公开(公告)号：US20240262842A1

公开(公告)日：2024-08-08

申请号：US18557487

申请日：2022-04-27

申请人： Merck Sharp & Dohme LLC

发明人： Kazuaki SHIBATA ,  Hiroki Asakura ,  Kei AKEMOTO ,  Toshihiro SAKAMOTO ,  Hitomi KONDO ,  Tomohiro YAMAMOTO ,  Risako MIURA ,  Patrick SCHÖPF ,  Juan DEL POZO ,  George Madalin GIAMBUSU ,  Thomas H. GRAHAM ,  Yongxin HAN ,  Elisabeth T. HENNESSY ,  Anandan PALANI ,  Michael RYAN ,  David L. Sloman ,  Steven HOWARD

IPC分类号： C07D491/22 ,  A61K31/407 ,  A61K31/4188 ,  A61K31/437 ,  A61P35/00 ,  C07D471/16 ,  C07D487/16 ,  C07D498/06 ,  C07D498/16

CPC分类号： C07D491/22 ,  A61K31/407 ,  A61K31/4188 ,  A61K31/437 ,  A61P35/00 ,  C07D471/16 ,  C07D487/16 ,  C07D498/06 ,  C07D498/16

摘要： Compounds of Formula (I) or (Ia) or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds of Formula (I) or (Ia) or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.

公开(公告)号：US20230337537A1

公开(公告)日：2023-10-19

申请号：US17912871

申请日：2021-03-19

申请人： Merck Patent GmbH

发明人： Amir Hossain PARHAM

IPC分类号： H10K85/60 ,  C09K11/06 ,  C07F5/02 ,  C07D487/16 ,  C07D487/06 ,  C07D513/16 ,  C07D498/16 ,  C07D498/06 ,  C07D513/06

CPC分类号： H10K85/658 ,  C07D487/06 ,  C07D487/16 ,  C07D498/06 ,  C07D498/16 ,  C07D513/06 ,  C07D513/16 ,  C07F5/027 ,  C09K11/06 ,  H10K85/657 ,  H10K85/6572 ,  C09K2211/1018 ,  H10K50/121

摘要： Abstract: The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic device.

公开(公告)号：US20230329106A1

公开(公告)日：2023-10-12

申请号：US18209996

申请日：2023-06-14

申请人： LG CHEM, LTD.

发明人： Minseung CHUN ,  Sang Young JEON ,  Tae Yoon PARK ,  Seongmi CHO

IPC分类号： H10K85/60 ,  C07D487/04 ,  C07D209/86 ,  C07D487/14 ,  C07D471/06 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D403/12 ,  C09K11/06 ,  C07C211/61 ,  C07D307/91 ,  C07D471/10 ,  C07D487/16 ,  C07D498/06

CPC分类号： H10K85/6572 ,  C07D487/04 ,  C07D209/86 ,  C07D487/14 ,  C07D471/06 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D403/12 ,  H10K85/615 ,  H10K85/622 ,  H10K85/626 ,  H10K85/633 ,  H10K85/636 ,  H10K85/654 ,  H10K85/657 ,  C09K11/06 ,  C07C211/61 ,  C07D307/91 ,  C07D471/10 ,  C07D487/16 ,  C07D498/06 ,  H10K50/11

摘要： The present specification relates to an organic light emitting element comprising: an anode; a cathode disposed opposite to the anode; and a light emitting layer disposed between the anode and the cathode, wherein the light emitting layer comprises: a host including a P-type host and an N-type host for generating an exciplex; and a phosphorescent dopant, and the host including the P-type host and the N-type host for generating an exciplex emits photoluminescence light having a longer wavelength than that emitted from each of the P-type host and the N-type host.

公开(公告)号：US11713340B2

公开(公告)日：2023-08-01

申请号：US17563570

申请日：2021-12-28

申请人： Carnegie Mellon University

发明人： Danith H. Ly ,  Suresh Kumar Gopalsamy ,  Arunava Manna

IPC分类号： C07K14/00 ,  C12Q1/68 ,  C12Q1/6809 ,  C07H21/04 ,  C07D239/47 ,  C07D239/54 ,  C07D251/16 ,  C07D471/04 ,  C07D475/08 ,  C07D487/04 ,  C07D487/16 ,  C07H1/06 ,  G01N33/53

CPC分类号： C07K14/003 ,  C07D239/47 ,  C07D239/54 ,  C07D251/16 ,  C07D471/04 ,  C07D475/08 ,  C07D487/04 ,  C07D487/16 ,  C07H1/06 ,  C07H21/04 ,  C12Q1/6809 ,  G01N33/5308

摘要： Described herein are novel divalent nucleobases that each bind two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone (a genetic recognition reagent, or genetic recognition reagent). In one embodiment, the genetic recognition reagent is a peptide nucleic acid (PNA) or gamma PNA (γPNA) oligomer. Uses of the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.

