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    AN IRON SEQUESTERING ANTIMICROBIAL COMPOSITION
    95.
    发明申请
    AN IRON SEQUESTERING ANTIMICROBIAL COMPOSITION 审中-公开
    铁核苷酸抗体组成

    公开(公告)号：WO2005122729A2

    公开(公告)日：2005-12-29

    申请号：PCT/US2005/020444

    申请日：2005-06-09

    申请人： EASTMAN KODAK COMPANY ,  BRINGLEY, Joseph, Francis ,  LERAT, Yannick, J.

    发明人： BRINGLEY, Joseph, Francis ,  LERAT, Yannick, J.

    IPC分类号： A01N25/10 ,  A01N33/12 ,  A01N55/00 ,  A01N59/16 ,  A61K9/16

    CPC分类号： A01N25/10 ,  A01N33/12 ,  A01N55/00 ,  A01N59/16 ,  A61K9/5115 ,  A61K9/7007 ,  A01N37/44

    摘要： This invention relates to a composition of matter comprising an immobilized metal-ion sequestrant/antimicrobial comprising a metal-ion sequestrant that has a high stability constant for a target metal ion and that has attached thereto an antimicrobial metal-ion, wherein the stability constant of the metal-ion sequestrant for the antimicrobial metal-ion is less than the stability constant of the metal-ion sequestrant for the target metal-ion. It further relates to articles comprising said composition and to a method of removing target metal-ions from an environment and releasing antimicrobial metal ions into the environment comprising contacting the environment with said composition

    摘要翻译： 本发明涉及一种物质组合物，其包含固定化的金属离子螯合剂/抗微生物剂，其包含对靶金属离子具有高稳定性常数并且附着有抗微生物金属离子的金属离子螯合剂，其中稳定常数 用于抗微生物金属离子的金属离子螯合剂小于目标金属离子的金属离子螯合剂的稳定常数。 它还涉及包含所述组合物的制品和从环境中除去目标金属离子并将抗微生物金属离子释放到环境中的方法，包括使环境与所述组合物接触

    BIOMIMETIC HIERARCHIES USING FUNCTIONALIZED NANOPARTICLES AS BUILDING BLOCKS
    96.
    发明申请
    BIOMIMETIC HIERARCHIES USING FUNCTIONALIZED NANOPARTICLES AS BUILDING BLOCKS 审中-公开
    使用功能化纳米颗粒作为建筑块的生物分层

    公开(公告)号：WO2004085998A3

    公开(公告)日：2005-12-29

    申请号：PCT/US2004009192

    申请日：2004-03-26

    申请人： PHILADELPHIA CHILDREN HOSPITAL ,  UNIV PENNSYLVANIA ,  SHASTRI VENKATRAM P ,  CHEN I-WEI ,  ZNIDARSIC WILLIAM

    发明人： SHASTRI VENKATRAM P ,  CHEN I-WEI ,  ZNIDARSIC WILLIAM

    IPC分类号： A61K9/00 ,  A61K33/06 ,  A61K38/17 ,  G01N20060101 ,  A61K7/00

    CPC分类号： A61K33/00 ,  A61K9/06 ,  A61K9/5115 ,  A61K9/5138 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/185 ,  A61K38/1858 ,  A61K38/1875 ,  A61K38/30

    摘要： The invention provides a three-dimensional construct including a polymeric matrix and a nanoparticle as shown in Fig. 1 having a diameter of about 5 nm to about 10 microns, wherein the nanoparticle is (a) coated with at least two monomolecular layers each carrying biological information and (b) dispersed in the polymeric matrix at a density of at least 0.01 vol%. The invention further provides a method of presenting biological information to a cell or a tissue and thereby affecting at least one parameter of the cell or the tissue, the method involves providing the three-dimensional construct and contacting it with the cell or the tissue to present the biological information and thereby affecting at least one characteristic of the cell or the tissue. In certain embodiments, the diameter, the biological information and the density are selected to affect at least one characteristic of the cell or the tissue.

