,3′-tetramethyl-1,1′-spirobiindane is used as a raw material and the compound represented by formula III serves as the key intermediate. The new phosphine ligand developed by the present application can be used in catalytic organic reaction, in particular as a chiral phosphine ligand that is widely used in many asymmetric catalytic reactions including asymmetric hydrogenation and asymmetric allyl alkylation, and thus it has economic practicability and industrial application prospect.

公开(公告)号：US10995182B2

公开(公告)日：2021-05-04

申请号：US16377935

申请日：2019-04-08

Applicant: SABIC GLOBAL TECHNOLOGIES B.V.

Inventor： Eylem Tarkin-Tas ,  Huseyin Tas

IPC: C08G81/02 ,  C07C39/17 ,  C08G65/40

Abstract: A phenylene ether oligomer has repeating units of the structure and less than 30 weight percent of repeating units derived from a monohydric phenol having identical substituents in the 2- and 6-positions, wherein the phenylene ether oligomer includes a vinyl benzene ether end group, an amine end group, maleimide end group, a norbornene end group, an anhydride end group, or a combination comprising at least one of the foregoing. The phenylene ether oligomer can be used to provide a curable composition. The curable composition can be cured to provide a thermoset composition. Articles comprising the thermoset composition are also described.

公开(公告)号：US10946306B1

公开(公告)日：2021-03-16

申请号：US16697733

申请日：2019-11-27

Applicant: World Class Extractions Inc.

Inventor： Shane Lander ,  Tamas Jozsa

IPC: B01D11/02 ,  C07D311/80 ,  C07C39/17

Abstract: Solvent-based methods for the extraction and concentration of cannabinoids and other target compounds from large-scale harvests of cannabis and hemp crops. Select portions of cannabis or hemp plants are harvested, ground to a desired particle size and ultimately powderized where the powder is mixed with a solvent, preferably ethanol or water, to form a slurry that is subjected to at least two, and preferably five or more separate inverting filter centrifugation steps until cannabinoid extraction is maximized. The filtrate from the first inverting centrifugation step is isolated and purified to derive an extract whereas the powderized filtride is subjected to further centrifugation steps. Fresh solvent is introduced at the last inverting centrifugation step and subsequently used upstream in sequentially-earlier centrifugation steps until ultimately utilized in a first inverting filter centrifugation step.

公开(公告)号：US10858591B2

公开(公告)日：2020-12-08

申请号：US15585312

申请日：2017-05-03

Applicant: Shijiazhuang Chengzhi Yonghua Display Materials Co., Ltd

Inventor： Gang Wen ,  Jingsong Meng ,  Hongyong Shang ,  Limei Zhang ,  Guoliang Yun ,  Xing Zhang

IPC: C09K19/54 ,  C09K19/20 ,  C09K19/30 ,  C09K19/34 ,  C09K19/12 ,  G02F1/137 ,  C09K19/04 ,  G02F1/1368 ,  C07C39/17 ,  C07C43/23 ,  C07C43/253 ,  C07D309/06 ,  C07D319/06

Abstract: A stabilizer represented by formula I, wherein M represents cyclopentyl, cyclobutyl or cyclopropyl; Z1 and Z2 each independently represent a single bond, —CH2—, —CH2CH2—, —O—, —CH2O—, —OCH2— or —COO—; represents one or two of and n represents 0, 1 or 2.

公开(公告)号：US20200331828A1

公开(公告)日：2020-10-22

申请号：US16919466

申请日：2020-07-02

Applicant: The Board of Trustees of the University of Illinois ,  Board of Regents of the University of Texas System

Inventor： John A. Katzenellenbogen ,  Benita Katzenellenbogen ,  Sung Hoon Kim ,  Zeynep Madak-Erdogan ,  Philip Shaul

IPC: C07C39/17 ,  C07C255/47 ,  C07C39/42 ,  C07C235/34 ,  C07C49/755 ,  C07C43/196 ,  C07C49/733 ,  C07C39/12 ,  C07C39/14 ,  C07C57/38 ,  C07C39/367 ,  C07C39/23 ,  A61P25/00 ,  A61P35/00 ,  C07C39/06

Abstract: Provided are compounds of formulae provided herein. The compounds may include pathway-preferential estrogens (PaPEs) derivatives with tissue-selective activities. Also provided are pharmaceutical compositions comprising the compounds, as well as methods of treating a disease or condition including administering the compounds. The disease or condition may include postmenopausal symptoms, cardiovascular disease, stroke, vascular disease, bone disease, metabolic disease, arthritis, osteoporosis, obesity, vasomotor/hot flush, cognitive decline, cancer including breast cancer.