公开(公告)号：US20240310374A1

公开(公告)日：2024-09-19

申请号：US18277717

申请日：2022-02-17

申请人： FUJITA ACADEMY ,  NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM

发明人： Yoshihisa SUGIMURA ,  Atsushi SUZUKI ,  Haruki FUJISAWA ,  Naoko IWATA ,  Takashi WATANABE ,  Kozo KAIBUCHI ,  Tomoki NISHIOKA

IPC分类号： G01N33/564

CPC分类号： G01N33/564 ,  G01N2800/24 ,  G01N2800/56

摘要： The purpose of the present disclosure is to provide a technique that can contribute to less invasive or more reliable diagnosis of lymphocytic anterior hypophysitis and its related diseases. For this purpose, the KCNMA1 (calcium-activated potassium channel subunit alpha-1) protein or an epitope thereof is used as a diagnostic agent for lymphocytic anterior hypophysitis.

公开(公告)号：US20240302366A1

公开(公告)日：2024-09-12

申请号：US18273153

申请日：2022-01-25

申请人： SEKISUI MEDICAL CO., LTD.

发明人： Kengo FUJIMURA ,  Daigo NOMOTO ,  Tomo SHIMIZU ,  Yuki KORA

IPC分类号： G01N33/564 ,  G01N33/543

CPC分类号： G01N33/564 ,  G01N33/54313 ,  G01N2333/4716

摘要： An object of the invention is to suppress non-specific reaction in an immunoreaction measurement method. An immunoassay method characterized by conducting immunoreaction in the presence of an anti-C3 antibody in a method for measuring an analyte in a sample immunologically is provided. Moreover, a method for suppressing non-specific reaction in a method for immunologically measuring an analyte in a sample which is characterized by conducting immunoreaction in the presence of an anti-C3 antibody is provided.

公开(公告)号：US20240302365A1

公开(公告)日：2024-09-12

申请号：US18255680

申请日：2021-11-12

申请人： MD HEALTHCARE INC. ,  AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

发明人： Hae-Sim PARK ,  Youngwoo CHOI ,  Yoon-Keun KIM

IPC分类号： G01N33/564 ,  G01N33/68

CPC分类号： G01N33/564 ,  G01N33/6854 ,  G01N2333/212 ,  G01N2800/24

摘要： Provided is a method for providing information on chronic urticaria and, more specifically, the provided is a method for diagnosing chronic urticaria by measuring an allergen-specific IgE antibody for a vesicle derived from Acinetobacter bacteria; a diagnostic composition using the same; and the like.

公开(公告)号：US20240298956A1

公开(公告)日：2024-09-12

申请号：US18588150

申请日：2024-02-27

申请人： Abbott Laboratories

发明人： Beth McQuiston ,  Frederick Korley ,  Agim Beshiri ,  Jaime Marino ,  Saul Datwyler

IPC分类号： A61B5/00 ,  C12Q1/6883 ,  G01N33/533 ,  G01N33/543 ,  G01N33/564 ,  G01N33/577 ,  G01N33/68

CPC分类号： A61B5/4064 ,  G01N33/54346 ,  G01N33/54366 ,  G01N33/577 ,  G01N33/6896 ,  C12Q1/6883 ,  G01N33/533 ,  G01N33/564 ,  G01N33/6893 ,  G01N2800/28 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/60

摘要： Disclosed herein are methods that aid in the diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or a moderate, severe, or moderate to severe traumatic brain injury (TBI), by detecting levels of cardiac troponin I (cTnI) and one or more early biomarkers which are not cTnI, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof, in biological samples taken from a human subject at time points within about 24 hours of injury after the subject has sustained or may have sustained the injury to the head.

公开(公告)号：US20240254556A1

公开(公告)日：2024-08-01

申请号：US18560569

申请日：2022-05-13

申请人： GENZYME CORPORATION

发明人： Darren Phillip BAKER ,  Emanuele DE RINALDIS ,  Richa HANAMSAGAR ,  Evis HAVARI ,  Virginia SAVOVA ,  Srinivas SHANKARA

IPC分类号： C12Q1/6883 ,  C12Q1/6874 ,  G01N33/564

CPC分类号： C12Q1/6883 ,  C12Q1/6874 ,  G01N33/564 ,  C12Q2600/158 ,  G01N2800/046 ,  G01N2800/285 ,  G01N2800/50 ,  G01N2800/52

摘要： The invention provides methods of assessing the risk of secondary autoimmunity in a patient with a primary autoimmune disease (e.g., MS) following lymphocyte depleting therapy (e.g., anti-CD52 antibody therapy) based on the fraction of a novel cell type termed platelet lineage cells (PLCs) among total cells, and/or the Immature Platelet Fraction (IPF) value, in a biological sample from the patient.

