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73 条记录 (耗时 0.031 秒)

    Method for the antibiotic coating of bodies with interconnecting microcavities as well as coated bodies and their usage
    7.
    发明授权
    Method for the antibiotic coating of bodies with interconnecting microcavities as well as coated bodies and their usage 有权
    具有互连微腔以及涂层体的物体的抗生素涂层方法及其用途

    公开(公告)号：US07358232B2

    公开(公告)日：2008-04-15

    申请号：US10174682

    申请日：2002-06-19

    申请人： Sebastian Vogt ,  Matthias Schnabelrauch ,  Klaus-Dieter Kühn

    发明人： Sebastian Vogt ,  Matthias Schnabelrauch ,  Klaus-Dieter Kühn

    IPC分类号： A61K31/70 ,  C07H15/02

    CPC分类号： A61K9/0024

    摘要： The invention relates to a method for the antibiotic coating of bodies with interconnecting microcavities as well as bodies coated this way and their usage. The invented method is characterized in that in the microcavities of non-metallic bodies an aqueous solution 1, which contains at least one easily water-soluble antibiotic component from the groups of the aminoglycoside antibiotics, the tetracycline antibiotics, the lincosamide antibiotics and the 4-quinolone antibiotics, and an aqueous solution 2, which contains at least one easily water-soluble amphiphilic component from the groups of the alkyl sulfates, alkyl sulfonates, alkylaryl sulfates, dialkylaryl sulfates, alkylaryl sulfonates, dialkylaryl sulfonates, cycloalkyl sulfates, cycloalkyl sulfonates, alkylcycloalkyl sulfates, are introduced, wherein between the introduction of solutions 1 and 2 the water is basically removed through vaporization and/or evaporation, and whereby from the components of solutions 1 and 2 in the microcavities a deposit is formed, which is sparingly soluble in water.

    摘要翻译： 本发明涉及一种用于具有互连微腔的物体的抗生素包被的方法以及这种方式涂覆的物体及其用途。 本发明的方法的特征在于，在非金属体的微腔中，含有来自氨基糖苷类抗生素组的至少一种容易水溶性抗生素成分的水溶液1，四环素抗生素，林可素类抗生素和4- 喹诺酮抗生素和水溶液2，其含有至少一种容易水溶性的两亲成分，分别为烷基硫酸盐，烷基磺酸盐，烷基芳基硫酸盐，二烷基芳基硫酸盐，烷基芳基磺酸盐，二烷基芳基磺酸盐，环烷基硫酸盐，环烷基磺酸盐，烷基环烷基 硫酸盐，其中在引入溶液1和2之间基本上通过蒸发和/或蒸发除去水，并且由此在微腔中的溶液1和2的组分中形成沉积物，其沉积物微溶于水 。

    Oligosaccharide derivative
    9.
    发明申请
    Oligosaccharide derivative 失效
    寡糖衍生物

    公开(公告)号：US20060025350A1

    公开(公告)日：2006-02-02

    申请号：US11193655

    申请日：2005-07-28

    申请人： Takeshi Honda ,  Akira Okuno ,  Masanori Izumi ,  Xiaoliu Li

    发明人： Takeshi Honda ,  Akira Okuno ,  Masanori Izumi ,  Xiaoliu Li

    IPC分类号： C07H15/02 ,  A61K31/7052

    CPC分类号： C07H15/203 ,  C07H17/02

    摘要： Compounds having the formula (I): wherein A represents a group such as a cyclic group, R1 and R2 represent groups such as alkyl groups or hydroxymethyl groups, and n represents 1 or 2, or pharmacologically acceptable salts thereof or pharmacologically acceptable esters thereof have superior activity and stability, and are useful for the treatment and/or prevention of diabetes mellitus, or the like.

    摘要翻译： 具有式（I）的化合物：其中A表示诸如环状基团的基团，R 1和R 2表示例如烷基或羟甲基的基团，n 代表1或2，或其药学上可接受的盐或其药理学上可接受的酯具有优异的活性和稳定性，并且可用于治疗和/或预防糖尿病等。

    Hepatic-directed compounds and reagents for preparation thereof
    10.
    发明授权
    Hepatic-directed compounds and reagents for preparation thereof 失效
    肝取向化合物及其制备试剂

    公开(公告)号：US5886143A

    公开(公告)日：1999-03-23

    申请号：US351651

    申请日：1994-12-07

    申请人： Louis J. Theodore ,  Donald B. Axworthy ,  John M. Reno

    发明人： Louis J. Theodore ,  Donald B. Axworthy ,  John M. Reno

    IPC分类号： A61K31/7028 ,  A61K47/48 ,  A61K51/08 ,  A61P1/16 ,  C07H15/04 ,  C07H15/14 ,  C07H15/26 ,  A61K38/14 ,  C07H15/02 ,  C07K9/00

    CPC分类号： B82Y5/00 ,  A61K47/4873 ,  A61K51/0465 ,  C07H15/04 ,  C07H15/14 ,  A61K2121/00

    摘要： Hepatic-directed compounds, reagents useful in making such compounds and associated methods and compositions are discussed. Hepatic-directed compounds are processed by metabolic mechanisms, which generally differ in degree or in kind from the metabolic mechanisms encountered by compounds which are not so directed. Reagents useful in the preparation of hepatic-directed compounds include a hexose cluster characterized by multiple hexose residues connected in an iteratively branched configuration. In one embodiment, the hexose cluster comprises at least four hexose residues with each branch of the configuration having two prongs. In another embodiment, the hexose cluster comprises at least nine hexose residues with each branch of the configuration having three prongs.

    摘要翻译： 讨论了肝取向化合物，可用于制备这些化合物的试剂和相关方法和组合物。 肝取向化合物通过代谢机制进行处理，其代谢机制通常在程度上或种类上不同于未被引导的化合物所遇到的代谢机制。 可用于制备肝取向化合物的试剂包括以反复分支构型连接的多个己糖残基为特征的己糖簇。 在一个实施方案中，己糖簇包含至少四个己糖残基，其中每个分支具有两个分支。 在另一个实施方案中，己糖簇包含至少九个己糖残基，其中每个分支具有三个分支。