公开(公告)号：US20210002351A1

公开(公告)日：2021-01-07

申请号：US16931736

申请日：2020-07-17

申请人： Omniox, Inc.

发明人： Gregory Kapp ,  Laura Serwer ,  Natacha Le Moan ,  Stephen P. L. Cary

IPC分类号： C07K14/795 ,  A61K38/41 ,  A61K38/16 ,  A61K45/06

摘要： The invention provides polymeric H-NOX proteins for the delivery of oxygen with longer circulation half-lives compared to monomeric H-NOX proteins. Polymeric H-NOX proteins extravasate into and preferentially accumulate in tumor tissue for sustained delivery of oxygen. The invention also provides the use of H-NOX proteins as radiosensitizers for the treatment of brain cancers.

公开(公告)号：US20200095538A1

公开(公告)日：2020-03-26

申请号：US16608867

申请日：2018-12-26

申请人： SOUTH CHINA SEA INSTITUTE OF OCEANOLOGY, CHINESE ACADEMY OF SCIENCES ,  GUANGZHOU BAIYUN LIANJIA FINE CHEMICAL PLANT

发明人： Wenzhou XIANG ,  Li TAN ,  Tao LI ,  Hualian WU ,  Jiayi WU ,  Zishuo CHEN ,  Dehai LIU ,  Dengliang YANG ,  Shengjie LIN ,  Weijie ZHANG ,  Chubiao ZHANG ,  Hao CHEN

IPC分类号： C12N1/20 ,  C12R1/01 ,  C12P21/00 ,  C12P19/04 ,  C12P5/00 ,  C07K14/795

摘要： A space-bred seawater Spirulina H11 strain. The strain exhibits high growth rate, capacity of simultaneously accumulating high contents of phycocyanin, Spirulina polysaccharides and β-carotene, and excellent adaptability to outdoor environment, thus can be used to produce high-quality Spirulina powders, phycocyanin, Spirulina polysaccharides, and β-carotene-rich Spirulina oil.

公开(公告)号：US10272160B2

公开(公告)日：2019-04-30

申请号：US15566140

申请日：2016-04-18

申请人： The Research Foundation for The State University of New York

发明人： Jonathan Lovell ,  Shuai Shao ,  Jumin Geng ,  Wei-Chiao Huang ,  Shwu-Maan Lee ,  Charles Richter King

IPC分类号： A61K39/395 ,  A61K47/69 ,  A61K38/41 ,  A61K9/127 ,  C07K14/795 ,  A61K38/16 ,  A61K47/54 ,  B82Y5/00

摘要： The present disclosure provides nanostructures (e.g., monolayer or bilayer nanostructures) comprising porphyrins with cobalt chelated thereto such that the cobalt metal resides within monolayer or bilayer in the porphyrin macrocycle. The nanostructures can have presentation molecules with a histidine tag attached thereto, such that at least a part of the his-tag is within the monolayer or bilayer and coordinated to the cobalt metal core and the presentation molecules are exposed to the outside of the nanostructures. The nanostructures can further comprise a cargo. The nanostructures can be used to deliver the cargo to an individual.

公开(公告)号：US20180118810A1

公开(公告)日：2018-05-03

申请号：US15726779

申请日：2017-10-06

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Mark T. Gladwin ,  Jesus Tejero Bravo

IPC分类号： C07K14/795 ,  A61K38/41 ,  A61K9/00 ,  A61K38/00

摘要： Described herein is a new antidote for the rapid elimination of carbon monoxide from hemoglobin, including brain, heart, and red cell hemoglobin. The disclosed therapy involves the use of modified human globins, particularly neuroglobins modified at residue 64 and cytoglobins modified at residue 81, which bind carbon monoxide with extremely high affinity. The monomeric mutant globins are infused into blood, where they rapidly and irreversibly sequester carbon monoxide, and thus limit toxic effects of carbon monoxide on cellular respiration and oxygen transport and utilization.