    摘要翻译： 本发明提供了包括如图1所示的聚合物基质和纳米颗粒的三维结构。 1，其直径为约5nm至约10微米，其中所述纳米颗粒（a）涂覆有至少两个携带生物信息的单分子层，和（b）以至少0.01vol％的密度分散在所述聚合物基质中。 本发明还提供了向细胞或组织呈递生物学信息从而影响细胞或组织的至少一个参数的方法，所述方法包括提供三维构建体并使其与细胞或组织接触以呈现 生物信息，从而影响细胞或组织的至少一种特征。 在某些实施方案中，选择直径，生物信息和密度以影响细胞或组织的至少一种特征。

    LAYERED SILICATE NANOPARTICLES FOR CONTROLLED DELIVERY OF THERAPEUTIC AGENTS FROM MEDICAL ARTICLES
    97.
    发明申请
    LAYERED SILICATE NANOPARTICLES FOR CONTROLLED DELIVERY OF THERAPEUTIC AGENTS FROM MEDICAL ARTICLES 审中-公开
    用于从医疗文章控制输送治疗药物的层状硅酸盐纳米颗粒

    公开(公告)号：WO2005079754A2

    公开(公告)日：2005-09-01

    申请号：PCT/US2005004585

    申请日：2005-02-11

    申请人： BOSTON SCIENT SCIMED INC ,  ZHONG SHENG-PING SAMUEL

    发明人： ZHONG SHENG-PING SAMUEL

    IPC分类号： A61K9/51 ,  A61L29/12 ,  A61L29/16 ,  A61L31/12 ,  A61L31/16 ,  A61K9/00

    CPC分类号： A61K9/5115 ,  A61K9/5161 ,  A61L24/0057 ,  A61L29/126 ,  A61L29/16 ,  A61L31/128 ,  A61L31/16 ,  A61L2300/624

    摘要： Medical articles (for instance, a drug delivery patch or an implantable or insertable medical device) are provided that comprise a release region, which in turn comprises (a) polymeric carrier comprising a polymer (for instance, a hydrophobic polymer) and (b) drug loaded nanoparticles, which are dispersed within the polymeric carrier. The drug loaded nanoparticles comprise a layered silicate material (for instance synthetic or naturally occurring smectite clay nanoparticles) and a therapeutic agent (for instance, a hydrophilic or hydrophobic therapeutic agent). Also described are methods of releasing a therapeutic agent to a patient using such medical articles, and methods of making such medical articles.

    摘要翻译： 提供包括释放区域的医疗制品（例如，药物递送贴剂或可植入或可插入的医疗装置），释放区域又包含（a）包含聚合物（例如，疏水性聚合物）的聚合物载体和（b） 药物负载的纳米颗粒，其分散在聚合物载体内。 负载药物的纳米颗粒包含层状硅酸盐材料（例如合成或天然存在的蒙脱石粘土纳米颗粒）和治疗剂（例如，亲水或疏水治疗剂）。 还描述了使用这种医疗制品将治疗剂释放到患者的方法，以及制造这种医疗用品的方法。

    INTRAOCULAR DELIVERY COMPOSITIONS AND METHODS
    98.
    发明申请
    INTRAOCULAR DELIVERY COMPOSITIONS AND METHODS 审中-公开
    内分泌物组合物和方法

    公开(公告)号：WO2004050065A1

    公开(公告)日：2004-06-17

    申请号：PCT/US2003/036335

    申请日：2003-11-13

    申请人： BIOSANTE PHARMACEUTICALS, INC. ,  CHU, Teh-Ching ,  POTTER, David, E.

