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公开(公告)号：US12128092B2
公开(公告)日：2024-10-29
申请号：US16995173
申请日：2020-08-17
CPC分类号： A61K38/4846 , A61K9/0019 , A61K9/19 , A61K47/183 , A61K47/22 , A61K47/26 , C12Y304/21022 , F26B5/06
摘要： The present invention provides, among other things, pre-lyophilization formulations, reconstituted formulations, and lyophilate powder compositions comprising a Factor IX (FIX) polypeptide. The present invention also provides lyophilization methods for producing lyophilate powder comprising a FIX polypeptide.
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2.发明公开公开(公告)号：US20240240860A1
公开(公告)日：2024-07-18
申请号：US18288327
申请日：2022-03-21
申请人： MEDIKAN CO., LTD.
发明人： Hee Young LEE , Byung Young JUHN , Min Jae LEE
摘要： A vacuum freeze-dryer for freeze-drying a sample in a pressure state of below the triple point of water according to an embodiment of the disclosure includes a freeze-drying chamber that is sealed and in which the sample is arranged, a first pump comprising an inlet connected to the freeze-drying chamber and configured to suck water vapor vaporized from the sample, an outlet configured to discharge the water vapor sucked, a storage tank having an inlet and an outlet formed therein and accommodating oil for maintaining seal during when the water vapor sucked from the inlet is moved to the outlet, an apparatus for separating moisture from oil connected to the first pump and separating moisture from the oil in the first pump, and a second pump connected to the apparatus for separating moisture from oil and generating a negative pressure in the apparatus for separating moisture from oil.
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公开(公告)号：US20240142172A1
公开(公告)日：2024-05-02
申请号：US18279629
申请日：2022-03-02
申请人： GEA Lyophil GmbH
摘要： A freeze dryer that includes a product chamber configured to accommodate products to be freeze-dried; a condenser connected to the product chamber and configured to trap water during a freeze-drying process; a product chamber cooling circuit configured to cool the product chamber, the product chamber cooling circuit having a first heat transfer fluid; a condenser cooling circuit configured to cool the condenser, the condenser cooling circuit having a second heat transfer fluid and being separate from the product chamber cooling circuit; a first additional cooling circuit having carbon dioxide or ammonia or liquid nitrogen as refrigerant; and a first heat exchanger configured to transfer heat between the condenser cooling circuit and the first additional cooling circuit.
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公开(公告)号：US20240053099A1
公开(公告)日：2024-02-15
申请号：US18474051
申请日：2023-09-25
申请人： FUJIFILM Corporation
发明人： Yusuke MOCHIZUKI , Hideo FUSHIMI , Nobuhiko KATO
摘要： The present disclosure provides a freeze-drying container which includes a container body storing liquid to be freeze-dried and a first heat transfer body being in contact with the liquid to be freeze-dried and a cold source and in which the container body is a non-heat transfer body or a second heat transfer body of which at least a part is in contact with a liquid surface of the liquid to be freeze-dried and the cold source and at least one of a first shortest distance between an arbitrary point on the liquid surface of the liquid to be freeze-dried and the first heat transfer body or a second shortest distance in the liquid surface between the arbitrary point on the liquid surface of the liquid to be freeze-dried and the second heat transfer body is 20 mm or less.
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公开(公告)号：US11887867B2
公开(公告)日：2024-01-30
申请号：US16452560
申请日：2019-06-26
发明人： Torsten Dsaak , Thomas Meyer , Bernd Teichert , Ralf Biedermann
CPC分类号： H01L21/67034 , C23C14/566 , F26B5/042 , F26B5/06
摘要： According to various embodiments, a vacuum arrangement may comprise the following: a first dehydration chamber and a second dehydration chamber, which are gas-separated from one another; a substrate transfer chamber for changing clocked substrate transport into continuous substrate transport towards the second dehydration chamber; a first high-vacuum pump of gas-transfer type for evacuating the first dehydration chamber; and a second high-vacuum pump of gas-binding type for evacuating the second dehydration chamber; wherein the first dehydration chamber is, with respect to the substrate transport, arranged between the second dehydration chamber and the substrate transfer chamber.
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公开(公告)号：US20240000711A1
公开(公告)日：2024-01-04
申请号：US18348675
申请日：2023-07-07
摘要： Herein described are an assembly, apparatus, and method for lyophilization that utilizes a thermal block made from a conductive material, the block having multiple wells designed and dimensioned to receive containers carrying material to be lyophilized in situ. In preferred embodiments, a vented silicone pad covers the wells and secures the containers therein, and a similarly vented rigid plate in turn secures the silicone pad by fastening it to the thermal block. The assembly can be turned up to 90 degrees resulting in the turning of the containers from an upright position to a horizontal position, a position in which the distance through which sublimation must progress is drastically reduced so as to greatly enhance the efficiency of the lyophilization process.
