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    Synthesis of polymers from cyclic diolides
    3.
    发明授权
    Synthesis of polymers from cyclic diolides 有权

    公开(公告)号：US11629223B2

    公开(公告)日：2023-04-18

    申请号：US17206400

    申请日：2021-03-19

    申请人： Colorado State University Research Foundation

    发明人： Eugene Y. Chen ,  Xiaoyan Tang

    IPC分类号： C08G63/08 ,  C08L67/04 ,  C08G63/82 ,  B01J31/22 ,  C08G63/664

    摘要： Biodegradable polymers with advantageous physical and chemical properties are described, as well as methods for making such polymers. In one embodiment, a new chemical synthesis route to technologically important biodegradable poly(3-hydroxybutyrate) (P3HB) with high isotacticity and molecular weight required for a practical use is described. The new route can utilize racemic eight-membered cyclic diolide (rac-DL), meso-DL, or a rac-DL and meso-DL mixture, derived from bio-sourced dimethyl succinate, and enantiomeric (R,R)-DL and (S,S)-DL, optically resolved by metal-based catalysts. With a stereoselective racemic molecular catalyst, the ROP of rac-DL under ambient conditions produces rapidly P3HB with essentially perfect isotacticity ([mm]>99%), high crystallinity and melting temperature (Tm=171° C.), as well as high molecular weight and low dispersity (Mn=1.54×105 g/mol, Ð=1.01).

    COMPOSITIONS COMPRISING TRIBLOCK COPOLYMERS
    7.
    发明申请
    COMPOSITIONS COMPRISING TRIBLOCK COPOLYMERS 审中-公开

    公开(公告)号：US20190211206A1

    公开(公告)日：2019-07-11

    申请号：US15772992

    申请日：2016-11-04

    申请人： INGELL TECHNOLOGIES HOLDING B.V.

    发明人： Ronald MEIJBOOM ,  Paul Marcel VAN MIDWOUD ,  Maarten VAN DIJK ,  Theodorus Adrianus Cornelius FLIPSEN ,  Esther DE BOEF

    IPC分类号： C08L71/02 ,  C08G63/664 ,  A61L27/18 ,  A61L27/54 ,  A61K9/00 ,  A61K9/107 ,  A61K47/10 ,  A61K47/34 ,  A61L27/58

    摘要： A composition including a) 55-98.9 wt % of at least one type of triblock copolymer (A) of formula (1) R—B-A-B—R   (1) b) 0.1-15 wt % of at least one surfactant (B) and c) 1-30 wt % of water, wherein A is a hydrophilic block having a number average molecular weight (Mn) of 100-1,000 Da, B is a hydrophobic block made from monomers having at least a monomer B1 and a monomer B2, wherein B1 and B2 have the largest weight contents in the hydrophobic block and B1 has a lower molecular weight than B2, wherein R is an end group which is H or a C1-C30 organic moiety, wherein the composition is fluid in a temperature range of 0° C. to 37° C., wherein the weight % are relative to the sum of a), b) and c), and wherein the sum of components a), b) and c) is at least 80 wt % of the entire composition, preferably at least 90 wt %; to the use of the composition and to pharmaceutical composiitons having said composition and an active pharmaceutical ingredient.