公开(公告)号：WO2015195580A2

公开(公告)日：2015-12-23

申请号：PCT/US2015035885

申请日：2015-06-15

Applicant: UNIV LOMA LINDA ,  UNIV LOMA LINDA MED ,  UNIV NORTH CAROLINA STATE

Inventor： KIRSCH WOLFF M ,  HUDSON SAMUEL M ,  CROFTON ANDREW

IPC: A61K31/722

CPC classification number: A61K31/722 ,  A61L24/08 ,  A61L31/042 ,  A61L2400/04 ,  A61L2430/26 ,  C08L5/08

Abstract: A thin chitosan-based material can be used for biomedical applications. The chitosan has been treated in a nitrogen field by applying energy to ionize nitrogen in and around the chitosan material. A single or multiple such treatments may be employed. For example, the chitosan material may be irradiated under nitrogen using γ-irradiation, treated under a nitrogen plasma, or both. A thin chitosan material can be readily treated by surface modifying treatments such as irradiating under nitrogen using γ-irradiation, treating under a nitrogen plasma, or both. A treated thin chitosan material can be utilized to control bleeding and assist in treatment and healing during a surgical procedure, including laparoscopic partial nephrectomy.

Abstract translation: 薄壳聚糖基材料可用于生物医学应用。 壳聚糖已经在氮气田中通过施加能量来电离壳聚糖材料中和周围的氮而被处理。 可以使用单次或多次这样的治疗。 例如，可以使用γ-照射在氮气下照射壳聚糖材料，在氮等离子体下进行处理，或者两者。 通过表面改性处理可以容易地处理薄壳聚糖材料，例如使用γ照射在氮气下照射，在氮等离子体下处理或两者。 经处理的薄壳聚糖材料可用于控制出血并辅助外科手术中的治疗和愈合，包括腹腔镜部分肾切除术。

公开(公告)号：WO2015160719A2

公开(公告)日：2015-10-22

申请号：PCT/US2015025605

申请日：2015-04-13

Applicant: UNIV LOMA LINDA ,  UNIV LOMA LINDA MED ,  UNIV NORTH CAROLINA STATE

Inventor： KIRSCH WOLFF M ,  HUDSON SAMUEL M ,  CROFTON ANDREW

IPC: A61K47/36

CPC classification number: A61F13/00987 ,  A61F13/00012 ,  A61F2013/00106 ,  A61K9/70 ,  A61K47/36 ,  A61L2/0035 ,  A61L2/081 ,  A61L24/0015 ,  A61L24/0042 ,  A61L24/08 ,  A61L2300/232 ,  A61L2300/404 ,  A61L2400/04 ,  A61L2400/18 ,  B29C43/003 ,  B29C2043/561 ,  B29C2793/009 ,  B29K2005/00 ,  B29L2031/7722 ,  C08L5/08

Abstract: A thin chitosan-based material can be used for biomedical applications. The chitosan has been treated in a nitrogen field by applying energy to ionize nitrogen in and around the chitosan material. A single or multiple such treatments may be employed. For example, the chitosan material may be irradiated under nitrogen using γ-irradiation, treated under a nitrogen plasma, or both. A thin chitosan material can be readily treated by surface modifying treatments such as irradiating under nitrogen using γ-irradiation, treating under a nitrogen plasma, or both.

Abstract translation: 薄壳聚糖基材料可用于生物医学应用。 壳聚糖已经在氮气田中通过施加能量来电离壳聚糖材料中和周围的氮而被处理。 可以使用单次或多次这样的治疗。 例如，可以使用γ-照射在氮气下照射壳聚糖材料，在氮等离子体下进行处理，或者两者。 通过表面改性处理可以容易地处理薄壳聚糖材料，例如使用γ照射在氮气下照射，在氮等离子体下处理或两者。

公开(公告)号：WO2015195580A3

公开(公告)日：2016-03-17

申请号：PCT/US2015035885

申请日：2015-06-15

Applicant: UNIV LOMA LINDA ,  UNIV LOMA LINDA MED ,  UNIV NORTH CAROLINA STATE

Inventor： KIRSCH WOLFF M ,  HUDSON SAMUEL M ,  CROFTON ANDREW

IPC: A61K31/722

CPC classification number: A61K31/722 ,  A61L24/08 ,  A61L31/042 ,  A61L2400/04 ,  A61L2430/26 ,  C08L5/08

