公开(公告)号：US20210403442A1

公开(公告)日：2021-12-30

申请号：US17329034

申请日：2021-05-24

申请人： ICEUTICA PTY LTD.

发明人： Aaron DODD ,  Felix MEISER ,  Marck NORRET ,  Adrian RUSSELL ,  H. William BOSCH

IPC分类号： C07D263/20 ,  A61K9/14 ,  A61K9/16 ,  A61K31/421

摘要： The present invention relates to methods for producing particles of metaxalone using dry milling processes as well as compositions comprising metaxalone, medicaments produced using metaxalone in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of metaxalone administered by way of said medicaments.

公开(公告)号：US20200039914A1

公开(公告)日：2020-02-06

申请号：US16342697

申请日：2017-10-24

申请人： Janssen Pharmaceutica NV

发明人： Hui Huang ,  James C. Lanter ,  Sanath K. Meegalla ,  Mark R. Player

IPC分类号： C07C59/72 ,  C07D213/64 ,  C07C229/42 ,  C07D263/20 ,  C07D401/14 ,  C07D401/12 ,  C07D257/04 ,  A61P3/10

摘要： Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, A, W, L, Ra, and G are defined herein: and by Formula (II) as follows: wherein R1B, WB, LB, , and GB are defined herein.

公开(公告)号：US10428011B2

公开(公告)日：2019-10-01

申请号：US16074496

申请日：2017-02-10

申请人： Akzo Nobel Chemicals International B.V.

发明人： Rolf Krister Edvinsson ,  Eike Nicolas Kantzer ,  Per Fredrik Olmo Larsson ,  Karl Fredrik Lake ,  Antoon Jacob Berend Ten Kate

IPC分类号： C07C209/62 ,  C07C273/18 ,  C07C209/16 ,  C07C269/06 ,  C07C275/14 ,  B01D53/62 ,  C07C211/14 ,  C07D263/20

摘要： The present invention relates to a process to prepare ethyleneamines of the formula NH2—(C2H4—NH—)pH wherein p is at least 3 or derivatives thereof wherein one or more units —NH—C2H4—NH— may be present as a cyclic ethylene urea unit or between two units —NH—C2H4—NH— a carbonyl moiety is present, by reacting an ethanolamine-functional compound, an amine-functional compound in the presence of a carbon oxide delivering agent, wherein the molar ratio of ethanolamine-functional compound to amine-functional compound is at least 0.7:1 and the molar ratio of carbon oxide delivering agent to amine-functional compound is at least 0.05:1.

公开(公告)号：US10266485B2

公开(公告)日：2019-04-23

申请号：US16005286

申请日：2018-06-11

申请人： ModernaTX, Inc.

发明人： Kerry E. Benenato

IPC分类号： A61K48/00 ,  A61K9/127 ,  C07C229/12 ,  C07C271/20 ,  C07C279/12 ,  C07C279/28 ,  C07C279/32 ,  C07D233/72 ,  C07D249/04 ,  C07D263/20 ,  C07D265/33 ,  C07D271/06 ,  C07D271/10 ,  C07D207/27 ,  C07D277/38 ,  C07C275/14 ,  C07C279/24 ,  C07C311/05 ,  C07C229/16 ,  C07C335/08 ,  C07C233/36 ,  C07C235/10 ,  C07C255/24 ,  C07F9/09 ,  A61K9/16 ,  A61K38/18 ,  C07K14/505 ,  A61K9/00 ,  A61K47/54 ,  A61K47/69 ,  C07C227/16 ,  A61K9/51 ,  A61K31/7105 ,  A61K38/17 ,  C07C227/18

摘要： The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US10202340B2

公开(公告)日：2019-02-12

申请号：US15546320

申请日：2016-02-01

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Scott D. Larsen ,  Akira Abe ,  Liming Shu ,  Michael William Wilson ,  Richard F. Keep ,  Duxin Sun ,  James A. Shayman

IPC分类号： A61K31/4015 ,  C07D207/06 ,  C07D263/20 ,  C07D207/04 ,  C07D263/24 ,  C07D205/04 ,  C07D207/09 ,  C07D207/10 ,  C07D295/125 ,  C07D295/13

摘要： Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.

公开(公告)号：US20180290987A1

公开(公告)日：2018-10-11

申请号：US15766395

申请日：2016-10-17

申请人： Mihir B. MANDAL ,  David B. OLSEN ,  Jing SU ,  Lihu YANG ,  Katherine YOUNG ,  Takao SUZUKI ,  Lanying YOU ,  Merck Sharp & Dohme Corp.

