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公开(公告)号：WO2017134685A2
公开(公告)日：2017-08-10
申请号：PCT/IN2017/050048
申请日：2017-02-02
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED
Inventor： KADIYALA, V.S.N. Murty , RAUT, Virendra Narendra , SAVANT, Pratit , SHETH, Chetana Kaushal , CHAUDHARI, Umesh Vishnu , RATHOD, Rajendrasinh Jashvantsinh , BHATT, Tushar Bhupendrabhai , CHITTURI, Trinadha Rao
IPC: C07D487/02
CPC classification number: C07D487/04
Abstract: The present invention relates to novel hydrazino compounds of Formula (I) as Bruton tyrosine kinase inhibitors, process of preparation thereof, and to the use of the compounds in the preparation of pharmaceutical compositions for the therapeutic treatment of disorders involving mediation of Bruton tyrosine kinase in humans.
Abstract translation: 本发明涉及作为布鲁顿酪氨酸激酶抑制剂的式（I）的新型肼基化合物，其制备方法以及该化合物在制备用于治疗 涉及人体中布鲁顿酪氨酸激酶介导的疾病。
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公开(公告)号：WO2017168454A3
公开(公告)日：2017-10-05
申请号：PCT/IN2017/050127
申请日：2017-04-03
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED
Inventor： SENGUPTA, Prabal , KADIYALA, V.S.N. Murty , DESAI, Dipali Manubhai , CHIMANWALA, Sabbirhusen Yusufbhai , JARAG, Tushar Mukund , SHETH, Gaurav Sanjivkumar , CHITTURI, Trinadha Rao
IPC: C07D417/12
Abstract: The present invention relates to novel compounds of Formula I as Bruton tyrosine kinase inhibitors, process of preparation thereof, and to the use of the compounds in the preparation of pharmaceutical compositions for the therapeutic treatment of disorders involving mediation of Bruton tyrosine kinase in humans.
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公开(公告)号：WO2017168454A2
公开(公告)日：2017-10-05
申请号：PCT/IN2017/050127
申请日：2017-04-03
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED
Inventor： SENGUPTA, Prabal , KADIYALA, V.S.N. Murty , DESAI, Dipali Manubhai , CHIMANWALA, Sabbirhusen Yusufbhai , JARAG, Tushar Mukund , SHETH, Gaurav Sanjivkumar , CHITTURI, Trinadha Rao
CPC classification number: C07D417/12 , C07D417/14
Abstract: The present invention relates to novel compounds of Formula I as Bruton tyrosine kinase inhibitors, process of preparation thereof, and to the use of the compounds in the preparation 5 of pharmaceutical compositions for the therapeutic treatment of disorders involving mediation of Bruton tyrosine kinase in humans.
Abstract translation: 本发明涉及作为布鲁顿酪氨酸激酶抑制剂的式I的新化合物，其制备方法，以及涉及所述化合物在用于治疗性治疗涉及病症的药物组合物的制备5中的用途 Bruton酪氨酸激酶在人体内的介导。
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公开(公告)号：WO2021038540A1
公开(公告)日：2021-03-04
申请号：PCT/IB2020/058106
申请日：2020-08-31
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED
Inventor： RATHOD, Rajendrasinh Jashvantsinh , RAUT, Virendra Narendra , ΒΗΑΤΤ, Tushar Bhupendrabhai , SAVANT, Pratit Viram , JOSHI, Kiritkumar Parmeshkumar , JARAG, Tushar Mukund , CHIMANWALA, Sabbirhusen Yusufbhai , SENGUPTA, Prabal , KADIYALA, V.S.N. Murty , CHITTURI, Trinadha Rao
IPC: C07D487/04 , C07D473/34 , C07D239/48 , A61K31/505 , A61K31/519 , A61K31/522 , A61P35/00
Abstract: The present invention relates to novel cycloalkylidene carboxylic acids and derivatives thereof useful as Bruton tyrosine kinase (BTK) inhibitors. The present disclosure also relates to processes for their preparation, pharmaceutical compositions containing one or more such compounds, and to the use of such compounds and pharmaceutical compositions for the treatment of disorders involving mediation of BTK in humans (Formula I).
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公开(公告)号：WO2021014386A1
公开(公告)日：2021-01-28
申请号：PCT/IB2020/056914
申请日：2020-07-22
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED
Inventor： PAL, Ranjan Kumar , SAMANTA, Biswajit , ARADHYE, Jayraj Dilipbhai , PATHAK, Sandeep Pankajkumar , PRAJAPATI, Kaushik Dhanjibhai , PANCHAL, Bhavesh Mohanbhai , CHITTURI, Trinadha Rao
IPC: A61P35/00 , C07D405/10 , A61K31/397
Abstract: A selective estrogen receptor degrader (SERD), a compound 3-(3,5-difluorophenyl)-2-[4-[( E )-3-[3-(fluoromethyl)azetidin-1-yl]prop-1-enyl]phenyl]-4-methyl-2 H -chromen-7-ol, and its S enantiomer, (2S)-3-(3,5-difluorophenyl)-2-[4-[( E )-3-[3-(fluoromethyl)azetidin-1-yl]prop-1-enyl]phenyl]-4-methyl-2 H -chromen-7-ol, or pharmaceutically acceptable salts thereof. Also provided are processes for their preparation. Also provided for is the use of these compounds for the treatment of diseases which are related to modulation of estrogen receptors, such as ER-positive breast cancer.
