公开(公告)号：US12049448B2

公开(公告)日：2024-07-30

申请号：US17871065

申请日：2022-07-22

申请人： PRAXIS PRECISION MEDICINES, INC.

发明人： Kiran Reddy ,  Margaret S. Lee ,  Gabriel Maurice Belfort ,  Sapna Makhija Garad ,  Mahesh Padval ,  Randall Wagner ,  Marion Wittmann

IPC分类号： C07D211/34 ,  A61K9/00 ,  A61K9/20 ,  A61K9/48 ,  A61K31/445 ,  A61K47/38 ,  A61P25/14 ,  C07D211/26

CPC分类号： C07D211/34 ,  A61K9/0053 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/4825 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/445 ,  A61K47/38 ,  A61P25/14 ,  C07D211/26 ,  C07B2200/13

摘要： Described herein, in part, are dosage forms and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a T-type calcium channel, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or a genetic epilepsy), tremor (e.g., essential tremor), and psychiatric disorder (e.g., mood disorders (e.g., major depressive disorder)). The present invention further comprises methods for modulating the function of a T-type calcium channel.

公开(公告)号：US20240182412A1

公开(公告)日：2024-06-06

申请号：US18335836

申请日：2023-06-15

申请人： ReNAgade Therapeutics Management Inc.

发明人： Muthusamy Jayaraman ,  Stephen Scully

IPC分类号： C07D207/08 ,  C07D211/34 ,  C07D401/06

CPC分类号： C07D207/08 ,  C07D211/34 ,  C07D401/06

摘要： The present disclosure details various lipids, compositions, and/or methods of optimized systems and delivery vehicles for the delivery of nucleic acid sequences, polypeptides or peptides for use in vaccinating against infectious agents.

公开(公告)号：US20230416202A1

公开(公告)日：2023-12-28

申请号：US18037935

申请日：2021-11-19

申请人： Telo Therapeutics, Inc.

发明人： Katherine Widdowson ,  Robert Joseph Allen Bell ,  Santosh Kulkarni ,  Adrian Hall ,  Mark Patrick Healy ,  David George Hubert Livermore ,  James William Myatt ,  Mairi Simie

IPC分类号： C07D211/34 ,  A61P35/00 ,  A61K47/20

CPC分类号： C07D211/34 ,  A61P35/00 ,  A61K47/20

摘要： Provided herein are compounds and compositions that inhibit telomerase and/or the TERT gene with a mutant promoter. Further provided are small molecule compounds or compositions having beneficial effects in cancer treatment. Methods of making the compounds and compositions and methods of using the compounds and compositions, such as using the compounds and compositions to treat cancer, are also provided.

公开(公告)号：US20230250077A1

公开(公告)日：2023-08-10

申请号：US18004532

申请日：2021-07-09

申请人： Jiangsu Hengrui Pharmaceuticals Co., Ltd. ,  Shanghai Hengrui Pharmaceutical Co., Ltd.

发明人： Jianyan XU ,  Jianhong GAO ,  Ying ZHANG ,  Feng HE ,  Weikang TAO

IPC分类号： C07D401/12 ,  A61P35/00 ,  C07D211/34 ,  C07D401/14

CPC分类号： C07D401/12 ,  A61P35/00 ,  C07D211/34 ,  C07D401/14

摘要： Provided are a sulfonylbenzamide derivative and a conjugate thereof, a preparation method therefor, and the use thereof. In particular, provided is a sulfonylbenzamide derivative having a structure as represented by formula (D), a conjugate thereof, a preparation method therefor, a pharmaceutical composition containing same, and the use thereof in the preparation of a drug for treating cancers by means of receptor regulation. Each substituent in general formula (D) is as defined in the description.

公开(公告)号：US20230202977A1

公开(公告)日：2023-06-29

申请号：US17972399

申请日：2022-10-24

申请人： Renagade Therapeutics Management Inc.

发明人： Muthusamy Jayaraman ,  Stephen Scully

IPC分类号： C07D207/08 ,  C07D211/34 ,  C07D401/06

CPC分类号： C07D207/08 ,  C07D211/34 ,  C07D401/06

摘要： The present disclosure details various lipids, compositions, and/or methods of optimized systems and delivery vehicles for the delivery of nucleic acid sequences, polypeptides or peptides for use in vaccinating against infectious agents.