发明人： Mihir B. Mandal ,  David B. Olsen ,  Jing Su ,  Lihu Yang ,  Katherine Young ,  Takao Suzuki ,  Lanying You

IPC分类号： C07D263/20 ,  C07D471/04 ,  C07D413/10 ,  C07D417/10 ,  C07D413/04 ,  C07D487/04 ,  C07D413/06 ,  C07D417/14 ,  C07D413/14 ,  A61K31/421 ,  A61K31/437 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/553 ,  A61K31/4985 ,  A61K31/541 ,  A61K31/5377 ,  A61K45/06

摘要： The present invention relates to oxazolidinone compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, E, and R1 are as defined herein. The present invention also relates to compositions which comprise at least one oxazolidinone compound of the invention. The invention also provides methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis comprising administering a therapeutically effective amount of an oxazolidinone of the invention and/or a pharmaceutically acceptable salt thereof, or a composition comprising such compound and/or salt.

公开(公告)号：US20180009853A1

公开(公告)日：2018-01-11

申请号：US15547499

申请日：2016-01-26

申请人： Yeda Research And Development Co. Ltd.

发明人： Ada YONATH ,  Zohar EYAL ,  Donna MATZOV ,  Haim ROZENBERG ,  Ella ZIMMERMAN ,  Anat BASHAN

IPC分类号： C07K14/31 ,  C07H17/08 ,  C07D211/54 ,  C07D263/20 ,  G06F19/00 ,  G06F19/16

CPC分类号： C07K14/31 ,  C07D211/54 ,  C07D263/20 ,  C07H17/08 ,  C07K2299/00 ,  G16B15/00 ,  G16B30/00 ,  G16B35/00 ,  G16C20/50 ,  G16C20/60

摘要： A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the three-dimensional structure thereof are provided herein, as well as methods for crystallizing the same, and using the atomic coordinates of the same to design de novo ligands with high specificity thereto.

公开(公告)号：US20160272597A1

公开(公告)日：2016-09-22

申请号：US15034878

申请日：2014-07-28

申请人： LEE PHARMA LIMITED

发明人： Raghu Mitra Alla ,  Ajay Kumar Dubey ,  Srinivas Reddy Mallepalli ,  Ramakrishna Reddy Pongilati

IPC分类号： C07D263/20

CPC分类号： C07D263/20 ,  A61K31/5377 ,  C07B2200/07 ,  Y02A50/473 ,  Y02A50/481 ,  Y02A50/483

摘要： The invention relates to novel oxazolidinone compound. More particularly, the invention relates to novel [(S)—N-[[3-[4-fluoro-3-morpholino phenyl]-2-oxooxazolidin-5-yl] methyl] acetamide] compound of Formula-I which was disclosed in Indian Patent Application No. 5063/CHE/2013 and corresponding PCT/IN2014/000018. The compound is a broad spectrum antimicrobial agent effective against Multi-Drug Resistant S. Maltophilia pathogen and a large number of gram positive and gram negative pathogens. The compound has shown excellent biological activities against S. Maltophilia which has developed resistance against a large number of antibiotics including some of the known and widely used oxazolidinone derivatives.

公开(公告)号：US09206141B2

公开(公告)日：2015-12-08

申请号：US13695211

申请日：2011-04-28

申请人： James R. McCarthy

发明人： James R. McCarthy

IPC分类号： C07D265/30 ,  C07D263/20

CPC分类号： C07D263/20

摘要： Processes and intermediates for preparing linezolid, and pharmaceutically acceptable salts thereof, are described herein.

摘要翻译： 本文描述了制备利奈唑胺的方法和中间体及其药学上可接受的盐。

公开(公告)号：US20150246894A1

公开(公告)日：2015-09-03

申请号：US14699144

申请日：2015-04-29

申请人： Hoffmann-La Roche Inc.

发明人： Luke Green ,  Haiyan Wang

IPC分类号： C07D263/20 ,  C07D413/04 ,  C07D413/06

CPC分类号： C07D263/20 ,  C07D263/32 ,  C07D413/04 ,  C07D413/06

摘要： The invention provides compounds having the general formula I wherein n, R1, R2a, R2b, R3a and R3b are as herein defined, composition comprising the compounds and methods of using the compounds.

摘要翻译： 本发明提供具有通式I的化合物，其中n，R1，R2a，R2b，R3a和R3b如本文所定义，组合物包含化合物和使用该化合物的方法。