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    RAPID THERMAL CYCLING FOR SAMPLE ANALYSES AND PROCESSING
    91.
    发明申请
    RAPID THERMAL CYCLING FOR SAMPLE ANALYSES AND PROCESSING 审中-公开
    快速热循环用于样品分析和处理

    公开(公告)号：WO2017213586A1

    公开(公告)日：2017-12-14

    申请号：PCT/SG2017/050285

    申请日：2017-06-06

    Applicant: STAR ARRAY PTE LTD

    Inventor： GONG, Haiqing ,  WEN, Yan ,  ZENG, Xudong

    IPC: B01L7/02 ,  B01L7/00 ,  B01L9/06 ,  C12Q1/68

    CPC classification number: B01L9/06 ,  B01F11/0005 ,  B01L3/5082 ,  B01L7/02 ,  B01L7/5255 ,  B01L2300/0618 ,  B01L2300/0858 ,  B01L2400/065 ,  C12Q1/686 ,  G01N35/04 ,  G01N2035/0401 ,  G01N2035/0412 ,  G01N2035/0482

    Abstract: Apparatus for thermal processing of nucleic acid in a thermal profile is provided. The apparatus employs a reactor holder for holding reactors to accommodate reaction material containing nucleic acid. The apparatus comprises: at least two baths separated by thermally insulating partition plate(s) where bath mediums are each maintainable at a predetermined temperature; and a transfer means for allowing the reactors to change position once or plurality of times between any two adjacent baths by selectively opening the partition plate(s) and without lifting the reactors out of the baths.

    Abstract translation: 提供了用于热分布中的核酸热加工的设备。 该设备采用反应器保持器来保持反应器以容纳含有核酸的反应材料。 该设备包括：至少两个浴槽，通过隔热隔板隔开，其中浴室介质各自可维持在预定温度; 以及一个传送装置，用于通过选择性地打开隔板并且不将反应器从浴槽中提出来，允许反应器在任何两个相邻浴槽之间一次或多次改变位置。

    METHOD OF EVAPORATING LIQUID IN MICRO-CAPILLARIES
    92.
    发明申请
    METHOD OF EVAPORATING LIQUID IN MICRO-CAPILLARIES 审中-公开
    微型液体蒸发方法

    公开(公告)号：WO2016190817A1

    公开(公告)日：2016-12-01

    申请号：PCT/SG2016/050248

    申请日：2016-05-26

    Applicant: JN MEDSYS PTE LTD

    Inventor： NG, Kian Kok Johnson ,  TEU, Koon Kiat ,  LING, Mei Tze Belinda ,  SIM, Jia Wen

    IPC: G01N1/28 ,  G01N1/40 ,  B01L3/00

    CPC classification number: G01N1/40 ,  B01L3/5082 ,  B01L3/50857 ,  B01L2200/06 ,  B01L2200/141 ,  B01L2200/16 ,  B01L2300/043 ,  B01L2300/0832 ,  B01L2300/0838 ,  B01L2400/0406 ,  B01L2400/049 ,  C12Q1/6848 ,  C12Q1/686

    Abstract: There is provided a method of charging an array of micro-capillaries, the micro-capillaries having at least one end that is open for fluid communication, the method comprising the steps of: (a) filling the array of micro-capillaries with an assay liquid; (b) controllably evaporating at least some of the assay liquid to remove it from the microcapillary and creating a void space in each of the capillaries between the assay liquid and the open end; and (c) filling the void space with a liquid that is immiscible with said assay liquid. There is also provided a use of the disclosed method for conducting a polymerase chain reaction and a device for charging an array of micro-capillaries.

    Abstract translation: 提供了一种对微毛细管阵列进行充电的方法，所述微毛细管具有至少一个开放的用于流体连通的端部，所述方法包括以下步骤：（a）用测定法填充微毛细管阵列 液体; （b）可控地蒸发至少一些分析液体以将其从微毛细管中除去并在测定液体和开放端之间的每个毛细管中产生空隙空间; 和（c）用与所述测定液体不混溶的液体填充空隙空间。 还提供了用于进行聚合酶链反应的所公开的方法的使用和用于对微毛细管阵列进行充电的装置。

    METHOD FOR PRODUCING A MINI-VIAL WITH A REDUCED NUMBER OF COMPONENTS AND THE MINI-VIAL THUS OBTAINED
    95.
    发明申请
    METHOD FOR PRODUCING A MINI-VIAL WITH A REDUCED NUMBER OF COMPONENTS AND THE MINI-VIAL THUS OBTAINED 审中-公开
    用于生产具有减少数量的组件和获得的MINI-VIAL的MINI-VIAL的方法

    公开(公告)号：WO2015036909A3

    公开(公告)日：2016-07-21

    申请号：PCT/IB2014064306

    申请日：2014-09-08

    Applicant: GVS SPA

    Inventor： SCAGLIARINI MASSIMO ,  PANDOLFO WILLIAM

    IPC: B01L3/00

    CPC classification number: B01L3/502 ,  B01L3/502707 ,  B01L3/508 ,  B01L3/5082 ,  B01L2200/12 ,  B01L2300/042 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2400/0478

    Abstract: A method for producing a mini-vial (1) of the type comprising a tubular container or vial (2), closed at a first end (5) and open at its second end (6) and capable of containing a product in fluid phase, a plunger (3) sealingly movable in said vial (2) through said second end (6) and having an internal cavity (13) capable of receiving the fluid from said vial (2), the plunger (3) having a first end (9) on which is placed a sealing cap and a second end (11) movably slidable in the vial (2) and at which is located a membrane filter (16), said plunger (3) and vial (2) being obtained by moulding; the plunger (3) being envisaged as overmoulded onto the filter located at its second end, said membrane filter forming a single body with said plunger.

