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    HMO PRODUCTION
    2.
    发明申请
    HMO PRODUCTION 审中-公开

    公开(公告)号：WO2021148615A1

    公开(公告)日：2021-07-29

    申请号：PCT/EP2021/051473

    申请日：2021-01-22

    Applicant: GLYCOM A/S

    Inventor： PEDERSEN, Margit ,  PAPADAKIS, Manos ,  KAMPMANN, Katrine, Bych

    IPC: C07K14/24 ,  C12P19/04

    Abstract: The present inventive concept relates to a genetically modified cell enabled for the production of an oligosaccharide, preferably, an HMO, comprising a recombinant nucleic encoding a putative transporter protein of the MFS superfamily; and methods using said cell for the production of oligosaccharide(s), preferably an HMO.

    HMO PRODUCTION
    3.
    发明申请
    HMO PRODUCTION 审中-公开

    公开(公告)号：WO2021148610A1

    公开(公告)日：2021-07-29

    申请号：PCT/EP2021/051466

    申请日：2021-01-22

    Applicant: GLYCOM A/S

    Inventor： PAPADAKIS, Manos

    IPC: C07K14/24 ,  C12P19/04

    Abstract: The present inventive concept relates to a genetically modified cell enabled for the production of an oligosaccharide, preferably, an HMO, comprising a recombinant nucleic acid encoding a protein of the MFS superfamily; and methods using said cell for the production the oligosaccharide, preferably an HMO.

    SYNTHETIC COMPOSITION AND METHOD FOR TREATING IRRITABLE BOWEL SYNDROME
    6.
    发明申请
    SYNTHETIC COMPOSITION AND METHOD FOR TREATING IRRITABLE BOWEL SYNDROME 审中-公开
    合成组合物和治疗有效的牙龈综合征的方法

    公开(公告)号：WO2016066175A1

    公开(公告)日：2016-05-06

    申请号：PCT/DK2015/050332

    申请日：2015-10-29

    Applicant: GLYCOM A/S

    Inventor： HENNET, Thierry ,  MCCONNELL, Bruce ,  SALOMONSSON, Emma ,  VIGSNÆS, Louise Kristine

    IPC: A61K31/702 ,  A61K31/7004 ,  A61K31/7012 ,  A61P1/04

    CPC classification number: A61K31/702 ,  A23C9/206 ,  A23L33/21 ,  A23V2002/00 ,  A61K31/7004 ,  A61K31/7012 ,  A61P1/04 ,  A61K2300/00

    Abstract: The application relates to synthetic compositions containing one or more human milk mono- or oligosaccharides for use treating irritable bowel syndrome and symptoms relating to irritable bowel syndrome. The HMS is preferably selected from sialic acid and fucose and the HMO is preferably selected from 2'-fucosyllactose (2'-FL), 3-fucosyllactose (3-FL), difucosyllactose (DFL), 3'-sialyllactose (3'-SL), 6'-sialyllactose (6'-SL), lacto-N-tetraose (LNT), lacto-N-neotetraose (LNnT), lacto-N-fucopentaose (LNFP-I) and 3',6-disialyllacto-N- tetraose (DSLNT).

    Abstract translation: 本申请涉及含有一种或多种用于治疗肠易激综合征的人乳单糖或寡糖的合成组合物和与肠易激综合征相关的症状。 HMS优选选自唾液酸和岩藻糖，HMO优选选自2'-岩藻糖基乳糖（2'-FL），3-岩藻糖基乳糖（3-FL），二糖基乳糖（DFL），3'-唾液酸乳糖（3'- SL），6'-唾液乳糖（6'-SL），乳-N-四糖（LNT），乳-N-新四糖（LNnT），乳-N-硝酸五糖（LNFP-1）和3'，6-二唾液酸乳糖 N-四糖（DSLNT）。

    SYNTHESIS OF SIALYLATED/FUCOSYLATED HUMAN MILK OLIGOSACCHARIDES
    7.
    发明申请
    SYNTHESIS OF SIALYLATED/FUCOSYLATED HUMAN MILK OLIGOSACCHARIDES 审中-公开
    异亮氨酸/ FOSOSLIL人乳酪寡糖的合成

    公开(公告)号：WO2014167538A1

    公开(公告)日：2014-10-16

    申请号：PCT/IB2014/060648

    申请日：2014-04-11

    Applicant: GLYCOM A/S

    Inventor： CHASSAGNE, Pierre ,  KHANZHIN, Nikolay ,  HEDEROS, Markus ,  CHAMPION, Elise ,  MATWIEJUK, Martin ,  DEKANY, Gyula

    IPC: C07H1/00 ,  C07H5/04

    CPC classification number: C07H5/04 ,  C07H1/00

    Abstract: This invention relates to achemo-enzymatic synthesis of oligosaccharides of formula 1 I wherein R is selected from -OH, -N 3 and -OR 6 wherein R 6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, -(CH 2 ) n -NH 2 and -(CH 2 ) n -N 3 wherein integer n is to 10,preferably 2 or 3, R is selected from sialyl moiety, -SO 3 H and -CH(R )-COOH wherein R is selected from H, alkyl and benzyl, R 2 is selected from H and fucosyl, R 3 is selected from H and sialyl, R 4 is selected from H and fucosyl, provided that at leastone of R 3 and R 4 is H, and A is a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.

    Abstract translation: 本发明涉及式Ⅰ的寡糖的急速 - 酶合成，其中R选自-OH，-N 3和-OR 6，其中R 6选自任选被一个或多个甲基取代的烯丙基，炔丙基任选地被一个或多个 更多的甲基，2-三甲基甲硅烷基 - 乙基， - （CH 2）n -NH 2和 - （CH 2）n -N 3其中整数n为10，优选2或3，R选自唾液酰基部分，-SO 3 H和-CH（R）-COOH其中R选自H，烷基和苄基，R 2选自H和岩藻糖基，R 3选自H和唾液酸，R 4选自H和岩藻糖基，条件是在 R 3和R 4的leastone为H，且A为二价连接基的碳水化合物，其具有重要的生物活性和用于医药和食品工业显著商业价值。

    METHOD FOR MAKING N-SUBSTITUTED MANNOSAMINE DERIVATIVES
    8.
    发明申请
    METHOD FOR MAKING N-SUBSTITUTED MANNOSAMINE DERIVATIVES 审中-公开
    制备N-取代的曼诺糖胺衍生物的方法

    公开(公告)号：WO2014096331A1

    公开(公告)日：2014-06-26

    申请号：PCT/EP2013/077628

    申请日：2013-12-20

    Applicant: GLYCOM A/S

    Inventor： VRASIDAS, Ioannis ,  VLÁD, Gábor ,  DEKANY, Gyula

    IPC: C07H15/18

    CPC classification number: C07H5/06 ,  C07H15/18

    Abstract: The invention relates to a method for making an N -substituted D-mannosamine derivative of the following formula 1 and its salts wherein R 1 is a non-electron-withdrawing group,and wherein R 2 is -OH or R 2 is –NHR 3 wherein R 3 is a group removable by hydrogenolysis; by epimerizingan N -substituted D-glucosamine derivative of the following formula 2 wherein R 1 and R 2 are as defined above.

    Abstract translation: 本发明涉及制备下式1的N-取代的D-甘露糖胺衍生物及其盐，其中R1是非吸电子基团，其中R2是-OH或R2是-NHR3，其中R3是 通过氢解除去组; 通过下式2的差异异构化N-取代的D-葡糖胺衍生物，其中R 1和R 2如上所定义。

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