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    Iodine based germicidal composition
    2.
    发明授权
    Iodine based germicidal composition 失效
    碘基杀菌组成

    公开(公告)号：US5648075A

    公开(公告)日：1997-07-15

    申请号：US684334

    申请日：1996-07-19

    申请人： Jack H. Kessler ,  James C. Richards

    发明人： Jack H. Kessler ,  James C. Richards

    IPC分类号： A61K33/40 ,  A61K38/44 ,  A61K33/36 ,  C12N9/96

    CPC分类号： A61K33/40 ,  A61K38/44 ,  C12Y111/01007

    摘要： The present invention relates generally to an enzymatically generated iodine microbiocide and more specifically to the use of such a microbiocide for the inactivation of pathogenic organisms that are contaminants in sensitive biological materials. The biocidal agent from the enzymatic reaction is free molecular iodine generated so as to (1) establish a minimum level above 10 ppm of free molecular iodine and (2) to establish defined ratios of free molecular iodine to other iodine species such that free molecular iodine comprises at least 10% of the total iodine species present on a molar basis.

    摘要翻译： 本发明一般涉及酶促生成的杀微生物剂，更具体地涉及使用这种杀微生物剂来灭活作为敏感生物材料中的污染物的致病生物体。 来自酶反应的杀生物剂是产生的游离分子碘，以便（1）建立高于10ppm的游离分子碘的最低水平，和（2）建立游离分子碘与其它碘物质的定义比例，使得游离分子碘 包含以摩尔计存在的总碘物质的至少10％。

    Carrier acquisition scheme for QAM and QPSK data
    3.
    发明授权
    Carrier acquisition scheme for QAM and QPSK data 失效
    QAM和QPSK数据的载波采集方案

    公开(公告)号：US5042052A

    公开(公告)日：1991-08-20

    申请号：US481089

    申请日：1990-02-16

    申请人： Richard D. Roberts ,  James C. Richards ,  James F. Roesch ,  Scott W. Stewart ,  Mark A. Webster

    发明人： Richard D. Roberts ,  James C. Richards ,  James F. Roesch ,  Scott W. Stewart ,  Mark A. Webster

    IPC分类号： H04L27/00 ,  H04L27/227

    CPC分类号： H04L27/2273 ,  H04L2027/0051

    摘要： The invention involves an apparatus for recovering the carrier signal in OPSK or QAM data. First an energy directed phase detector controls a voltage controlled oscillator so that the output signal has a phase that is within a few degrees of the carrier phase. Following this coarse acquisition, the system clock timing is recovered and established. A decision directed phase detector, using the system clock information, then controls the VCO to adjust the output signal phase to within a very small tolerance of the actual carrier phase.

    摘要翻译： 本发明涉及一种用于以OPSK或QAM数据恢复载波信号的装置。 首先，能量定向相位检测器控制压控振荡器，使得输出信号具有在载波相位的几度内的相位。 在这种粗略采集之后，系统时钟定时被恢复和建立。 使用系统时钟信息的判决定向相位检测器然后控制VCO将输出信号相位调整到实际载波相位的非常小的公差内。

    Signal amplification in an assay employing a piezoelectric oscillator
    4.
    发明授权
    Signal amplification in an assay employing a piezoelectric oscillator 失效
    使用压电振荡器的测定中的信号放大

    公开(公告)号：US4847193A

    公开(公告)日：1989-07-11

    申请号：US64266

    申请日：1987-06-18

    申请人： James C. Richards ,  David T. Bach

    发明人： James C. Richards ,  David T. Bach

    IPC分类号： C12Q1/68 ,  G01N27/00 ,  G01N33/543

    CPC分类号： G01N29/036 ,  C12Q1/6825 ,  C12Q1/689 ,  G01N33/54373 ,  G01N2291/0256 ,  G01N2291/0257 ,  Y10S436/806

    摘要： A method for detecting a first member of a specific binding pair in a sample, the first member being capable of forming a complex with a second member of the specific binding pair, includes immobilizing the second member on a surface of a piezoelectric oscillator, determining a first vibrational frequency of the oscillator on which the second member has been immobilized, contacting the surface of the oscillator on which the second member has been immobilized with the sample under conditions permitting formation of the complex, and with a particle under conditions permitting binding of the particle with the first member, mass coupling the bound particle with the oscillator, and determining a second vibrational frequency of the oscillator with which the particle has been mass coupled, the difference between the first vibrational frequency and the second vibrational frequency providing a measure of the quantity of the first member in the sample.