    Abstract translation: 一种用于生产包括管状容器或小瓶（2）的微型小瓶（1）的方法，其在第一端（5）处封闭并且在其第二端（6）处开放并且能够容纳流体相 ，柱塞（3），其通过所述第二端（6）可密封地在所述小瓶（2）中移动并且具有能够从所述小瓶（2）接收流体的内腔（13），所述柱塞（3）具有第一端 （9），其上放置有密封帽和可移动地在所述小瓶（2）中滑动的第二端（11），并且位于所述膜过滤器（16）处，所述柱塞（3）和小瓶（2）由 成型; 柱塞（3）被设想为包覆成型在位于其第二端的过滤器上，所述膜过滤器与所述柱塞形成单体。

    THAWING METHODS AND APPARATUS
    96.
    发明申请
    THAWING METHODS AND APPARATUS 审中-公开
    THAWING方法和装置

    公开(公告)号：WO2016087873A2

    公开(公告)日：2016-06-09

    申请号：PCT/GB2015053720

    申请日：2015-12-04

    Applicant: MILNE STUART ,  LAMB STEPHEN ,  ASYMPTOTE LTD

    Inventor： MILNE STUART ,  LAMB STEPHEN ,  CREASEY CHRISTOPHER ,  NANCEKIEVILL ALEX ,  RUTLEDGE RUPERT

    IPC: G01N1/44 ,  B01L7/00

    CPC classification number: G01N1/44 ,  A01N1/0242 ,  A01N1/0284 ,  B01L3/5082 ,  B01L7/54 ,  B01L2300/1827

    Abstract: The invention provides a method of thawing a sample comprised in a container, the method comprising the steps of: a) calculating an agitation program as a function of either or both of the sample volume and the type of the container, and the ice fraction in the sample, and optionally the thermal conductivity of the sample container; b) agitating said sample according to the program to agitate at least one region of the sample; and c) changing the agitation program applied to at least one region of the sample in response to changes in the sample volume and/or sample ice fraction. The invention further provides a method of reducing shearing to cells during a method of agitation, and methods for thawing a sample wherein a sample container is differentially heated. An apparatus for use in the methods is also provided, as is an apparatus for thawing and/or cooling a sample which comprises a resilient vessel wall.

    Abstract translation: 本发明提供一种解冻包含在容器中的样品的方法，该方法包括以下步骤：a）根据样品体积和容器类型中的任一个或两者计算搅动程序，并且将冰分数 样品和任选的样品容器的热导率; b）根据程序搅动所述样品以搅拌样品的至少一个区域; 以及c）响应于样品体积和/或样品冰分数的变化而改变施加到样品的至少一个区域的搅动程序。 本发明还提供了一种在搅拌方法中减少对细胞的剪切的方法，以及用于解冻样品的方法，其中样品容器被差异加热。 还提供了用于该方法的装置，以及用于解冻和/或冷却包括弹性容器壁的样品的装置。

    SYSTEM AND METHOD FOR COLLECTING A SAMPLE OF NUCLEIC ACID
    97.
    发明申请
    SYSTEM AND METHOD FOR COLLECTING A SAMPLE OF NUCLEIC ACID 审中-公开
    用于收集核酸样品的系统和方法

    公开(公告)号：WO2016081860A1

    公开(公告)日：2016-05-26

    申请号：PCT/US2015/061917

    申请日：2015-11-20

    Applicant: OCCAM BIOLABS, INC.

    Inventor： QIAN, Mingwei

    IPC: B01L3/14 ,  C12M1/12 ,  G01N1/34

    CPC classification number: C12N15/1017 ,  B01L3/502 ,  B01L3/5082 ,  B01L2200/026 ,  B01L2200/0631 ,  B01L2200/0689 ,  B01L2200/185 ,  B01L2300/042 ,  B01L2300/046 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2300/123 ,  C12Q1/6806 ,  G01N1/40 ,  G01N2001/005

    Abstract: A system for collecting biomolecules comprising an extractor assembly comprising a top cap, an extractor core, an extractor core adaptor, an extractor body having an internal volume, and a bottom cap ring. The top cap comprises a sample connection port and is configured to be secured to the extractor body by the bottom cap ring. The extractor core is adapted to be removably attached to a connection interface of the top cap and contains a substrate for collecting the biomolecules. The extractor core adaptor has an upstream open end for mating with the downstream end of the extractor core and a downstream protrusion configured to project through an opening in the extractor body. Methods for using the system to collect samples for transport and further processing to detect disease are also disclosed.