公开(公告)号：US09605013B2

公开(公告)日：2017-03-28

申请号：US14358998

申请日：2012-11-15

申请人： OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIYU “PHARMENTERPRISES”

发明人： Vladimir Evgenievich Nebolsin ,  Galina Alexandrovna Zheltukhina ,  Sergei Alexandrovich Okorochenkov

IPC分类号： C07D487/22 ,  C07K14/795 ,  A61K31/555 ,  A61K38/00 ,  C07F15/02 ,  C07K5/062 ,  C07K5/072

CPC分类号： C07F15/025 ,  A61K31/555 ,  A61K38/00 ,  C07D487/22 ,  C07K5/06069 ,  C07K5/06095 ,  C07K5/06104 ,  C07K14/795 ,  Y02A50/473

摘要： The invention relates to hemin derivatives of general formula (I), preparing and use thereof as antibacterial and/or antiviral agents, including, as a component in a pharmaceutical compositions. Advantages of the antibacterial and antiviral agents based on the hemin derivatives are in their biocompatibility, biodegradability, a high efficacy against resistant bacteria and widespread viruses which are dangerous to humans, and the lack of toxicity.

公开(公告)号：US20110243849A1

公开(公告)日：2011-10-06

申请号：US13077686

申请日：2011-03-31

申请人： Michael A. Marletta ,  Michael B. Winter ,  Emily J. McLaurin ,  Steven Y. Reece ,  Charles Olea, JR. ,  Daniel G. Nocera

发明人： Michael A. Marletta ,  Michael B. Winter ,  Emily J. McLaurin ,  Steven Y. Reece ,  Charles Olea, JR. ,  Daniel G. Nocera

IPC分类号： A61K49/00 ,  C07K14/795 ,  C07K14/805 ,  C07K14/80 ,  C12N9/96 ,  C12P21/00 ,  G01N21/75 ,  C12N13/00 ,  C07K19/00 ,  B82Y15/00

CPC分类号： C07K14/80 ,  A61K41/0071 ,  B82Y15/00 ,  C07K14/795 ,  C07K14/805 ,  G01N33/52

摘要： The present disclosure provides photoactive polypeptides. A subject photoactive polypeptide is useful in a variety of applications, which are also provided.

摘要翻译： 本公开提供光活性多肽。 受试者光活性多肽在各种应用中是有用的，其也被提供。

公开(公告)号：US20050054037A1

公开(公告)日：2005-03-10

申请号：US10490795

申请日：2002-10-01

申请人： Daniel Wallace ,  Katherine Arden ,  Palle Pedersen ,  Nathan Subramaniam

发明人： Daniel Wallace ,  Katherine Arden ,  Palle Pedersen ,  Nathan Subramaniam

IPC分类号： A61P43/00 ,  C07K14/47 ,  C12Q1/68 ,  C12Q1/6883 ,  C07H21/04 ,  C12P21/04 ,  C07K16/18 ,  C07K14/795

CPC分类号： C07K14/47 ,  C12Q1/6883 ,  C12Q2600/156

摘要： A mutant, human ferroportin-1 protein and encoding nucleic acid are provided. The mutant ferroportin-1 protein has a deletion of valine 162 compared to wild-type ferroportin-1 protein. The mutant protein and nucleic acid may be useful in detection of a predisposition to iron overload disorders such as haemochromatosis. Furthermore, it is proposed that the valine 162 deletion is a loss-of-function mutation that may underlie iron overload disorders such as haemochromatosis. Therefore, methods of both diagnosis and treatment of haemochromatosis are provided.

摘要翻译： 提供了一种突变型人铁红蛋白-1蛋白和编码核酸。 与野生型铁路蛋白-1蛋白相比，突变体ferroportin-1蛋白具有缬氨酸162的缺失。 突变体蛋白质和核酸可用于检测铁过度失调如血色素沉着症的倾向。 此外，提出缬氨酸162缺失是功能丧失突变，其可能是铁过度失调如血色素沉着症的基础。 因此，提供了诊断和治疗血色素沉着症的方法。

公开(公告)号：US5770404A

公开(公告)日：1998-06-23

申请号：US659416

申请日：1996-06-06

申请人： Gerald W. Camiener

发明人： Gerald W. Camiener

IPC分类号： A61K38/00 ,  C07K14/795 ,  C12P17/10 ,  C12P21/02 ,  C12P21/04 ,  A61K35/14 ,  A61K38/16 ,  C07B47/00

CPC分类号： C07K14/795 ,  C12P17/10 ,  C12P21/02 ,  A61K38/00

摘要： Hemin-like porphyrins can be prepared from chlorophylls which may be used as intermediates to form functionally active hemoproteins. The porphyrins can be reacted with apoproteins in vitro or added to a cell culture and combined intracellularly with apoproteins to form functionally active hemoproteins.

