公开(公告)号：US12055535B2

公开(公告)日：2024-08-06

申请号：US16781409

申请日：2020-02-04

申请人： The Cleveland Clinic Foundation

发明人： Stanley L. Hazen ,  Zeneng Wang ,  Bruce S. Levison

IPC分类号： G01N33/48 ,  G01N33/483 ,  G01N33/49 ,  G01N33/493 ,  G01N33/68 ,  G01N33/92 ,  H01J49/00

CPC分类号： G01N33/49 ,  G01N33/493 ,  G01N33/6893 ,  G01N33/92 ,  H01J49/0036 ,  G01N2800/32 ,  G01N2800/323 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56 ,  Y10T436/174614

摘要： Methods of characterizing a test subject's risk of having or developing cardiovascular disease are provided. The methods include using an analytic device to determine levels of choline-related trimethylamine-containing compounds such as trimethylamine N-oxide, choline, or betaine in a biological sample obtained from the subject and comparing the levels of the choline-related trimethylamine-containing compound in the subject's biological sample to a control value. The test subject's risk of having cardiovascular disease is then characterized as higher if the levels of the choline-related trimethylamine-containing compound are higher than the control value. Also provided are methods of identifying a subject at risk of experiencing a complication of atherosclerotic cardiovascular disease, and methods of evaluating the efficacy of a cardiovascular therapeutic agent in a subject with cardiovascular disease using levels of choline-related trimethylamine-containing compounds.

公开(公告)号：US20240230623A9

公开(公告)日：2024-07-11

申请号：US18403577

申请日：2024-01-03

申请人： Shanghai Kohler Electronics, Ltd.

发明人： Qintao Sun

IPC分类号： G01N33/493 ,  A61B5/20 ,  A61B10/00

CPC分类号： G01N33/493 ,  A61B5/207 ,  A61B10/007 ,  G16H80/00

摘要： A method of automatically tracking urine in a toilet includes creating a background image of an interior of a toilet bowl using an image sensor, wherein the background image shows the interior of the toilet bowl. The method also includes acquiring an image of the interior of the toilet bowl using the image sensor, wherein the acquired image shows urine and a collecting and tracking member in the interior of the toilet bowl. The method further includes producing a difference image that shows a difference between the acquired image and the background image, and processing the difference image to identify a location of the urine and the collecting and tracking member, and moving the collecting and tracking member to the identified location of the urine.

公开(公告)号：US12019062B2

公开(公告)日：2024-06-25

申请号：US17742204

申请日：2022-05-11

申请人： Shanghai Kohler Electronics, Ltd.

发明人： Zhiyu Qin

IPC分类号： B65D83/08 ,  G01N33/48 ,  G01N33/487 ,  G01N33/493

CPC分类号： G01N33/48757 ,  B65D83/08 ,  G01N33/48 ,  G01N33/493

摘要： The present invention provides a test paper box and a smart toilet containing same. The test paper box comprises a support and a housing arranged at the outside of the support. The support comprises a base and an elongated cavity arranged at the base for storing test paper. The base is provided with a through hole arranged at a location corresponding to a bottom surface of the elongated cavity. A paper-receiving slot is arranged below the through hole. The paper-receiving slot is fixed to the bottom of the base to receive the bottommost piece of test paper exposed from the elongated cavity, and the paper-receiving slot is provided with a paper outlet. The test paper box can be attached and detached conveniently, delivers test paper smoothly, can be replaced easily, has low costs, and is suitable for smart toilets.

公开(公告)号：US11971356B2

公开(公告)日：2024-04-30

申请号：US18085685

申请日：2022-12-21

申请人： OUTSENSE DIAGNOSTICS LTD.

发明人： Ishay Attar ,  Yaara Kapp-Barnea

IPC分类号： G01N21/64 ,  A61B10/00 ,  E03D11/13 ,  G01J3/10 ,  G01J3/28 ,  G01J3/42 ,  G01J5/0806 ,  G01J5/0808 ,  G01J5/10 ,  G01N21/31 ,  G01N33/493 ,  G01N33/574

CPC分类号： G01N21/6486 ,  A61B10/0038 ,  A61B10/007 ,  G01J3/10 ,  G01J3/2803 ,  G01J5/0806 ,  G01J5/0808 ,  G01J5/10 ,  G01N21/31 ,  G01N21/645 ,  G01N33/493 ,  A61B2010/0006 ,  E03D11/13 ,  G01J2003/104 ,  G01J3/42 ,  G01N2021/6421 ,  G01N33/57419

摘要： Apparatus and methods are described for use with feces of a subject that are disposed within a toilet bowl. One or more light sensors receive light from the toilet bowl, while the feces are disposed within the toilet bowl. A computer processor detects a set of three or more spectral components that have a characteristic relationship with each other in a light spectrum of bile, by analyzing the received light, and detects a presence of bile within the feces, in response to detecting the set of three or more spectral components. The computer processor generates an output in response thereto. Other applications are also described.

公开(公告)号：US11971335B2

公开(公告)日：2024-04-30

申请号：US18198968

申请日：2023-05-18

申请人： Shanghai Kohler Electronics, Ltd.