Abstract: A thin chitosan-based material can be used for biomedical applications. The chitosan has been treated in a nitrogen field by applying energy to ionize nitrogen in and around the chitosan material. A single or multiple such treatments may be employed. For example, the chitosan material may be irradiated under nitrogen using γ-irradiation, treated under a nitrogen plasma, or both. A thin chitosan material can be readily treated by surface modifying treatments such as irradiating under nitrogen using γ-irradiation, treating under a nitrogen plasma, or both. A treated thin chitosan material can be utilized to control bleeding and assist in treatment and healing during a surgical procedure, including laparoscopic partial nephrectomy.

Abstract translation: 薄的基于壳聚糖的材料可用于生物医学应用。 壳聚糖已经通过在壳聚糖材料中和周围施加能量以电离氮气而在氮场中进行处理。 可以采用单个或多个这样的处理。 例如，壳聚糖材料可以在使用γ-照射的氮气下，在氮气等离子体下处理或两者照射。 薄壳聚糖材料可容易地通过表面改性处理来处理，例如使用γ-照射在氮下照射，在氮等离子体下处理或两者处理。 处理后的薄壳聚糖材料可用于控制出血并在包括腹腔镜部分肾切除术在内的手术过程中协助治疗和愈合。

公开(公告)号：WO2012161852A3

公开(公告)日：2013-01-24

申请号：PCT/US2012027911

申请日：2012-03-06

Applicant: UNIV LOMA LINDA MED ,  SCHULTE REINHARD W ,  HURLEY R FORD

Inventor： SCHULTE REINHARD W ,  HURLEY R FORD

IPC: A61B6/03 ,  G12B13/00

CPC classification number: G01T7/005 ,  A61B6/032 ,  A61B6/035 ,  A61B6/4258 ,  A61B6/548 ,  A61B6/583 ,  A61B6/585 ,  G01N23/04 ,  G01N23/046 ,  G01N35/00693 ,  G01N2223/107 ,  G01T1/169 ,  G01T1/2985

Abstract: Disclosed are systems, devices and methodologies related to calibration of an ion based imaging apparatus such as a proton computed tomography scanner. In some implementations, energy degrader plates having known water-equivalent thickness (WET) values can be introduced to an ion beam to introduce different energy degradation settings. Energy detector responses to individual ions subject to such energy degradation settings can be obtained. Such responses can be normalized and correlated to water-equivalent path lengths (WEPL) of the ions based on the known WET values. Such calibration utilizing degrader plates can be performed relatively quickly and can yield accurate WEPL values that facilitate estimation of, for example, a CT image based on relative stopping power of an object.

Abstract translation: 公开了与基于离子的成像装置如质子计算机断层摄影扫描仪的校准相关的系统，装置和方法。 在一些实施方案中，具有已知水当量厚度（WET）值的能量降解板可被引入离子束以引入不同的能量降解设置。 可以获得能量检测器对受到这种能量劣化设置影响的个体离子的响应。 这些响应可以根据已知的WET值被归一化并且与离子的水当量路径长度（WEPL）相关。 利用降解板的这种校准可以相对快速地进行，并且可以产生准确的WEPL值，其有助于基于对象的相对停止功率来估计例如CT图像。

公开(公告)号：WO2008039980A3

公开(公告)日：2008-12-31

申请号：PCT/US2007079876

申请日：2007-09-28

Applicant: UNIV LOMA LINDA ,  LI FENGCHUN ,  ESCHER ALAN P

Inventor： LI FENGCHUN ,  ESCHER ALAN P

IPC: C07H21/02 ,  A01N43/04 ,  A61K31/70 ,  C07H21/04 ,  C12N15/11

CPC classification number: C12N5/0602 ,  A61K31/7088 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/531

Abstract: Mammalian host cells for use in a cell-mediated tranfection process, which contain an RNAi molecule and an expression vector for a pro-apoptotic protein. The method includes inducing apoptotic cell (AC) death in mammalian cells that contain an RNAi molecule capable of downregulating a chosen target gene. Living cells expressing the target gene are then exposed to the ACs. The ACs are processed by the living cells, and the RNAi molecule in the ACs downregulates the expression of the target gene in living cells.

