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1.发明申请公开(公告)号：US20230099139A1
公开(公告)日：2023-03-30
申请号：US18059765
申请日：2022-11-29
IPC分类号： C07D243/08 , A61K9/127 , C07C229/30 , C07D211/14 , C07D233/02 , C07D241/04
摘要： The present embodiment provides a compound represented by the formula (1): Q-CHR2 (1) (Q is a nitrogen-containing aliphatic group containing two or more tertiary nitrogens but no oxygen, and R is an aliphatic group containing a biodegradable group). From the compound in combination with other lipids such as a lipid capable of reducing aggregation, lipid particles can be formed. Further, the compound can be used for a pharmaceutical composition to deliver an activator into cells.
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公开(公告)号：US20230096980A1
公开(公告)日：2023-03-30
申请号：US17816691
申请日：2022-08-01
申请人： Cowper Sciences Inc.
发明人： Robert KUIMELIS , Gaurav SAINI , David SMITH , Tommy ARMSBY
IPC分类号： C07D233/02 , G03F7/20 , C07C233/13 , C07C319/06 , C07C231/12 , C07F7/18 , G03F9/00
摘要： Provided herein are molecules and salts thereof, arrays containing molecules and salts thereof, solid supports containing molecules and salts thereof, kits containing molecules or salts thereof, and methods of determining alignment of photolithographic masks comprising molecules or salts thereof.
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3.发明授权公开(公告)号：US11584721B2
公开(公告)日：2023-02-21
申请号：US16630287
申请日：2018-07-03
发明人： Hendrik Van Dam , Karl Fredrik Lake , Eike Nicolas Kantzer , Antoon Jacob Berend Ten Kate , Rolf Krister Edvinsson , Michiel Jozef Thomas Raaijmakers , Rens Veneman , Ina Ehlers , Jenny Valborg Therese Adrian Meredith , Slavisa Jovic
IPC分类号： C07D233/02 , C07C209/70 , C07C209/16
摘要： A process for manufacturing a mixture of straight-chain higher ethyleneamines and non-straight-chain higher ethyleneamines selected from branched higher ethyleneamines and cyclic higher ethyleneamines, or the urea derivatives thereof, includes reacting an amine-functional compound with an ethanolamine-functional compound in the presence of a carbon oxide delivering agent, wherein a) an amine-functional compound comprises a combination of straight-chain amine-functional compound and non-straight-chain amine-functional compound and is reacted with straight-chain ethanolamine-functional compound, or b) a straight-chain amine-functional compound is reacted with ethanolamine-functional compound comprising a combination of straight-chain ethanolamine-functional compound and non-straight-chain ethanolamine-functional compound, or c) an amine-functional compound comprising a combination of straight-chain amine-functional compound and non-straight-chain amine-functional compound is reacted with ethanolamine-functional compound comprising a combination of straight-chain ethanolamine-functional compound and non-straight-chain ethanolamine-functional compound.
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公开(公告)号：US11548857B2
公开(公告)日：2023-01-10
申请号：US16812625
申请日：2020-03-09
IPC分类号： C07D243/08 , C07C229/30 , C07D233/02 , C07D241/04 , C07D211/14 , A61K9/127 , A61K31/7088
摘要： The present embodiment provides a compound represented by the formula (1): Q-CHR2 (1) (Q is a nitrogen-containing aliphatic group containing two or more tertiary nitrogens but no oxygen, and R is an aliphatic group containing a biodegradable group). From the compound in combination with other lipids such as a lipid capable of reducing aggregation, lipid particles can be formed. Further, the compound can be used for a pharmaceutical composition to deliver an activator into cells.
