公开(公告)号：US20240287005A1

公开(公告)日：2024-08-29

申请号：US18569408

申请日：2022-06-15

申请人： Elanco Tiergesundheit AG ,  Bayer Animal Health GmbH

发明人： Pierre DUCRAY ,  Denise RAGEOT ,  Andreas TURBERG

IPC分类号： C07D261/04 ,  A01N43/80 ,  A01P7/02 ,  A01P7/04 ,  A61K31/42 ,  A61K31/422 ,  A61P33/14 ,  C07D413/12

CPC分类号： C07D261/04 ,  A01N43/80 ,  A01P7/02 ,  A01P7/04 ,  A61K31/42 ,  A61K31/422 ,  A61P33/14 ,  C07D413/12

摘要： The present invention provides compounds of formula (I):




which are useful for long-lasting treatment and control of pests, for example fleas and ticks, in companion animals and livestock, and pharmaceutical compositions and methods of using the same.

公开(公告)号：US12065414B2

公开(公告)日：2024-08-20

申请号：US17465197

申请日：2021-09-02

申请人： CADILA HEALTHCARE LIMITED

发明人： Kumar Kamlesh Singh ,  Sanjay Jagdish Desai ,  Kuldeep Natwarlal Jain ,  Jitesh Amratlal Desai ,  Sarvil Dhirajbhai Patel

IPC分类号： C07D261/04

CPC分类号： C07D261/04

摘要： The invention relates to process for the preparation of isoxazoline-substituted benzamide compound and intermediates thereof. The invention also relates to process for the preparation of Fluralaner and intermediates thereof.

公开(公告)号：US11858904B2

公开(公告)日：2024-01-02

申请号：US16761695

申请日：2018-11-06

申请人： Intervet Inc.

发明人： Luke Ryan Schenck ,  Athanas Koynov ,  George X. Zhou ,  Aaron Cote

IPC分类号： C07D261/04 ,  A01N43/80

CPC分类号： C07D261/04 ,  A01N43/80 ,  C07B2200/13

摘要： The application relates to a process to produce large isoxazoline compound particles which comprises initiating crystallization and then maintaining the temperature of the crystallization in the metastable region by removing, reheating and recycling a portion of the solvent thereby allowing the existing crystals to grow larger while minimizing the formation of newer smaller crystals.

公开(公告)号：US11753385B2

公开(公告)日：2023-09-12

申请号：US17495481

申请日：2021-10-06

申请人： OP BIO FACTORY CO., LTD. ,  SEED RESEARCH INSTITUTE CO., LTD.

发明人： Teruhiko Ishikawa ,  Morita Iwami

IPC分类号： C07D211/44 ,  C07D211/46 ,  C07D211/74 ,  C07D261/04 ,  C07D498/04 ,  C07B33/00 ,  C07C225/06 ,  C07C271/18

CPC分类号： C07D261/04 ,  C07B33/00 ,  C07C225/06 ,  C07C271/18 ,  C07D211/44 ,  C07D211/46 ,  C07D211/74 ,  C07D498/04 ,  Y02P20/55

摘要： Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1):




wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2):





wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.

公开(公告)号：US11753384B2

公开(公告)日：2023-09-12

申请号：US17049128

申请日：2019-04-24

申请人： KUMIAI CHEMICAL INDUSTRY CO., LTD.

发明人： Toshihiro Nagata ,  Daisuke Shikama

IPC分类号： C07D261/04 ,  B01J31/02

CPC分类号： C07D261/04 ,  B01J31/0232 ,  B01J31/0237 ,  B01J2231/348 ,  B01J2531/002

摘要： The objective of the present invention is to provide a production method for a 4,5-dihydroisoxazole represented by formula (3), which is safe, industrially desirable, economical, and environmentally friendly.




The present invention causes the compound of formula (1) to react with hydroxylamine in the presence of an acid catalyst to produce the compound of formula (3) through the reaction represented by the reaction equation.