Abstract translation: 用于细胞介导的转染过程的哺乳动物宿主细胞，其含有RNAi分子和促凋亡蛋白的表达载体。 该方法包括在含有能够下调所选靶基因的RNAi分子的哺乳动物细胞中诱导凋亡细胞（AC）死亡。 然后将表达靶基因的活细胞暴露于AC。 AC由活细胞处理，并且AC中的RNAi分子下调活细胞中靶基因的表达。

公开(公告)号：WO2008063369A3

公开(公告)日：2008-10-30

申请号：PCT/US2007023026

申请日：2007-11-01

Applicant: GEORGE MASON INTELLECTUAL PROP ,  UNIV LOMA LINDA ,  LIOTTA LANCE ,  ZHOU WEDIONG ,  KIRSCH WOLFF ,  ESPINA VIRGINIA ,  PETRICOIN EMANUEL ,  ROSS MARK ,  MUELLER CLAUDIUS ,  MAGAKI SHINO

Inventor： LIOTTA LANCE ,  ZHOU WEDIONG ,  KIRSCH WOLFF ,  ESPINA VIRGINIA ,  PETRICOIN EMANUEL ,  ROSS MARK ,  MUELLER CLAUDIUS ,  MAGAKI SHINO

IPC: A61K38/10

CPC classification number: G01N33/6896 ,  G01N2800/2821 ,  G01N2800/2871

Abstract: Low molecular weight (LMW) peptides have been discovered that are indicative of neurological conditions, such as Alzheimer's Disease (AD), cognitive impairment and brain microhemmorhages. Evaluating patient samples for the presence of such LMW peptides is an effective means of detecting neurological conditions and monitoring the progression of the disease. The LMW peptides are particularly useful in detecting neurological conditions during the early stages without invasive procedures.

Abstract translation: 已经发现了低分子量（LMW）肽，其指示诸如阿尔茨海默氏病（AD），认知障碍和脑微血管损伤之类的神经病学状况。 评估患者样本中存在这样的LMW肽是检测神经系统疾病和监测疾病进展的有效手段。 LMW肽特别可用于在早期阶段检测神经系统疾病而无侵入性手术。

公开(公告)号：WO2005016152B1

公开(公告)日：2005-09-15

申请号：PCT/US2004026609

申请日：2004-08-16

Applicant: UNIV LOMA LINDA MED

Inventor： ZHU YONG HUA ,  KIRSCH WOLFF M

IPC: A61B17/00 ,  A61B17/02 ,  A61B17/08

CPC classification number: A61B17/0057 ,  A61B17/00491 ,  A61B17/02 ,  A61B2017/00637 ,  A61B2017/00654

Abstract: An apparatus (430) for closing a vascular wound includes an apparatus that can be threaded over a guidewire(458) into place at or adjacent the wound. The apparatus includes a chamber(520) that encloses a hemostatic material (270) therein. When the apparatus is positioned adjacent the wound as desired, the hemostatic material is deployed from the chamber. Blood contacts the hemostatic material, and blood clotting preferably is facilitated by a hemostatic agent within the material. Thus, the vascular puncture wound is sealed by blood clot formation.

Abstract translation: 用于封闭血管伤口的装置（430）包括可以将导丝（458）穿过伤口处或邻近伤口处的位置的装置。 该装置包括在其中包围止血材料（270）的腔室（520）。 当根据需要将装置定位在伤口附近时，止血材料从腔室展开。 血液接触止血材料，血液凝固优选由材料内的止血剂促进。 因此，血管穿刺伤口被血块形成密封。

公开(公告)号：WO0212284A3

公开(公告)日：2003-08-21

申请号：PCT/US0124747

申请日：2001-08-06

Applicant: UNIV LOMA LINDA MED ,  US GOV HEALTH & HUMAN SERV

Inventor： KIRSCH WOLFF M ,  LENNART ANTON ,  KELLN WAYNE J ,  KANG DAE-KYUNG ,  LEVINE RODNEY L ,  ROUALT TRACEY A

IPC: C12N15/09 ,  C07K14/00 ,  C07K14/47 ,  C07K16/18 ,  C12P21/08 ,  C12Q1/68

CPC classification number: G01N33/6896 ,  C07K14/4702 ,  C07K16/18 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2800/04 ,  G01N2800/2821