公开(公告)号：US20240254243A1

公开(公告)日：2024-08-01

申请号：US18563818

申请日：2022-06-16

申请人： Prometheus Laboratories Inc.

发明人： Thierry DERVIEUX

IPC分类号： C07K16/28 ,  C07K16/24 ,  G01N33/564 ,  G16H10/40 ,  G16H20/10

CPC分类号： C07K16/2866 ,  C07K16/241 ,  G01N33/564 ,  G16H10/40 ,  G16H20/10 ,  C07K2317/21 ,  C07K2317/24 ,  G01N2800/52

摘要： Provided herein are systems and methods for optimizing a biological therapy regimen for a subject. The subject may be a patient diagnosed with an immune mediated inflammatory disease. In some embodiments, the systems and methods may involve inputting patient data into a model to forecast a drug concentration level in a patient and establish a dosing regimen for maintaining a pre-specified threshold drug concentration level in the patient. The pre-specified threshold may be a target concentration level for effective treatment of the immune mediated inflammatory disease in the patient.

公开(公告)号：US20240245712A1

公开(公告)日：2024-07-25

申请号：US18413949

申请日：2024-01-16

申请人： Mayo Foundation for Medical Education and Research

发明人： Sanjeev Sethi ,  Fernando C. Fervenza ,  Benjamin J. Madden

IPC分类号： A61K31/65 ,  A61K31/43 ,  A61P13/12 ,  G01N33/564

CPC分类号： A61K31/65 ,  A61K31/43 ,  A61P13/12 ,  G01N33/564 ,  G01N2800/347

摘要： This document relates to methods and materials involved in identifying and/or treating mammals having membranous nephropathy (e.g., membranous nephropathy with an elevated level of a neuron-derived neurotrophic factor (NDNF) polypeptide in the glomerular basement membrane (GBM)). For example, methods and materials for administering one or more antimicrobial agents to treat a mammal (e.g., a human) having membranous nephropathy are provided.

公开(公告)号：US20240241118A1

公开(公告)日：2024-07-18

申请号：US18289332

申请日：2022-01-24

申请人： The Johns Hopkins University

发明人： Antony Rosen ,  Brittany Adler ,  Livia A. Casciola-Rosen

IPC分类号： G01N33/564 ,  C12Q1/6841 ,  C12Q1/6851 ,  C12Q1/6883

CPC分类号： G01N33/564 ,  C12Q1/6883 ,  C12Q1/6841 ,  C12Q1/6851 ,  G01N2800/12 ,  G01N2800/24

摘要： Provided herein are methods of identifying a disease in a subject that include: (a) providing a biological sample from a subject; and (b) detecting an autoantibody that targets an antigen present in a telomerase/shelterin complex in the biological sample, thereby identifying a disease in the subject.

公开(公告)号：US20240230640A1

公开(公告)日：2024-07-11

申请号：US18459908

申请日：2023-09-01

申请人： Prometheus Laboratories Inc.

发明人： Anjali JAIN ,  Venkateswarlu KONDRAGUNTA ,  Michael HALE

IPC分类号： G01N33/564 ,  G01N33/68

CPC分类号： G01N33/564 ,  G01N33/6893 ,  G01N2800/065 ,  G01N2800/52

摘要： The present disclosure provides methods for assessing mucosal healing in a patient with Crohn's Disease. The methods include detecting expression levels of analytes in a serum sample from a patient, and applying a mathematical algorithm to the expression levels, thereby producing a Mucosal Healing Index score for the patient. The present disclosure also provides kits that include two or more binding partners, each or which is capable of binding a different analyte measured in the disclosed mucosal healing assessment methods.

公开(公告)号：US20240210393A1

公开(公告)日：2024-06-27

申请号：US18400666

申请日：2023-12-29

申请人： Seattle Children's Hospital

发明人： Neelufar Mozaffarian ,  Anne M. Stevens

IPC分类号： G01N33/564 ,  A61B5/00 ,  A61K31/713 ,  A61K38/06 ,  A61K38/07 ,  A61K39/395 ,  C07K16/28

CPC分类号： G01N33/564 ,  A61B5/0082 ,  A61B5/4842 ,  A61K31/713 ,  A61K38/06 ,  A61K38/07 ,  A61K39/3955 ,  C07K16/2803 ,  C07K2317/76 ,  G01N2333/70503 ,  G01N2800/102 ,  G01N2800/104 ,  G01N2800/56 ,  Y10S436/811

摘要： Disclosed herein are methods of treatment of autoimmune diseases such as systemic lupus erythematosus (SLE) as well as clinical assays for detection of autoimmune disease activity in patients utilizing a PD1 ligand.