公开(公告)号：US11643414B2

公开(公告)日：2023-05-09

申请号：US16095991

申请日：2017-04-26

申请人： Merck Patent GmbH

发明人： Amir Parham ,  Tobias Grossmann ,  Jonas Kroeber

IPC分类号： C07D487/04 ,  H01L51/00 ,  C07F15/00 ,  C07D487/16 ,  C07D495/04 ,  C07D493/16 ,  C09K11/06 ,  C07D495/16 ,  C07D493/04 ,  H01L51/50 ,  C07D209/86 ,  C07D519/00

CPC分类号： C07D487/04 ,  C07D209/86 ,  C07D487/16 ,  C07D493/04 ,  C07D493/16 ,  C07D495/04 ,  C07D495/16 ,  C07D519/00 ,  C07F15/0033 ,  C09K11/06 ,  H01L51/006 ,  H01L51/0061 ,  H01L51/0065 ,  H01L51/0067 ,  H01L51/0072 ,  H01L51/0073 ,  H01L51/0074 ,  H01L51/5016 ,  H01L51/5024 ,  H01L51/5096 ,  H01L51/5012 ,  H01L51/5072 ,  H01L2251/5384 ,  Y02E10/549

摘要： The present invention relates to compounds of formula (1). The compounds are suitable for use in electronic devices, in particular organic electroluminescent devices, comprising these compounds. In some embodiments, the compounds are used as matrix materials for phosphorescent or fluorescent emitters as well as a hole-blocking or electron-transport.

公开(公告)号：US11634420B2

公开(公告)日：2023-04-25

申请号：US16622270

申请日：2018-06-14

申请人： Sumitomo Chemical Company Limited

发明人： William Tarran ,  James Lee ,  Nazrul Islam

IPC分类号： C07D471/16 ,  H01L51/00 ,  C07D487/16 ,  H01L51/50

摘要： A compound of formula (I): (Formula (I)) wherein Ar1, Ar2 and Ar3 independently in each occurrence is a C6-20 aryl group or a 5-20 membered heteroaryl group which is unsubstituted or substituted with one or more substituents; X1, X2 and X3 in each occurrence is independently a direct bond or a group of formula —C(R1)2— wherein R1 in each occurrence is independently H or a substituent. The compound of formula (I) may be used to form an n-dopant for doping an organic semiconductor. A film formed by such n-doping may be used in an organic electronic device, for example an electron injection layer of an organic light-emitting device.

公开(公告)号：US20220407026A1

公开(公告)日：2022-12-22

申请号：US17825854

申请日：2022-05-26

申请人： BEIJING SUMMER SPROUT TECHNOLOGY CO., LTD.

发明人： Huiqing PANG ,  Jing WANG ,  Zhihao CUI ,  Hualong DING ,  Renjie ZHENG ,  Chi Yuen Raymond KWONG

IPC分类号： H01L51/50 ,  C07D209/82 ,  C07D409/12 ,  C07D401/12 ,  C07D405/12 ,  C07D403/12 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D403/14 ,  C07C211/54 ,  C07C15/28 ,  C07D487/16 ,  C07C255/51 ,  C07D498/04 ,  H01L51/00

摘要： The device provided herein is an organic electroluminescent device and includes a substrate; a first electrode on the substrate and with high reflectivity; a translucent or transparent second electrode over the first electrode; and a first, a second and a third organic layer included between the first and the second electrode; where the second organic layer has a thickness >80 nm and is made of a second organic material; the third organic layer is a light-emitting layer including at least one light-emitting material and at least one host material; the first organic layer has a conductivity >1×10−4 S/m and

公开(公告)号：US20220380278A1

公开(公告)日：2022-12-01

申请号：US17642661

申请日：2020-09-11

申请人： IDEMITSU KOSAN CO.,LTD.