公开(公告)号：US11633390B2

公开(公告)日：2023-04-25

申请号：US17349255

申请日：2021-06-16

申请人： Lophora ApS

发明人： Jesper Langgaard Kristensen ,  Anders Asbjørn Jensen ,  Emil Märcher-Rørsted ,  Sebastian Leth-Petersen

IPC分类号： A61K31/452 ,  A61P25/24 ,  A61K31/397 ,  A61K31/40 ,  A61K31/451 ,  C07D205/04 ,  C07D207/08 ,  C07D211/22 ,  C07D211/34

摘要： The present invention relates to agonists of the 5-HT2A serotonin receptors and their medical uses. In one aspect the invention relates to 5-HT2A agonists of formula (I). In second aspect, the invention relates to selective 5-HT2A agonists of formula (II). In another aspect, the invention relates to mixed 5-HT2A/5-HT2C agonists of formula (III). In yet another aspect, the invention relates to 5-HT2A agonists for use in the treatment of a depressive disorder, more particular a 5-HT2A agonist for the use in the treatment of treatment-resistant depression.

公开(公告)号：US20230096766A1

公开(公告)日：2023-03-30

申请号：US17312296

申请日：2019-12-12

申请人： Chugai Seiyaku Kabushiki Kaisha

发明人： Terushige MURAOKA ,  Shota TANAKA

IPC分类号： C07C229/22 ,  C07C229/36 ,  C07C311/51 ,  C07C311/02 ,  C07C237/30 ,  C07C237/20 ,  C07K11/02 ,  C07K7/56 ,  C40B40/10 ,  C40B40/08 ,  C07D413/12 ,  C07D211/34 ,  C07D309/10 ,  C07D265/30 ,  C07D207/10 ,  C07D271/07 ,  C07D277/30 ,  C07D213/55

摘要： It has been found that the membrane permeability of peptide compounds can be improved by making at least one of amino acids constituting the peptide compound be an amino acid having a side chain capable of forming an intramolecular hydrogen bond.

公开(公告)号：US20230094175A1

公开(公告)日：2023-03-30

申请号：US17837129

申请日：2022-06-10

申请人： Nocion Therapeutics, Inc.

发明人： Bridget McCarthy Cole ,  James Lamond Ellis

IPC分类号： C07D211/34 ,  C07C237/04 ,  C07D207/09 ,  C07D223/04 ,  C07D225/02 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06

摘要： The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

公开(公告)号：US11603355B2

公开(公告)日：2023-03-14

申请号：US17095949

申请日：2020-11-12

申请人： Nocion Therapeutics, Inc.

发明人： Bridget McCarthy Cole ,  James Lamond Ellis

IPC分类号： A61K31/55 ,  A61K31/4425 ,  A61K31/452 ,  C07D207/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  C07D225/02 ,  C07D223/04 ,  C07D211/00 ,  C07D211/34 ,  C07C237/04 ,  C07D207/09 ,  A61K45/06

摘要： The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

公开(公告)号：US20220411442A1

公开(公告)日：2022-12-29

申请号：US16885604

申请日：2020-05-28

申请人： XIAODONG WANG ,  Hua Zhong

发明人： XIAODONG WANG ,  Hua Zhong

IPC分类号： C07F5/02 ,  C07D401/04 ,  C07D205/04 ,  C07D409/04 ,  C07D211/14 ,  C07D417/04 ,  C07D413/04 ,  C07D401/14 ,  C07D207/09 ,  C07D211/34 ,  C07D405/04 ,  C07D417/06 ,  C07D223/04 ,  C07D401/12 ,  C07D223/06 ,  C07D417/10 ,  C07D409/14 ,  C07D409/06 ,  C07D417/14 ,  C07D405/14 ,  C07D451/02 ,  C07D473/00 ,  C07D471/08 ,  C07D513/04 ,  C07D475/00

摘要： The present invention provides a genus of polycyclic amines that are useful as opioid receptor modulators. The compounds of the invention are useful in both therapeutic and diagnostic methods, including for treating pain, neurological disorders, cardiac disorders, bowel disorders, drug and alcohol addiction, drug overdose, urinary disorders, respiratory disorders, sexual dysfunction, psoriasis, graft rejection or cancer.