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公开(公告)号：US20230392867A1
公开(公告)日：2023-12-07
申请号：US18205140
申请日：2023-06-02
发明人： Amanda Copple , William C. Beeler
摘要： Disclosed is a document remediation system including a dryer configured to dry a document and output a dried document; one or more sensors configured to detect a moisture content of the document within the dryer; a cleaning device configured to receive the dried document, remove debris therefrom, and output a cleaned document; a sanitizer configured to receive the cleaned document, disinfect the cleaned document, and output a remediated document; a vacuum connected to at least one of the dryer, the cleaning device and the sanitizer and configured to remove document debris from one or more of the dryer, the cleaning device, and the sanitizer; and a transportation device interconnecting the dryer, the cleaning device and the sanitizer, the transportation device being configured to receive the document and convey the document through at least the dryer, the cleaning device, and the sanitizer.
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公开(公告)号：US11806431B2
公开(公告)日：2023-11-07
申请号：US17337306
申请日：2021-06-02
申请人： Velico Medical Inc.
发明人： Qiyong Peter Liu , Junqing Cui , Rud Karly Lucien , Ryan Carney , Jihae Sohn , Michelle Arya , Abdul W. Khan
IPC分类号： A61K9/16 , F26B3/06 , F26B3/12 , F26B5/04 , A61K35/16 , B01J19/06 , F26B3/04 , F26B5/06 , B65D81/26 , B65D51/30
CPC分类号： A61K9/1682 , A61K9/16 , A61K9/1617 , A61K9/1688 , A61K35/16 , B01J19/06 , F26B3/04 , F26B3/06 , F26B3/12 , F26B5/04 , B01J2219/00177 , B65D51/30 , B65D81/266 , F26B5/065
摘要： A method of treatment of plasma with a physiologically compatible spray dry stable acidic substance (SDSAS) prior to or contemporaneously with spray drying of the plasma that results in greater recovery and greater long-term stabilization of the dried plasma proteins as compared to spray dried plasma that has not be subject to the formulation method of the present invention, as well as compositions related to plasma dried by the methods of the present invention.
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公开(公告)号：US11747082B2
公开(公告)日：2023-09-05
申请号：US18070085
申请日：2022-11-28
发明人： Kestas P. Parakininkas , Eric T. Hansen , Kirk L. Weimer , Nathaniel T. Johnson , Dennis J. Hlavinka
IPC分类号： F26B5/06 , A61M1/02 , A01N1/02 , A61J1/10 , F26B21/14 , A61J1/14 , B65D51/24 , F26B25/06 , F26B25/18
CPC分类号： F26B5/06 , A01N1/0263 , A01N1/0284 , A01N1/0289 , A61J1/10 , A61M1/0277 , F26B21/14 , A01N1/0252 , A61J1/1468 , A61M2202/0415 , A61M2205/3389 , A61M2205/584 , B65D51/241 , F26B25/063 , F26B25/18
摘要： Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and a peelable region including a peelable seal encompassing a boundary between the non-breathable section and the breathable section. The method includes inputting a fluid into a non-breathable section of the container, freezing the fluid, applying, in a lyophilization chamber, vacuum pressure, opening the peelable seal using a pressure differential, applying heat energy, sublimating the fluid and creating a temporary occlusion in a peelable region of the container.
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公开(公告)号：US11744776B2
公开(公告)日：2023-09-05
申请号：US18054252
申请日：2022-11-10
IPC分类号： A61J1/20 , A61J1/14 , A61K31/4184 , A61K31/706 , A61K45/06 , A61M5/14 , B65D77/04 , B65D81/32 , A61J1/10 , B65D75/58 , A61K9/19 , C08L25/08 , F26B5/06 , F26B25/06
CPC分类号： A61J1/2024 , A61J1/10 , A61J1/1468 , A61J1/1475 , A61J1/2089 , A61J1/2093 , A61K31/4184 , A61K31/706 , A61K45/06 , A61M5/1407 , A61M5/1411 , A61M5/1413 , B65D75/5883 , B65D77/04 , B65D81/3261 , B65D81/3266 , B65D81/3272 , A61J1/1481 , A61K9/19 , A61M2205/3606 , C08L25/08 , F26B5/06 , F26B25/063
摘要： A method of preparing a pharmaceutical product in a single multiple chamber flexible bag. A pharmaceutical product is introduced in a liquid state into a first chamber of the flexible bag through a first port. The pharmaceutical product is lyophilized within the first chamber of the flexible bag to provide a lyophilized pharmaceutical product. The flexible bag has a second chamber and the first chamber and the second chamber are separated by a breakable seal. The second chamber further includes a reconstituting solution for reconstituting the lyophilized pharmaceutical product in the first chamber. A user may apply pressure to the flexible bag to break the seal and mix the lyophilized pharmaceutical product and the reconstituting solution to order to administer the pharmaceutical product to a patient.
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