摘要翻译： 血红素卟啉可由叶绿素制备，可用作中间体形成功能活性血红蛋白。 卟啉可以在体外与脱辅酶蛋白反应或加入到细胞培养物中，并与细胞内的蛋白质组合以形成功能活性的血红蛋白。

公开(公告)号：US5700770A

公开(公告)日：1997-12-23

申请号：US447853

申请日：1995-05-23

申请人： Ture Damhus ,  Ole Kirk ,  Gitte Pedersen ,  Manuel Garcia Venegas

发明人： Ture Damhus ,  Ole Kirk ,  Gitte Pedersen ,  Manuel Garcia Venegas

IPC分类号： C07K14/32 ,  C07K14/795 ,  C11D3/00 ,  C11D3/386 ,  C12N9/08 ,  D06L3/02 ,  C11D3/395

CPC分类号： C12N9/0065 ,  C07K14/32 ,  C07K14/795 ,  C11D3/0021 ,  C11D3/38654 ,  D06L3/021

摘要： The transfer of a textile dye from a dyed fabric to another fabric during washing or rinsing is inhibited by adding an enzyme exhibiting peroxidase activity or an enzyme exhibiting a suitable oxidase activity to the wash liquor in which said fabrics are washed and/or rinsed. Peroxidase is produced extracellularly by some strains of Bacillus pumilus. The novel peroxidase preparation from B. pumilus is a microperoxidase, i.e. it contains hemopeptide as an active component. The preparation has improved stability at high temperature, at high pH and at high concentrations of hydrogen peroxide. It can be produced without undesired catalase activity.

摘要翻译： 在洗涤或漂洗中洗涤液中加入显示过氧化物酶活性的酶或显示出合适的氧化酶活性的酶，可以抑制纺织染料从染色织物转移到另一种织物。 过氧化物酶由一些短小芽孢杆菌菌株细胞外产生。 来自短小芽孢杆菌的新型过氧化物酶制剂是微过氧化物酶，即它含有血肽作为活性成分。 该制剂改善了高温下，高pH和高浓度过氧化氢的稳定性。 可以产生没有不需要的过氧化氢酶活性。

公开(公告)号：US5171679A

公开(公告)日：1992-12-15

申请号：US461215

申请日：1990-01-05

申请人： Erasmus Huber ,  Josef Dieckhoff ,  Christian Klein ,  Konrad Kurzinger

发明人： Erasmus Huber ,  Josef Dieckhoff ,  Christian Klein ,  Konrad Kurzinger

IPC分类号： G01N33/53 ,  C07H23/00 ,  C07K14/00 ,  C07K14/795 ,  G01N33/531 ,  G01N33/82

CPC分类号： C07H23/00 ,  G01N33/531 ,  G01N33/82

摘要： The present invention provides cobalamin acid hydrazides of the general formula:B--CO--NH--NH--R--CO--NH--NH).sub.x H (I)wherein B is a residue formed from a cobalamin by the splitting off of a --CONH.sub.2 group, R is a spacer and x is 0 or 1, as well as a process for the preparation thereof.The present invention also provides cobalamin conjugates of the general formula:B--d--CO--NH--NH--R--CO--NH).sub.x N.dbd.GP (II)in which B, R and x have the above-given meanings and d signifies the position of --CO--NH--, as well as a process for the preparation thereof. These cobalamin conjugates are very suitable for use in immunoassays, especially for the determination of cyanocobalamin.

摘要翻译： 本发明提供了以下通式的钴胺酸酰肼：B-CO-NH-NH-R-CO-NH-NH）xH（I）其中B是通过分解-CONH 2基团由钴胺素形成的残基 ，R为间隔基，x为0或1，以及其制备方法。 本发明还提供了以下通式的钴胺素共轭物：Bd-CO-NH-NH-R-CO-NH）xN = GP（II）其中B，R和x具有上述含义，d表示位置 的-CO-NH-，以及其制备方法。 这些钴胺素共轭物非常适用于免疫测定，特别是用于测定氰钴胺素。