    LPS Based Vaccines
    5.
    发明申请
    LPS Based Vaccines 审中-公开
    基于LPS的疫苗

    公开(公告)号：US20110229513A1

    公开(公告)日：2011-09-22

    申请号：US13062299

    申请日：2009-09-08

    申请人： Andrew D. Cox ,  Frank St. Michael ,  James C. Richards ,  Richard E. Moxon

    发明人： Andrew D. Cox ,  Frank St. Michael ,  James C. Richards ,  Richard E. Moxon

    IPC分类号： A61K39/385 ,  C07K14/00 ,  C07K14/765 ,  C07K14/34 ,  C07K14/33 ,  C07K1/113 ,  C12P21/00 ,  A61P37/04 ,  A61P31/04

    CPC分类号： A61K39/095 ,  A61K39/102 ,  A61K39/1045 ,  A61K2039/55566 ,  A61K2039/6037 ,  C08B37/0063

    摘要： The removal of the glycosidic phosphate from the reducing end of the derived LPS molecule creates an aldehydo functionality which causes the formation of an immunologically dominant neo-epitope. Conjugation to the reducing end of a carbohydrate molecule following removal of the glycosidic phosphate traps the reducing glucosamine residue in an open-chain form which surprisingly was found to dominate the immune response. We therefore modified our conjugation strategy to avoid this open-chain form, by utilising the amino functionality created by the isolated amidase activity from Dictyostelium discoideum, concomitant with a unique blocking and un-blocking strategy to protect the immunologically important phosphoethanolamine inner core residue. These antigenic structures are useful in producing vaccines and compounds helpful in combating Gram-negative bacteria. Also described are specific structures of the carbohydrate molecules derived from a variety of Gram-negative bacteria, which when presented appropriately as a glycoconjugate will facilitate a functional immune response to the target core oligosaccharide region.

    摘要翻译： 从衍生的LPS分子的还原端去除糖苷磷酸形成醛官能团，其导致形成免疫优势的新表位。 在除去糖苷磷酸盐后，与碳水化合物分子的还原末端的缀合物以开放链形式释放还原葡糖胺残基，令人惊讶地发现其主导免疫应答。 因此，我们修改了我们的共轭策略，以避免这种开链形式，通过利用由盘基网柄菌分离的分离的酰胺酶活性产生的氨基功能，伴随着独特的阻断和非阻断策略来保护免疫重要的磷酸乙醇胺内核残基。 这些抗原结构可用于生产有助于抗革兰氏阴性菌的疫苗和化合物。 还描述了衍生自各种革兰氏阴性细菌的碳水化合物分子的特异性结构，当作为糖缀合物适当地呈现时，将促进对靶核心寡糖区域的功能性免疫应答。

    Automated method and system for introducing molecular iodine into drinking water
    9.
    发明授权
    Automated method and system for introducing molecular iodine into drinking water 有权
    将分子碘引入饮用水的自动化方法和系统

    公开(公告)号：US08470303B2

    公开(公告)日：2013-06-25

    申请号：US13018955

    申请日：2011-02-01

    申请人： James C. Richards

    发明人： James C. Richards

    IPC分类号： A61K8/20

    CPC分类号： A01K7/02 ,  A01K7/06 ,  A01N59/12 ,  A61K8/20 ,  A61K33/18 ,  A61Q11/00 ,  C02F1/003 ,  C02F1/008 ,  C02F1/283 ,  C02F1/686 ,  C02F1/766 ,  C02F2001/427 ,  C02F2103/026 ,  C02F2103/20 ,  C02F2303/185 ,  C02F2307/10

    摘要： A system and method for delivering molecular iodine or any other substance into a pet's drinking water on a daily basis without exceeding the safe amount allowed for the pet. The present invention delivers a particular amount of molecular iodine into the pet water supply to achieve maximum benefit of I2 to reduce or eliminate bad pet breath and minimize total iodine in the pet diet so that 20-40 μg/mL/Kg/day iodine is consumed for optimum thyroid health. The preferred method is to use a solution created by dissolving iodine crystals in absolute ethanol. The iodine will only be in solution as I2 for a short time as it undergoes out gassing and hydrolysis at neutral pH. The present invention removes the iodine from the drinking water after the pet drinks. Therefore, during the day, pets will get no additional iodine—only fresh water from the water reservoir. Each enrolled pet is recognized by the system using an ID tag such as an RFID tag. This insures that, when there are multiple enrolled pets, each pet receives its specific dose, and only as often as is programmed. Vitamins, drugs and other substances can also be administered to pets using the present invention.