    Abstract translation: 一种用于收集生物分子的系统，其包括提取器组件，该提取器组件包括顶盖，提取器芯，提取器芯适配器，具有内部容积的提取器主体和底盖环。 顶盖包括样品连接端口，并且被配置为通过底盖环固定到提取器主体。 提取器芯适于可移除地附接到顶盖的连接界面并且包含用于收集生物分子的基板。 提取器芯适配器具有用于与提取器芯的下游端配合的上游开口端和配置成突出通过提取器主体中的开口的下游突起。 还公开了使用该系统收集样品进行运输和进一步处理以检测疾病的方法。

    NUCLEIC ACID EXTRACTION USING ORGANIC SOLVENTS TO REMOVE INHIBITORS
    98.
    发明申请
    NUCLEIC ACID EXTRACTION USING ORGANIC SOLVENTS TO REMOVE INHIBITORS 审中-公开
    使用有机溶剂除去抑制剂的核酸提取物

    公开(公告)号：WO2016037099A1

    公开(公告)日：2016-03-10

    申请号：PCT/US2015/048628

    申请日：2015-09-04

    Applicant: TECHLAB INC.

    Inventor： CHEN, Li ,  STEVENS, Jodie ,  SCHWAB, Kristen ,  BOONE, James ,  LYERLY, David

    IPC: C12Q1/68

    CPC classification number: C12N15/1017 ,  B01L3/5082 ,  B01L2300/042 ,  B01L2300/0681 ,  B01L2400/0481 ,  C12N15/1003 ,  C12Q1/6806 ,  G01N1/12 ,  G01N1/20 ,  C12Q2527/101 ,  C12Q2527/125

    Abstract: Nucleic acid amplification tests have been widely used in clinical laboratories. Nucleic acid extraction from biological materials is challenging because different unfavorable substances may co-extract and inhibit downstream applications. The present claimed invention relates to a composition of and a method for treating the sample prior, during or post extraction of nucleic acid. More specifically, the claimed invention relates to a composition of and a method for using low concentrations of common organic solvents to remove inhibitors of nucleic acid amplification. The present claimed invention can be used for extracting nucleic acids (DNA/RNA) from bacteria, viruses, parasites, and other biological materials or matrices, including but not limit to, stool samples, body fluids, plants and cultures. The method is rapid, low-cost, and easy to use in a laboratory setting. The nucleic acid extracted in accordance with the claimed invention can be used for nucleic acid amplification reactions.

    Abstract translation: 核酸扩增试验已广泛应用于临床实验室。 从生物材料中提取核酸是具有挑战性的，因为不同的不利物质可以共同提取和抑制下游应用。 本发明涉及在提取核酸之前，期间或之后处理样品的组合物和方法。 更具体地，要求保护的发明涉及使用低浓度的常见有机溶剂以除去核酸扩增抑制剂的组合物和方法。 本发明可用于从细菌，病毒，寄生虫和其他生物材料或基质中提取核酸（DNA / RNA），包括但不限于粪便样品，体液，植物和培养物。 该方法在实验室环境中快速，低成本，易于使用。 根据要求保护的发明提取的核酸可用于核酸扩增反应。

    SAMPLE COLLECTION UNIT
    99.
    发明申请
    SAMPLE COLLECTION UNIT 审中-公开
    样品收集单元

    公开(公告)号：WO2015164113A1

    公开(公告)日：2015-10-29

    申请号：PCT/US2015/025558

    申请日：2015-04-13

    Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.

    Inventor： ZERCHER, Amy ,  GOLDSBURG, Jennifer

    IPC: B01L3/00 ,  G01N21/00 ,  G01N21/29

    CPC classification number: B01L3/5023 ,  A61B10/007 ,  A61B2010/0006 ,  B01L3/5082 ,  B01L9/52 ,  B01L2300/0825 ,  B01L2300/0832 ,  B01L2300/0854 ,  G01N21/293 ,  G01N21/78

    Abstract: An insert for a sample collection tube includes a generally hollow tubular body insertable into the sample collection tube. The tubular body is open at least at one end. The tubular body of the insert has an internal cross-sectional area dimensioned to accommodate a width of test strip which comprises a plurality of test areas arranged along its length. The internal cross-sectional area of the tubular body is further dimensioned such that volume of 2.5mL of a liquid sample inside the insert occupies a height which is at least sufficient to wet all of the test areas of the test strip when the strip is inserted lengthwise into insert containing the liquid sample.

    Abstract translation: 用于样品收集管的插入件包括可插入样品收集管中的大致中空的管状体。 管状体至少在一端开口。 插入件的管状体具有内部横截面积，该内部横截面面积的尺寸适于容纳测试条的宽度，该测试条包括沿其长度布置的多个测试区域。 管状体的内部横截面积进一步确定尺寸，使得当插入条带时，插入物内2.5mL的液体样品的体积至少足以使测试条的所有测试区域湿润 纵向插入含有液体样品的插入物。

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