发明人： Zhiyu Qin ,  Qintao Sun

IPC分类号： G01N1/14 ,  E03D9/00 ,  G01F23/263 ,  G01N33/493

CPC分类号： G01N1/14 ,  E03D9/00 ,  G01F23/263 ,  G01N33/493

摘要： The present disclosure provides a method for collecting liquid comprising: collecting the liquid, by a pump body mechanism, into a cavity of a suction tube assembly; monitoring, by a liquid-level sensing mechanism, an amount of the liquid collected in the cavity; controlling, by the liquid-level sensing mechanism, a start and a stop of collecting the liquid in response to the amount of the liquid collected in the cavity; and cleaning the cavity by delivering, by the pump body mechanism, water into the cavity in response to the stop of collecting the liquid.

公开(公告)号：US20240117407A1

公开(公告)日：2024-04-11

申请号：US18306710

申请日：2023-04-25

申请人： Concert Pharmaceuticals, Inc.

发明人： Roger Tung

IPC分类号： C12Q1/28 ,  A61K31/195 ,  A61K31/4709 ,  A61K31/485 ,  A61K31/49 ,  C07B59/00 ,  C07D221/28 ,  C07D471/08 ,  G01N33/49 ,  G01N33/493

CPC分类号： C12Q1/28 ,  A61K31/195 ,  A61K31/4709 ,  A61K31/485 ,  A61K31/49 ,  C07B59/002 ,  C07D221/28 ,  C07D471/08 ,  G01N33/491 ,  G01N33/493

摘要： This disclosure relates to novel morphinan compounds and their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides compositions comprising a compound of this disclosure and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a σ1 receptor agonist that also has NMDA antagonist activity.

公开(公告)号：US20240103020A1

公开(公告)日：2024-03-28

申请号：US18272428

申请日：2022-01-13

申请人： QSM Diagnostics, Inc.

发明人： Edgar D. GOLUCH ,  Nicholas CADIROV

IPC分类号： G01N33/68 ,  G01N27/327 ,  G01N33/487 ,  G01N33/49 ,  G01N33/493

CPC分类号： G01N33/6893 ,  G01N27/3277 ,  G01N33/48714 ,  G01N33/492 ,  G01N33/493 ,  G01N2800/348

摘要： The present disclosure relates to, inter alia, materials, and methods for detection of infection. More particularly materials, and methods for detecting an infection in a subject's urine or wound exudate are described, e.g. by electrochemically measuring a target molecule and/or a metabolic activity associated with infection using an electrochemical sensor array.

公开(公告)号：US20240102901A1

公开(公告)日：2024-03-28

申请号：US18373110

申请日：2023-09-26

申请人： SALUS DISCOVERY, LLC

发明人： Jay Warrick ,  Cody Carrell ,  Brianna Mullins ,  David Beebe ,  Ryan Shogren ,  Patrick McMinn ,  Mitch Geiger ,  Madalyn Gill ,  Jeffrey Robert Staszak ,  Visnu Devi Fraenkel ,  Antonio Gatta ,  Eric S. Mackey ,  McKayla Rae Barber ,  Randi Marie Degg ,  Madeline Sides ,  Douglas Paul Barnes ,  Franklin Cheng Zhong ,  Mindy Phung

IPC分类号： G01N1/40 ,  G01N33/493

CPC分类号： G01N1/4005 ,  G01N33/493 ,  G01N2001/4088

摘要： Provided herein are devices and methods for isolation and detection of an analyte from a sample. In some embodiments, provided herein are devices and methods of use thereof for vertical flow-based isolation and detection of analytes in a liquid sample, such as a urine sample.

公开(公告)号：US20240085400A1

公开(公告)日：2024-03-14

申请号：US18260701

申请日：2021-12-24

申请人： SUMITOMO CHEMICAL COMPANY, LIMITED ,  NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY ,  AINO UNIVERSITY

发明人： Atsufumi OZOE ,  Kentaro KOBAYASHI ,  Yasuhiko TAKAHASHI ,  Kohei MATSUNAGA ,  Takaaki SATO ,  Yoichi MIZUTANI

IPC分类号： G01N33/493 ,  G01N30/72 ,  G01N30/86

CPC分类号： G01N33/493 ,  G01N30/7206 ,  G01N30/8631 ,  G01N2496/00 ,  G01N2560/00

摘要： The present invention provides a technology for performing a test for prostate cancer. This method is for testing the possibility of having prostate cancer, the method comprising (1) measuring the amount or concentration of a biomarker in a body fluid sample collected from a subject, the biomarker being at least one member selected from the group consisting of dimethyl glutarate, 2,6-xylidine, 2-hydroxy-2-methylpropiophenone, 2,6-di(propan-2-yl) phenol, dimethyl succinate, acetophenone, 2-phenyl-2-propanol, and 3,5,5-trimetyl-2-cyclohexenone.

公开(公告)号：US11927588B2

公开(公告)日：2024-03-12

申请号：US17989341

申请日：2022-11-17

申请人： Kohler Co.

发明人： Luncheak Tan ,  Chinghua Chen

IPC分类号： G01N33/493 ,  E03D5/00 ,  E03D5/02 ,  E03D9/00 ,  G01N1/10

CPC分类号： G01N33/493 ,  E03D5/00 ,  E03D5/022 ,  E03D9/00 ,  G01N1/10

摘要： An intelligent toilet that includes a toilet base having a bowl, a seat assembly comprising a seat, and a urine collection system integrated with the seat assembly, wherein the urine collection system includes an analyzer that is configured to test urine from a user and provide output health data of the user.