    发明人： CHU, Teh-Ching ,  POTTER, David, E. ,  BELL, Steve, J., D. ,  HE, Qing

    IPC分类号： A61K9/16

    CPC分类号： A61K9/5115 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/0048 ,  A61K9/1611 ,  A61K9/1676 ,  A61K9/51 ,  A61K9/5161 ,  A61K9/5192

    摘要： The present invention relates to intraocular drug delivery for treating ocular diseases. Particularly, the invention relates to particles useful for the delivery of certain pharmacologically active agents to treat ocular diseases. The particles contain calcium phosphate core particles, particularly nanoparticles, as delivery agents and adjuvants. The invention also relates to methods of making such particles and to methods of treating ocular disease by delivery of a therapeutic drug to an ocular surface using the particles of this invention. The invention further relates to methods of regulating ocular pressure using certain formulations according to the present invention.

    摘要翻译： 本发明涉及用于治疗眼部疾病的眼内药物递送。 特别地，本发明涉及可用于递送某些药理活性剂以治疗眼部疾病的颗粒。 颗粒含有磷酸钙核心颗粒，特别是纳米颗粒，作为递送剂和助剂。 本发明还涉及制备这种颗粒的方法以及使用本发明的颗粒将治疗药物递送至眼表面来治疗眼部疾病的方法。 本发明还涉及使用根据本发明的某些制剂调节眼压的方法。

    NANOPARTICULATE COMPOSITIONS COMPRISING INORGANIC CORES
    99.
    发明申请
    NANOPARTICULATE COMPOSITIONS COMPRISING INORGANIC CORES 审中-公开
    包含无机碳的纳米颗粒组合物

    公开(公告)号：WO03032959A9

    公开(公告)日：2004-05-13

    申请号：PCT/US0232619

    申请日：2002-10-15

    申请人： BOSCH WILLIAM H ,  COOPER EUGENE R ,  MATIJEVIC EGON ,  RYDE NIELS P

    发明人： BOSCH WILLIAM H ,  COOPER EUGENE R ,  MATIJEVIC EGON ,  RYDE NIELS P

    IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K9/51

    CPC分类号： A61K9/5115 ,  A61K9/143 ,  A61K9/1676

    摘要： The invention is directed to nanoparticulate compositions comprising inorganic cores and methods of making and using such compositions. The nonoparticulate compositions comprise at least one type of organic core having adsorbed or bound to the surface thereof at least one type of active molecule. The compositions exhibit superior properties as compared to conventional micronized and nanoparticulate active agent formulations.

    摘要翻译： 本发明涉及包含无机芯的纳米颗粒组合物以及制备和使用这些组合物的方法。 非颗粒组合物包含至少一种类型的有机核心，其吸附或结合至少一种活性分子的表面。 与常规的微粉化和纳米颗粒活性剂配方相比，组合物表现出优异的性能。

    OPHTHALMIC DRUG DELIVERY SYSTEM
    100.
    发明申请
    OPHTHALMIC DRUG DELIVERY SYSTEM 审中-公开
    OPHTHALMIC药物递送系统

    公开(公告)号：WO2003103549A1

    公开(公告)日：2003-12-18

    申请号：PCT/US2003/017736

    申请日：2003-06-05

    申请人： UNIVERSITY OF FLORIDA ,  CHAUHAN, Anuj ,  GULSEN, Derya

    发明人： CHAUHAN, Anuj ,  GULSEN, Derya

    IPC分类号： A61F13/00

    CPC分类号： A61K9/5115 ,  A61F2250/0067 ,  A61K9/0048 ,  A61K9/1075 ,  A61K9/5138 ,  A61K9/5192 ,  A61K31/41 ,  G02C7/04

    摘要： A drug delivery system comprising a contact lens having dispersed therein as nanoparticles having a particle size less than about 50 nm, an ophthalmic drug nanoencapsulated in a material from which said ophthalmic drug is capable of diffusion into and migration through said contact lens and into the post-lens tear film when said contact lens is placed on the eye.

    摘要翻译： 一种药物递送系统，其包含其中分散有粒径小于约50nm的纳米颗粒的隐形眼镜，纳米胶囊包封在所述眼药物能够从其中扩散进入并通过所述隐形眼镜迁移到所述柱中的材料中的眼药 当所述隐形眼镜放置在眼睛上时，将其撕开。