公开(公告)号：US20230174460A1

公开(公告)日：2023-06-08

申请号：US17920588

申请日：2021-04-21

申请人： President and Fellowes of Harvard College

发明人： Emily Balskus ,  Chi Le

IPC分类号： C07C229/42 ,  C07D261/04 ,  C07D239/34 ,  C07D241/18 ,  C07D239/42 ,  C07D237/14 ,  C07D231/56 ,  C07D213/65 ,  C07C229/36 ,  C07D213/64 ,  C07C291/04

CPC分类号： C07C229/42 ,  C07D261/04 ,  C07D239/34 ,  C07D241/18 ,  C07D239/42 ,  C07D237/14 ,  C07D231/56 ,  C07D213/65 ,  C07C229/36 ,  C07D213/64 ,  C07C291/04

摘要： The present disclosure provides compounds of formula (I), (II), and (Ia):




Methods of preparing these molecules and their use for treatment of Parkinson's Disease are described.

公开(公告)号：US11649219B2

公开(公告)日：2023-05-16

申请号：US16406768

申请日：2019-05-08

申请人： ROTAM AGROCHEM INTERNATIONAL COMPANY LIMITED

发明人： James Timothy Bristow

IPC分类号： C07D261/04 ,  A01N43/80

CPC分类号： C07D261/04 ,  A01N43/80 ,  C07B2200/13 ,  A01N43/80 ,  A01N25/12

摘要： A process for preparing clomazone is provided, the process comprising reacting 4,4-dimethyl-3-isoxazolidinone with 2-chlorobenzyl chloride in an aqueous medium in the presence of a base, in particular an alkali metal hydroxide. A method for preparing clomazone is also disclosed, the method comprising (a) crystallizing clomazone from solution in an organic solvent; and (b) isolating the resulting crystals. N-benzene is a particularly suitable solvent. Further, there is provided Form I crystalline 2-[(2-chlorophenyl)methyl]-4,4-dimethyl-3-isoxazolidinone (clomazone), wherein the polymorph Form I is characterized by at least one of the following properties:



(i) an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2θ(+/−0.20° θ) at one or more of the following positions: about 10.63, 16.07, 18.08, 19.11, 19.34, 21.20, 24.78 and 28.80; and
(ii) an infrared (IR) spectrum having a characteristic peak: at about 2967 and 2870 cm−1.

公开(公告)号：US11576382B2

公开(公告)日：2023-02-14

申请号：US16968913

申请日：2019-02-01

申请人： FMC Corporation

发明人： Ming Xu ,  George Philip Lahm ,  Jeffrey Keith Long

IPC分类号： A01N43/80 ,  C07D261/04 ,  C07D413/12

摘要： Disclosed are compounds of Formula 1, wherein J is and R1a, R1b, R2, R3, R4, R5, R6, R7, R8, R14, R15, R16, Q and X are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

公开(公告)号：US11324220B2

公开(公告)日：2022-05-10

申请号：US16928493

申请日：2020-07-14

申请人： BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.

发明人： Chunhua Yang

IPC分类号： C07D453/04 ,  C07D261/04 ,  A01N43/80 ,  A01N43/42 ,  A61K31/42

摘要： This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine-based chiral phase transfer catalyst. The invention also relates to novel quinine-based phase transfer catalysts and to a toluene solvent form of the isoxazoline compound of the invention.

公开(公告)号：US20220073479A1

公开(公告)日：2022-03-10

申请号：US17414477

申请日：2019-12-20

申请人： Intervet Inc.

发明人： Harald Schmitt

IPC分类号： C07D261/04

摘要： The present invention relates to a novel method for preparing (5S)-4-[5-(3,5-di-chlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-benzoic acid, which can preferably be used in the synthesis of (5S)-4-[5-(3,5-dichlorophenyl)-5-(trifluoro-Q methyl)-4H-isoxazol-3-yl]-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-2-methyl-benzamide.