    摘要翻译： 一种将分子碘或任何其他物质每天输送到宠物饮用水中而不超过宠物允许的安全量的系统和方法。 本发明将特定量的分子碘输送到宠物水供应中以实现I2的最大益处以减少或消除宠物饮食中的不良宠物呼吸并使宠物饮食中的总碘最小化，使得20-40ug / mL / Kg /天碘为 消耗为最佳甲状腺健康。 优选的方法是使用通过将碘晶体溶解在无水乙醇中产生的溶液。 由于碘在中性pH下经历放气和水解，所以碘将仅在I2溶液中短时间存在。 本发明在宠物饮料之后从饮用水中除去碘。 因此，白天，宠物不会再从水库中获得额外的碘纯淡水。 每个登记的宠物被系统识别，使用诸如RFID标签的ID标签。 这确保了当有多个登记的宠物时，每只宠物收到其特定的剂量，并且只有经常编程。 维生素，药物和其他物质也可以使用本发明给予宠物。

    Automated Method and System for Introducing Molecular Iodine into Drinking Water
    10.
    发明申请
    Automated Method and System for Introducing Molecular Iodine into Drinking Water 有权
    将分子碘引入饮用水的自动化方法和系统

    公开(公告)号：US20110195033A1

    公开(公告)日：2011-08-11

    申请号：US13018955

    申请日：2011-02-01

    申请人： James C. Richards

    发明人： James C. Richards

    IPC分类号： A61K8/20 ,  A61L2/18 ,  A61Q11/00 ,  A01P1/00 ,  A01N59/12

    CPC分类号： A01K7/02 ,  A01K7/06 ,  A01N59/12 ,  A61K8/20 ,  A61K33/18 ,  A61Q11/00 ,  C02F1/003 ,  C02F1/008 ,  C02F1/283 ,  C02F1/686 ,  C02F1/766 ,  C02F2001/427 ,  C02F2103/026 ,  C02F2103/20 ,  C02F2303/185 ,  C02F2307/10

    摘要： A system and method for delivering molecular iodine or any other substance into a pet's drinking water on a daily basis without exceeding the safe amount allowed for the pet. The present invention delivers a particular amount of molecular iodine into the pet water supply to achieve maximum benefit of I2 to reduce or eliminate bad pet breath and minimize total iodine in the pet diet so that 20-40 μg/mL/Kg/day iodine is consumed for optimum thyroid health. The preferred method is to use a solution created by dissolving iodine crystals in absolute ethanol. The iodine will only be in solution as I2 for a short time as it undergoes out gassing and hydrolysis at neutral pH. The present invention removes the iodine from the drinking water after the pet drinks. Therefore, during the day, pets will get no additional iodine—only fresh water from the water reservoir. Each enrolled pet is recognized by the system using an ID tag such as an RFID tag. This insures that, when there are multiple enrolled pets, each pet receives its specific dose, and only as often as is programmed. Vitamins, drugs and other substances can also be administered to pets using the present invention.

    摘要翻译： 一种将分子碘或任何其他物质每天输送到宠物饮用水中而不超过宠物允许的安全量的系统和方法。 本发明将特定量的分子碘输送到宠物水供应中以实现I2的最大益处以减少或消除宠物饮食中的不良宠物呼吸并使宠物饮食中的总碘最小化，使得20-40μg/ mL / Kg /天碘 消耗为最佳甲状腺健康。 优选的方法是使用通过将碘晶体溶解在无水乙醇中产生的溶液。 由于碘在中性pH下经历放气和水解，所以碘将仅在I2溶液中短时间存在。 本发明在宠物饮料之后从饮用水中除去碘。 因此，白天，宠物不会再从水库中获得额外的碘纯淡水。 每个登记的宠物被系统识别，使用诸如RFID标签的ID标签。 这确保了当有多个登记的宠物时，每只宠物收到其特定的剂量，并且只有经常编程。 维生素，药物和其他物质也可以使用本发明给予宠物。