发明人： Satomi TASAKI ,  Kazuki NISHIMURA ,  Yuki NAKANO

IPC分类号： C07C15/38 ,  C07D307/91 ,  C07C15/28 ,  C07C15/30 ,  C07D333/76 ,  C07D311/82 ,  C07F7/08 ,  C07D405/10 ,  C07D407/10 ,  C07C13/72 ,  C07C211/54 ,  C07C255/51 ,  C07D487/06 ,  C07D491/22 ,  C07D491/06 ,  C07D487/16 ,  C07D495/22 ,  C07D519/00 ,  C07F5/02 ,  C07D493/04 ,  C07D495/04 ,  H01L51/00

摘要： An organic electroluminescence device includes an anode, a cathode, a first emitting layer, and a second emitting layer provided between the first emitting layer and the cathode, in which the first emitting layer includes, as a first host material, a first compound that includes at least one group represented by a formula (11) below, the first compound being represented by a formula (1) below, the second emitting layer includes a second compound represented by a formula (2) below as a second host material, and the first emitting layer is in direct contact with the second emitting layer. L101 is a single bond or a substituted or unsubstituted arylene group having 6 to 50 ring carbon atoms. Ar101 is a substituted or unsubstituted aryl group having 6 to 50 ring carbon atoms. mx is 0, 1, 2, 3, 4, or 5.

公开(公告)号：US20220371974A1

公开(公告)日：2022-11-24

申请号：US17642222

申请日：2020-09-11

申请人： IDEMITSU KOSAN CO.,LTD.

发明人： Kazuki NISHIMURA ,  Satomi TASAKI

IPC分类号： C07C15/38 ,  C07D307/91 ,  C07C15/28 ,  C07C15/30 ,  C07D333/76 ,  C07D311/82 ,  C07D407/10 ,  C07F7/08 ,  C07D405/10 ,  C07C211/54 ,  C07D487/06 ,  C07D491/22 ,  C07D491/16 ,  C07D487/16 ,  C07D495/22 ,  C07D487/22 ,  C07D519/00 ,  C07F5/02 ,  C07D493/04 ,  C07D495/04 ,  C07D405/12 ,  C07D403/14 ,  C07D235/08 ,  C07D251/24 ,  C07F1/02 ,  H01L51/00

摘要： An organic electroluminescence device includes: an anode; a cathode; a first emitting layer; and a second emitting layer provided between the first emitting layer and the cathode, in which the first emitting layer contains, as a first host material, a first compound that has at least one group represented by a formula (11) below and that is represented by a formula (1) below, the second emitting layer contains, as a second host material, a second compound represented by one of formulae (2-1A) to (2-4A) below, and the first emitting layer and the second emitting layer are in direct contact with each other.

公开(公告)号：US11437582B2

公开(公告)日：2022-09-06

申请号：US15737179

申请日：2016-06-15

申请人： KUNSHAN GO-VISIONOX OPTO-ELECTRONICS CO., LTD. ,  TSINGHUA UNIVERSITY

发明人： Lian Duan ,  Dongdong Zhang ,  Song Liu ,  Jing Xie ,  Fei Zhao

IPC分类号： H01L51/54 ,  H01L51/00 ,  H01L51/50 ,  C07C211/61 ,  C07C255/58 ,  C07C317/36 ,  C07D209/80 ,  C07D209/86 ,  C07D219/02 ,  C07D221/20 ,  C07D241/48 ,  C07D265/38 ,  C07D285/14 ,  C07D403/10 ,  C07D403/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D417/10 ,  C07D417/14 ,  C07D471/20 ,  C07D487/14 ,  C07D487/16 ,  C07F1/02 ,  C07F3/02 ,  C07F3/06

摘要： Disclosed is an organic electroluminescent device, comprising a substrate and light emitting units formed in sequence on the substrate, characterized in that, each of the light emitting units comprises a first electrode layer (1), a light emitting layer (2) and a second electrode layer (3), the light emitting layer comprises a host material and a dye, the host material is made of materials having both electron transport capability and hole transport capability; at least one material in the host material has a CT excited triplet state energy level T1 greater than its n-π excited triplet state energy level S1, and T1-S1≤0.3 eV; or, at least one material in the host material has a CT excited triplet state energy level T1 greater than its n-π excited triplet state energy level S1, and T1-S1≥1 eV, with the difference between its n-π excited second triplet state energy level and its CT excited first singlet state energy level being in the range of −0.1 eV to 0.1 eV. The organic electroluminescent device configuration can sufficiently utilize the triplet state energy in the host material and the dye to increase the luminous efficiency and prolong the service life of the device.