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公开(公告)号：US20220071935A1
公开(公告)日：2022-03-10
申请号：US17321928
申请日：2021-05-17
IPC分类号： A61K31/18 , C07D237/02 , C07D307/52 , C07D233/02 , C07D261/02 , C07D275/02 , C07D295/084 , C07D231/04 , C07D239/04 , C07C311/39 , C07D211/44 , C07D265/30 , C07D277/04 , C07D241/04 , C07D279/12 , C07D263/04 , A61K31/4355
摘要： The present invention provides bumetanide analogs and compositions comprising such analogs. The present invention also provides pharmaceutical compositions containing these bumetanide analogs and methods for their use. These analogs are believed useful for the treatment and/or prophylaxis of conditions that involve the Na+K+Cl− co-transporter or GABAA receptor.
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公开(公告)号：US20220023835A1
公开(公告)日：2022-01-27
申请号：US17244760
申请日：2021-04-29
发明人： Sai Reddy Pinappu , Jerry J. Weers
IPC分类号： B01J20/34 , C10G25/12 , C07D233/02 , B01D15/20
摘要： A regeneration solvent comprised of one or more ethylene amines may contact an adsorbent bed that has been used to remove sulfur compounds from a hydrocarbon stream to extract adsorbed sulfur compounds from the adsorbent material in the bed to regenerate it. The one or more ethyleneamines may have structure (I), (II), or (III): where R1, R2, R5 and R6 are, to the extent chemically possible, independently H, C1-C4 linear or branched alkyl, amido (RRNC═O), or hydroxyalkyl, where each R in the amido group is independently H or C1 alkyl, where R3 and R4 are alkylene of from 1 to 4 carbon atoms, where x ranges from 0 to 3, y ranges from 1 to 6. The regenerated adsorbent bed may be reused, either alone or in combination with a liquid-liquid extraction column, to remove sulfur compounds from a hydrocarbon stream.
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7.发明申请公开(公告)号：US20200270217A1
公开(公告)日：2020-08-27
申请号：US16812625
申请日：2020-03-09
IPC分类号： C07D243/08 , C07C229/30 , C07D233/02 , C07D241/04 , C07D211/14 , A61K9/127
摘要： The present embodiment provides a compound represented by the formula (1): Q-CHR2 (1) (Q is a nitrogen-containing aliphatic group containing two or more tertiary nitrogens but no oxygen, and R is an aliphatic group containing a biodegradable group). From the compound in combination with other lipids such as a lipid capable of reducing aggregation, lipid particles can be formed. Further, the compound can be used for a pharmaceutical composition to deliver an activator into cells.
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公开(公告)号：US20200148647A1
公开(公告)日：2020-05-14
申请号：US16535453
申请日：2019-08-08
发明人： Marco Jonas , Irene Vaulont , Antonio Soi , Gunther Schmidt
IPC分类号： C07D233/02 , C07C55/10 , C07C57/145 , C07C57/15 , C07C209/48 , C07C209/62 , C07C211/10 , C07C211/14 , C07D233/26 , C07C211/13 , C07C209/76 , C07C255/30
摘要： Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and triethylenetetramine salts of high purity.
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公开(公告)号：US10577357B2
公开(公告)日：2020-03-03
申请号：US16334285
申请日：2017-09-19
发明人： Kevin Burgess
IPC分类号： C07D241/04 , C07D241/12 , C07D403/06 , C07D405/14 , A61P3/06 , C07D233/02 , C07D403/14
摘要： Compounds that disrupt the interaction between PCSK9 and LDLR, compositions that include the compounds, and methods for making and using the compounds and compositions.
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公开(公告)号：US20190211001A1
公开(公告)日：2019-07-11
申请号：US16334285
申请日：2017-09-19
发明人： Kevin Burgess
IPC分类号： C07D405/14 , C07D233/02 , C07D403/14 , A61P3/06
CPC分类号： C07D405/14 , A61P3/06 , C07D233/02 , C07D233/61 , C07D403/14 , C07D405/12
摘要： Compounds that disrupt the interaction between PCSK9 and LDLR, compositions that include the compounds, and methods for making and using the compounds and compositions.
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