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Patent Agency Ranking
公开(公告)号：WO2017072792A1
公开(公告)日：2017-05-04
申请号：PCT/IN2016/050364
申请日：2016-10-26
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED
Inventor： PAL, Ranjan Kumar , SEDANI, Amit Pravinbhai , PRAJAPATI, Kaushikkumar Dhanjibhai , RANA, Dijixa Pinakin , PATHAK, Sandeep Pankajbhai , DESAI, Japan Nitinkumar , ARADHYE, Jayraj Dilipbhai , PANCHAL, Bhavesh Mohanbhai , GHOSH, Indraneel , CHITTURI, Trinadha Rao
IPC: C07D311/60 , C07D215/12 , C07D335/06
CPC classification number: C07D215/12 , C07D311/60 , C07D335/06 , C07D405/10
Abstract: The present invention provides novel heterocyclic compounds as anticancer agents, especially as estrogen receptor (ER) antagonists/ degraders and process for their preparation.
Abstract translation: 本发明提供新的杂环化合物作为抗癌剂，特别是作为雌激素受体（ER）拮抗剂/降解剂及其制备方法。
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公开(公告)号：WO2021074898A1
公开(公告)日：2021-04-22
申请号：PCT/IB2020/059785
申请日：2020-10-16
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED
Inventor： SHETH, Gaurav Sanjivkumar , CHIMANWALA, Sabbirhusen Yusufbhai , JARAG, Tushar Mukund , HAMPIHOLI, Aishwarya , MAITY, Saikat , SENGUPTA, Prabal , QURESHI, Gulamnizami Abdulsattar , CHAUDHARI, Umesh Vishnu , VENKAT, Raj Gopal , KADIYALA, V.s.n. Murty , KALAPATAPU, Sairam Vvm , JAIN, Vaibhav , CHITTURI, Trinadha Rao
IPC: C07D401/04 , C07D295/096 , A61K31/496 , A61K31/495 , A61P35/00
Abstract: The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans.
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公开(公告)号：WO2021038540A
公开(公告)日：2021-03-04
申请号：PCT/IB2020/058106
申请日：2020-08-31
Inventor： RATHOD, Rajendrasinh Jashvantsinh , RAUT, Virendra Narendra , ΒΗΑΤΤ, Tushar Bhupendrabhai , SAVANT, Pratit Viram , JOSHI, Kiritkumar Parmeshkumar , JARAG, Tushar Mukund , CHIMANWALA, Sabbirhusen Yusufbhai , SENGUPTA, Prabal , KADIYALA, V.S.N. Murty , CHITTURI, Trinadha Rao
IPC: C07D487/04 , C07D473/34 , C07D239/48 , A61K31/505 , A61K31/519 , A61K31/522 , A61P35/00
Abstract: The present invention relates to novel cycloalkylidene carboxylic acids and derivatives thereof useful as Bruton tyrosine kinase (BTK) inhibitors. The present disclosure also relates to processes for their preparation, pharmaceutical compositions containing one or more such compounds, and to the use of such compounds and pharmaceutical compositions for the treatment of disorders involving mediation of BTK in humans (Formula I).
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公开(公告)号：WO2018002958A1
公开(公告)日：2018-01-04
申请号：PCT/IN2017/050268
申请日：2017-06-30
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED
Inventor： KADIYALA, V.S.N. Murty , DESAI, Dipali Manubhai , RAUT, Virendra Narendra , SAVANT, Pratit Viram , JOSHI, Kiritkumar Parmeshkumar , CHAUDHARI, Umesh Vishnu , RATHOD, Rajendrasinh Jashvantsinh , BHATT, Tushar Bhupendrabhai , CHITTURI, Trinadha Rao
IPC: C07D487/04 , A61P35/00 , A61K31/519 , A61K31/52 , A61K31/522
Abstract: The present invention relates to novel hydrazide containing compounds as Bruton tyrosine kinase inhibitors, process of preparation thereof, and to the use of the compounds in the preparation of pharmaceutical compositions for the therapeutic treatment of disorders involving mediation of Bruton tyrosine kinase in humans.
Abstract translation: 本发明涉及作为布鲁顿酪氨酸激酶抑制剂的含有新型酰肼化合物，其制备方法，以及涉及这些化合物在制备用于治疗性治疗涉及调节 人类中的布鲁顿酪氨酸激酶。
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公开(公告)号：WO2017134685A3
公开(公告)日：2017-08-10
申请号：PCT/IN2017/050048
申请日：2017-02-02
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED
Inventor： KADIYALA, V.S.N. Murty , RAUT, Virendra Narendra , SAVANT, Pratit , SHETH, Chetana Kaushal , CHAUDHARI, Umesh Vishnu , RATHOD, Rajendrasinh Jashvantsinh , BHATT, Tushar Bhupendrabhai , CHITTURI, Trinadha Rao
IPC: C07D487/02
Abstract: The present invention relates to novel hydrazino compounds of Formula (I) as Bruton tyrosine kinase inhibitors, process of preparation thereof, and to the use of the compounds in the preparation of pharmaceutical compositions for the therapeutic treatment of disorders involving mediation of Bruton tyrosine kinase in humans.
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