Abstract: The present invention relates to the discovery of markers for neurodegenerative disease. More particularly, it was discovered that forms of IRP-2 protein that are unable to undergo oxidation at critical cysteine residues are diagnostic for neurodegenerative disease including, but not limited to Alzheimer's Disease (AD). Embodiments include nucleic acids that encode mutant IRP-2 proteins and fragments thereof, mutant IRP-2 proteins and fragments thereof, antibodies directed to epitopes present on mutant IRP-2 proteins and fragments thereof, methods of making these nucleic acids and polypeptides, as well as, approaches to diagnose neurodegenerative disease in animals, such as humans at risk of contracting AD or mild cognitive impairment syndrome (MCI). The level or distribution of iron in a human brain, as determined by magnetic resonance imaging (MRI), can be used to diagnose AD and/or MCI.

Abstract translation: 本发明涉及神经变性疾病标记物的发现。 更具体地，已经发现不能在关键半胱氨酸残基处经历氧化的IRP-2蛋白的形式是对神经变性疾病的诊断，包括但不限于阿尔茨海默病（AD）。 实施方案包括编码突变体IRP-2蛋白及其片段，突变体IRP-2蛋白及其片段的核酸，针对存在于突变体IRP-2蛋白及其片段上的表位的抗体，以及制备这些核酸和多肽的方法 作为诊断动物中的神经变性疾病的方法，例如患有AD或轻度认知障碍综合征（MCI）的风险的人。 通过磁共振成像（MRI）测定的人脑中铁的水平或分布可用于诊断AD和/或MCI。

公开(公告)号：WO0205719A8

公开(公告)日：2002-09-19

申请号：PCT/US0122406

申请日：2001-07-17

Applicant: UNIV LOMA LINDA MED

Inventor： KIRSCH WOLFF M ,  ZHU YONG HUA ,  TORREY ROBERT J JR

IPC: A61B17/11 ,  A61B17/115 ,  A61B

CPC classification number: A61B17/11 ,  A61B17/1152 ,  A61B2017/1103

Abstract: l'invention concerne un dispositif et une méthode améliorés permettant d'effectuer la jonction de l'urètre et de la vessie après une chirurgie. Un trocart est introduit dans l'urètre. Puis il est fixé amovible à ladite urètre afin de permettre la progression de son extrémité proximale vers la vessie. Une gaine est introduite dans la vessie et y est fixée afin d'accompagner la progression de la vessie vers l'urètre. Le système amélioré permet au personnel médical de clamper l'urètre et la vessie sans avoir recours à l'introduction de sutures laborieuses et consommatrices de temps. L'invention concerne également une méthode de jonction de l'urètre et de la vessie à l'aide du dispositif précité.

公开(公告)号：WO2006028551A3

公开(公告)日：2006-11-09

申请号：PCT/US2005022005

申请日：2005-06-22

Applicant: UNIV LOMA LINDA MED

Inventor： MOYERS MICHAEL F

IPC: A61F11/00 ,  A61N5/10 ,  G21G4/00 ,  H05H1/00

CPC classification number: A61N5/10 ,  A61B5/055 ,  A61B6/037 ,  A61B90/18 ,  A61N5/1039 ,  A61N5/1049 ,  A61N2005/1087 ,  A61N2005/1089 ,  A61N2005/1097

Abstract: Support devices and pods for the head and neck region of patients undergoing radiation therapy are provided herein. The pod generally includes a support shell shaped to generally conform to the shape of the head and neck region of the patient, a foam insert that conforms to the head and neck region of the patient, and an immobilization facemask attached directly to the shell, thereby facilitating close placement of the radiation beam delivery device to the patient and reducing any attenuation and perturbation of radiation doses directed at the patient. The components of the pod are made from materials having properties that reduce any attenuation and perturbation of prescribed radiation doses.

Abstract translation: 本文提供了用于正在接受放射治疗的患者的头部和颈部区域的支撑装置和囊。 舱体通常包括成形为大致符合患者的头部和颈部区域的形状的支撑壳体，符合患者的头部和颈部区域的泡沫插入物以及直接附接到壳体的固定面罩，由此 便于将辐射束传送装置关闭放置到患者身上并减少对患者的辐射剂量的任何衰减和扰动。 荚的组件由具有减少规定辐射剂量的任何衰减和扰动的性质的材料制成。